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The map label for this gene is uvrD [H]

Identifier: 119899502

GI number: 119899502

Start: 3541853

End: 3544072

Strand: Reverse

Name: uvrD [H]

Synonym: azo3213

Alternate gene names: 119899502

Gene position: 3544072-3541853 (Counterclockwise)

Preceding gene: 119899511

Following gene: 119899500

Centisome position: 80.99

GC content: 66.67

Gene sequence:

>2220_bases
ATGTCCAACCTGCTTGCCAACCTTAACGAACAGCAACATCAGGCAGTCACCCTGCCATCCCAGCACGCCCTGATCCTCGC
CGGTGCCGGCTCTGGCAAGACCCGCGTGTTGACCACCCGCATCGCCTGGCTGGTGCAGTCGGGCCAGGCCAGCCCGGCGG
AAATCCTCGCCGTCACCTTCACTAACAAGGCGGCCAAGGAAATGCATGCCCGCCTCGCCGCGATGCTGCCGATCAACACC
CGCAGCATGTGGATCGGCACCTTCCACGGCCTCTGCAACCGGCTGTTGCGGGCCCACCATCGCGATGCCGGCTTGCCGCA
GCTGTTCCAGATCCTCGATTCCGGCGATCAGCTCGCTGCGATCAAGCGGCTGCTGAAGACGCTCAACGTCGACGACGAGA
AATTCCCGCCGCGCGAGTTGCAGCACTTCATCAATGGCCAGAAGGAAGCCGGCTTCCGCCCCCACGCGGTGGAGGCCTGG
GACGAATTCACGCGCCAGCGTGTACAGCTTTACCAAGAGTATGAAGCGCAGTGCCAGCGCGAGTCAGTTGTGGATTTTGC
GGAGTTGCTGCTGCGCACCTATGAGCTGCTGGAGCGCAACGAGCCGATCCGGCGGCACTACCAGCGGCGCTTCCGCCACA
TCCTCGTCGATGAGTTCCAGGACACCAACGTGTTGCAGTACCGCTGGCTGAAGTTGCTCGCGGACGAAGGTCGGGAGGGG
GGCGCGTCGCTGTTCTGCGTCGGCGACGACGACCAGTCGATCTACCGCTTCCGCGGCGCAGAGGTCGGCAACATGCGTGA
CTTCGAGCGAGAGTTCCGGGTGCAGAACGTGATCCGGCTGGAGCAGAACTACCGTTCCCGCGGCAACATTCTCGACGCCG
CCAACGCGATCATCCGGAACAACTCCGACCGCCTCGGCAAGAACCTGTGGACCGACCAGGGCGCGGGCGAGCCGATCCGT
GTGTTCGAGGCCTTTTCCGATGCCGACGAGGCGCGCTGGCTCGTCGACGAGGTCCGCGGGCTGGTGCGCGACGGCGCGCT
GCGCAGCGAGATCGCACTGCTGTACCGATCCAATGCCCAGTCGCGGGTGCTGGAGCATCAACTGTTTACCGCCGGGGTGC
CCTACCGGGTGTATGGCGGCCTGCGCTTCTTCGAACGGCAGGAGATCAAGCACGCGCTCGCCTACCTGCGCCTGATCGCC
AATCCCGACGACGACACGGCGTTCGCGCGCGTGGTCAACTTCCCCACGCGCGGCATCGGCGCGCGGTCGCTGGAAGCGCT
GCAGGATGCCGCGCGCACCTACAACACCAGCCTGTACGCCACGGTGCCGCACCTGTCGGGCAAGGCCGGCACGGTGCTCG
CGCAGTTCGTCCGCCTGGTGGAAGACCTGCGCCGGGACACCGCCCGTCTGCCGTTGCCCGAGCTGATCGACCACGTGCTC
GACGCGAGCGGGCTGCGGGCGCACTACAAATCCGAAAAGGAAGGGCAGGAGCGGCTGGAGAACCTGGACGAACTGCTGGG
CGCAGGCAGCAATTTCGTCGCCGAGGCGCAAGCGGATGCAGAGGTGCTGGCCGGCGACCACGCCCTGCTCGCGGACTTCC
TTGCCCACGCCTCGCTCGAAGCGGGCGACCATCAGGCAGACCAGGGGGCCGACGCGGTGCAGTTGATGACCGTGCATTCG
GCCAAGGGGCTGGAGTTCAACGTGGTTTTCGTCTCGGGGCTGGAGGAAGGCCTGTTTCCGCACGAGAACAGCATTCTCGA
AGCCGAAGGGCTGGAAGAGGAGCGCCGCCTGATGTACGTGGCGGTGACGCGGGCACGCGAGCGTCTTTACCTCTCCTTCG
CGCAGAGCCGCATGCTGCACGGCCAGACGCGCTACAACCTGCGCTCGCGTTTCCTGGAGGAAATCCCGGCCGGGCTCGTC
AAGTGGCTGACACCGCCGAATCCGCGTTCGATGGCGGGCGGCGCGCTCGCCGGCATGGGCGGCGGCTACTTCAAGCCGGG
CGCCAGCGTGGCTCCGGTGGCGGCGCGGCAAGCGCGGGGCACGTCGGCGCATCTGCCCAACGGGCTGCGCATCGGCCAGT
CGGTGGCGCACGCGAAGTTCGGGCAGGGGGTCATCGTCGCTGCCGAGGGCAGCGGGTCGGACGCGAAGGTGCAGATCAAC
TTCGGCCCCGCGGGCGTCAAATGGCTGCTGCTGGCGGTGGCGAAGCTGGAGCCGGTGTAA

Upstream 100 bases:

>100_bases
GGCGACAAGGTGTTGCAGGCGTGACTCACGTCACGTCCCGCGCCTTGGGCGGGATGTCCCGGAGCGCCCGGGTAGAATGG
CGGCACCACGAGGAAGCCCC

Downstream 100 bases:

>100_bases
GGCCGGGCGGGTACGGCGCTCAGGCGCCGTACTTGCGCGCCAGCGTGTCGTGCAGGGCGACGAACTCCTGCGACAACTTG
TGCTTGGGTTCGAGGTGGAT

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MSNLLANLNEQQHQAVTLPSQHALILAGAGSGKTRVLTTRIAWLVQSGQASPAEILAVTFTNKAAKEMHARLAAMLPINT
RSMWIGTFHGLCNRLLRAHHRDAGLPQLFQILDSGDQLAAIKRLLKTLNVDDEKFPPRELQHFINGQKEAGFRPHAVEAW
DEFTRQRVQLYQEYEAQCQRESVVDFAELLLRTYELLERNEPIRRHYQRRFRHILVDEFQDTNVLQYRWLKLLADEGREG
GASLFCVGDDDQSIYRFRGAEVGNMRDFEREFRVQNVIRLEQNYRSRGNILDAANAIIRNNSDRLGKNLWTDQGAGEPIR
VFEAFSDADEARWLVDEVRGLVRDGALRSEIALLYRSNAQSRVLEHQLFTAGVPYRVYGGLRFFERQEIKHALAYLRLIA
NPDDDTAFARVVNFPTRGIGARSLEALQDAARTYNTSLYATVPHLSGKAGTVLAQFVRLVEDLRRDTARLPLPELIDHVL
DASGLRAHYKSEKEGQERLENLDELLGAGSNFVAEAQADAEVLAGDHALLADFLAHASLEAGDHQADQGADAVQLMTVHS
AKGLEFNVVFVSGLEEGLFPHENSILEAEGLEEERRLMYVAVTRARERLYLSFAQSRMLHGQTRYNLRSRFLEEIPAGLV
KWLTPPNPRSMAGGALAGMGGGYFKPGASVAPVAARQARGTSAHLPNGLRIGQSVAHAKFGQGVIVAAEGSGSDAKVQIN
FGPAGVKWLLLAVAKLEPV

