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The map label for this gene is prs [H]

Identifier: 119870364

GI number: 119870364

Start: 4554903

End: 4555883

Strand: Direct

Name: prs [H]

Synonym: Mkms_4335

Alternate gene names: 119870364

Gene position: 4554903-4555883 (Clockwise)

Preceding gene: 119870363

Following gene: 119870365

Centisome position: 79.39

GC content: 66.67

Gene sequence:

>981_bases
GTGGGCACCGAGTGGACCGACAACCGCAAGAATCTGATGCTCTTCTCGGGCCGCGCGCACCCGGAACTGGCTGAACAGGT
CGCCAAGGAGCTCGACACTCCGGTGACCGCGCAGACCGCGCGCGACTTCGCCAACGGCGAGATCTTCGTCCGCTTCGACG
AATCCGTACGTGGCTGCGACGCATTCGTCCTGCAGTCCCATCCGGCACCGCTGAACCAGTGGCTGATGGAACAGCTCATC
ATGATCGACGCGCTCAAGCGCGGCAGCGCCAAGCGGATCACCGCGATCCTGCCGTTCTACCCGTACGCGCGGCAGGACAA
GAAGCACCGCGGCCGCGAGCCGATCTCGGCCCGTTTGGTCGCCGACCTGCTCAAGACCGCAGGCGCCAACCGGATCCTCA
CCGTCGACCTGCACACCGACCAGATCCAGGGGTTCTTCGACGGACCCGTCGACCACATGCGGGCGCAGAAGCTGCTGACC
GGCTACATCGCCGAGCACTATCCCTCCGAGGACATGGTCGTGGTCTCCCCCGACTCGGGCCGGGTGCGCGTGGCGGAGAA
GTGGGCCGACTCGCTCGGTGGTACGCCGCTGGCCTTCATCCACAAGACCCGCGATCCGCTGGTGCCGAACCAGGTGGTGT
CCAACCGCGTGGTCGGCGACGTGCGCGGTAAGACCTGCGTGCTGACCGACGACATGATCGACACCGGCGGCACCATCGCC
GGAGCGGTGAAGCTGCTCAAGCAGGAGGGTGCGGGCGATGTGATCATCGCCGCGACCCACGGGGTGCTGTCGCATCCGGC
GCGCGAACGCCTCGCCGAATGCGGCGCCCGCGAGGTCATCGTCACCAACACCCTGCCCATCGGCGAGGACAAGCAGTTCC
CGCAACTGACCGTGCTGTCCATCGCCCCGCTGCTGGCCAACACGATCCGCGCGGTGTTCGACAACGGTTCGGTGACAAGC
CTTTTCGACGGGTCGGCGTAA

Upstream 100 bases:

>100_bases
CTCGACCACTTCTGTTCTCGATCCGGTAACCCGGGCACGAACGACCAGAAACGCTACGTACGATTGGGCCGACACGATCC
CCGACCGGCGAGGGCGCACA

Downstream 100 bases:

>100_bases
GTGGCATCGACTGACGGGCGGCCCGCCGCCGTGATCTACCACAACCCGAAGTGCTCGACGTCGCGTAAGACCCTGGATCT
GTTGCGCGAGAACGGTATCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MGTEWTDNRKNLMLFSGRAHPELAEQVAKELDTPVTAQTARDFANGEIFVRFDESVRGCDAFVLQSHPAPLNQWLMEQLI
MIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLLKTAGANRILTVDLHTDQIQGFFDGPVDHMRAQKLLT
GYIAEHYPSEDMVVVSPDSGRVRVAEKWADSLGGTPLAFIHKTRDPLVPNQVVSNRVVGDVRGKTCVLTDDMIDTGGTIA
GAVKLLKQEGAGDVIIAATHGVLSHPARERLAECGAREVIVTNTLPIGEDKQFPQLTVLSIAPLLANTIRAVFDNGSVTS
LFDGSA

Sequences:

