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The map label for this gene is glmU

Identifier: 119870363

GI number: 119870363

Start: 4553308

End: 4554801

Strand: Direct

Name: glmU

Synonym: Mkms_4334

Alternate gene names: 119870363

Gene position: 4553308-4554801 (Clockwise)

Preceding gene: 119870361

Following gene: 119870364

Centisome position: 79.36

GC content: 72.29

Gene sequence:

>1494_bases
ATGACCTCTTCGACGACCTCTTCGACCGATACTGCAGTTCTCGTGCTGGCCGCGGGCGCGGGCACCCGGATGCGCTCGGA
CATCCCGAAGGTGCTGCACACCCTCGGCGGCCGCAGCATGCTCGCGCACGCCCTGCACACCGTGGCGAAGGTGGCCCCGC
AGCACCTGGTGGTGGTGCTCGGACACGACCGCGAACGCATCGCCCCCGCCGTCGAGGCGCTGGCCACCGACCTCGGCCGC
CCGATCGACGTCGCGATCCAGGATCAGCAGCTCGGCACCGGCCACGCCGCCGAGTGCGGGCTCGCGGCGCTGCCCGAGGA
CTTCACGGGGGTCGTCGTGGTGACCGCGGGCGACGTCCCGCTGCTCGACGCCGACACCATGGCCGACCTGCTGGCCACCC
ACGGTTCGGCCGCGGCCACCGTGCTGACCACGACCGTCGACGACCCGACCGGGTACGGGCGCATCCTGCGGACCCAGGAC
AACGAGGTCACCAGCATCGTCGAACAGGCCGACGCCAGCCCGTCGCAGCGGGCCATCCGCGAGGTCAACGCCGGCGTCTA
CGCCTTCGACATCACCGCGCTGCGTTCGGCGCTGCGCCGCCTGCGGTCCGACAACGCCCAGCACGAGCTGTACCTCACCG
ACGTCATCGCGATCTTCCGGCAGGACGGCCTCAGCGTGCGGGCCCGGCACGTCGACGACAGCGCCCTGGTGGCCGGCGTC
AACGACCGCGTGCAGTTGGCGGCGCTGGGCGCCGAGCTCAACCGCCGCATCGTCACCGCCCACCAGCGCGCCGGTGTCAC
CGTGATCGACCCGGGCTCCACCTGGATCGACGTCGACGTGACCATCGGCCGCGACACCGTCATCCGGCCCGGCACCCAGT
TGCTCGGCCGCACCCGCGTCGGCGGGCGTTGTGACGTCGGACCGGACACCACGCTGAGCGACGTCACCGTCGGCGACGGC
GCCTCGGTGGTCCGCACCCACGGCTCGGAGTCCCTCATCGGCGCCGGCGCCACCGTCGGCCCGTTCACCTATCTGCGGCC
GGGCACCGCGCTGGGCGCCGAGGGCAAACTCGGTGCATTCGTGGAGACGAAGAACGCGACGATCGGTGCAGGCACCAAGG
TGCCGCACCTGACCTACGTCGGCGACGCCGACATCGGCGAGCACAGCAACATCGGCGCGTCGAGCGTCTTCGTCAACTAC
GACGGCGAGACCAAGAACCGCACGACCATCGGGTCGCACGTGCGGACCGGCTCGGACACCATGTTCGTCGCGCCCGTGAC
CGTCGGGGACGGCGCCTACACCGGTGCGGGCACGGTGATCCGGCGCAACGTGCCGCCGGGCGCGCTGGCGGTCTCGGCCG
GGTCGCAGCGCAACATCGAGGGCTGGGTGGTCCGCAAACGCCCGGGTTCGGCCGCGGCACGCGCGGCGGAGCGCGCATCG
GGTGAAGCAGCGGAGCAGGCGCTCGGCCACCACGACGACTCCCAGGGGTCGTGA

Upstream 100 bases:

