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The map label for this gene is iscS2 [H]

Identifier: 119898308

GI number: 119898308

Start: 2221203

End: 2222351

Strand: Reverse

Name: iscS2 [H]

Synonym: azo2017

Alternate gene names: 119898308

Gene position: 2222351-2221203 (Counterclockwise)

Preceding gene: 119898309

Following gene: 119898307

Centisome position: 50.78

GC content: 70.58

Gene sequence:

>1149_bases
ATGTTCCGTCCGGCCTACCTCGACTGGAACGCCACCACGCCGCTCGATCCGGCCGTGCGCGATGCGATGCTGCCGTGGCT
GGGTGAGCGCTTCGGCAACGCGTCCAGCCGCCACGAATACGGACGGCAGGCGCGGGCGGCAATCGACGAGGCGAGGGCGC
GGGTTGCTGCCGCAGTCGGCGCGCACCCCACCGAGGTGATCTTCACCAGCGGCGGCTCGGAAGCGAACAATCTCTTCGTC
AAAGGTGCCGCAGCCTTGCTCAAGCCGGCCACGGTGGCGGTCAGCGCGATCGAACACCCGTGTGTGCGCGAACCGGCACG
CCAACTGCGACGCCAGGGCTGGAGCTTCCAAGAGATCGCGGTGGACGCGGAAGGCGTCGTGGCCGGGCCGGCGTGGCGGG
CAGCGCTCGACGCGCGTCCGGCCTTGATCTCGGTGATGCTCGCCAACAACGAGACCGGGGTGCTGCAGGACATCCCTCGG
CTGGCGGAGGAAGCCCGCCCCACGCGCGCCTGGTTCCACACCGATGCGGTGCAGGCCCTGGGCAAGCTGCCGGTGGATTT
CCGCGCGCTGGGCGTGCATGCGTTGTCGCTGTCCGCGCACAAGGTCGGCGGCCCGCTCGGCGCGGGCGCGCTGGTGCTGG
ACAAGCGGGTCGAACTCGCGCCCCTGGTTGCGGGCGGGGGGCAGGAGCGCAATCTGCGCTCCGGCACCGAAAACGTCGCG
GCCATCGTGGGGTTTGGCGTCGCCTGCGAACGCGCAGCGGGCCGTGTCGCCGATGAAGCGCCGCGCCTGCGGCGGCTGCG
CGAGGTCGTAGAGGCGGGCGTTGTCGCACTGGGCGCCCGGGTGTTCTCGATGGGGGCCGAGCGCCTGCCGAACACCGTGT
TTTTTGCACTTGAGGGGCTGGACGGCGAGACCCTGGTCGGCAAGCTCGATCGCGCTGGCCACGCCGTGGCCAGCGGCTCG
GCTTGCTCCAGCGCCAACCCGGAACCCTCCCATACGCTGCTTGCGATGGGTGTTGAGCCCACCGTCGCGCGTGGCGCGGT
ACGGGTCAGCCTCGGACGCGACACCACCGCCGCGGATGTCGATGCCTTCCTGGCAACGCTGGGCGTCCTTGCGGCAGAAC
TGAGACAAATGACCGCGCTTGCGGTCTGA

Upstream 100 bases:

>100_bases
GCAACGCGAGATCAAGCCGGACCCGGACATGAACGTGCTCAAGGACGTGCGTCGTCGCGCCGCGATTGCCCTGCGCGAGA
CTGCCGCTGCCTGACGCCCC

Downstream 100 bases:

>100_bases
CATGAAAAGACGAATCGCTAACGGAGTGACCCCATGTTGAAGTTTCCGATCTACCTCGACTACTCGGCGACGACGCCGGT
CGACCCGCGCGTGGCGGCGA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MFRPAYLDWNATTPLDPAVRDAMLPWLGERFGNASSRHEYGRQARAAIDEARARVAAAVGAHPTEVIFTSGGSEANNLFV
KGAAALLKPATVAVSAIEHPCVREPARQLRRQGWSFQEIAVDAEGVVAGPAWRAALDARPALISVMLANNETGVLQDIPR
LAEEARPTRAWFHTDAVQALGKLPVDFRALGVHALSLSAHKVGGPLGAGALVLDKRVELAPLVAGGGQERNLRSGTENVA
AIVGFGVACERAAGRVADEAPRLRRLREVVEAGVVALGARVFSMGAERLPNTVFFALEGLDGETLVGKLDRAGHAVASGS
ACSSANPEPSHTLLAMGVEPTVARGAVRVSLGRDTTAADVDAFLATLGVLAAELRQMTALAV

