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The map label for this gene is wecC [H]

Identifier: 119944209

GI number: 119944209

Start: 544307

End: 545557

Strand: Reverse

Name: wecC [H]

Synonym: Ping_0430

Alternate gene names: 119944209

Gene position: 545557-544307 (Counterclockwise)

Preceding gene: 119944210

Following gene: 119944208

Centisome position: 11.97

GC content: 42.85

Gene sequence:

>1251_bases
ATGGATTTTGAAAAAGTATCCGTCATCGGGCTTGGCTATATCGGCCTGCCTACAGCGGCAATTATTGCTTCGCGAGGCAT
GACTGTGATTGGTGTTGAAGTGAACCAAAATGCAGTAGATCTCATTAACGCGGGGAAAATTCATATCGTCGAGCCAGATC
TCGATATTGTCGTTCGCAGTGTTGTTTCCACTGGAAATTTACGCGCAGTGACTATTGCAGAGCCTGCTAATGTATTTATG
ATTGCCGTGCCAACGCCTTTTATCCATCGCGATGATGATAGCCACCAACCTGACCTCAGTTATATTGAGTCTGCTGCTAA
CACTATCGCGCCAGTACTTGAAAAAGGTAATTTAGTCATTCTTGAATCGACATCCCCGGTGGGAACCACTGAAAAACTGG
CAACTTGGTTAGCGAAAGCACGCCCTGATCTCTCATTTCCTCAAGATAAAGGGAATGCTGCAGATATCAATATCGCACAT
TGCCCTGAACGTGTATTGCCCGGTTATGTTCTACAAGAATTAGTGTCTAATGATCGCGTCATCGGCGGCATGAGCAAAAC
CTGTAGCGAGAAAGCCGTTGCTCTTTACCGCACATTTGTGCGCGGTGAATGTATCATCACCAATGCACGCACAGCAGAAA
TGGCAAAACTGACTGAAAATTCATTCCGTGACGTCAATATTGCATTTGCAAATGAATTATCTATTATTTGTGATAAATTA
AAAATAAATGTATGGGAATTAATCAAACTGGCCAATCGCCACCCCCGCGTTGATATTTTAAATCCAGGACCGGGCGTCGG
TGGTCACTGTATCGCCGTGGATCCTTGGTTTATTGTCGACAGCTGCCCCGAAGAAGCAAATCTGATTAGACAAGCACGCT
TAACCAATGATCACAAACCACATTATGTGATCGAGCAAATAACGCATGCGGCAGATGAGTTTAAGCGTCCAGTTATTGCA
TGCTTAGGACTCGCTTTTAAAGCTGATATTGACGATCTGCGAGAAAGTCCGGCATTGCAGATAGTTAAGCAACTAGCCGA
TAAAAAGGTAGGTCAAATAATGGCAGTAGAGCCCAATATTAAATTCTTGCCAGAGCATTTACTTAAAGAAAACATACAAC
TTACAAGCTTAGAACATGCCCTCGAAGTTGCCAATATCATCGTCATACTAGTCGATCATCAAGAATTTAAATTAACAGAT
AAAACTCTTTTAGCAACCAAAGTGGTCATTGATACACGCGGAATATTATAG

Upstream 100 bases:

>100_bases
TACACAAAAGGTGGAAGCAGTCACTGCGGCTTCAGAGCCTATTACAGTTTAGTTTAACAAAAACACTTAATAGATAAATA
CAAGGCTACAGGGAGTTATC

Downstream 100 bases:

>100_bases
CCTTATATCAATCTATTTGGGAACAGTAGCTTGCCAGTTTTAATTTACTGACTGTATTGAGACAAGGAAAATAAAGTGTT
TATGATGAGTGGTTACCCAA

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDFEKVSVIGLGYIGLPTAAIIASRGMTVIGVEVNQNAVDLINAGKIHIVEPDLDIVVRSVVSTGNLRAVTIAEPANVFM
IAVPTPFIHRDDDSHQPDLSYIESAANTIAPVLEKGNLVILESTSPVGTTEKLATWLAKARPDLSFPQDKGNAADINIAH
CPERVLPGYVLQELVSNDRVIGGMSKTCSEKAVALYRTFVRGECIITNARTAEMAKLTENSFRDVNIAFANELSIICDKL
KINVWELIKLANRHPRVDILNPGPGVGGHCIAVDPWFIVDSCPEEANLIRQARLTNDHKPHYVIEQITHAADEFKRPVIA
CLGLAFKADIDDLRESPALQIVKQLADKKVGQIMAVEPNIKFLPEHLLKENIQLTSLEHALEVANIIVILVDHQEFKLTD
KTLLATKVVIDTRGIL

Sequences:

>Translated_416_residues
MDFEKVSVIGLGYIGLPTAAIIASRGMTVIGVEVNQNAVDLINAGKIHIVEPDLDIVVRSVVSTGNLRAVTIAEPANVFM
IAVPTPFIHRDDDSHQPDLSYIESAANTIAPVLEKGNLVILESTSPVGTTEKLATWLAKARPDLSFPQDKGNAADINIAH
CPERVLPGYVLQELVSNDRVIGGMSKTCSEKAVALYRTFVRGECIITNARTAEMAKLTENSFRDVNIAFANELSIICDKL
KINVWELIKLANRHPRVDILNPGPGVGGHCIAVDPWFIVDSCPEEANLIRQARLTNDHKPHYVIEQITHAADEFKRPVIA
CLGLAFKADIDDLRESPALQIVKQLADKKVGQIMAVEPNIKFLPEHLLKENIQLTSLEHALEVANIIVILVDHQEFKLTD
KTLLATKVVIDTRGIL
>Mature_416_residues
MDFEKVSVIGLGYIGLPTAAIIASRGMTVIGVEVNQNAVDLINAGKIHIVEPDLDIVVRSVVSTGNLRAVTIAEPANVFM
IAVPTPFIHRDDDSHQPDLSYIESAANTIAPVLEKGNLVILESTSPVGTTEKLATWLAKARPDLSFPQDKGNAADINIAH
CPERVLPGYVLQELVSNDRVIGGMSKTCSEKAVALYRTFVRGECIITNARTAEMAKLTENSFRDVNIAFANELSIICDKL
KINVWELIKLANRHPRVDILNPGPGVGGHCIAVDPWFIVDSCPEEANLIRQARLTNDHKPHYVIEQITHAADEFKRPVIA
CLGLAFKADIDDLRESPALQIVKQLADKKVGQIMAVEPNIKFLPEHLLKENIQLTSLEHALEVANIIVILVDHQEFKLTD
KTLLATKVVIDTRGIL

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=26.8131868131868, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI296040438, Length=352, Percent_Identity=26.7045454545455, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI296040443, Length=293, Percent_Identity=26.962457337884, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI48994968, Length=426, Percent_Identity=59.6244131455399, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1788340, Length=367, Percent_Identity=24.5231607629428, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=428, Percent_Identity=27.803738317757, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136908, Length=452, Percent_Identity=25.8849557522124, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45586; Mature: 45586

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEKVSVIGLGYIGLPTAAIIASRGMTVIGVEVNQNAVDLINAGKIHIVEPDLDIVVRS
CCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCEEEEECCCHHHHHHH
VVSTGNLRAVTIAEPANVFMIAVPTPFIHRDDDSHQPDLSYIESAANTIAPVLEKGNLVI
HHCCCCEEEEEEECCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LESTSPVGTTEKLATWLAKARPDLSFPQDKGNAADINIAHCPERVLPGYVLQELVSNDRV
EECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEHCCCCHHHCCHHHHHHHHCCCCE
IGGMSKTCSEKAVALYRTFVRGECIITNARTAEMAKLTENSFRDVNIAFANELSIICDKL
ECCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
KINVWELIKLANRHPRVDILNPGPGVGGHCIAVDPWFIVDSCPEEANLIRQARLTNDHKP
HCCHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHCCCCCCC
HYVIEQITHAADEFKRPVIACLGLAFKADIDDLRESPALQIVKQLADKKVGQIMAVEPNI
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCEEEEECCCC
KFLPEHLLKENIQLTSLEHALEVANIIVILVDHQEFKLTDKTLLATKVVIDTRGIL
HHHHHHHHHCCCEEHHHHHHHHHEEEEEEEECCCCEEECCHHHHHEEEEEECCCCC
>Mature Secondary Structure
MDFEKVSVIGLGYIGLPTAAIIASRGMTVIGVEVNQNAVDLINAGKIHIVEPDLDIVVRS
CCCCEEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCEEEEECCCHHHHHHH
VVSTGNLRAVTIAEPANVFMIAVPTPFIHRDDDSHQPDLSYIESAANTIAPVLEKGNLVI
HHCCCCEEEEEEECCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LESTSPVGTTEKLATWLAKARPDLSFPQDKGNAADINIAHCPERVLPGYVLQELVSNDRV
EECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEHCCCCHHHCCHHHHHHHHCCCCE
IGGMSKTCSEKAVALYRTFVRGECIITNARTAEMAKLTENSFRDVNIAFANELSIICDKL
ECCCHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
KINVWELIKLANRHPRVDILNPGPGVGGHCIAVDPWFIVDSCPEEANLIRQARLTNDHKP
HCCHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHCCCCCCC
HYVIEQITHAADEFKRPVIACLGLAFKADIDDLRESPALQIVKQLADKKVGQIMAVEPNI
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCEEEEECCCC
KFLPEHLLKENIQLTSLEHALEVANIIVILVDHQEFKLTDKTLLATKVVIDTRGIL
HHHHHHHHHCCCEEHHHHHHHHHEEEEEEEECCCCEEECCHHHHHEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]