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The map label for this gene is pkn1 [H]

Identifier: 119870220

GI number: 119870220

Start: 4417000

End: 4417875

Strand: Direct

Name: pkn1 [H]

Synonym: Mkms_4190

Alternate gene names: 119870220

Gene position: 4417000-4417875 (Clockwise)

Preceding gene: 119870219

Following gene: 119870221

Centisome position: 76.99

GC content: 71.0

Gene sequence:

>876_bases
GTGACTGAAGACCTCGTCCGGATTCCCGCGCAGAGCGCGACGATCGGTTCCGACCGGCACTACCCCGAAGAGGCGCCGGC
CCGCGACGTGACCGTCGACGGTTTCTGGATCCAGGCACATGCGGTCACCAACGCCGAATTCGCCGCGTTCGTCGACGCCA
CCGGCTACCGGACCGTCGCCGAACGCCCCCTCGACCCCGCGAACTATCCCGACGCGCCGGCACAAAATCTGCAGCCGGGG
TCGATGGTGTTCCGCCGCACCGCCGGGCCCGTCGATCTGCGTCACCTGAACCAGTGGTGGTACTGGACGCCCGGGGCGTC
GTGGCGCCACCCGATCGGGCCGGGCTCCTCGATCGTCAACCGAGCCGACCACCCGGTCGTGCACGTCGCCTACGACGACG
CCGAGGCGTATGCGGCATGGGCAGGGCTGGAACTACCCACCGAGGCGGAATGGGAGGTCGCCGCTCGGGGCGGGCTCCCC
CACGCCGGCTACACGTGGGGCGACGAGCCCGAGGGGCCGGGGCACAAGCTCGCCAACTATTGGCACGGCGAGTTCCCCTG
GCGTCCGGACCGGGGCTATGGCCGCACCGCCCCCGTCGGCAGCTACCCACCCAACGGCTACGGGCTGTACGACATGGCGG
GCAACGTGTGGGAGTGGACCACCGACTGGTACACCGACACCGGTGGTTCCGCGTGCTGCGCCGAGGACAGCTACGACCCG
GCCCAGCCGCAGTTCCCGGTGCCGCGCCGCGTCGTCAAGGGGGGGTCGTTCCTCTGTGCCGACTCGTACTGCGCCCGCTA
CCGTCCCGCGGCGCGGCGCCCGCAACCCGTCGACACCGGTATGAGCCACATCGGCTTCCGCTGCGTGCGCCACTGA

Upstream 100 bases:

>100_bases
GAATTCGCCTACACCGCAGGCGCCGAACGCGCGCTGGCGCATGCAGACGCCTGGGGGTGGACGGTCGTGAGCATGAGAAA
CGATTGGGCGACCATCTTCG

Downstream 100 bases:

>100_bases
GATGGTGCGTTTCGACGACGGCGCCTGAAACCTGTTCTAGTTTGAGTGATTGTGACCACCAACCGCACCGCCGTCGTGAT
CGGCGCCGCCTCGGGTATCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTEDLVRIPAQSATIGSDRHYPEEAPARDVTVDGFWIQAHAVTNAEFAAFVDATGYRTVAERPLDPANYPDAPAQNLQPG
SMVFRRTAGPVDLRHLNQWWYWTPGASWRHPIGPGSSIVNRADHPVVHVAYDDAEAYAAWAGLELPTEAEWEVAARGGLP
HAGYTWGDEPEGPGHKLANYWHGEFPWRPDRGYGRTAPVGSYPPNGYGLYDMAGNVWEWTTDWYTDTGGSACCAEDSYDP
AQPQFPVPRRVVKGGSFLCADSYCARYRPAARRPQPVDTGMSHIGFRCVRH

Sequences:

>Translated_291_residues
MTEDLVRIPAQSATIGSDRHYPEEAPARDVTVDGFWIQAHAVTNAEFAAFVDATGYRTVAERPLDPANYPDAPAQNLQPG
SMVFRRTAGPVDLRHLNQWWYWTPGASWRHPIGPGSSIVNRADHPVVHVAYDDAEAYAAWAGLELPTEAEWEVAARGGLP
HAGYTWGDEPEGPGHKLANYWHGEFPWRPDRGYGRTAPVGSYPPNGYGLYDMAGNVWEWTTDWYTDTGGSACCAEDSYDP
AQPQFPVPRRVVKGGSFLCADSYCARYRPAARRPQPVDTGMSHIGFRCVRH
>Mature_290_residues
TEDLVRIPAQSATIGSDRHYPEEAPARDVTVDGFWIQAHAVTNAEFAAFVDATGYRTVAERPLDPANYPDAPAQNLQPGS
MVFRRTAGPVDLRHLNQWWYWTPGASWRHPIGPGSSIVNRADHPVVHVAYDDAEAYAAWAGLELPTEAEWEVAARGGLPH
AGYTWGDEPEGPGHKLANYWHGEFPWRPDRGYGRTAPVGSYPPNGYGLYDMAGNVWEWTTDWYTDTGGSACCAEDSYDPA
QPQFPVPRRVVKGGSFLCADSYCARYRPAARRPQPVDTGMSHIGFRCVRH

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=298, Percent_Identity=43.6241610738255, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI257470975, Length=294, Percent_Identity=42.8571428571429, Blast_Score=212, Evalue=2e-55,
Organism=Homo sapiens, GI257470977, Length=296, Percent_Identity=40.8783783783784, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI194248088, Length=272, Percent_Identity=37.5, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI194248087, Length=272, Percent_Identity=35.6617647058824, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI226437577, Length=197, Percent_Identity=41.1167512690355, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI194248090, Length=190, Percent_Identity=38.9473684210526, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20130397, Length=300, Percent_Identity=37.3333333333333, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32258; Mature: 32126

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDLVRIPAQSATIGSDRHYPEEAPARDVTVDGFWIQAHAVTNAEFAAFVDATGYRTVA
CCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECEEEEEEEEECCCCEEEEECCCCCHHHH
ERPLDPANYPDAPAQNLQPGSMVFRRTAGPVDLRHLNQWWYWTPGASWRHPIGPGSSIVN
HCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCEECCCCEEECCCCCCCCCCCCCHHHHH
RADHPVVHVAYDDAEAYAAWAGLELPTEAEWEVAARGGLPHAGYTWGDEPEGPGHKLANY
CCCCCEEEEEECCCHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHC
WHGEFPWRPDRGYGRTAPVGSYPPNGYGLYDMAGNVWEWTTDWYTDTGGSACCAEDSYDP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEECCCEECCCCCEEECCCCCCC
AQPQFPVPRRVVKGGSFLCADSYCARYRPAARRPQPVDTGMSHIGFRCVRH
CCCCCCCCHHHHCCCCEEEECCHHHHCCCCCCCCCCHHHCHHHHHHHHHCC
>Mature Secondary Structure 
TEDLVRIPAQSATIGSDRHYPEEAPARDVTVDGFWIQAHAVTNAEFAAFVDATGYRTVA
CCCCEECCCCCCCCCCCCCCCCCCCCCEEEECEEEEEEEEECCCCEEEEECCCCCHHHH
ERPLDPANYPDAPAQNLQPGSMVFRRTAGPVDLRHLNQWWYWTPGASWRHPIGPGSSIVN
HCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCEECCCCEEECCCCCCCCCCCCCHHHHH
RADHPVVHVAYDDAEAYAAWAGLELPTEAEWEVAARGGLPHAGYTWGDEPEGPGHKLANY
CCCCCEEEEEECCCHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHC
WHGEFPWRPDRGYGRTAPVGSYPPNGYGLYDMAGNVWEWTTDWYTDTGGSACCAEDSYDP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEECCCEECCCCCEEECCCCCCC
AQPQFPVPRRVVKGGSFLCADSYCARYRPAARRPQPVDTGMSHIGFRCVRH
CCCCCCCCHHHHCCCCEEEECCHHHHCCCCCCCCCCHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]