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The map label for this gene is maeB2 [H]

Identifier: 119899500

GI number: 119899500

Start: 3538418

End: 3540706

Strand: Reverse

Name: maeB2 [H]

Synonym: azo3211

Alternate gene names: 119899500

Gene position: 3540706-3538418 (Counterclockwise)

Preceding gene: 119899502

Following gene: 119899499

Centisome position: 80.91

GC content: 66.14

Gene sequence:

>2289_bases
ATGGATCAGGATTTCATCGCCGCGGCGCTGGATTATCACCGTGCACCGACGCGCGGCAAGATTTCGGTCGTCCCCACCAA
AGGCCTCACCAACCAGCGCGATCTGGCGCTGGCCTACTCGCCGGGCGTGGCCGCCGCGTGCGACGCCATCGTTGCCGACC
CGGCCGAAGCGCGCGAACTCACCAGCCGCGGCAACCTCGTCGCCGTGGTCACCAACGGCACCGCGGTGCTCGGCCTGGGC
AACATCGGCCCGCTGGCCGCCAAGCCGGTGATGGAAGGCAAGGGCTGCCTGTTCAAGAAGTTCGCCAACATCGACGTGTT
CGACATCGAACTCGCCGAGAACGACCCCGACAAGCTGATCGACATCATCGCCTCGCTGGAGCCCACGCTGGGCGGTATCA
ACCTCGAGGACATCAAGGCGCCCGAGTGCTTCTACATCGAGAAGAAGCTGCGCGAGCGCATGAAGATTCCGGTCTTCCAC
GATGACCAGCACGGCACCGCGATCATCTCTGCGGCCGGCCTGATCAACGGCCTCAAGGTCATCGGCAAGAACATCGCCGA
GGTCAAGCTGGTGTGTTCCGGCGCCGGCGCGGCCGCGATCGCCTGCCTCGACCTGATGGTCAGCGTGGGCCTGAAGCGCG
AGAACGTCTACGTCTGCGACTCCAAGGGCGTGATCTACCAGGGTCGCGAAGAGAACATGGAGCCGACCAAGGCGCGCTAT
GCGCAGATCACCGAGGCCCGCACGCTGGGCGACGTGATCGCCGGCGCCGACGTCTTCCTCGGCTTGTCCACCGCCGGCGT
GCTGAAGCCGGAAATGGTGGCGAAGATGGCCGACAAGCCGCTGATCTTCGCGCTCGCCAACCCCAATCCGGAAATCCTGC
CGGCCGACGCCAAGGCGGTGCGCCCGGACTGCATCATCGCCACCGGCCGTTCGGACTTCCCGAACCAGGTGAACAACGTG
CTGTGCTTCCCCTTCATCTTCCGTGGTGCGCTTGACGTCGGCGCCACCACGATCAATGAAGAGATGAAGCTCGCCTGCGT
GAAGGCGATCGCCGAACTGGCCCAGGCCGAGCAGAGCGACGTGGTCGCCTCCGCTTACGGCGGCGCCGAACTCAGCTTTG
GCCCGGAATACATCATTCCGAAGCCCTTCGATCCGCGCCTGATCGTCAAGGTGGCCCCGGCGGTCGCCAAGGCGGCGATG
GAATCCGGTGTCGCCACGCGCCCGATCGAGGATTTCGAAGCCTACATCGCCAGCCTCACCGATCTGGTTTACACCTCCGG
CATGGTCATGAAGCCGGTGTTCTCCGCCGCCAAGCGTGTGCCGCTGGAGCAAAAGCGCGTGGTGTACGCGGAAGGCGAGG
ACGAGCGCGTGCTGCACGCGACCCGCGTCGTGATCGATGAAGGCCTGGCGCGCCCGATCCTGGTGGGCCGCCCGAGCGTG
ATCGAGATGCGGATCAAGAAGATCGGCCTCAACCTGGTGCCGGGCCGCGACTTCGACGTCGTCAATCCCGAGTCCGACCC
GCGCTATCGCGACCTGTGGAACGAGTACTACCGCCTCAAGGGCCGCGACGGCGTCACCCCCGACATCGCCAAGGCCAAGA
TGCGCCGCGACACCACGCTGATCGGCGCGATGCTGCTGCGCACCGGCGACGCCGACGCGCTGGTGTGCGGTACCTTCGGC
ACCTACGAGTACCACTTCCAGCATGTGCAGGACGTCATCGGGCTGCGCGCCGGCGCCAAGCAGTTCGCCGCGATGAACCT
GTTGATGCTGCCCAAGCGCACGCTGGCGATCACCGACACTTACGTGAACGAGGATCCGAGCGCGGAGGAAGTCGCCGAGA
TCGCCCGCATGGCGGCCGAGGAACTGCGCCGCTTCGGCATCGAGCCGCGCGTCGCGCTGCTGTCGCACTCCAACTTCGGC
AGCTCGCGTTCGGCTTCCGCGCGCAAGATGCGCGAAGCCAGCGAACTGCTGCGCCAGCTCGCGCCGGAACTCGAATGCGA
CGGCGAAATGCACGGCGACGCCGCGCTGTCGGTCGAGATCCGCAACAAGGTCCATCCGGATTCCAGCCTCGTCGGCGAAG
CCAACCTGCTGGTGATGCCCAACCTGGATGCTGCCAACATCTCGTTCAACCTGATGAAGATCGCCAACGGCGACGGCGTG
TCGGTGGGGCCGATCCTGCTCGGCGCGGCCAAGCCGGTGCACATCCTGACGCCGTCGGCCACCGTGCGCCGGCTGGTGAA
CATCACCGCGCTGGCCGTGGTCGATGCGCAGGAGTCGCGCCGCGCCTGA

Upstream 100 bases:

>100_bases
ACATTCCAACACGCTGCGAATGGTCTCAGTTGGCGAGGCGACGGCGCGCGCCTGCAGTTCGCCCGACGCACATACCCACA
CCGTTCCGAGAGGAAAAAGA

Downstream 100 bases:

>100_bases
TCAGGGCGGACGGAAACAAGAAGGGCGCCGCAAGGCGCCCTTCTTGTTTGAGCCATCGAAAACTTTGCTGACGCCCCGGC
CGGGCGCTGCTCGCTAGAAT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MDQDFIAAALDYHRAPTRGKISVVPTKGLTNQRDLALAYSPGVAAACDAIVADPAEARELTSRGNLVAVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFANIDVFDIELAENDPDKLIDIIASLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIISAAGLINGLKVIGKNIAEVKLVCSGAGAAAIACLDLMVSVGLKRENVYVCDSKGVIYQGREENMEPTKARY
AQITEARTLGDVIAGADVFLGLSTAGVLKPEMVAKMADKPLIFALANPNPEILPADAKAVRPDCIIATGRSDFPNQVNNV
LCFPFIFRGALDVGATTINEEMKLACVKAIAELAQAEQSDVVASAYGGAELSFGPEYIIPKPFDPRLIVKVAPAVAKAAM
ESGVATRPIEDFEAYIASLTDLVYTSGMVMKPVFSAAKRVPLEQKRVVYAEGEDERVLHATRVVIDEGLARPILVGRPSV
IEMRIKKIGLNLVPGRDFDVVNPESDPRYRDLWNEYYRLKGRDGVTPDIAKAKMRRDTTLIGAMLLRTGDADALVCGTFG
TYEYHFQHVQDVIGLRAGAKQFAAMNLLMLPKRTLAITDTYVNEDPSAEEVAEIARMAAEELRRFGIEPRVALLSHSNFG
SSRSASARKMREASELLRQLAPELECDGEMHGDAALSVEIRNKVHPDSSLVGEANLLVMPNLDAANISFNLMKIANGDGV
SVGPILLGAAKPVHILTPSATVRRLVNITALAVVDAQESRRA

Sequences:

>Translated_762_residues
MDQDFIAAALDYHRAPTRGKISVVPTKGLTNQRDLALAYSPGVAAACDAIVADPAEARELTSRGNLVAVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFANIDVFDIELAENDPDKLIDIIASLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIISAAGLINGLKVIGKNIAEVKLVCSGAGAAAIACLDLMVSVGLKRENVYVCDSKGVIYQGREENMEPTKARY
AQITEARTLGDVIAGADVFLGLSTAGVLKPEMVAKMADKPLIFALANPNPEILPADAKAVRPDCIIATGRSDFPNQVNNV
LCFPFIFRGALDVGATTINEEMKLACVKAIAELAQAEQSDVVASAYGGAELSFGPEYIIPKPFDPRLIVKVAPAVAKAAM
ESGVATRPIEDFEAYIASLTDLVYTSGMVMKPVFSAAKRVPLEQKRVVYAEGEDERVLHATRVVIDEGLARPILVGRPSV
IEMRIKKIGLNLVPGRDFDVVNPESDPRYRDLWNEYYRLKGRDGVTPDIAKAKMRRDTTLIGAMLLRTGDADALVCGTFG
TYEYHFQHVQDVIGLRAGAKQFAAMNLLMLPKRTLAITDTYVNEDPSAEEVAEIARMAAEELRRFGIEPRVALLSHSNFG
SSRSASARKMREASELLRQLAPELECDGEMHGDAALSVEIRNKVHPDSSLVGEANLLVMPNLDAANISFNLMKIANGDGV
SVGPILLGAAKPVHILTPSATVRRLVNITALAVVDAQESRRA
>Mature_762_residues
MDQDFIAAALDYHRAPTRGKISVVPTKGLTNQRDLALAYSPGVAAACDAIVADPAEARELTSRGNLVAVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFANIDVFDIELAENDPDKLIDIIASLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIISAAGLINGLKVIGKNIAEVKLVCSGAGAAAIACLDLMVSVGLKRENVYVCDSKGVIYQGREENMEPTKARY
AQITEARTLGDVIAGADVFLGLSTAGVLKPEMVAKMADKPLIFALANPNPEILPADAKAVRPDCIIATGRSDFPNQVNNV
LCFPFIFRGALDVGATTINEEMKLACVKAIAELAQAEQSDVVASAYGGAELSFGPEYIIPKPFDPRLIVKVAPAVAKAAM
ESGVATRPIEDFEAYIASLTDLVYTSGMVMKPVFSAAKRVPLEQKRVVYAEGEDERVLHATRVVIDEGLARPILVGRPSV
IEMRIKKIGLNLVPGRDFDVVNPESDPRYRDLWNEYYRLKGRDGVTPDIAKAKMRRDTTLIGAMLLRTGDADALVCGTFG
TYEYHFQHVQDVIGLRAGAKQFAAMNLLMLPKRTLAITDTYVNEDPSAEEVAEIARMAAEELRRFGIEPRVALLSHSNFG
SSRSASARKMREASELLRQLAPELECDGEMHGDAALSVEIRNKVHPDSSLVGEANLLVMPNLDAANISFNLMKIANGDGV
SVGPILLGAAKPVHILTPSATVRRLVNITALAVVDAQESRRA

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=401, Percent_Identity=25.1870324189526, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI62420880, Length=401, Percent_Identity=25.1870324189526, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI239049447, Length=401, Percent_Identity=25.1870324189526, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4505145, Length=407, Percent_Identity=25.7985257985258, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4505143, Length=395, Percent_Identity=22.7848101265823, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI270265879, Length=369, Percent_Identity=26.2872628726287, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=66.3588390501319, Blast_Score=1029, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=353, Percent_Identity=28.8951841359773, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788800, Length=337, Percent_Identity=32.0474777448071, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI87081919, Length=458, Percent_Identity=23.7991266375546, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=274, Percent_Identity=29.9270072992701, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362674, Length=405, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356279, Length=405, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362672, Length=405, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=28.9855072463768, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707242, Length=371, Percent_Identity=26.1455525606469, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI78707238, Length=371, Percent_Identity=26.1455525606469, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI78707240, Length=351, Percent_Identity=24.7863247863248, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82029; Mature: 82029