>100_bases
CGACTACCATCTCGAGGTGATCGATCCGTCGTGGTGTAATCGGCAGCACCTCTGATTTTGGTTCAGATAGTTCAGGTTCG
AGTCCTGGCGACGGAGCAAT

Downstream 100 bases:

>100_bases
CCTCGACCACTTCTGTTCTCGATCCGGTAACCCGGGCACGAACGACCAGAAACGCTACGTACGATTGGGCCGACACGATC
CCCGACCGGCGAGGGCGCAC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTSSTTSSTDTAVLVLAAGAGTRMRSDIPKVLHTLGGRSMLAHALHTVAKVAPQHLVVVLGHDRERIAPAVEALATDLGR
PIDVAIQDQQLGTGHAAECGLAALPEDFTGVVVVTAGDVPLLDADTMADLLATHGSAAATVLTTTVDDPTGYGRILRTQD
NEVTSIVEQADASPSQRAIREVNAGVYAFDITALRSALRRLRSDNAQHELYLTDVIAIFRQDGLSVRARHVDDSALVAGV
NDRVQLAALGAELNRRIVTAHQRAGVTVIDPGSTWIDVDVTIGRDTVIRPGTQLLGRTRVGGRCDVGPDTTLSDVTVGDG
ASVVRTHGSESLIGAGATVGPFTYLRPGTALGAEGKLGAFVETKNATIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNY
DGETKNRTTIGSHVRTGSDTMFVAPVTVGDGAYTGAGTVIRRNVPPGALAVSAGSQRNIEGWVVRKRPGSAAARAAERAS
GEAAEQALGHHDDSQGS

Sequences:

>Translated_497_residues
MTSSTTSSTDTAVLVLAAGAGTRMRSDIPKVLHTLGGRSMLAHALHTVAKVAPQHLVVVLGHDRERIAPAVEALATDLGR
PIDVAIQDQQLGTGHAAECGLAALPEDFTGVVVVTAGDVPLLDADTMADLLATHGSAAATVLTTTVDDPTGYGRILRTQD
NEVTSIVEQADASPSQRAIREVNAGVYAFDITALRSALRRLRSDNAQHELYLTDVIAIFRQDGLSVRARHVDDSALVAGV
NDRVQLAALGAELNRRIVTAHQRAGVTVIDPGSTWIDVDVTIGRDTVIRPGTQLLGRTRVGGRCDVGPDTTLSDVTVGDG
ASVVRTHGSESLIGAGATVGPFTYLRPGTALGAEGKLGAFVETKNATIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNY
DGETKNRTTIGSHVRTGSDTMFVAPVTVGDGAYTGAGTVIRRNVPPGALAVSAGSQRNIEGWVVRKRPGSAAARAAERAS
GEAAEQALGHHDDSQGS
>Mature_496_residues
TSSTTSSTDTAVLVLAAGAGTRMRSDIPKVLHTLGGRSMLAHALHTVAKVAPQHLVVVLGHDRERIAPAVEALATDLGRP
IDVAIQDQQLGTGHAAECGLAALPEDFTGVVVVTAGDVPLLDADTMADLLATHGSAAATVLTTTVDDPTGYGRILRTQDN
EVTSIVEQADASPSQRAIREVNAGVYAFDITALRSALRRLRSDNAQHELYLTDVIAIFRQDGLSVRARHVDDSALVAGVN
DRVQLAALGAELNRRIVTAHQRAGVTVIDPGSTWIDVDVTIGRDTVIRPGTQLLGRTRVGGRCDVGPDTTLSDVTVGDGA
SVVRTHGSESLIGAGATVGPFTYLRPGTALGAEGKLGAFVETKNATIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNYD
GETKNRTTIGSHVRTGSDTMFVAPVTVGDGAYTGAGTVIRRNVPPGALAVSAGSQRNIEGWVVRKRPGSAAARAAERASG
EAAEQALGHHDDSQGS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=463, Percent_Identity=39.0928725701944, Blast_Score=298, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6320148, Length=384, Percent_Identity=21.3541666666667, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355443, Length=410, Percent_Identity=21.219512195122, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=410, Percent_Identity=21.219512195122, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_MYCSJ (A3Q5G5)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001072883.1
- ProteinModelPortal:   A3Q5G5
- SMR:   A3Q5G5
- STRING:   A3Q5G5
- EnsemblBacteria:   EBMYCT00000050023
- GeneID:   4881573
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_4627
- eggNOG:   COG1207
- GeneTree:   EBGT00050000016064
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A3Q5G5
- ProtClustDB:   PRK14352
- BioCyc:   MSP164757:MJLS_4627-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 51455; Mature: 51324

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 376-376 BINDING 87-87 BINDING 153-153 BINDING 168-168 BINDING 183-183 BINDING 400-400 BINDING 418-418 BINDING 436-436

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSTTSSTDTAVLVLAAGAGTRMRSDIPKVLHTLGGRSMLAHALHTVAKVAPQHLVVVL
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEE
GHDRERIAPAVEALATDLGRPIDVAIQDQQLGTGHAAECGLAALPEDFTGVVVVTAGDVP
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
LLDADTMADLLATHGSAAATVLTTTVDDPTGYGRILRTQDNEVTSIVEQADASPSQRAIR
EECHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHH
EVNAGVYAFDITALRSALRRLRSDNAQHELYLTDVIAIFRQDGLSVRARHVDDSALVAGV
HHCCCEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCEEEEEECCCCEEEECC
NDRVQLAALGAELNRRIVTAHQRAGVTVIDPGSTWIDVDVTIGRDTVIRPGTQLLGRTRV
CCCEEEEEECHHHCCEEEEEHHHCCEEEECCCCEEEEEEEEECCCCEECCCHHHHCCCCC
GGRCDVGPDTTLSDVTVGDGASVVRTHGSESLIGAGATVGPFTYLRPGTALGAEGKLGAF
CCCCCCCCCCCCCEEEECCCCCEEEECCCCCEEECCCCCCCEEEECCCCCCCCCCCCCEE
VETKNATIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNYDGETKNRTTIGSHVRTGSDT
EEECCCEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCE
MFVAPVTVGDGAYTGAGTVIRRNVPPGALAVSAGSQRNIEGWVVRKRPGSAAARAAERAS
EEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHCC
GEAAEQALGHHDDSQGS
CHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TSSTTSSTDTAVLVLAAGAGTRMRSDIPKVLHTLGGRSMLAHALHTVAKVAPQHLVVVL
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEE
GHDRERIAPAVEALATDLGRPIDVAIQDQQLGTGHAAECGLAALPEDFTGVVVVTAGDVP
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
LLDADTMADLLATHGSAAATVLTTTVDDPTGYGRILRTQDNEVTSIVEQADASPSQRAIR
EECHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHH
EVNAGVYAFDITALRSALRRLRSDNAQHELYLTDVIAIFRQDGLSVRARHVDDSALVAGV
HHCCCEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCEEEEEECCCCEEEECC
NDRVQLAALGAELNRRIVTAHQRAGVTVIDPGSTWIDVDVTIGRDTVIRPGTQLLGRTRV
CCCEEEEEECHHHCCEEEEEHHHCCEEEECCCCEEEEEEEEECCCCEECCCHHHHCCCCC
GGRCDVGPDTTLSDVTVGDGASVVRTHGSESLIGAGATVGPFTYLRPGTALGAEGKLGAF
CCCCCCCCCCCCCEEEECCCCCEEEECCCCCEEECCCCCCCEEEECCCCCCCCCCCCCEE
VETKNATIGAGTKVPHLTYVGDADIGEHSNIGASSVFVNYDGETKNRTTIGSHVRTGSDT
EEECCCEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCE
MFVAPVTVGDGAYTGAGTVIRRNVPPGALAVSAGSQRNIEGWVVRKRPGSAAARAAERAS
EEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHCC
GEAAEQALGHHDDSQGS
CHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA