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The map label for this gene is bdhA [H]

Identifier: 119868369

GI number: 119868369

Start: 2445491

End: 2446648

Strand: Reverse

Name: bdhA [H]

Synonym: Mkms_2333

Alternate gene names: 119868369

Gene position: 2446648-2445491 (Counterclockwise)

Preceding gene: 119868370

Following gene: 119868366

Centisome position: 42.65

GC content: 70.55

Gene sequence:

>1158_bases
ATGAAAGCCGTCAGCTGCGAGCGCGGCACCCTGTCCGTGGTCGACCTGCCCACCCCGCGGCCGGCCAAAGGCCAGCTGCT
GCTCGAGGTGCGGCGCTGCGGGATCTGCGGATCCGACCTGCACGCCAAGGACCACGCCGACGAGTTGACCGAGGTGATGG
ACCGGATCGGCTATCCGGACTTCATGCGCGGGGACACCCCGGTGGTTCTCGGTCACGAGTTCTGCGGTGAGGTGGCCGAC
CGCGGTAAGGGTGTCGGTAAGGAGTTCAAACCGGGCACGCCGGTCGTGTCCTTCCCGCTGGTGCGGGCCGCCGGCGGCAT
CCACCTCACCGGGCTCTCCCCGCTGGCGCCCGGTGGCTTCGCCGAACAGGTCGTCGCCGAGGCGTCGATGAGCTTCGTCA
TCCCCAACGGACTCGACCTGGACACCGCGGCGCTGACCGAGCCGATGGCCGTCGCTCTGCACGCCGTGCGGCGCAGTGAG
ATCCGCAGACGCGACACCGCGATCGTGATCGGCTGCGGGCCGGTCGGCCTCGCGGTGATCTGCCACCTCAAGGCGCTCGG
CGTGCGCACGATCGTCGCCAGCGACTTCTCCGCCACCCGGCGCGCCCTGGCCACCCGCTGCGGGGCGCACGTGGTCGTCG
ACCCGGCCGTCGACTCACCGTACGAGGCGGGCGGTCAGCGCGGTGCGATCACCGAGGCCCCGCAGCTCTACGAATTGGGC
GTGGGCTCCATGGAGAAGCTGCGCCGGGTGCCGGGCTGGATCCACCTCTACCGGGCCGCCGAGGCGCTCGGCGCCGCGGG
ACCGAAACGACCGATCGTGTTCGAATGCGTCGGGCTGCCCGGCGTTATCGACGGCATCATCGGCGCGGCCCCGCTGCAAT
CCCGCGTGGTGGTCGTCGGCGTCTGCATGGGCGAGGACCGGCTGCACCCGACCATCGCCAACGCCAAGGAGATCGACCTG
CGGTTCGTATTCGCCTACACGCCCCTGGAGTTCCGCGACACGCTGTACATGCTCGCCGAGGGCAAGCTCGACGCGTCACC
GCTGATCACCGGCACCGTCGGGCTCGACGGCGTCGCGAACGCCTTCGACGTGCTGGGATCGGCCGAGGCGCACGCCAAAA
TCCTCATCGACCCCCGCAGCACCGCCGTCGCACCCTAG

Upstream 100 bases:

>100_bases
CATCCTCGAAGCCGGTCGGATCACCTCCAGCGGCACCGGAGGGTCCGCCTCGGAGGCCGACGTGCGGGCCGCGATGGCCA
TCTGAGCTACTGTCGGCGGC

Downstream 100 bases:

>100_bases
CCGAGCCGCGAAACCACCTCCGCGACAACGGCTTCCCGCGCCATCTCGATCTGGTCACCGGTGCCGAGGTCCTTCACCTT
CACGGTGGCGACGCCGGGGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKAVSCERGTLSVVDLPTPRPAKGQLLLEVRRCGICGSDLHAKDHADELTEVMDRIGYPDFMRGDTPVVLGHEFCGEVAD
RGKGVGKEFKPGTPVVSFPLVRAAGGIHLTGLSPLAPGGFAEQVVAEASMSFVIPNGLDLDTAALTEPMAVALHAVRRSE
IRRRDTAIVIGCGPVGLAVICHLKALGVRTIVASDFSATRRALATRCGAHVVVDPAVDSPYEAGGQRGAITEAPQLYELG
VGSMEKLRRVPGWIHLYRAAEALGAAGPKRPIVFECVGLPGVIDGIIGAAPLQSRVVVVGVCMGEDRLHPTIANAKEIDL
RFVFAYTPLEFRDTLYMLAEGKLDASPLITGTVGLDGVANAFDVLGSAEAHAKILIDPRSTAVAP

Sequences:

>Translated_385_residues
MKAVSCERGTLSVVDLPTPRPAKGQLLLEVRRCGICGSDLHAKDHADELTEVMDRIGYPDFMRGDTPVVLGHEFCGEVAD
RGKGVGKEFKPGTPVVSFPLVRAAGGIHLTGLSPLAPGGFAEQVVAEASMSFVIPNGLDLDTAALTEPMAVALHAVRRSE
IRRRDTAIVIGCGPVGLAVICHLKALGVRTIVASDFSATRRALATRCGAHVVVDPAVDSPYEAGGQRGAITEAPQLYELG
VGSMEKLRRVPGWIHLYRAAEALGAAGPKRPIVFECVGLPGVIDGIIGAAPLQSRVVVVGVCMGEDRLHPTIANAKEIDL
RFVFAYTPLEFRDTLYMLAEGKLDASPLITGTVGLDGVANAFDVLGSAEAHAKILIDPRSTAVAP
>Mature_385_residues
MKAVSCERGTLSVVDLPTPRPAKGQLLLEVRRCGICGSDLHAKDHADELTEVMDRIGYPDFMRGDTPVVLGHEFCGEVAD
RGKGVGKEFKPGTPVVSFPLVRAAGGIHLTGLSPLAPGGFAEQVVAEASMSFVIPNGLDLDTAALTEPMAVALHAVRRSE
IRRRDTAIVIGCGPVGLAVICHLKALGVRTIVASDFSATRRALATRCGAHVVVDPAVDSPYEAGGQRGAITEAPQLYELG
VGSMEKLRRVPGWIHLYRAAEALGAAGPKRPIVFECVGLPGVIDGIIGAAPLQSRVVVVGVCMGEDRLHPTIANAKEIDL
RFVFAYTPLEFRDTLYMLAEGKLDASPLITGTVGLDGVANAFDVLGSAEAHAKILIDPRSTAVAP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=369, Percent_Identity=27.10027100271, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1790045, Length=389, Percent_Identity=24.6786632390745, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.4794520547945, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788073, Length=377, Percent_Identity=23.342175066313, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790718, Length=365, Percent_Identity=24.3835616438356, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=214, Percent_Identity=28.9719626168224, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787863, Length=389, Percent_Identity=24.1645244215938, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788407, Length=379, Percent_Identity=23.7467018469657, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=367, Percent_Identity=27.7929155313352, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=361, Percent_Identity=27.4238227146814, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=396, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=238, Percent_Identity=32.3529411764706, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=377, Percent_Identity=22.8116710875332, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137530, Length=380, Percent_Identity=25.7894736842105, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737897, Length=360, Percent_Identity=25.5555555555556, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 40500; Mature: 40500

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVSCERGTLSVVDLPTPRPAKGQLLLEVRRCGICGSDLHAKDHADELTEVMDRIGYPD
CCCCCCCCCCEEEEECCCCCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
FMRGDTPVVLGHEFCGEVADRGKGVGKEFKPGTPVVSFPLVRAAGGIHLTGLSPLAPGGF
HHCCCCCEEECHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCCCCCH
AEQVVAEASMSFVIPNGLDLDTAALTEPMAVALHAVRRSEIRRRDTAIVIGCGPVGLAVI
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
CHLKALGVRTIVASDFSATRRALATRCGAHVVVDPAVDSPYEAGGQRGAITEAPQLYELG
HHHHHHHHHHEECCCHHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCHHHHCC
VGSMEKLRRVPGWIHLYRAAEALGAAGPKRPIVFECVGLPGVIDGIIGAAPLQSRVVVVG
CCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCEEEEE
VCMGEDRLHPTIANAKEIDLRFVFAYTPLEFRDTLYMLAEGKLDASPLITGTVGLDGVAN
EEECCCCCCCCCCCCEEEEEEEEEEECCHHHHCEEEEEECCCCCCCCEEEEECCCCHHHH
AFDVLGSAEAHAKILIDPRSTAVAP
HHHHHCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKAVSCERGTLSVVDLPTPRPAKGQLLLEVRRCGICGSDLHAKDHADELTEVMDRIGYPD
CCCCCCCCCCEEEEECCCCCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
FMRGDTPVVLGHEFCGEVADRGKGVGKEFKPGTPVVSFPLVRAAGGIHLTGLSPLAPGGF
HHCCCCCEEECHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCCCCCH
AEQVVAEASMSFVIPNGLDLDTAALTEPMAVALHAVRRSEIRRRDTAIVIGCGPVGLAVI
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
CHLKALGVRTIVASDFSATRRALATRCGAHVVVDPAVDSPYEAGGQRGAITEAPQLYELG
HHHHHHHHHHEECCCHHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCHHHHCC
VGSMEKLRRVPGWIHLYRAAEALGAAGPKRPIVFECVGLPGVIDGIIGAAPLQSRVVVVG
CCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCEEEEE
VCMGEDRLHPTIANAKEIDLRFVFAYTPLEFRDTLYMLAEGKLDASPLITGTVGLDGVAN
EEECCCCCCCCCCCCEEEEEEEEEEECCHHHHCEEEEEECCCCCCCCEEEEECCCCHHHH
AFDVLGSAEAHAKILIDPRSTAVAP
HHHHHCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]