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The map label for this gene is ndh2 [H]

Identifier: 119898125

GI number: 119898125

Start: 2012480

End: 2013760

Strand: Reverse

Name: ndh2 [H]

Synonym: azo1834

Alternate gene names: 119898125

Gene position: 2013760-2012480 (Counterclockwise)

Preceding gene: 119898126

Following gene: 119898121

Centisome position: 46.02

GC content: 68.77

Gene sequence:

>1281_bases
ATGCATTTCGACATCGTGATCGTCGGCGGTGGTGCCGGTGGCCTGGAACTCGCCGCGAAGCTCGGCCGCAAACTCGGCCC
GCGTCTTGGCCGCGAACGGGTACTGCTGGTGGACCGCGCGGTATTCCACATCTGGAAACCGACCTTGCACGAAGTCGCCG
CGGGCACGCTGGATGCGCACCAGGAGGGGCTGTCCTACACGGTGCTCGCGCGCCGCAACCACTTCAGCTTTGCGCTGGGC
GAACTCAGCGCGCTCGACACCGAACGGCGCCTGATCACGCTGGGCGAGACCCGCGACGAGCGCGGCGAAGTGCTGGTGCC
GACGCGCACCGTCAGCTTCACCCGGCTGGTGCTGGCGATGGGCAGCGGCTCCAACTCCTTCGGCACGCCGGGCGCGGACA
ACGCCTACGTGCTGGAACACGCCAGCGACGCCCAGCGCTTCCACGCCAAGCTGCTGGCCGCGTTTGCGCGCGCCTCCTTC
TCCGCCGAGAAGACGCTGGCGGTGGCGATCGTCGGCGGAGGCGCCACCGGCGTGGAGCTGTCGGCCGAACTGATCGAAGC
GCACAACGAACTGCTCGAAGGCCTGGGCAGCGAACAGCGCTTCCGCCTCGACATCGCGCTGGTGGAAGCCGGCGACCGCA
TCCTTGCCGGCCTGCCGCCGCAGATTTCGGCGCAGGCGCGCCTGGCGCTGGAGCGCAAGAACGTGCGCGTGCTCACCGGC
ACCCGCGTCACCGAAGTGCAGCGCGACCGGCTGGTGACCACCGCGGGCGAGATTCCCGCCTCCATCATCGTGTGGGCCGC
GGGCATCAAGGCCGCCGACGCCAACCGCGGTTTCGGGCTGGAAACCAACCGCATCAACCAGTTCGTGGTGAACGACCGGC
TGGAGACCTCGGTATCGGGCATCTATGCGCTGGGCGACTGTGCCGCCTGCAAATGGGAAGGCGACAAGCTGGTGCCGGCG
CGCGCCCAGGCCGCACACCAGCAGGCCGACTACCTCACCGCGGTACTGCTGGCCGCGCTCAACGAAGGCCGGGTGGATGC
GCCCTTCGTCTATCGCGACTTCGGCTCGCTGGTGTCGCTGGGCGAGAACAAGGGCATCGGCAACCTGATGGGCGGGCTGT
CGGGCCGCAACTTCTTCGTCGAGGGCCTGATCGCCAAGTGGATGTACATGTCGCTGCACCTGATGCACCACCGCGCCATC
CTCGGCATCGGCAAGACCGCGGTGCTGGCGCTGGCGCGGCTGCTGCAGCAGCGCGTGTCCGGCCGGCTCAAGCTGCACTG
A

Upstream 100 bases:

>100_bases
GCTGTACACTCGCGCGCTGCCGCCGGAGGCGCCTCCCTCATTCGCCAACGGTGACATATCCCAAACCAGCAGCCTGGCTG
CGCATAACAAGGATGCCCCT

Downstream 100 bases:

>100_bases
GAGAGGCTGCCGCGCTCGCCGCGTCGGCGAAGGGTCGGCTCGGCACGGCCGACCCGCTCAGCGGCTCCGGGCGGCCGGGC
GCCACCGCGGTTGCACGGGC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHFDIVIVGGGAGGLELAAKLGRKLGPRLGRERVLLVDRAVFHIWKPTLHEVAAGTLDAHQEGLSYTVLARRNHFSFALG
ELSALDTERRLITLGETRDERGEVLVPTRTVSFTRLVLAMGSGSNSFGTPGADNAYVLEHASDAQRFHAKLLAAFARASF
SAEKTLAVAIVGGGATGVELSAELIEAHNELLEGLGSEQRFRLDIALVEAGDRILAGLPPQISAQARLALERKNVRVLTG
TRVTEVQRDRLVTTAGEIPASIIVWAAGIKAADANRGFGLETNRINQFVVNDRLETSVSGIYALGDCAACKWEGDKLVPA
RAQAAHQQADYLTAVLLAALNEGRVDAPFVYRDFGSLVSLGENKGIGNLMGGLSGRNFFVEGLIAKWMYMSLHLMHHRAI
LGIGKTAVLALARLLQQRVSGRLKLH

Sequences:

