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The map label for this gene is trpE [H]

Identifier: 119899614

GI number: 119899614

Start: 3664662

End: 3666134

Strand: Reverse

Name: trpE [H]

Synonym: azo3325

Alternate gene names: 119899614

Gene position: 3666134-3664662 (Counterclockwise)

Preceding gene: 119899615

Following gene: 119899613

Centisome position: 83.78

GC content: 66.53

Gene sequence:

>1473_bases
ATGCTCGAACAGGAATTCAATGCCCTGGCTGAACAGGGCTACAACCGCATCCCGGTCACGCTCGAGACCTTCGCCGATCT
CGACACGCCGCTCTCCATCTACCTGAAGCTCGCCAACGAGCCCTACACCTACCTGCTGGAATCGGTGCAGGGCGGAGAGC
GCTTCGGCCGTTACTCCTTCATCGGACTCGCATCGCCGACGCGCATCGAGGTGTATGGCCGTTCGGCGCTGCTGCTCACC
GGCAACCGCCTCGTCGAGCGCCGCGACTACGGCGACCCGCTCAACTTCGTCGCCGAGTTCATGAACCGCATCAAGGTGCC
GCCGCGCGAGCATCTGCCGCGCTTCGCGGGTGGGTTGGTTGGTTGCTTCGGCTACGACACCGTGCGCTACATCGAGCCCC
GCCTCGCCAAGACCGACAAACCCGACGCGATCGGTACGCCGGACATCCTGCTGATGCTGTCGGAGGAGATCGCCATCGTC
GACAACCTCACCGGCAAGCTCACGCTGGTGGTGTATGCCGAGCCCGAGGTGCCGGGCGCCTTCAAGCGCGCCAAGAAGCG
CCTGCAGGAACTGCTCGCCCGGCTGCGCGCGCCGGTGGCCATCCCGGAGGAGTCGCGCGCCGAGTCCGCGCCGGCGGTCT
CCAGCTTCGGCGAGGAGGCCTTCAAGGACGCGGTGCGCCGCGCCAAGCAGTACATCGTCGACGGCGACATCATGCAGGTG
GTGTTGTCGCAGCGCATGAGCAAGCCGTTCGCCGCGCATCCGATGGCGCTTTACCGGGCGATCCGCTCGCTGAATCCTTC
GCCCTACATGTTCTACTTCAACCTCGAGGACTTCCATGTCGTCGGCGCCTCGCCGGAAATCCTGGTGCGGCTGGAGGACG
ATACGGTGACAGTGCGGCCGATCGCCGGCACCCGCAAGCGGGGCGCCACCGTCGCCGAGGATGCGGCGCTGGAAGAGGAC
CTGCTGGCCGACCAGAAGGAGTGCGCGGAGCACCTGCAGTTGCTCGATCTCGGCCGCAACGATGCCGGCCGGGTGTCGGA
GACGGGTACGGTGAAGGTCACCGAACGCTTCACCGTCGAGCGCTATTCCCACGTGATGCATATCGTGTCCAACGTCGAAG
GACAGTTGAAGGAGGGGCTGGACGCGCTGGCGGTGCTGCGCGCCACTTTCCCGGCCGGCACGGTGTCGGGCGCGCCCAAG
CTGCGCGCGATGGAGATCATCGACGAGCTGGAGCCGGTCAAGCGGGGCATCTACGCCGGGTCGGTGGGTTATGTCGGTTT
CCACGGCGACATGGACCTGGCGATCGCGATCCGCACCGCGGTGCTGAAGGACGGTCAGATCCACGTGCAGGCGGGGGCGG
GCATCGTTGCCGATTCCGACCCGGACGCCGAATGGCAGGAAACGCAGAACAAGGCGCGCGCCATGCTGCGGGCGGCCGAG
ATGGCCGAGGGCGGGCTGGATACGCAGGTTTGA

Upstream 100 bases:

>100_bases
CCTCGCGGGTCCCGGCATCTCACTGCGCCTCTTGGCGCGCACCTCCGCCGGCTCCACCCGCCCAGCAGTCTTCCGGATCA
ACCGTTTTCGTGGAGCACCC

Downstream 100 bases:

>100_bases
GGTTTGTGCCGCTGGTGGCTTGGTGAGCTGAAACCGGCGGCACGGGTGGTATTTGTTCCAGTTCTGCGGAACCCGCTCGC
TCGGACAGTCCTCGCCCTTC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLEQEFNALAEQGYNRIPVTLETFADLDTPLSIYLKLANEPYTYLLESVQGGERFGRYSFIGLASPTRIEVYGRSALLLT
GNRLVERRDYGDPLNFVAEFMNRIKVPPREHLPRFAGGLVGCFGYDTVRYIEPRLAKTDKPDAIGTPDILLMLSEEIAIV
DNLTGKLTLVVYAEPEVPGAFKRAKKRLQELLARLRAPVAIPEESRAESAPAVSSFGEEAFKDAVRRAKQYIVDGDIMQV
VLSQRMSKPFAAHPMALYRAIRSLNPSPYMFYFNLEDFHVVGASPEILVRLEDDTVTVRPIAGTRKRGATVAEDAALEED
LLADQKECAEHLQLLDLGRNDAGRVSETGTVKVTERFTVERYSHVMHIVSNVEGQLKEGLDALAVLRATFPAGTVSGAPK
LRAMEIIDELEPVKRGIYAGSVGYVGFHGDMDLAIAIRTAVLKDGQIHVQAGAGIVADSDPDAEWQETQNKARAMLRAAE
MAEGGLDTQV

Sequences:

>Translated_490_residues
MLEQEFNALAEQGYNRIPVTLETFADLDTPLSIYLKLANEPYTYLLESVQGGERFGRYSFIGLASPTRIEVYGRSALLLT
GNRLVERRDYGDPLNFVAEFMNRIKVPPREHLPRFAGGLVGCFGYDTVRYIEPRLAKTDKPDAIGTPDILLMLSEEIAIV
DNLTGKLTLVVYAEPEVPGAFKRAKKRLQELLARLRAPVAIPEESRAESAPAVSSFGEEAFKDAVRRAKQYIVDGDIMQV
VLSQRMSKPFAAHPMALYRAIRSLNPSPYMFYFNLEDFHVVGASPEILVRLEDDTVTVRPIAGTRKRGATVAEDAALEED
LLADQKECAEHLQLLDLGRNDAGRVSETGTVKVTERFTVERYSHVMHIVSNVEGQLKEGLDALAVLRATFPAGTVSGAPK
LRAMEIIDELEPVKRGIYAGSVGYVGFHGDMDLAIAIRTAVLKDGQIHVQAGAGIVADSDPDAEWQETQNKARAMLRAAE
MAEGGLDTQV
>Mature_490_residues
MLEQEFNALAEQGYNRIPVTLETFADLDTPLSIYLKLANEPYTYLLESVQGGERFGRYSFIGLASPTRIEVYGRSALLLT
GNRLVERRDYGDPLNFVAEFMNRIKVPPREHLPRFAGGLVGCFGYDTVRYIEPRLAKTDKPDAIGTPDILLMLSEEIAIV
DNLTGKLTLVVYAEPEVPGAFKRAKKRLQELLARLRAPVAIPEESRAESAPAVSSFGEEAFKDAVRRAKQYIVDGDIMQV
VLSQRMSKPFAAHPMALYRAIRSLNPSPYMFYFNLEDFHVVGASPEILVRLEDDTVTVRPIAGTRKRGATVAEDAALEED
LLADQKECAEHLQLLDLGRNDAGRVSETGTVKVTERFTVERYSHVMHIVSNVEGQLKEGLDALAVLRATFPAGTVSGAPK
LRAMEIIDELEPVKRGIYAGSVGYVGFHGDMDLAIAIRTAVLKDGQIHVQAGAGIVADSDPDAEWQETQNKARAMLRAAE
MAEGGLDTQV

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=451, Percent_Identity=33.2594235033259, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1787518, Length=408, Percent_Identity=39.2156862745098, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1786809, Length=262, Percent_Identity=29.7709923664122, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87082077, Length=258, Percent_Identity=30.2325581395349, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=463, Percent_Identity=39.9568034557235, Blast_Score=307, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324361, Length=418, Percent_Identity=26.7942583732057, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54024; Mature: 54024

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQEFNALAEQGYNRIPVTLETFADLDTPLSIYLKLANEPYTYLLESVQGGERFGRYSF
CCCHHHHHHHHCCCCCCCEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCEEE
IGLASPTRIEVYGRSALLLTGNRLVERRDYGDPLNFVAEFMNRIKVPPREHLPRFAGGLV
EECCCCCEEEEECCEEEEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCHHHHCCCE
GCFGYDTVRYIEPRLAKTDKPDAIGTPDILLMLSEEIAIVDNLTGKLTLVVYAEPEVPGA
EHHCCCHHHHHCCHHCCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCHH
FKRAKKRLQELLARLRAPVAIPEESRAESAPAVSSFGEEAFKDAVRRAKQYIVDGDIMQV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VLSQRMSKPFAAHPMALYRAIRSLNPSPYMFYFNLEDFHVVGASPEILVRLEDDTVTVRP
HHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCEEEEEECCCEEEEEE
IAGTRKRGATVAEDAALEEDLLADQKECAEHLQLLDLGRNDAGRVSETGTVKVTERFTVE
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
RYSHVMHIVSNVEGQLKEGLDALAVLRATFPAGTVSGAPKLRAMEIIDELEPVKRGIYAG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEC
SVGYVGFHGDMDLAIAIRTAVLKDGQIHVQAGAGIVADSDPDAEWQETQNKARAMLRAAE
CCCEEEECCCCEEHHEEHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHH
MAEGGLDTQV
HHCCCCCCCC
>Mature Secondary Structure
MLEQEFNALAEQGYNRIPVTLETFADLDTPLSIYLKLANEPYTYLLESVQGGERFGRYSF
CCCHHHHHHHHCCCCCCCEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCEEE
IGLASPTRIEVYGRSALLLTGNRLVERRDYGDPLNFVAEFMNRIKVPPREHLPRFAGGLV
EECCCCCEEEEECCEEEEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCHHHHCCCE
GCFGYDTVRYIEPRLAKTDKPDAIGTPDILLMLSEEIAIVDNLTGKLTLVVYAEPEVPGA
EHHCCCHHHHHCCHHCCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCHH
FKRAKKRLQELLARLRAPVAIPEESRAESAPAVSSFGEEAFKDAVRRAKQYIVDGDIMQV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VLSQRMSKPFAAHPMALYRAIRSLNPSPYMFYFNLEDFHVVGASPEILVRLEDDTVTVRP
HHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCEEEEEECCCEEEEEE
IAGTRKRGATVAEDAALEEDLLADQKECAEHLQLLDLGRNDAGRVSETGTVKVTERFTVE
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
RYSHVMHIVSNVEGQLKEGLDALAVLRATFPAGTVSGAPKLRAMEIIDELEPVKRGIYAG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEC
SVGYVGFHGDMDLAIAIRTAVLKDGQIHVQAGAGIVADSDPDAEWQETQNKARAMLRAAE
CCCEEEECCCCEEHHEEHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHH
MAEGGLDTQV
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]