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The map label for this gene is glxR1 [H]

Identifier: 119899651

GI number: 119899651

Start: 3698348

End: 3699238

Strand: Reverse

Name: glxR1 [H]

Synonym: azo3362

Alternate gene names: 119899651

Gene position: 3699238-3698348 (Counterclockwise)

Preceding gene: 119899652

Following gene: 119899648

Centisome position: 84.53

GC content: 72.84

Gene sequence:

>891_bases
ATGAAGGTCGGCTTCGTCGGCCTCGGCGTGATGGGCGTGCCGATGGCCGGCCATCTGCTCAAGGCCGGTCATCAGGTGGC
GATCTGGGCGCGGCGGCCCGATGCGGCGCAGGCACTGATTGCCGATGGCACGCTCGCCGGCGCCGAGCTGTGCGCCACGC
CGGCGGCGCTGGCGGCGCGCAGCGAGGTCGTGATCAGCATCATCACCGCCAGCGCCGACGTCGAGGCGCTGGCTTTCGGC
GACGACGGACTGGCGGCCGGTTTCGCGCCCGGCGCGATCCATGTGGACATGAGCACGATCGCGCCGGCCACCGCGCGCGC
ACTCGCCGCGCGCTATGCGAAGCAGGGCGTGGGCTGGGTGGATGCGCCGGTGTCCGGCGGCGGCACGGGCGCGCGCGAGG
CGACGTTGGCGATCATGGCCGGCGGCGAGGCAGAAACCCTGGCTCGCGTGCGGCCGCTGTTCGAGGTGCTTGGCCGCACC
GTGGTGCACATCGGCCCGGCCGGGGCGGGGCAGGTGGCCAAGGCCTGCAACCAGATGATCATGGTGGCCGCGATCCAGGC
GAGCGCCGAGGCGATGCACCTGGCCAACGCCCACGGCGTCGACCTGGCGGCGGTGCAGCGCGCCTTGATGGGCGGTTCCG
CGGCTTCGCGCGTGATGGAGGTGATGGGCGGGCGCATGGTGGCGCGCGACTTCGGCGCCGGCATCGAGGCCCGCCTGCAT
CACAAGGATTTCGCCATCCTGATGGGCGAGGCGGTGGGGCTCGGGGTGCCGCTGCCGGTGGCGGCGCAGGTGTGGCAGCA
GCTGAATGCGCTGATGGCCTCGGGCATGGGGCGCGACGACACCAGCAGCCTGCTGCGCGTGCTCGAAAACATGGCGGCGC
GGCCATCGTGA

Upstream 100 bases:

>100_bases
CCGCGCAGATGTTCAACGCGATGGTCGGCAGCGGCCTCGGTGAGGACGATTCGATCGCGATGCTGAAGCTGCTCGAACGC
ATGAGCGGGGGCGCGGGCGA

Downstream 100 bases:

>100_bases
GCGCGCTGCGGATTGCCGCCGCGGTCGTTCTGGTCGTTGCACTGCAGGGGTGTGCGGTGTTCGCGGTGGCCGATGCGGTC
ATCACCGTGGGTGCCACCGC

Product: putative 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKVGFVGLGVMGVPMAGHLLKAGHQVAIWARRPDAAQALIADGTLAGAELCATPAALAARSEVVISIITASADVEALAFG
DDGLAAGFAPGAIHVDMSTIAPATARALAARYAKQGVGWVDAPVSGGGTGAREATLAIMAGGEAETLARVRPLFEVLGRT
VVHIGPAGAGQVAKACNQMIMVAAIQASAEAMHLANAHGVDLAAVQRALMGGSAASRVMEVMGGRMVARDFGAGIEARLH
HKDFAILMGEAVGLGVPLPVAAQVWQQLNALMASGMGRDDTSSLLRVLENMAARPS

Sequences:

>Translated_296_residues
MKVGFVGLGVMGVPMAGHLLKAGHQVAIWARRPDAAQALIADGTLAGAELCATPAALAARSEVVISIITASADVEALAFG
DDGLAAGFAPGAIHVDMSTIAPATARALAARYAKQGVGWVDAPVSGGGTGAREATLAIMAGGEAETLARVRPLFEVLGRT
VVHIGPAGAGQVAKACNQMIMVAAIQASAEAMHLANAHGVDLAAVQRALMGGSAASRVMEVMGGRMVARDFGAGIEARLH
HKDFAILMGEAVGLGVPLPVAAQVWQQLNALMASGMGRDDTSSLLRVLENMAARPS
>Mature_296_residues
MKVGFVGLGVMGVPMAGHLLKAGHQVAIWARRPDAAQALIADGTLAGAELCATPAALAARSEVVISIITASADVEALAFG
DDGLAAGFAPGAIHVDMSTIAPATARALAARYAKQGVGWVDAPVSGGGTGAREATLAIMAGGEAETLARVRPLFEVLGRT
VVHIGPAGAGQVAKACNQMIMVAAIQASAEAMHLANAHGVDLAAVQRALMGGSAASRVMEVMGGRMVARDFGAGIEARLH
HKDFAILMGEAVGLGVPLPVAAQVWQQLNALMASGMGRDDTSSLLRVLENMAARPS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=32.312925170068, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI40556376, Length=293, Percent_Identity=28.6689419795222, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=39.2491467576792, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=38.6986301369863, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=31.3131313131313, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=28.0821917808219, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=277, Percent_Identity=30.6859205776173, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=32.2033898305085, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=32.2033898305085, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=23.943661971831, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29906; Mature: 29906

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFVGLGVMGVPMAGHLLKAGHQVAIWARRPDAAQALIADGTLAGAELCATPAALAAR
CCEEEEECCHHCCCHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCCCHHHHCCHHHHHHC
SEVVISIITASADVEALAFGDDGLAAGFAPGAIHVDMSTIAPATARALAARYAKQGVGWV
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHCCCEE
DAPVSGGGTGAREATLAIMAGGEAETLARVRPLFEVLGRTVVHIGPAGAGQVAKACNQMI
ECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
MVAAIQASAEAMHLANAHGVDLAAVQRALMGGSAASRVMEVMGGRMVARDFGAGIEARLH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEEHHHCCCCEEEEE
HKDFAILMGEAVGLGVPLPVAAQVWQQLNALMASGMGRDDTSSLLRVLENMAARPS
CCCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVGFVGLGVMGVPMAGHLLKAGHQVAIWARRPDAAQALIADGTLAGAELCATPAALAAR
CCEEEEECCHHCCCHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCCCHHHHCCHHHHHHC
SEVVISIITASADVEALAFGDDGLAAGFAPGAIHVDMSTIAPATARALAARYAKQGVGWV
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHCCCEE
DAPVSGGGTGAREATLAIMAGGEAETLARVRPLFEVLGRTVVHIGPAGAGQVAKACNQMI
ECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
MVAAIQASAEAMHLANAHGVDLAAVQRALMGGSAASRVMEVMGGRMVARDFGAGIEARLH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEEHHHCCCCEEEEE
HKDFAILMGEAVGLGVPLPVAAQVWQQLNALMASGMGRDDTSSLLRVLENMAARPS
CCCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]