| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is yxbG [H]
Identifier: 119870221
GI number: 119870221
Start: 4417921
End: 4418691
Strand: Direct
Name: yxbG [H]
Synonym: Mkms_4191
Alternate gene names: 119870221
Gene position: 4417921-4418691 (Clockwise)
Preceding gene: 119870220
Following gene: 119870222
Centisome position: 77.0
GC content: 70.82
Gene sequence:
>771_bases GTGATTGTGACCACCAACCGCACCGCCGTCGTGATCGGCGCCGCCTCGGGTATCGGCTGGGCGACCGCCCGGGCGCTGGC CGCCGACGGTTTCCGCATCGTCCTGGCCGACCGCAACGCCGACGGCGCCCGTGAGCGTGCCGCCACCCTCGGCGAACCCC ACACGTCGGCCTACGCCGACGTCACCGACGAGGCGTCGGTGCAGCGCGTCTTCGACCAGACCGGCCCCCTCGACGCGGTG GTGAACTGCGCCGGGTTCAGCAACGTCGGCCTCATCACCGACATGCCGGTCGACCAGTTCCGCGAGGTCGTCGACGTCTG CCTGACCGGAGGCTTCGTCGTCGCCAAACACGCCGGCAGGCAGCTTCGCGAAGGTGGTGTGCTGGTGCAGATCTCGTCGC TCAACGGCCGCCAGCCGGCCTCCGGGATGAGCGCGTACTGCGCCGCCAAGGCCGGCCTGTCGATGCTGACCCAGGTGGCG GCGCTGGAGATGGCGCCGCGCGGCATCCGGGTCAACGCCGTCGCCCCCGGCTTCGTGCACACGCCGCTGACCGATCCCGC GGCCAGCGTTCCGGGTGTGGTCGAGGAGTACCTCGAGAACACACCGCTCGGCCGGGCCGGGCAACCCGAGGACGTCGCCG CCGCGGTGGCGTTCCTGTGTTCACCCGGTGCCTCGTGGATGACCGGGGAGGTACTCGACCTCAACGGCGGGGCCCACCTC AAGAGGTATCCCGACATCCTCAGCCACGTCATGAAACTCGCGGGGGCATAG
Upstream 100 bases:
>100_bases GCAACCCGTCGACACCGGTATGAGCCACATCGGCTTCCGCTGCGTGCGCCACTGAGATGGTGCGTTTCGACGACGGCGCC TGAAACCTGTTCTAGTTTGA
Downstream 100 bases:
>100_bases ATGGACTTCGCGGGCAGACAGGCGATCGTCACCGGCGCCGGTTCGGGCATCGGCGCCGCTCTGTGCCGGGCACTGGTGGC GGCCGGGGCCGAGGTGTTGT
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 256; Mature: 256
Protein sequence:
>256_residues MIVTTNRTAVVIGAASGIGWATARALAADGFRIVLADRNADGARERAATLGEPHTSAYADVTDEASVQRVFDQTGPLDAV VNCAGFSNVGLITDMPVDQFREVVDVCLTGGFVVAKHAGRQLREGGVLVQISSLNGRQPASGMSAYCAAKAGLSMLTQVA ALEMAPRGIRVNAVAPGFVHTPLTDPAASVPGVVEEYLENTPLGRAGQPEDVAAAVAFLCSPGASWMTGEVLDLNGGAHL KRYPDILSHVMKLAGA
Sequences:
>Translated_256_residues MIVTTNRTAVVIGAASGIGWATARALAADGFRIVLADRNADGARERAATLGEPHTSAYADVTDEASVQRVFDQTGPLDAV VNCAGFSNVGLITDMPVDQFREVVDVCLTGGFVVAKHAGRQLREGGVLVQISSLNGRQPASGMSAYCAAKAGLSMLTQVA ALEMAPRGIRVNAVAPGFVHTPLTDPAASVPGVVEEYLENTPLGRAGQPEDVAAAVAFLCSPGASWMTGEVLDLNGGAHL KRYPDILSHVMKLAGA >Mature_256_residues MIVTTNRTAVVIGAASGIGWATARALAADGFRIVLADRNADGARERAATLGEPHTSAYADVTDEASVQRVFDQTGPLDAV VNCAGFSNVGLITDMPVDQFREVVDVCLTGGFVVAKHAGRQLREGGVLVQISSLNGRQPASGMSAYCAAKAGLSMLTQVA ALEMAPRGIRVNAVAPGFVHTPLTDPAASVPGVVEEYLENTPLGRAGQPEDVAAAVAFLCSPGASWMTGEVLDLNGGAHL KRYPDILSHVMKLAGA
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=36.6255144032922, Blast_Score=135, Evalue=3e-32, Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=35.4581673306773, Blast_Score=128, Evalue=5e-30, Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=32.6446280991736, Blast_Score=108, Evalue=6e-24, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI7705925, Length=236, Percent_Identity=33.4745762711864, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=33.8582677165354, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=34.8017621145374, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI126723750, Length=246, Percent_Identity=29.6747967479675, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI10190704, Length=269, Percent_Identity=30.1115241635688, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=29.6153846153846, Blast_Score=88, Evalue=6e-18, Organism=Homo sapiens, GI31542939, Length=190, Percent_Identity=33.1578947368421, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=31.496062992126, Blast_Score=78, Evalue=9e-15, Organism=Homo sapiens, GI4503301, Length=230, Percent_Identity=25.6521739130435, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI44680136, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI44680133, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI17738292, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI224922801, Length=164, Percent_Identity=32.3170731707317, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=1e-10, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=34.2857142857143, Blast_Score=127, Evalue=8e-31, Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=33.0578512396694, Blast_Score=115, Evalue=3e-27, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=34.6938775510204, Blast_Score=114, Evalue=8e-27, Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=34.2629482071713, Blast_Score=111, Evalue=4e-26, Organism=Escherichia coli, GI2367365, Length=236, Percent_Identity=32.6271186440678, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=31.8367346938775, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=33.0708661417323, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI1790717, Length=240, Percent_Identity=27.9166666666667, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=31.2, Blast_Score=102, Evalue=3e-23, Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=29.2682926829268, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI87082160, Length=239, Percent_Identity=28.4518828451883, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI1789208, Length=239, Percent_Identity=27.1966527196653, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1787545, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=6e-12, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=35.655737704918, Blast_Score=132, Evalue=2e-31, Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=34.8547717842324, Blast_Score=132, Evalue=2e-31, Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=31.8367346938775, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=32.258064516129, Blast_Score=114, Evalue=6e-26, Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=31.0204081632653, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=31.0861423220974, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=28.4132841328413, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.5171102661597, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17560150, Length=257, Percent_Identity=27.2373540856031, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=29.3233082706767, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI115534694, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17563726, Length=257, Percent_Identity=28.0155642023346, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=33.8289962825279, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=28.4615384615385, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=29.5275590551181, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.4339622641509, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=28.4, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=28.6259541984733, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=28.8, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17561272, Length=224, Percent_Identity=27.6785714285714, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17544670, Length=260, Percent_Identity=28.0769230769231, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI72000259, Length=256, Percent_Identity=27.734375, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=27.1698113207547, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=28.4, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=28.9156626506024, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=25.6704980842912, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=25.8555133079848, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17564282, Length=247, Percent_Identity=25.1012145748988, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=182, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=6e-17, Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=29.9465240641711, Blast_Score=67, Evalue=4e-12, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=38.3064516129032, Blast_Score=150, Evalue=1e-36, Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=36.2139917695473, Blast_Score=137, Evalue=5e-33, Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=34.0080971659919, Blast_Score=123, Evalue=1e-28, Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=34.5528455284553, Blast_Score=121, Evalue=5e-28, Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=34.0080971659919, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI21355319, Length=241, Percent_Identity=31.5352697095436, Blast_Score=103, Evalue=8e-23, Organism=Drosophila melanogaster, GI24643142, Length=236, Percent_Identity=29.6610169491525, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24644337, Length=221, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=5e-19, Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=31.25, Blast_Score=91, Evalue=5e-19, Organism=Drosophila melanogaster, GI24641232, Length=233, Percent_Identity=29.6137339055794, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI28571387, Length=235, Percent_Identity=28.0851063829787, Blast_Score=70, Evalue=9e-13, Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 26437; Mature: 26437
Theoretical pI: Translated: 5.27; Mature: 5.27
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIVTTNRTAVVIGAASGIGWATARALAADGFRIVLADRNADGARERAATLGEPHTSAYAD CEEECCCCEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC VTDEASVQRVFDQTGPLDAVVNCAGFSNVGLITDMPVDQFREVVDVCLTGGFVVAKHAGR CCCHHHHHHHHHCCCCHHHHEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEHHHHH QLREGGVLVQISSLNGRQPASGMSAYCAAKAGLSMLTQVAALEMAPRGIRVNAVAPGFVH HHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE TPLTDPAASVPGVVEEYLENTPLGRAGQPEDVAAAVAFLCSPGASWMTGEVLDLNGGAHL CCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCH KRYPDILSHVMKLAGA HHHHHHHHHHHHHHCC >Mature Secondary Structure MIVTTNRTAVVIGAASGIGWATARALAADGFRIVLADRNADGARERAATLGEPHTSAYAD CEEECCCCEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC VTDEASVQRVFDQTGPLDAVVNCAGFSNVGLITDMPVDQFREVVDVCLTGGFVVAKHAGR CCCHHHHHHHHHCCCCHHHHEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEHHHHH QLREGGVLVQISSLNGRQPASGMSAYCAAKAGLSMLTQVAALEMAPRGIRVNAVAPGFVH HHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE TPLTDPAASVPGVVEEYLENTPLGRAGQPEDVAAAVAFLCSPGASWMTGEVLDLNGGAHL CCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCH KRYPDILSHVMKLAGA HHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7584049; 9384377 [H]