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The map label for this gene is bioC1 [H]

Identifier: 119898182

GI number: 119898182

Start: 2076399

End: 2077193

Strand: Direct

Name: bioC1 [H]

Synonym: azo1891

Alternate gene names: 119898182

Gene position: 2076399-2077193 (Clockwise)

Preceding gene: 119898181

Following gene: 119898183

Centisome position: 47.45

GC content: 73.33

Gene sequence:

>795_bases
ATGCTTGAACCCACGGCACGCAAAGCGGCGGTCAGGCGCGCGTTCGACCGCGCGGCCGACGGTTACGATCGCGCGGCGGA
CATCCAGCGCGCAGCCTGCGACCGCTTGGCCGTGCTGGCACACCGTCATCCGCCTGCCCACGGTGCCACGTGCGTGATCG
ACGCCGGCTGCGGCACGGGCTACGGCGCGGCTGCGCTCACGGCGTTGTGCCCCGCCGCCAGCCGGATCGGCGTGGATTTC
GCGCCGGCGATGCTGCAGCAGATGAGACGGGTTGCCGGGGCGGTTGCGCCGGTGTGCGCGGATATCGAAGCGCTCCCGCT
GGCCACCGGCTGTGCGGACGCGCTGTGGTCCAGCCTGGCGATGCAGTGGTGTACGCCGGCGCGGGTGCTGGCCGAGTGCG
CGCGGGTGCTGCGGCCCGGTGGCGCAGGCTGGATTGCGACGCTGGGTCCGCGCACCCTGTACGAGTTGCGGGCGGCTTTC
GCCGAAGTGGATGGTGCCGCCCATGTGCTCGACATGCACGACGCCGCCGTGTGGTGCGCCGCGGCGCGGGGGGCGGGCCT
GGCGGTGCTGGCGTGCGAAAGCGCTGAGCTGCAGGCGCACGCACCCAACTTGCGCACGCTGCTGCATAACATCAAGGCGG
TCGGCGCGCAGACCGTGCCCGGCGATCGCCGCCGTGCCCCGCTCGGCCGCAGCGCGTGGCGGCGGCTGGAGCACGCCTAC
GAGGCCTACCGCGACGCCGACGGCCGCCTGCCCGCCACCTACGATCTCATCCTGCTCGCGCTGTTCCGCCCATGA

Upstream 100 bases:

>100_bases
GCCTTGCCGCACGCGCGCCTGGAGGTTTTCGCCGACAGCGGCCACGCGCCTTTCTTGTCCGATCCCGAGCGCTTCGTCGC
CCTGCTGGGGGCGCTTGGCG

Downstream 100 bases:

>100_bases
CTGCTTCCGCTCACGCCAACGCCTGGTTCGTTACCGGCACCGATACCGAAGTCGGCAAGACCTTCGCCACCTGTGCGCTG
ATCCACGCCGCCCGTGCAAA

Product: biotin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MLEPTARKAAVRRAFDRAADGYDRAADIQRAACDRLAVLAHRHPPAHGATCVIDAGCGTGYGAAALTALCPAASRIGVDF
APAMLQQMRRVAGAVAPVCADIEALPLATGCADALWSSLAMQWCTPARVLAECARVLRPGGAGWIATLGPRTLYELRAAF
AEVDGAAHVLDMHDAAVWCAAARGAGLAVLACESAELQAHAPNLRTLLHNIKAVGAQTVPGDRRRAPLGRSAWRRLEHAY
EAYRDADGRLPATYDLILLALFRP

Sequences:

>Translated_264_residues
MLEPTARKAAVRRAFDRAADGYDRAADIQRAACDRLAVLAHRHPPAHGATCVIDAGCGTGYGAAALTALCPAASRIGVDF
APAMLQQMRRVAGAVAPVCADIEALPLATGCADALWSSLAMQWCTPARVLAECARVLRPGGAGWIATLGPRTLYELRAAF
AEVDGAAHVLDMHDAAVWCAAARGAGLAVLACESAELQAHAPNLRTLLHNIKAVGAQTVPGDRRRAPLGRSAWRRLEHAY
EAYRDADGRLPATYDLILLALFRP
>Mature_264_residues
MLEPTARKAAVRRAFDRAADGYDRAADIQRAACDRLAVLAHRHPPAHGATCVIDAGCGTGYGAAALTALCPAASRIGVDF
APAMLQQMRRVAGAVAPVCADIEALPLATGCADALWSSLAMQWCTPARVLAECARVLRPGGAGWIATLGPRTLYELRAAF
AEVDGAAHVLDMHDAAVWCAAARGAGLAVLACESAELQAHAPNLRTLLHNIKAVGAQTVPGDRRRAPLGRSAWRRLEHAY
EAYRDADGRLPATYDLILLALFRP

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786994, Length=245, Percent_Identity=31.0204081632653, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 27888; Mature: 27888

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEPTARKAAVRRAFDRAADGYDRAADIQRAACDRLAVLAHRHPPAHGATCVIDAGCGTG
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
YGAAALTALCPAASRIGVDFAPAMLQQMRRVAGAVAPVCADIEALPLATGCADALWSSLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHH
MQWCTPARVLAECARVLRPGGAGWIATLGPRTLYELRAAFAEVDGAAHVLDMHDAAVWCA
HHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AARGAGLAVLACESAELQAHAPNLRTLLHNIKAVGAQTVPGDRRRAPLGRSAWRRLEHAY
HHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
EAYRDADGRLPATYDLILLALFRP
HHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLEPTARKAAVRRAFDRAADGYDRAADIQRAACDRLAVLAHRHPPAHGATCVIDAGCGTG
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
YGAAALTALCPAASRIGVDFAPAMLQQMRRVAGAVAPVCADIEALPLATGCADALWSSLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHH
MQWCTPARVLAECARVLRPGGAGWIATLGPRTLYELRAAFAEVDGAAHVLDMHDAAVWCA
HHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AARGAGLAVLACESAELQAHAPNLRTLLHNIKAVGAQTVPGDRRRAPLGRSAWRRLEHAY
HHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
EAYRDADGRLPATYDLILLALFRP
HHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]