Sequences:

>Translated_739_residues
MSNLLANLNEQQHQAVTLPSQHALILAGAGSGKTRVLTTRIAWLVQSGQASPAEILAVTFTNKAAKEMHARLAAMLPINT
RSMWIGTFHGLCNRLLRAHHRDAGLPQLFQILDSGDQLAAIKRLLKTLNVDDEKFPPRELQHFINGQKEAGFRPHAVEAW
DEFTRQRVQLYQEYEAQCQRESVVDFAELLLRTYELLERNEPIRRHYQRRFRHILVDEFQDTNVLQYRWLKLLADEGREG
GASLFCVGDDDQSIYRFRGAEVGNMRDFEREFRVQNVIRLEQNYRSRGNILDAANAIIRNNSDRLGKNLWTDQGAGEPIR
VFEAFSDADEARWLVDEVRGLVRDGALRSEIALLYRSNAQSRVLEHQLFTAGVPYRVYGGLRFFERQEIKHALAYLRLIA
NPDDDTAFARVVNFPTRGIGARSLEALQDAARTYNTSLYATVPHLSGKAGTVLAQFVRLVEDLRRDTARLPLPELIDHVL
DASGLRAHYKSEKEGQERLENLDELLGAGSNFVAEAQADAEVLAGDHALLADFLAHASLEAGDHQADQGADAVQLMTVHS
AKGLEFNVVFVSGLEEGLFPHENSILEAEGLEEERRLMYVAVTRARERLYLSFAQSRMLHGQTRYNLRSRFLEEIPAGLV
KWLTPPNPRSMAGGALAGMGGGYFKPGASVAPVAARQARGTSAHLPNGLRIGQSVAHAKFGQGVIVAAEGSGSDAKVQIN
FGPAGVKWLLLAVAKLEPV
>Mature_738_residues
SNLLANLNEQQHQAVTLPSQHALILAGAGSGKTRVLTTRIAWLVQSGQASPAEILAVTFTNKAAKEMHARLAAMLPINTR
SMWIGTFHGLCNRLLRAHHRDAGLPQLFQILDSGDQLAAIKRLLKTLNVDDEKFPPRELQHFINGQKEAGFRPHAVEAWD
EFTRQRVQLYQEYEAQCQRESVVDFAELLLRTYELLERNEPIRRHYQRRFRHILVDEFQDTNVLQYRWLKLLADEGREGG
ASLFCVGDDDQSIYRFRGAEVGNMRDFEREFRVQNVIRLEQNYRSRGNILDAANAIIRNNSDRLGKNLWTDQGAGEPIRV
FEAFSDADEARWLVDEVRGLVRDGALRSEIALLYRSNAQSRVLEHQLFTAGVPYRVYGGLRFFERQEIKHALAYLRLIAN
PDDDTAFARVVNFPTRGIGARSLEALQDAARTYNTSLYATVPHLSGKAGTVLAQFVRLVEDLRRDTARLPLPELIDHVLD
ASGLRAHYKSEKEGQERLENLDELLGAGSNFVAEAQADAEVLAGDHALLADFLAHASLEAGDHQADQGADAVQLMTVHSA
KGLEFNVVFVSGLEEGLFPHENSILEAEGLEEERRLMYVAVTRARERLYLSFAQSRMLHGQTRYNLRSRFLEEIPAGLVK
WLTPPNPRSMAGGALAGMGGGYFKPGASVAPVAARQARGTSAHLPNGLRIGQSVAHAKFGQGVIVAAEGSGSDAKVQINF
GPAGVKWLLLAVAKLEPV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=750, Percent_Identity=49.0666666666667, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=648, Percent_Identity=37.5, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=30.2941176470588, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=753, Percent_Identity=27.8884462151394, Blast_Score=209, Evalue=1e-54,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82320; Mature: 82189