>Translated_326_residues
MGTEWTDNRKNLMLFSGRAHPELAEQVAKELDTPVTAQTARDFANGEIFVRFDESVRGCDAFVLQSHPAPLNQWLMEQLI
MIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLLKTAGANRILTVDLHTDQIQGFFDGPVDHMRAQKLLT
GYIAEHYPSEDMVVVSPDSGRVRVAEKWADSLGGTPLAFIHKTRDPLVPNQVVSNRVVGDVRGKTCVLTDDMIDTGGTIA
GAVKLLKQEGAGDVIIAATHGVLSHPARERLAECGAREVIVTNTLPIGEDKQFPQLTVLSIAPLLANTIRAVFDNGSVTS
LFDGSA
>Mature_325_residues
GTEWTDNRKNLMLFSGRAHPELAEQVAKELDTPVTAQTARDFANGEIFVRFDESVRGCDAFVLQSHPAPLNQWLMEQLIM
IDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLVADLLKTAGANRILTVDLHTDQIQGFFDGPVDHMRAQKLLTG
YIAEHYPSEDMVVVSPDSGRVRVAEKWADSLGGTPLAFIHKTRDPLVPNQVVSNRVVGDVRGKTCVLTDDMIDTGGTIAG
AVKLLKQEGAGDVIIAATHGVLSHPARERLAECGAREVIVTNTLPIGEDKQFPQLTVLSIAPLLANTIRAVFDNGSVTSL
FDGSA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=42.3566878980892, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=42.5396825396825, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=42.2222222222222, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=42.1383647798742, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI194018537, Length=337, Percent_Identity=34.4213649851632, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4506133, Length=355, Percent_Identity=32.112676056338, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=42.2222222222222, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=42.3566878980892, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=42.3566878980892, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=42.443729903537, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=42.3566878980892, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=346, Percent_Identity=32.9479768786127, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=40.6349206349206, Blast_Score=235, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=42.0382165605096, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=39.3650793650794, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=40.3061224489796, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=269, Percent_Identity=29.368029739777, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=42.0382165605096, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=39.4658753709199, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=32.112676056338, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=32.112676056338, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=32.112676056338, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=32.112676056338, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651462, Length=192, Percent_Identity=36.4583333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24651464, Length=192, Percent_Identity=36.4583333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45552010, Length=192, Percent_Identity=36.4583333333333, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35597; Mature: 35466

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEWTDNRKNLMLFSGRAHPELAEQVAKELDTPVTAQTARDFANGEIFVRFDESVRGCD
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCE
AFVLQSHPAPLNQWLMEQLIMIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLV
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLLKTAGANRILTVDLHTDQIQGFFDGPVDHMRAQKLLTGYIAEHYPSEDMVVVSPDSG
HHHHHHCCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RVRVAEKWADSLGGTPLAFIHKTRDPLVPNQVVSNRVVGDVRGKTCVLTDDMIDTGGTIA
CEEEHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCCHHH
GAVKLLKQEGAGDVIIAATHGVLSHPARERLAECGAREVIVTNTLPIGEDKQFPQLTVLS
HHHHHHHHCCCCCEEEEECCCHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHH
IAPLLANTIRAVFDNGSVTSLFDGSA
HHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
GTEWTDNRKNLMLFSGRAHPELAEQVAKELDTPVTAQTARDFANGEIFVRFDESVRGCD
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCE
AFVLQSHPAPLNQWLMEQLIMIDALKRGSAKRITAILPFYPYARQDKKHRGREPISARLV
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHHHH
ADLLKTAGANRILTVDLHTDQIQGFFDGPVDHMRAQKLLTGYIAEHYPSEDMVVVSPDSG
HHHHHHCCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RVRVAEKWADSLGGTPLAFIHKTRDPLVPNQVVSNRVVGDVRGKTCVLTDDMIDTGGTIA
CEEEHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCCHHH
GAVKLLKQEGAGDVIIAATHGVLSHPARERLAECGAREVIVTNTLPIGEDKQFPQLTVLS
HHHHHHHHCCCCCEEEEECCCHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHH
IAPLLANTIRAVFDNGSVTSLFDGSA
HHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]