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The map label for this gene is ppiB [H]

Identifier: 119868366

GI number: 119868366

Start: 2442563

End: 2443570

Strand: Reverse

Name: ppiB [H]

Synonym: Mkms_2330

Alternate gene names: 119868366

Gene position: 2443570-2442563 (Counterclockwise)

Preceding gene: 119868369

Following gene: 119868365

Centisome position: 42.59

GC content: 70.34

Gene sequence:

>1008_bases
ATGCCAGTTTCCCATGCCCGCCGCGGTGCGGTTTTCCAGCGGGTCGTTCACCTGACCCTCAGCAACTTTTGGCACACTCG
GTGCCGACCGGACGCGGGTATGACCGCGCAGACGAGGAGGACAGCGGCAGTGCCGACTAACGAACAGCGACGCGAGGCGG
CCAAACGCAAGCTCGAACGGCAGCTCGAGCGCCGGGCCGAGAAGGCGCGCAAGCGGCGGATCGCCACGATCGCCGGCTCG
GCGGTGGCGGCGGTCGTCGTGATCGGCGCCATCGTCGCGACCATCGTGCTCACCAAAAGTGACTCGTCGGACACCACCGC
CTCGGCACAGACCCCCACCCCCACCTCGGGGGCCCCCGCGCAGCCGGCCGCCGACGGCGGATTGCCGGCGTTCGCGCCGC
CCGCCGGGCTGGGCGCGGACTGCCAGTACCCCGCTTCCGGTGCGGCGAGCAAGCCGGTCGAACCGCCGCGCACCGGCCAG
GTGCCCACCGACCCGGCCGAGGTCAGCGTCAGCATGTCGACCAACCAGGGCAACCTGGGTCTGCTGCTCGACAACGCCAA
GGCGCCGTGCACGGTCAACAGCTTCGCCAGCCTGGCGCAGCAGGGCTACTTCAACGACACGCCGTGCCACCGGCTGACCA
CCACCCCGTCCCTGTCGGTGCTGCAGTGCGGCGACCCGACCGGTGAGGGCACCGGCGGGCCCGGGTACAAGTTCGCCAAC
GAGTACCCGACGAACCAGTACCAGCCCGACGACCCCGCCCTTGGCGAAGCGGTGCTCTACCCGCGCGGCACGATCGCGAT
GGCCAACGCCGGCCCCAACACCAACGGCAGCCAGTTCTTCCTGGTTTACAAGGATTCGCAGCTGCCGCCGGGCTACACCG
TGTTCGGCCGGATCGACGACACCGGCCTGGCCACCCTGGACAAGATCGCGGCGGCCGGGGTGCAAGGCGGCGGGCCCGAC
GGTGCACCGGCCGAAGAGGTACAGGTCAAGACGATCCTGCTCGACTGA

Upstream 100 bases:

>100_bases
TGTCCCGGGTCGACGACGATGGCGTCCGACCCCGGCCGCTGGGCGAGCACGTAGCAGTTGCACGCCAACATGCCCGCCGG
GAATCCGGTGATCAACACGT

Downstream 100 bases:

>100_bases
TGAGTTACCCGTCCTGGCCGCCCTACCCGCCACCGCCGGCGTACCCGCGTACCACCAACGCGTGGGCCGTCGCCGCGTTG
GTGTGCGCGTTCCTGTTCGC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPVSHARRGAVFQRVVHLTLSNFWHTRCRPDAGMTAQTRRTAAVPTNEQRREAAKRKLERQLERRAEKARKRRIATIAGS
AVAAVVVIGAIVATIVLTKSDSSDTTASAQTPTPTSGAPAQPAADGGLPAFAPPAGLGADCQYPASGAASKPVEPPRTGQ
VPTDPAEVSVSMSTNQGNLGLLLDNAKAPCTVNSFASLAQQGYFNDTPCHRLTTTPSLSVLQCGDPTGEGTGGPGYKFAN
EYPTNQYQPDDPALGEAVLYPRGTIAMANAGPNTNGSQFFLVYKDSQLPPGYTVFGRIDDTGLATLDKIAAAGVQGGGPD
GAPAEEVQVKTILLD

Sequences:

>Translated_335_residues
MPVSHARRGAVFQRVVHLTLSNFWHTRCRPDAGMTAQTRRTAAVPTNEQRREAAKRKLERQLERRAEKARKRRIATIAGS
AVAAVVVIGAIVATIVLTKSDSSDTTASAQTPTPTSGAPAQPAADGGLPAFAPPAGLGADCQYPASGAASKPVEPPRTGQ
VPTDPAEVSVSMSTNQGNLGLLLDNAKAPCTVNSFASLAQQGYFNDTPCHRLTTTPSLSVLQCGDPTGEGTGGPGYKFAN
EYPTNQYQPDDPALGEAVLYPRGTIAMANAGPNTNGSQFFLVYKDSQLPPGYTVFGRIDDTGLATLDKIAAAGVQGGGPD
GAPAEEVQVKTILLD
>Mature_334_residues
PVSHARRGAVFQRVVHLTLSNFWHTRCRPDAGMTAQTRRTAAVPTNEQRREAAKRKLERQLERRAEKARKRRIATIAGSA
VAAVVVIGAIVATIVLTKSDSSDTTASAQTPTPTSGAPAQPAADGGLPAFAPPAGLGADCQYPASGAASKPVEPPRTGQV
PTDPAEVSVSMSTNQGNLGLLLDNAKAPCTVNSFASLAQQGYFNDTPCHRLTTTPSLSVLQCGDPTGEGTGGPGYKFANE
YPTNQYQPDDPALGEAVLYPRGTIAMANAGPNTNGSQFFLVYKDSQLPPGYTVFGRIDDTGLATLDKIAAAGVQGGGPDG
APAEEVQVKTILLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=171, Percent_Identity=35.672514619883, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7706339, Length=148, Percent_Identity=39.1891891891892, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI24308049, Length=174, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI64276486, Length=149, Percent_Identity=31.5436241610738, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=147, Percent_Identity=36.734693877551, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=133, Percent_Identity=39.0977443609023, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=34.3373493975904, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=32.9268292682927, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357249, Length=150, Percent_Identity=31.3333333333333, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 34908; Mature: 34777

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSHARRGAVFQRVVHLTLSNFWHTRCRPDAGMTAQTRRTAAVPTNEQRREAAKRKLER
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QLERRAEKARKRRIATIAGSAVAAVVVIGAIVATIVLTKSDSSDTTASAQTPTPTSGAPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCC
QPAADGGLPAFAPPAGLGADCQYPASGAASKPVEPPRTGQVPTDPAEVSVSMSTNQGNLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEE
LLLDNAKAPCTVNSFASLAQQGYFNDTPCHRLTTTPSLSVLQCGDPTGEGTGGPGYKFAN
EEECCCCCCEEHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCC
EYPTNQYQPDDPALGEAVLYPRGTIAMANAGPNTNGSQFFLVYKDSQLPPGYTVFGRIDD
CCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCEEEEEEECCCCCCCEEEEEEECC
TGLATLDKIAAAGVQGGGPDGAPAEEVQVKTILLD
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure 
PVSHARRGAVFQRVVHLTLSNFWHTRCRPDAGMTAQTRRTAAVPTNEQRREAAKRKLER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QLERRAEKARKRRIATIAGSAVAAVVVIGAIVATIVLTKSDSSDTTASAQTPTPTSGAPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCC
QPAADGGLPAFAPPAGLGADCQYPASGAASKPVEPPRTGQVPTDPAEVSVSMSTNQGNLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEE
LLLDNAKAPCTVNSFASLAQQGYFNDTPCHRLTTTPSLSVLQCGDPTGEGTGGPGYKFAN
EEECCCCCCEEHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCC
EYPTNQYQPDDPALGEAVLYPRGTIAMANAGPNTNGSQFFLVYKDSQLPPGYTVFGRIDD
CCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCEEEEEEECCCCCCCEEEEEEECC
TGLATLDKIAAAGVQGGGPDGAPAEEVQVKTILLD
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]