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The map label for this gene is ppiB [H]

Identifier: 119868365

GI number: 119868365

Start: 2441601

End: 2442563

Strand: Reverse

Name: ppiB [H]

Synonym: Mkms_2329

Alternate gene names: 119868365

Gene position: 2442563-2441601 (Counterclockwise)

Preceding gene: 119868366

Following gene: 119868364

Centisome position: 42.57

GC content: 70.4

Gene sequence:

>963_bases
ATGAGTTACCCGTCCTGGCCGCCCTACCCGCCACCGCCGGCGTACCCGCGTACCACCAACGCGTGGGCCGTCGCCGCGTT
GGTGTGCGCGTTCCTGTTCGCGCCGCTGGGCATCGTCTTCGGCCACCTGTCGCTGTCCCAGATCAAACGGACCGGGGAGG
ACGGCCGCGGACTCGCGCTGGCCGGCCTGATCATCGGGTACGTCATGACGGCGCTGACCGTCATCGTCGTCGTGTTCAGC
GTGCTGTTCCTGGTGGCGGTGGCCCAGCACGTCGGCGAACTGCGCGTCGACGACGGATCCACCCGGAGCGCCGCACCGCC
CTCCGGTGACCGGCTGCCGGCGTTCGTCGCACCCCGCAACCTCGGCGCCAACTGCCAGTACCCCAAGGGCGACCTGCCCG
CCGGGGCACCGGTCACCCCGCCGCGCACCGGACGGGTGCCGACCGACCCGGCGAAGATCAGCGCCAGCGTGTCGACCAGT
CAGGGCAACATCGGCCTGGAACTCGACAACGGCAAGTCGCCCTGCACGGTGAACAACTTCGCCAGCCTCGCCCAACAGGG
CTTCTTCGACGACACCACCTGCCACCGGCTGACCACCGCCCGCTCCCTGAAGGTGCTGCAGTGCGGGGATCCGACCGGCA
CCGGCGCGGGTGGCCCGGGATACCGGTTCCCGAACGAATACCCGACCAGCCAGTACCGGTTGTCGGATCCGGGGCTGCGG
CGTCCGGTGGTGTACCCGCGGGGCACGCTGGTGATGGCCAACACCGGCCCGGGCACCAACGGCAGCCAGTTCATGCTCGT
GTACGGGGACACCCTGCTGCCGCCGACGTACACGGTCTTCGGGACCGTCGACTCCACCGGACTGGCGACACTCGACAGGA
TCGCGGCCCGCGGCGTTGCGGGCGGCGCTGACGACGGGAAGCCCGCCGCCGAGGTCAAGATCATTTCCGCGAGGCTCGAC
TGA

Upstream 100 bases:

>100_bases
TGGCCACCCTGGACAAGATCGCGGCGGCCGGGGTGCAAGGCGGCGGGCCCGACGGTGCACCGGCCGAAGAGGTACAGGTC
AAGACGATCCTGCTCGACTG

Downstream 100 bases:

>100_bases
TCCCAGTGCCGTTGCCACGCAACGGATATCGAAGGGCAACGATTTCGTGACGAGCGGTGCGCCGTCAGCCGTCGGCGGAC
TCATACCATGGTGACTCCGT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSYPSWPPYPPPPAYPRTTNAWAVAALVCAFLFAPLGIVFGHLSLSQIKRTGEDGRGLALAGLIIGYVMTALTVIVVVFS
VLFLVAVAQHVGELRVDDGSTRSAAPPSGDRLPAFVAPRNLGANCQYPKGDLPAGAPVTPPRTGRVPTDPAKISASVSTS
QGNIGLELDNGKSPCTVNNFASLAQQGFFDDTTCHRLTTARSLKVLQCGDPTGTGAGGPGYRFPNEYPTSQYRLSDPGLR
RPVVYPRGTLVMANTGPGTNGSQFMLVYGDTLLPPTYTVFGTVDSTGLATLDRIAARGVAGGADDGKPAAEVKIISARLD