>Translated_426_residues
MHFDIVIVGGGAGGLELAAKLGRKLGPRLGRERVLLVDRAVFHIWKPTLHEVAAGTLDAHQEGLSYTVLARRNHFSFALG
ELSALDTERRLITLGETRDERGEVLVPTRTVSFTRLVLAMGSGSNSFGTPGADNAYVLEHASDAQRFHAKLLAAFARASF
SAEKTLAVAIVGGGATGVELSAELIEAHNELLEGLGSEQRFRLDIALVEAGDRILAGLPPQISAQARLALERKNVRVLTG
TRVTEVQRDRLVTTAGEIPASIIVWAAGIKAADANRGFGLETNRINQFVVNDRLETSVSGIYALGDCAACKWEGDKLVPA
RAQAAHQQADYLTAVLLAALNEGRVDAPFVYRDFGSLVSLGENKGIGNLMGGLSGRNFFVEGLIAKWMYMSLHLMHHRAI
LGIGKTAVLALARLLQQRVSGRLKLH
>Mature_426_residues
MHFDIVIVGGGAGGLELAAKLGRKLGPRLGRERVLLVDRAVFHIWKPTLHEVAAGTLDAHQEGLSYTVLARRNHFSFALG
ELSALDTERRLITLGETRDERGEVLVPTRTVSFTRLVLAMGSGSNSFGTPGADNAYVLEHASDAQRFHAKLLAAFARASF
SAEKTLAVAIVGGGATGVELSAELIEAHNELLEGLGSEQRFRLDIALVEAGDRILAGLPPQISAQARLALERKNVRVLTG
TRVTEVQRDRLVTTAGEIPASIIVWAAGIKAADANRGFGLETNRINQFVVNDRLETSVSGIYALGDCAACKWEGDKLVPA
RAQAAHQQADYLTAVLLAALNEGRVDAPFVYRDFGSLVSLGENKGIGNLMGGLSGRNFFVEGLIAKWMYMSLHLMHHRAI
LGIGKTAVLALARLLQQRVSGRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=432, Percent_Identity=47.9166666666667, Blast_Score=333, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6320118, Length=462, Percent_Identity=26.1904761904762, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323515, Length=447, Percent_Identity=23.9373601789709, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323794, Length=460, Percent_Identity=23.695652173913, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 45828; Mature: 45828

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFDIVIVGGGAGGLELAAKLGRKLGPRLGRERVLLVDRAVFHIWKPTLHEVAAGTLDAH
CEEEEEEEECCCCHHHHHHHHHHHHCHHCCCCEEEEEHHHHHHHHCHHHHHHHCCCHHHH
QEGLSYTVLARRNHFSFALGELSALDTERRLITLGETRDERGEVLVPTRTVSFTRLVLAM
HCCCEEEEEEECCCCEEEHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCHHHEEEEEEE
GSGSNSFGTPGADNAYVLEHASDAQRFHAKLLAAFARASFSAEKTLAVAIVGGGATGVEL
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHH
SAELIEAHNELLEGLGSEQRFRLDIALVEAGDRILAGLPPQISAQARLALERKNVRVLTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEECCCCCCCCHHHEEEECCCEEEEEC
TRVTEVQRDRLVTTAGEIPASIIVWAAGIKAADANRGFGLETNRINQFVVNDRLETSVSG
CCHHHHHHHHEEEECCCCCCEEEEEECCCEECCCCCCCCCCCCCCHHEEECCCHHHHHCC
IYALGDCAACKWEGDKLVPARAQAAHQQADYLTAVLLAALNEGRVDAPFVYRDFGSLVSL
EEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
GENKGIGNLMGGLSGRNFFVEGLIAKWMYMSLHLMHHRAILGIGKTAVLALARLLQQRVS
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRLKLH
CCEECC
>Mature Secondary Structure
MHFDIVIVGGGAGGLELAAKLGRKLGPRLGRERVLLVDRAVFHIWKPTLHEVAAGTLDAH
CEEEEEEEECCCCHHHHHHHHHHHHCHHCCCCEEEEEHHHHHHHHCHHHHHHHCCCHHHH
QEGLSYTVLARRNHFSFALGELSALDTERRLITLGETRDERGEVLVPTRTVSFTRLVLAM
HCCCEEEEEEECCCCEEEHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCHHHEEEEEEE
GSGSNSFGTPGADNAYVLEHASDAQRFHAKLLAAFARASFSAEKTLAVAIVGGGATGVEL
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHH
SAELIEAHNELLEGLGSEQRFRLDIALVEAGDRILAGLPPQISAQARLALERKNVRVLTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEECCCCCCCCHHHEEEECCCEEEEEC
TRVTEVQRDRLVTTAGEIPASIIVWAAGIKAADANRGFGLETNRINQFVVNDRLETSVSG
CCHHHHHHHHEEEECCCCCCEEEEEECCCEECCCCCCCCCCCCCCHHEEECCCHHHHHCC
IYALGDCAACKWEGDKLVPARAQAAHQQADYLTAVLLAALNEGRVDAPFVYRDFGSLVSL
EEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
GENKGIGNLMGGLSGRNFFVEGLIAKWMYMSLHLMHHRAILGIGKTAVLALARLLQQRVS
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRLKLH
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]