Sequences:

>Translated_382_residues
MFRPAYLDWNATTPLDPAVRDAMLPWLGERFGNASSRHEYGRQARAAIDEARARVAAAVGAHPTEVIFTSGGSEANNLFV
KGAAALLKPATVAVSAIEHPCVREPARQLRRQGWSFQEIAVDAEGVVAGPAWRAALDARPALISVMLANNETGVLQDIPR
LAEEARPTRAWFHTDAVQALGKLPVDFRALGVHALSLSAHKVGGPLGAGALVLDKRVELAPLVAGGGQERNLRSGTENVA
AIVGFGVACERAAGRVADEAPRLRRLREVVEAGVVALGARVFSMGAERLPNTVFFALEGLDGETLVGKLDRAGHAVASGS
ACSSANPEPSHTLLAMGVEPTVARGAVRVSLGRDTTAADVDAFLATLGVLAAELRQMTALAV
>Mature_382_residues
MFRPAYLDWNATTPLDPAVRDAMLPWLGERFGNASSRHEYGRQARAAIDEARARVAAAVGAHPTEVIFTSGGSEANNLFV
KGAAALLKPATVAVSAIEHPCVREPARQLRRQGWSFQEIAVDAEGVVAGPAWRAALDARPALISVMLANNETGVLQDIPR
LAEEARPTRAWFHTDAVQALGKLPVDFRALGVHALSLSAHKVGGPLGAGALVLDKRVELAPLVAGGGQERNLRSGTENVA
AIVGFGVACERAAGRVADEAPRLRRLREVVEAGVVALGARVFSMGAERLPNTVFFALEGLDGETLVGKLDRAGHAVASGS
ACSSANPEPSHTLLAMGVEPTVARGAVRVSLGRDTTAADVDAFLATLGVLAAELRQMTALAV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=387, Percent_Identity=37.2093023255814, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI156713448, Length=421, Percent_Identity=34.4418052256532, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI48994898, Length=388, Percent_Identity=38.9175257731959, Blast_Score=251, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI25143064, Length=366, Percent_Identity=38.7978142076503, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17533177, Length=323, Percent_Identity=32.5077399380805, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=36.1979166666667, Blast_Score=249, Evalue=6e-67,
Organism=Drosophila melanogaster, GI20129463, Length=397, Percent_Identity=37.7833753148615, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39977; Mature: 39977

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPAYLDWNATTPLDPAVRDAMLPWLGERFGNASSRHEYGRQARAAIDEARARVAAAVG
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AHPTEVIFTSGGSEANNLFVKGAAALLKPATVAVSAIEHPCVREPARQLRRQGWSFQEIA
CCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHEE
VDAEGVVAGPAWRAALDARPALISVMLANNETGVLQDIPRLAEEARPTRAWFHTDAVQAL
ECCCCEEECCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
GKLPVDFRALGVHALSLSAHKVGGPLGAGALVLDKRVELAPLVAGGGQERNLRSGTENVA
HCCCCCHHHHCEEEEEECHHHCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCHHHH
AIVGFGVACERAAGRVADEAPRLRRLREVVEAGVVALGARVFSMGAERLPNTVFFALEGL
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
DGETLVGKLDRAGHAVASGSACSSANPEPSHTLLAMGVEPTVARGAVRVSLGRDTTAADV
CCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCEEEEECCCCHHHCCEEEEEECCCCCHHHH
DAFLATLGVLAAELRQMTALAV
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRPAYLDWNATTPLDPAVRDAMLPWLGERFGNASSRHEYGRQARAAIDEARARVAAAVG
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AHPTEVIFTSGGSEANNLFVKGAAALLKPATVAVSAIEHPCVREPARQLRRQGWSFQEIA
CCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHEE
VDAEGVVAGPAWRAALDARPALISVMLANNETGVLQDIPRLAEEARPTRAWFHTDAVQAL
ECCCCEEECCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
GKLPVDFRALGVHALSLSAHKVGGPLGAGALVLDKRVELAPLVAGGGQERNLRSGTENVA
HCCCCCHHHHCEEEEEECHHHCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCHHHH
AIVGFGVACERAAGRVADEAPRLRRLREVVEAGVVALGARVFSMGAERLPNTVFFALEGL
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
DGETLVGKLDRAGHAVASGSACSSANPEPSHTLLAMGVEPTVARGAVRVSLGRDTTAADV
CCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCEEEEECCCCHHHCCEEEEEECCCCCHHHH
DAFLATLGVLAAELRQMTALAV
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA