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The map label for this gene is trxA [H]

Identifier: 119871515

GI number: 119871515

Start: 5734708

End: 5735037

Strand: Direct

Name: trxA [H]

Synonym: Mkms_5492

Alternate gene names: 119871515

Gene position: 5734708-5735037 (Clockwise)

Preceding gene: 119871514

Following gene: 119871516

Centisome position: 99.96

GC content: 66.06

Gene sequence:

>330_bases
ATGGCCGACAGCGCCACCGTCACCGTCACCGACGACTCGTTCTCCGAGGACGTGCTGACCAGCAGCACGCCCGTCCTGGT
CGACTTCTGGGCCACCTGGTGCGGGCCGTGCAAGATGGTCGCCCCGGTCCTCGAGGAGATCGCCAGCGAGAAGGCCGGCG
CGCTGACCGTCGCCAAACTCGACGTCGACGCGAATCCGACCACCGCACGCGACTTCCAGGTCGTCTCGATCCCGACGATG
ATCCTGTTCAAGGACGGTGAACCGGTCAAGCGGATCGTCGGTGCGAAGGGCAAAGCCGCACTGCTGCGGGAACTCACCGA
CCTGCTCTGA

Upstream 100 bases:

>100_bases
GCCGAGCGCTGGCTGGCCGAAATCGGCGTCGCACCAAGCGATCAAGAGATCTCGGCCCCGATCTGAGACATCTGACACAC
CCCTATCCCGAGGAGCACAC

Downstream 100 bases:

>100_bases
CGGATCACGGCCTGATTCCGGTTCGCCTGGCGTTTTCCGGATTGACCGGAACTTCTGAGACAATGCCTTTCGGGCCTGTC
GTGCATATGTCGATGCCGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MADSATVTVTDDSFSEDVLTSSTPVLVDFWATWCGPCKMVAPVLEEIASEKAGALTVAKLDVDANPTTARDFQVVSIPTM
ILFKDGEPVKRIVGAKGKAALLRELTDLL

Sequences:

>Translated_109_residues
MADSATVTVTDDSFSEDVLTSSTPVLVDFWATWCGPCKMVAPVLEEIASEKAGALTVAKLDVDANPTTARDFQVVSIPTM
ILFKDGEPVKRIVGAKGKAALLRELTDLL
>Mature_108_residues
ADSATVTVTDDSFSEDVLTSSTPVLVDFWATWCGPCKMVAPVLEEIASEKAGALTVAKLDVDANPTTARDFQVVSIPTMI
LFKDGEPVKRIVGAKGKAALLRELTDLL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=38.5416666666667, Blast_Score=82, Evalue=7e-17,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=54.4554455445545, Blast_Score=117, Evalue=2e-28,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=33.9449541284404, Blast_Score=81, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=35.5769230769231, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=40.9638554216867, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=88, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=38.8888888888889, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=43.0555555555556, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=43.0555555555556, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=97, Percent_Identity=37.1134020618557, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=43.0555555555556, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=71, Percent_Identity=36.6197183098592, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=71, Percent_Identity=36.6197183098592, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=72, Percent_Identity=50, Blast_Score=78, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=91, Percent_Identity=42.8571428571429, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=36.5591397849462, Blast_Score=70, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=38.5416666666667, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358065, Length=83, Percent_Identity=40.9638554216867, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=42.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639826, Length=95, Percent_Identity=36.8421052631579, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11612; Mature: 11481

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSATVTVTDDSFSEDVLTSSTPVLVDFWATWCGPCKMVAPVLEEIASEKAGALTVAKL
CCCCCEEEEECCCCCCHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEE
DVDANPTTARDFQVVSIPTMILFKDGEPVKRIVGAKGKAALLRELTDLL
ECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ADSATVTVTDDSFSEDVLTSSTPVLVDFWATWCGPCKMVAPVLEEIASEKAGALTVAKL
CCCCEEEEECCCCCCHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEE
DVDANPTTARDFQVVSIPTMILFKDGEPVKRIVGAKGKAALLRELTDLL
ECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9795994 [H]