Sequences:

>Translated_320_residues
MSYPSWPPYPPPPAYPRTTNAWAVAALVCAFLFAPLGIVFGHLSLSQIKRTGEDGRGLALAGLIIGYVMTALTVIVVVFS
VLFLVAVAQHVGELRVDDGSTRSAAPPSGDRLPAFVAPRNLGANCQYPKGDLPAGAPVTPPRTGRVPTDPAKISASVSTS
QGNIGLELDNGKSPCTVNNFASLAQQGFFDDTTCHRLTTARSLKVLQCGDPTGTGAGGPGYRFPNEYPTSQYRLSDPGLR
RPVVYPRGTLVMANTGPGTNGSQFMLVYGDTLLPPTYTVFGTVDSTGLATLDRIAARGVAGGADDGKPAAEVKIISARLD
>Mature_319_residues
SYPSWPPYPPPPAYPRTTNAWAVAALVCAFLFAPLGIVFGHLSLSQIKRTGEDGRGLALAGLIIGYVMTALTVIVVVFSV
LFLVAVAQHVGELRVDDGSTRSAAPPSGDRLPAFVAPRNLGANCQYPKGDLPAGAPVTPPRTGRVPTDPAKISASVSTSQ
GNIGLELDNGKSPCTVNNFASLAQQGFFDDTTCHRLTTARSLKVLQCGDPTGTGAGGPGYRFPNEYPTSQYRLSDPGLRR
PVVYPRGTLVMANTGPGTNGSQFMLVYGDTLLPPTYTVFGTVDSTGLATLDRIAARGVAGGADDGKPAAEVKIISARLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=150, Percent_Identity=38.6666666666667, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=36.144578313253, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=167, Percent_Identity=36.5269461077844, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=30.5389221556886, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=165, Percent_Identity=35.1515151515151, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=169, Percent_Identity=31.9526627218935, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532641, Length=196, Percent_Identity=31.1224489795918, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=169, Percent_Identity=34.9112426035503, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=31.7365269461078, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 33417; Mature: 33286

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYPSWPPYPPPPAYPRTTNAWAVAALVCAFLFAPLGIVFGHLSLSQIKRTGEDGRGLAL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AGLIIGYVMTALTVIVVVFSVLFLVAVAQHVGELRVDDGSTRSAAPPSGDRLPAFVAPRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEECCCC
LGANCQYPKGDLPAGAPVTPPRTGRVPTDPAKISASVSTSQGNIGLELDNGKSPCTVNNF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEEEECCCCCCCCHHHH
ASLAQQGFFDDTTCHRLTTARSLKVLQCGDPTGTGAGGPGYRFPNEYPTSQYRLSDPGLR
HHHHHHCCCCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
RPVVYPRGTLVMANTGPGTNGSQFMLVYGDTLLPPTYTVFGTVDSTGLATLDRIAARGVA
CCEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
GGADDGKPAAEVKIISARLD
CCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
SYPSWPPYPPPPAYPRTTNAWAVAALVCAFLFAPLGIVFGHLSLSQIKRTGEDGRGLAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AGLIIGYVMTALTVIVVVFSVLFLVAVAQHVGELRVDDGSTRSAAPPSGDRLPAFVAPRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEECCCC
LGANCQYPKGDLPAGAPVTPPRTGRVPTDPAKISASVSTSQGNIGLELDNGKSPCTVNNF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEEEECCCCCCCCHHHH
ASLAQQGFFDDTTCHRLTTARSLKVLQCGDPTGTGAGGPGYRFPNEYPTSQYRLSDPGLR
HHHHHHCCCCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
RPVVYPRGTLVMANTGPGTNGSQFMLVYGDTLLPPTYTVFGTVDSTGLATLDRIAARGVA
CCEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
GGADDGKPAAEVKIISARLD
CCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]