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The map label for this gene is rmlA [H]

Identifier: 119898166

GI number: 119898166

Start: 2057467

End: 2058351

Strand: Reverse

Name: rmlA [H]

Synonym: azo1875

Alternate gene names: 119898166

Gene position: 2058351-2057467 (Counterclockwise)

Preceding gene: 119898167

Following gene: 119898165

Centisome position: 47.04

GC content: 63.28

Gene sequence:

>885_bases
TTGGCACGCCGCAAGGGCATCATCCTCGCCGGAGGCTCCGGCACACGCCTGCATCCCGCAACGCTCGCGGTTTCAAAGCA
GCTGCTGCCGGTTTATGACAAACCGATGATCTACTACCCGCTCTCCACGCTGATGCTGGCGGGCATACGGGAAATCCTGA
TCATCTCCACGCCCCAGGACGTACCGCGCTTCGAGCAACTGCTCGGTGACGGGAGTCGCTGGGGCCTGGAGTTGTCCTAC
GCCACGCAACTCAGCCCGGATGGGCTGGCGCAAGCCTTCATCATCGGTAAGGACTTCCTCGCCGGCGGTCCCTCCGCGCT
GGTGCTGGGCGACAACCTCTTCCACGGCCATGAATTTGCCGATGATCTGCGCAGGGCAGGGGAGCACAGCACAGGCGCCG
TTGTCTTCGCCTACCCGGTCCAGGATCCCGAACGCTATGGCGTCGTGGAATTCGACGGGGCGGGGCGCGCCATCAGCCTG
GAAGAAAAGCCCCTGCGCCCCAAGAGCCGCTACGCGGTCACCGGTCTCTATTTCTACGACGAACGGGTCGTCGATGTTGC
AAGCGCATTGAAGCCCAGCGTCCGCGGCGAACTCGAGATCACCGACGTCAACAAGCAGTACCTCGCCTGGGGCGAACTGG
ATGTGCAGGTCATGGGCCGGGGCCACGCCTGGCTCGACACCGGTACCCACGAGAGCTTGCTGGAAGCCAGCCTGTTCATC
CAGACCATCGAGAAGCGTCAGGGGCTGAAGATCGCCTGTCCCGAGGAAATCGCCTGGCGGCTCGGCTGGATCGACTCGGC
GGCACTGGAAGCACTGGCAGCGCCGCTGGCCAAGAACGGCTACGGCCAATACCTGAAACGTTTGCTCGAAGACAAGGTGT
TCTGA

Upstream 100 bases:

>100_bases
TCGACACTGCGTTGCTGCGCACGACGTTCGCCCTCAACCTGCCTGACTGGCGCAGCGGGGTCGACCGCATGCTTCAGGAA
ACCCTTTAAGGACCACTCAA

Downstream 100 bases:

>100_bases
TGCGCGTGATTCCCACCGCGATTCCCGAGGTGCTGATGCTTGAACCTCAAGTGTTTGGCGACAGCCGCGGTTTCTTCCTG
GAGAGTTTCAACGCGAACCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MARRKGIILAGGSGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDVPRFEQLLGDGSRWGLELSY
ATQLSPDGLAQAFIIGKDFLAGGPSALVLGDNLFHGHEFADDLRRAGEHSTGAVVFAYPVQDPERYGVVEFDGAGRAISL
EEKPLRPKSRYAVTGLYFYDERVVDVASALKPSVRGELEITDVNKQYLAWGELDVQVMGRGHAWLDTGTHESLLEASLFI
QTIEKRQGLKIACPEEIAWRLGWIDSAALEALAAPLAKNGYGQYLKRLLEDKVF

Sequences:

>Translated_294_residues
MARRKGIILAGGSGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDVPRFEQLLGDGSRWGLELSY
ATQLSPDGLAQAFIIGKDFLAGGPSALVLGDNLFHGHEFADDLRRAGEHSTGAVVFAYPVQDPERYGVVEFDGAGRAISL
EEKPLRPKSRYAVTGLYFYDERVVDVASALKPSVRGELEITDVNKQYLAWGELDVQVMGRGHAWLDTGTHESLLEASLFI
QTIEKRQGLKIACPEEIAWRLGWIDSAALEALAAPLAKNGYGQYLKRLLEDKVF
>Mature_293_residues
ARRKGIILAGGSGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDVPRFEQLLGDGSRWGLELSYA
TQLSPDGLAQAFIIGKDFLAGGPSALVLGDNLFHGHEFADDLRRAGEHSTGAVVFAYPVQDPERYGVVEFDGAGRAISLE
EKPLRPKSRYAVTGLYFYDERVVDVASALKPSVRGELEITDVNKQYLAWGELDVQVMGRGHAWLDTGTHESLLEASLFIQ
TIEKRQGLKIACPEEIAWRLGWIDSAALEALAAPLAKNGYGQYLKRLLEDKVF

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI11761619, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788351, Length=291, Percent_Identity=70.446735395189, Blast_Score=426, Evalue=1e-121,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=68.0701754385965, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=255, Percent_Identity=23.921568627451, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=260, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=25.0996015936255, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=25.0996015936255, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32355; Mature: 32224

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRKGIILAGGSGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQD
CCCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
VPRFEQLLGDGSRWGLELSYATQLSPDGLAQAFIIGKDFLAGGPSALVLGDNLFHGHEFA
CHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEEEECCHHHCCCCCEEEEECCCCCCHHHH
DDLRRAGEHSTGAVVFAYPVQDPERYGVVEFDGAGRAISLEEKPLRPKSRYAVTGLYFYD
HHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEEH
ERVVDVASALKPSVRGELEITDVNKQYLAWGELDVQVMGRGHAWLDTGTHESLLEASLFI
HHHHHHHHHHCCCCCCEEEEEECCCEEEEECCEEEEEEECCCEEECCCCHHHHHHHHHHH
QTIEKRQGLKIACPEEIAWRLGWIDSAALEALAAPLAKNGYGQYLKRLLEDKVF
HHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARRKGIILAGGSGTRLHPATLAVSKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQD
CCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
VPRFEQLLGDGSRWGLELSYATQLSPDGLAQAFIIGKDFLAGGPSALVLGDNLFHGHEFA
CHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEEEECCHHHCCCCCEEEEECCCCCCHHHH
DDLRRAGEHSTGAVVFAYPVQDPERYGVVEFDGAGRAISLEEKPLRPKSRYAVTGLYFYD
HHHHHCCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEEH
ERVVDVASALKPSVRGELEITDVNKQYLAWGELDVQVMGRGHAWLDTGTHESLLEASLFI
HHHHHHHHHHCCCCCCEEEEEECCCEEEEECCEEEEEEECCCEEECCCCHHHHHHHHHHH
QTIEKRQGLKIACPEEIAWRLGWIDSAALEALAAPLAKNGYGQYLKRLLEDKVF
HHHHHHCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]