Click here to switch to the map view.

The map label for this gene is tpa [H]

Identifier: 119943844

GI number: 119943844

Start: 72640

End: 74052

Strand: Direct

Name: tpa [H]

Synonym: Ping_0051

Alternate gene names: 119943844

Gene position: 72640-74052 (Clockwise)

Preceding gene: 119943842

Following gene: 119943850

Centisome position: 1.59

GC content: 42.82

Gene sequence:

>1413_bases
ATGGGTATCATGGCGTTACCAGCATCAGAGATAATAGAAAAAGACCGCAATCATGTATGGCATCACTTAAGCCAGCATAG
CGTGTTAAAACATCAAGACCCGCTAGTAATGGTGAAAGGGGTGGGATCACGCGTCTGGGATGCAAAGGGTAACAGTTATC
TTGACGCATCTTCCGGTGGTGTTTGGTGTGTGAATGTGGGTTATGGCCGAACAGAAATAGCAGATGCGATCCGCGATCAA
GTACTCAAATTAAATTTTTTTGCCAGCACCGCAGGTACCGCGCCAGCTGCTGAATTCGCTGAAAAATTATTAGAAAAAAT
GCCCGGAATGAGTCGTGTTTATTACGCCAGTTCAGGTTCGGAAGCAAATGAAAAAGCGTTTAAAATTGTGCGTCAAATTG
CCCAGCAAAAGCATGGTGGTAAGAAACATAAAATATTGTATCGCGATCGGGATTATCACGGCACGACTATTGCGGCACTA
AGTGCAACGGGCCAAGAAGAACGGCGTATGCATTATGGGCCATTTGTTCCAGGCTTTGTGGAGTTTCCTCATTGCTGCGA
GTACAGAAGTCAGTTTGGTGATGTCAGCAACTATGGCGTTTTAGCCGCTAATGAGCTTGAAAAAGTTATTCTGCGTGAAG
GACCGGACACGGTAGGTGCTGTTGTTTTTGAATCTATCACTGCTGGTGGAGGTGTGATTACTCCACCAGAAGGTTATTGG
CCAGCTGTTATGGAAATTTGTAAAAAATACAATGTGCTTATACACATGGATGAAGTCGTTTGTGGAATGGGTCGAACGGG
TAAATGGTTTGGTTATCAGCATTATGGCATTAAACCCGATATTGTAACCCTTGCTAAGGGGATAGCATCAAGCTATGCAC
CCATATCCTGTGTGGTTACCACAGAAGCCTTATTTGATGAGTTTATTGCCGATAGTAGTGACCGCGCAGCCTATTTTAGA
GATGTCAGTACTTATGCAGGCTGTACAGCCGGACCCGCCGCTGCTTTAGCTAATTTGCAAATATTAGAACGAGAAAATCT
TGTTAATAATAGTGCCCAAATGGGTGATTACTTGCTAAAACAGCTGGTTACTCTTAAGGACAAGTACTCTGTTATTGGTG
ATGTGCGTGGTAAAGGGTTGCTGCTTGGTATTGAGCTGATTAGTGATAGCAAAACAAAAAAACCGGTAGCTGAAGAAGTG
GCTATAAAAATTGCAGGTATGTGTATGAAAAAAGGACTGATTATAGGCCGCACTAACCGTTCCTTCACACATTTTAATAA
TACCTTATGTTTGTGTCCGGTATTAACGTTAACCCAAAAAGAAGCTGACTTTATTGTGGCCACGCTTGATGCTGTTTTTA
GGGAATTACTCGAGTCTGTTGATCTTTTGAGTTCAACTTTGGTTGAATCTTAA

Upstream 100 bases:

>100_bases
CCGCTGGCTCCATCAATTAAAGGGGCTGGTTCTAGGGAGGTCGCCGATTATTACGTTAGTGTTATTACATAGTAATTGGC
ACTTATTGCAGGAGATAATT

Downstream 100 bases:

>100_bases
GGTGTTTTGAGCAAAGTATGATAAGAAAAACCCGAGTTTTTTAAGTGAGCGATAAATCAGCTGGTTTTTGTTAATGCTAA
TCCGTTAAGCATTTAATGCG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MGIMALPASEIIEKDRNHVWHHLSQHSVLKHQDPLVMVKGVGSRVWDAKGNSYLDASSGGVWCVNVGYGRTEIADAIRDQ
VLKLNFFASTAGTAPAAEFAEKLLEKMPGMSRVYYASSGSEANEKAFKIVRQIAQQKHGGKKHKILYRDRDYHGTTIAAL
SATGQEERRMHYGPFVPGFVEFPHCCEYRSQFGDVSNYGVLAANELEKVILREGPDTVGAVVFESITAGGGVITPPEGYW
PAVMEICKKYNVLIHMDEVVCGMGRTGKWFGYQHYGIKPDIVTLAKGIASSYAPISCVVTTEALFDEFIADSSDRAAYFR
DVSTYAGCTAGPAAALANLQILERENLVNNSAQMGDYLLKQLVTLKDKYSVIGDVRGKGLLLGIELISDSKTKKPVAEEV
AIKIAGMCMKKGLIIGRTNRSFTHFNNTLCLCPVLTLTQKEADFIVATLDAVFRELLESVDLLSSTLVES

Sequences:

>Translated_470_residues
MGIMALPASEIIEKDRNHVWHHLSQHSVLKHQDPLVMVKGVGSRVWDAKGNSYLDASSGGVWCVNVGYGRTEIADAIRDQ
VLKLNFFASTAGTAPAAEFAEKLLEKMPGMSRVYYASSGSEANEKAFKIVRQIAQQKHGGKKHKILYRDRDYHGTTIAAL
SATGQEERRMHYGPFVPGFVEFPHCCEYRSQFGDVSNYGVLAANELEKVILREGPDTVGAVVFESITAGGGVITPPEGYW
PAVMEICKKYNVLIHMDEVVCGMGRTGKWFGYQHYGIKPDIVTLAKGIASSYAPISCVVTTEALFDEFIADSSDRAAYFR
DVSTYAGCTAGPAAALANLQILERENLVNNSAQMGDYLLKQLVTLKDKYSVIGDVRGKGLLLGIELISDSKTKKPVAEEV
AIKIAGMCMKKGLIIGRTNRSFTHFNNTLCLCPVLTLTQKEADFIVATLDAVFRELLESVDLLSSTLVES
>Mature_469_residues
GIMALPASEIIEKDRNHVWHHLSQHSVLKHQDPLVMVKGVGSRVWDAKGNSYLDASSGGVWCVNVGYGRTEIADAIRDQV
LKLNFFASTAGTAPAAEFAEKLLEKMPGMSRVYYASSGSEANEKAFKIVRQIAQQKHGGKKHKILYRDRDYHGTTIAALS
ATGQEERRMHYGPFVPGFVEFPHCCEYRSQFGDVSNYGVLAANELEKVILREGPDTVGAVVFESITAGGGVITPPEGYWP
AVMEICKKYNVLIHMDEVVCGMGRTGKWFGYQHYGIKPDIVTLAKGIASSYAPISCVVTTEALFDEFIADSSDRAAYFRD
VSTYAGCTAGPAAALANLQILERENLVNNSAQMGDYLLKQLVTLKDKYSVIGDVRGKGLLLGIELISDSKTKKPVAEEVA
IKIAGMCMKKGLIIGRTNRSFTHFNNTLCLCPVLTLTQKEADFIVATLDAVFRELLESVDLLSSTLVES

