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The map label for this gene is coaBC [H]

Identifier: 119943850

GI number: 119943850

Start: 78569

End: 79804

Strand: Direct

Name: coaBC [H]

Synonym: Ping_0057

Alternate gene names: 119943850

Gene position: 78569-79804 (Clockwise)

Preceding gene: 119943844

Following gene: 119943851

Centisome position: 1.72

GC content: 43.28

Gene sequence:

>1236_bases
ATGTCTGAACATCATATTTTAAGCGGGAAAAAAATATTACTTGGTATTGCCGGTGGCATTGCTGCGTATAAATGTGCAGA
ATTAACGCGCCGTTTAAAAGATCAGGGGGCAGATGTCCGTATTGTAATGACCTCTTCGGCGAAAGCGTTTATCACACCAC
TCACTATGCAGGCTGTCTCCGGACACGCTGTCGCCGATGATTTGTTAGACCCCAATGCAGAATCCGGGATGGGGCATATC
GAGTTGGCCAGATGGGCGGATCTTGTTTTGCTTGCGCCTGCCACTGCAAATTTAATCGCTCGATTACGTGCGGGCATGGC
GGATGACTTATTAACGACGTTATGTGTAGCGACATCCTCTCCTATTGCCGTTTCGCCGGCAATGAATCAGCAAATGTACC
TAGCACAGGCAACACAAGACAATATCAGCGTATTAAAGCAGCGTGGGGTGATGATTTGGGGGCCAGGACAAGGCGCGCAA
GCCTGTGGCGATATAGGGCCCGGCAGAATGCTTAATCCGGCGGACCTTGTGGAAAAGGTGATGGATTATTTTAGTGATAA
AAACAGCTATTTTACGGGTGTCAATATCACCATTACTGCAGGACCTACTCAGGAAGCATTAGATCCTGTGCGTTACATCA
GTAACCATAGTTCCGGTAAAATGGGTTTTGCATTGGCTGAAGTGGCACAAAAAATTGGGGCAAATGTTACTTTAATTAGT
GGCCCTGTGCAGTTGAGCACGCCGAACGGGGTGACTCGATTGAATGTGACAAGTGCATTAGAGATGCATCAGGCCAGTTT
ATCTGGCCTTAAGAACTGCGATATCTTTATTGCTTGTGCGGCTGTTGCCGACTATAGAGCAGAGACGGTCGCTGAGCAAA
AAATGAAAAAACAGCCAGGTATTGATGAGTTAACTATTAAGTTAGTAAAAAATCCGGATATTATTAAAGATGTCTCAAAT
CATCAAAATCGTCCTTTCTGCGTGGCTTTTGCTGCGGAAACGCAGCATCTTGAAGTTTATGCAAAAGATAAATTAAAACG
TAAAAATGTAGATTTAATTGCAGCAAATGATGTTGCAAAAAATGGCCAAGGTTTTAATAGTGAAAAAAATGCATTAAGCG
TATTTTCTAGCGAAGAACGATTTGATATAACGCTTGCCGATAAAAAGGCGGTTGCCAGCCAGCTACTTAAAATAATAAGC
CAACAATACGCTTTGAAAAATAAAGGATTTAAATAA

Upstream 100 bases:

>100_bases
CAGCCATTAAATTGCGACTAAATCTCGTCGATTTATTCACATTTTGCTTAATTACTTTGCTATTCTATGTTCTTCTTATT
TGTTATATTGAGTCTCGTAA

Downstream 100 bases:

>100_bases
TGAAACAGATAGAGCTTAAAATTCTCGATCCTCGCATTGGTAAGGAATTCCCGCTTCCTGAGCATGCGACGGCGGGATCT
GCTGGGATGGATTTGCGTGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSEHHILSGKKILLGIAGGIAAYKCAELTRRLKDQGADVRIVMTSSAKAFITPLTMQAVSGHAVADDLLDPNAESGMGHI
ELARWADLVLLAPATANLIARLRAGMADDLLTTLCVATSSPIAVSPAMNQQMYLAQATQDNISVLKQRGVMIWGPGQGAQ
ACGDIGPGRMLNPADLVEKVMDYFSDKNSYFTGVNITITAGPTQEALDPVRYISNHSSGKMGFALAEVAQKIGANVTLIS
GPVQLSTPNGVTRLNVTSALEMHQASLSGLKNCDIFIACAAVADYRAETVAEQKMKKQPGIDELTIKLVKNPDIIKDVSN
HQNRPFCVAFAAETQHLEVYAKDKLKRKNVDLIAANDVAKNGQGFNSEKNALSVFSSEERFDITLADKKAVASQLLKIIS
QQYALKNKGFK

Sequences:

>Translated_411_residues
MSEHHILSGKKILLGIAGGIAAYKCAELTRRLKDQGADVRIVMTSSAKAFITPLTMQAVSGHAVADDLLDPNAESGMGHI
ELARWADLVLLAPATANLIARLRAGMADDLLTTLCVATSSPIAVSPAMNQQMYLAQATQDNISVLKQRGVMIWGPGQGAQ
ACGDIGPGRMLNPADLVEKVMDYFSDKNSYFTGVNITITAGPTQEALDPVRYISNHSSGKMGFALAEVAQKIGANVTLIS
GPVQLSTPNGVTRLNVTSALEMHQASLSGLKNCDIFIACAAVADYRAETVAEQKMKKQPGIDELTIKLVKNPDIIKDVSN
HQNRPFCVAFAAETQHLEVYAKDKLKRKNVDLIAANDVAKNGQGFNSEKNALSVFSSEERFDITLADKKAVASQLLKIIS
QQYALKNKGFK
>Mature_410_residues
SEHHILSGKKILLGIAGGIAAYKCAELTRRLKDQGADVRIVMTSSAKAFITPLTMQAVSGHAVADDLLDPNAESGMGHIE
LARWADLVLLAPATANLIARLRAGMADDLLTTLCVATSSPIAVSPAMNQQMYLAQATQDNISVLKQRGVMIWGPGQGAQA
CGDIGPGRMLNPADLVEKVMDYFSDKNSYFTGVNITITAGPTQEALDPVRYISNHSSGKMGFALAEVAQKIGANVTLISG
PVQLSTPNGVTRLNVTSALEMHQASLSGLKNCDIFIACAAVADYRAETVAEQKMKKQPGIDELTIKLVKNPDIIKDVSNH
QNRPFCVAFAAETQHLEVYAKDKLKRKNVDLIAANDVAKNGQGFNSEKNALSVFSSEERFDITLADKKAVASQLLKIISQ
QYALKNKGFK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=32.7868852459016, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=59.9009900990099, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17560194, Length=196, Percent_Identity=32.1428571428571, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=31.7460317460317, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=27.5675675675676, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44095; Mature: 43964

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHILSGKKILLGIAGGIAAYKCAELTRRLKDQGADVRIVMTSSAKAFITPLTMQAVS
CCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHC
GHAVADDLLDPNAESGMGHIELARWADLVLLAPATANLIARLRAGMADDLLTTLCVATSS
CCHHHHHHCCCCCCCCCCCEEHHHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
PIAVSPAMNQQMYLAQATQDNISVLKQRGVMIWGPGQGAQACGDIGPGRMLNPADLVEKV
CEEECCCCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCHHHCCCCCCCCCCHHHHHHHH
MDYFSDKNSYFTGVNITITAGPTQEALDPVRYISNHSSGKMGFALAEVAQKIGANVTLIS
HHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEE
GPVQLSTPNGVTRLNVTSALEMHQASLSGLKNCDIFIACAAVADYRAETVAEQKMKKQPG
CCEEEECCCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCC
IDELTIKLVKNPDIIKDVSNHQNRPFCVAFAAETQHLEVYAKDKLKRKNVDLIAANDVAK
CCCEEEEEECCCHHHHHHHCCCCCCEEEEEECCCCEEEEEEHHHHHHCCCCEEEECCCCC
NGQGFNSEKNALSVFSSEERFDITLADKKAVASQLLKIISQQYALKNKGFK
CCCCCCCCCCHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEHHILSGKKILLGIAGGIAAYKCAELTRRLKDQGADVRIVMTSSAKAFITPLTMQAVS
CCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHC
GHAVADDLLDPNAESGMGHIELARWADLVLLAPATANLIARLRAGMADDLLTTLCVATSS
CCHHHHHHCCCCCCCCCCCEEHHHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
PIAVSPAMNQQMYLAQATQDNISVLKQRGVMIWGPGQGAQACGDIGPGRMLNPADLVEKV
CEEECCCCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCHHHCCCCCCCCCCHHHHHHHH
MDYFSDKNSYFTGVNITITAGPTQEALDPVRYISNHSSGKMGFALAEVAQKIGANVTLIS
HHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEE
GPVQLSTPNGVTRLNVTSALEMHQASLSGLKNCDIFIACAAVADYRAETVAEQKMKKQPG
CCEEEECCCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCC
IDELTIKLVKNPDIIKDVSNHQNRPFCVAFAAETQHLEVYAKDKLKRKNVDLIAANDVAK
CCCEEEEEECCCHHHHHHHCCCCCCEEEEEECCCCEEEEEEHHHHHHCCCCEEEECCCCC
NGQGFNSEKNALSVFSSEERFDITLADKKAVASQLLKIISQQYALKNKGFK
CCCCCCCCCCHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]