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLANLNEQQHQAVTLPSQHALILAGAGSGKTRVLTTRIAWLVQSGQASPAEILAVTF
CCCHHHCCCHHHHHEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMHARLAAMLPINTRSMWIGTFHGLCNRLLRAHHRDAGLPQLFQILDSGDQLAA
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHH
IKRLLKTLNVDDEKFPPRELQHFINGQKEAGFRPHAVEAWDEFTRQRVQLYQEYEAQCQR
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ESVVDFAELLLRTYELLERNEPIRRHYQRRFRHILVDEFQDTNVLQYRWLKLLADEGREG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GASLFCVGDDDQSIYRFRGAEVGNMRDFEREFRVQNVIRLEQNYRSRGNILDAANAIIRN
CCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
NSDRLGKNLWTDQGAGEPIRVFEAFSDADEARWLVDEVRGLVRDGALRSEIALLYRSNAQ
CCHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCH
SRVLEHQLFTAGVPYRVYGGLRFFERQEIKHALAYLRLIANPDDDTAFARVVNFPTRGIG
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCC
ARSLEALQDAARTYNTSLYATVPHLSGKAGTVLAQFVRLVEDLRRDTARLPLPELIDHVL
HHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DASGLRAHYKSEKEGQERLENLDELLGAGSNFVAEAQADAEVLAGDHALLADFLAHASLE
CCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHCCC
AGDHQADQGADAVQLMTVHSAKGLEFNVVFVSGLEEGLFPHENSILEAEGLEEERRLMYV
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECHHHCCCCCCCCEECCCCCCHHHHEEHH
AVTRARERLYLSFAQSRMLHGQTRYNLRSRFLEEIPAGLVKWLTPPNPRSMAGGALAGMG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGYFKPGASVAPVAARQARGTSAHLPNGLRIGQSVAHAKFGQGVIVAAEGSGSDAKVQIN
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
FGPAGVKWLLLAVAKLEPV
ECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNLLANLNEQQHQAVTLPSQHALILAGAGSGKTRVLTTRIAWLVQSGQASPAEILAVTF
CCHHHCCCHHHHHEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMHARLAAMLPINTRSMWIGTFHGLCNRLLRAHHRDAGLPQLFQILDSGDQLAA
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHH
IKRLLKTLNVDDEKFPPRELQHFINGQKEAGFRPHAVEAWDEFTRQRVQLYQEYEAQCQR
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ESVVDFAELLLRTYELLERNEPIRRHYQRRFRHILVDEFQDTNVLQYRWLKLLADEGREG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
GASLFCVGDDDQSIYRFRGAEVGNMRDFEREFRVQNVIRLEQNYRSRGNILDAANAIIRN
CCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
NSDRLGKNLWTDQGAGEPIRVFEAFSDADEARWLVDEVRGLVRDGALRSEIALLYRSNAQ
CCHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCH
SRVLEHQLFTAGVPYRVYGGLRFFERQEIKHALAYLRLIANPDDDTAFARVVNFPTRGIG
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCC
ARSLEALQDAARTYNTSLYATVPHLSGKAGTVLAQFVRLVEDLRRDTARLPLPELIDHVL
HHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DASGLRAHYKSEKEGQERLENLDELLGAGSNFVAEAQADAEVLAGDHALLADFLAHASLE
CCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHCCCHHHHHHHHHHHCCC
AGDHQADQGADAVQLMTVHSAKGLEFNVVFVSGLEEGLFPHENSILEAEGLEEERRLMYV
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECHHHCCCCCCCCEECCCCCCHHHHEEHH
AVTRARERLYLSFAQSRMLHGQTRYNLRSRFLEEIPAGLVKWLTPPNPRSMAGGALAGMG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGYFKPGASVAPVAARQARGTSAHLPNGLRIGQSVAHAKFGQGVIVAAEGSGSDAKVQIN
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
FGPAGVKWLLLAVAKLEPV
ECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]