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The map label for this gene is glxR2 [H]

Identifier: 119899652

GI number: 119899652

Start: 3699235

End: 3700116

Strand: Reverse

Name: glxR2 [H]

Synonym: azo3363

Alternate gene names: 119899652

Gene position: 3700116-3699235 (Counterclockwise)

Preceding gene: 119899654

Following gene: 119899651

Centisome position: 84.55

GC content: 70.41

Gene sequence:

>882_bases
ATGGAAGTCGGATTCATCGGACTCGGCCTGATGGGCCGCCCCATGGTGTTGAACCTGCTGAAGGCCGGCCACACGGTGCA
CGTGTGGAGCCGCCGGCGCGAATCCATGGTGCCGCTGCTCGAAGCCGGCGCCGGCGACTGTGCGAGCGCCGCCGAGGTGG
CGAGCCGCGCCGCGGTGACCTTCAGCATGGTGGCCGATGCCCCCGACGTCGAACAGGTGACGCTGGGCGAGGGCGGCGTC
GCCAGCGCGGCGCGTGCGGGGCACATCCATGTGGATATGAGCACGATCGCCCCTGCCGCTGCGCAGGCGATCGCCGCGCG
GCTGGCCGAGCGCGGCGTCACCCTGCTGGATGCGCCGGTGTCCGGCGGCGAGGTTGGCGCGATCGCCGGCACCCTCACCA
TCATGGTCGGCGGCGACGCCGCGGCCTTCGACACCGTGAAGCCGGCGTTCGAGGCGATGGGCAAGTCGATCAACCGCATC
GGCGACTCCGGCGCCGGGCAGGTCGCCAAGGCCTGCAACCAGATCCTCACCGGCGTCGGCGTGGCGGCGGTGGCCGAGGC
GCTCAACTTCGCCACCCGCAGCGGCGTCGATGCCACCAAGGTGCGCGAGGCCCTGCTCGGCGGCTTTGCCTACTCGCGCA
TCCTGGAAAACCACGGCCAGCGCATGCTCGACCGCAACTTCCGCCCCGGCTTCAAGGCCTGGATGCACCAGAAGGACATG
CGCATCGTGATGGAAGAGGCTCACCGCCTCGGTCTGGCGCTGCCGTCCTCGGCGGCCACCGCGCAGATGTTCAACGCGAT
GGTCGGCAGCGGCCTCGGTGAGGACGATTCGATCGCGATGCTGAAGCTGCTCGAACGCATGAGCGGGGGCGCGGGCGAAT
GA

Upstream 100 bases:

>100_bases
GCGTAGCTCATGCCGGCATTATCCGCGCCTGAGCAGCGCGCTGGAACCCGCGGCCGCCGCCTTTTTCTCCCTTTCCCTGT
TTCTCCCGGAGCCCACGATT

Downstream 100 bases:

>100_bases
AGGTCGGCTTCGTCGGCCTCGGCGTGATGGGCGTGCCGATGGCCGGCCATCTGCTCAAGGCCGGTCATCAGGTGGCGATC
TGGGCGCGGCGGCCCGATGC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MEVGFIGLGLMGRPMVLNLLKAGHTVHVWSRRRESMVPLLEAGAGDCASAAEVASRAAVTFSMVADAPDVEQVTLGEGGV
ASAARAGHIHVDMSTIAPAAAQAIAARLAERGVTLLDAPVSGGEVGAIAGTLTIMVGGDAAAFDTVKPAFEAMGKSINRI
GDSGAGQVAKACNQILTGVGVAAVAEALNFATRSGVDATKVREALLGGFAYSRILENHGQRMLDRNFRPGFKAWMHQKDM
RIVMEEAHRLGLALPSSAATAQMFNAMVGSGLGEDDSIAMLKLLERMSGGAGE

Sequences:

>Translated_293_residues
MEVGFIGLGLMGRPMVLNLLKAGHTVHVWSRRRESMVPLLEAGAGDCASAAEVASRAAVTFSMVADAPDVEQVTLGEGGV
ASAARAGHIHVDMSTIAPAAAQAIAARLAERGVTLLDAPVSGGEVGAIAGTLTIMVGGDAAAFDTVKPAFEAMGKSINRI
GDSGAGQVAKACNQILTGVGVAAVAEALNFATRSGVDATKVREALLGGFAYSRILENHGQRMLDRNFRPGFKAWMHQKDM
RIVMEEAHRLGLALPSSAATAQMFNAMVGSGLGEDDSIAMLKLLERMSGGAGE
>Mature_293_residues
MEVGFIGLGLMGRPMVLNLLKAGHTVHVWSRRRESMVPLLEAGAGDCASAAEVASRAAVTFSMVADAPDVEQVTLGEGGV
ASAARAGHIHVDMSTIAPAAAQAIAARLAERGVTLLDAPVSGGEVGAIAGTLTIMVGGDAAAFDTVKPAFEAMGKSINRI
GDSGAGQVAKACNQILTGVGVAAVAEALNFATRSGVDATKVREALLGGFAYSRILENHGQRMLDRNFRPGFKAWMHQKDM
RIVMEEAHRLGLALPSSAATAQMFNAMVGSGLGEDDSIAMLKLLERMSGGAGE

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=264, Percent_Identity=32.9545454545455, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=28.8659793814433, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=46.2328767123288, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=41.6666666666667, Blast_Score=236, Evalue=9e-64,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=33.448275862069, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=29.5918367346939, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557316, Length=196, Percent_Identity=35.2040816326531, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=30.1369863013699, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=30.1369863013699, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=28.673835125448, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30182; Mature: 30182

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGFIGLGLMGRPMVLNLLKAGHTVHVWSRRRESMVPLLEAGAGDCASAAEVASRAAVT
CCCEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHH
FSMVADAPDVEQVTLGEGGVASAARAGHIHVDMSTIAPAAAQAIAARLAERGVTLLDAPV
HHHHCCCCCCCEEECCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEECCC
SGGEVGAIAGTLTIMVGGDAAAFDTVKPAFEAMGKSINRIGDSGAGQVAKACNQILTGVG
CCCCHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VAAVAEALNFATRSGVDATKVREALLGGFAYSRILENHGQRMLDRNFRPGFKAWMHQKDM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RIVMEEAHRLGLALPSSAATAQMFNAMVGSGLGEDDSIAMLKLLERMSGGAGE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEVGFIGLGLMGRPMVLNLLKAGHTVHVWSRRRESMVPLLEAGAGDCASAAEVASRAAVT
CCCEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHH
FSMVADAPDVEQVTLGEGGVASAARAGHIHVDMSTIAPAAAQAIAARLAERGVTLLDAPV
HHHHCCCCCCCEEECCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEECCC
SGGEVGAIAGTLTIMVGGDAAAFDTVKPAFEAMGKSINRIGDSGAGQVAKACNQILTGVG
CCCCHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VAAVAEALNFATRSGVDATKVREALLGGFAYSRILENHGQRMLDRNFRPGFKAWMHQKDM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RIVMEEAHRLGLALPSSAATAQMFNAMVGSGLGEDDSIAMLKLLERMSGGAGE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]