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=467, Percent_Identity=27.4089935760171, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI24119277, Length=444, Percent_Identity=29.5045045045045, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=30.4740406320542, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=30.6818181818182, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=31.5508021390374, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4557809, Length=363, Percent_Identity=31.129476584022, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI284507298, Length=277, Percent_Identity=32.4909747292419, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI188536080, Length=423, Percent_Identity=23.8770685579196, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679950, Length=423, Percent_Identity=23.8770685579196, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679946, Length=423, Percent_Identity=23.8770685579196, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=30.5210918114144, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=26.7156862745098, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789759, Length=359, Percent_Identity=31.1977715877437, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789016, Length=386, Percent_Identity=28.2383419689119, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787560, Length=377, Percent_Identity=30.2387267904509, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786991, Length=381, Percent_Identity=27.2965879265092, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=451, Percent_Identity=34.1463414634146, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144271, Length=450, Percent_Identity=28.6666666666667, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=467, Percent_Identity=27.6231263383298, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=31.4754098360656, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71981843, Length=185, Percent_Identity=25.4054054054054, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541228, Length=451, Percent_Identity=21.0643015521064, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=427, Percent_Identity=30.2107728337237, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324432, Length=447, Percent_Identity=24.1610738255034, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324386, Length=367, Percent_Identity=27.7929155313352, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=466, Percent_Identity=30.4721030042918, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574759, Length=469, Percent_Identity=30.4904051172708, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI21356575, Length=458, Percent_Identity=28.82096069869, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21357415, Length=359, Percent_Identity=30.9192200557103, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281366494, Length=383, Percent_Identity=23.7597911227154, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667139, Length=383, Percent_Identity=23.7597911227154, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667143, Length=383, Percent_Identity=23.7597911227154, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 51451; Mature: 51319

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMALPASEIIEKDRNHVWHHLSQHSVLKHQDPLVMVKGVGSRVWDAKGNSYLDASSGG
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCEEECCCCC
VWCVNVGYGRTEIADAIRDQVLKLNFFASTAGTAPAAEFAEKLLEKMPGMSRVYYASSGS
EEEEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
EANEKAFKIVRQIAQQKHGGKKHKILYRDRDYHGTTIAALSATGQEERRMHYGPFVPGFV
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCHHHHCCCCCCCCCHH
EFPHCCEYRSQFGDVSNYGVLAANELEKVILREGPDTVGAVVFESITAGGGVITPPEGYW
CCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
PAVMEICKKYNVLIHMDEVVCGMGRTGKWFGYQHYGIKPDIVTLAKGIASSYAPISCVVT
HHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCEEEEEE
TEALFDEFIADSSDRAAYFRDVSTYAGCTAGPAAALANLQILERENLVNNSAQMGDYLLK
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QLVTLKDKYSVIGDVRGKGLLLGIELISDSKTKKPVAEEVAIKIAGMCMKKGLIIGRTNR
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCC
SFTHFNNTLCLCPVLTLTQKEADFIVATLDAVFRELLESVDLLSSTLVES
CCHHCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIMALPASEIIEKDRNHVWHHLSQHSVLKHQDPLVMVKGVGSRVWDAKGNSYLDASSGG
CEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCEEECCCCC
VWCVNVGYGRTEIADAIRDQVLKLNFFASTAGTAPAAEFAEKLLEKMPGMSRVYYASSGS
EEEEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
EANEKAFKIVRQIAQQKHGGKKHKILYRDRDYHGTTIAALSATGQEERRMHYGPFVPGFV
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCHHHHCCCCCCCCCHH
EFPHCCEYRSQFGDVSNYGVLAANELEKVILREGPDTVGAVVFESITAGGGVITPPEGYW
CCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
PAVMEICKKYNVLIHMDEVVCGMGRTGKWFGYQHYGIKPDIVTLAKGIASSYAPISCVVT
HHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCEEEEEE
TEALFDEFIADSSDRAAYFRDVSTYAGCTAGPAAALANLQILERENLVNNSAQMGDYLLK
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QLVTLKDKYSVIGDVRGKGLLLGIELISDSKTKKPVAEEVAIKIAGMCMKKGLIIGRTNR
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCC
SFTHFNNTLCLCPVLTLTQKEADFIVATLDAVFRELLESVDLLSSTLVES
CCHHCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]