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQDFIAAALDYHRAPTRGKISVVPTKGLTNQRDLALAYSPGVAAACDAIVADPAEAREL
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHH
TSRGNLVAVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFANIDVFDIELAENDPDKLI
HCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
DIIASLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIISAAGLINGLKV
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
IGKNIAEVKLVCSGAGAAAIACLDLMVSVGLKRENVYVCDSKGVIYQGREENMEPTKARY
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCHHHHHH
AQITEARTLGDVIAGADVFLGLSTAGVLKPEMVAKMADKPLIFALANPNPEILPADAKAV
HHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCEEECCCCCC
RPDCIIATGRSDFPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVKAIAELAQAEQSD
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
VVASAYGGAELSFGPEYIIPKPFDPRLIVKVAPAVAKAAMESGVATRPIEDFEAYIASLT
EEEECCCCCEECCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DLVYTSGMVMKPVFSAAKRVPLEQKRVVYAEGEDERVLHATRVVIDEGLARPILVGRPSV
HHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCHH
IEMRIKKIGLNLVPGRDFDVVNPESDPRYRDLWNEYYRLKGRDGVTPDIAKAKMRRDTTL
HHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHH
IGAMLLRTGDADALVCGTFGTYEYHFQHVQDVIGLRAGAKQFAAMNLLMLPKRTLAITDT
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEEEEE
YVNEDPSAEEVAEIARMAAEELRRFGIEPRVALLSHSNFGSSRSASARKMREASELLRQL
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
APELECDGEMHGDAALSVEIRNKVHPDSSLVGEANLLVMPNLDAANISFNLMKIANGDGV
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCC
SVGPILLGAAKPVHILTPSATVRRLVNITALAVVDAQESRRA
EECCEEEECCCCEEEECCCHHHHHHHHHHEEEEEECHHHCCC
>Mature Secondary Structure
MDQDFIAAALDYHRAPTRGKISVVPTKGLTNQRDLALAYSPGVAAACDAIVADPAEAREL
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHH
TSRGNLVAVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFANIDVFDIELAENDPDKLI
HCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
DIIASLEPTLGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIISAAGLINGLKV
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
IGKNIAEVKLVCSGAGAAAIACLDLMVSVGLKRENVYVCDSKGVIYQGREENMEPTKARY
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCHHHHHH
AQITEARTLGDVIAGADVFLGLSTAGVLKPEMVAKMADKPLIFALANPNPEILPADAKAV
HHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCEEECCCCCC
RPDCIIATGRSDFPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVKAIAELAQAEQSD
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
VVASAYGGAELSFGPEYIIPKPFDPRLIVKVAPAVAKAAMESGVATRPIEDFEAYIASLT
EEEECCCCCEECCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DLVYTSGMVMKPVFSAAKRVPLEQKRVVYAEGEDERVLHATRVVIDEGLARPILVGRPSV
HHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCHH
IEMRIKKIGLNLVPGRDFDVVNPESDPRYRDLWNEYYRLKGRDGVTPDIAKAKMRRDTTL
HHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHH
IGAMLLRTGDADALVCGTFGTYEYHFQHVQDVIGLRAGAKQFAAMNLLMLPKRTLAITDT
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEEEEE
YVNEDPSAEEVAEIARMAAEELRRFGIEPRVALLSHSNFGSSRSASARKMREASELLRQL
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
APELECDGEMHGDAALSVEIRNKVHPDSSLVGEANLLVMPNLDAANISFNLMKIANGDGV
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCC
SVGPILLGAAKPVHILTPSATVRRLVNITALAVVDAQESRRA
EECCEEEECCCCEEEECCCHHHHHHHHHHEEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]