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The map label for this gene is adk [H]

Identifier: 119897764

GI number: 119897764

Start: 1604626

End: 1605279

Strand: Direct

Name: adk [H]

Synonym: azo1473

Alternate gene names: 119897764

Gene position: 1604626-1605279 (Clockwise)

Preceding gene: 119897763

Following gene: 119897765

Centisome position: 36.67

GC content: 65.9

Gene sequence:

>654_bases
ATGCGACTGATTCTGTTGGGACCGCCGGGCGCCGGCAAGGGCACGCAAGCGAACTTCATCAAGGAGAAGTTCGGCATTCC
GCAGATCTCCACCGGCGACATGCTGCGCGCCGCGGTCAAGGCCGGCACCCCGCTGGGCATCGAGGCCAAGAAGGTGATGG
ACGCCGGTGGCCTGGTGTCCGACGAGATCATCATCGGCCTGGTGAAGGACCGCCTGCAGCAGGACGATTGCAAGGCCGGC
TACATGTTCGACGGCTTCCCGCGCACCATCCCTCAGGCCGACGCGATGAAGGACGCCGGCGTGCCGATCGACTTCGTGCT
CGAGATCGACGTGCCCGACAGCGAGATCGTGGAACGCATGAGCGGCCGCCGCGCCCACCTGGCCTCCGGCCGCACCTACC
ACGTCAAGTACAACCCGCCCAAGGTCGAGGGCAAGGATGACGTCACCGGCGAAGACCTGGTGCAGCGCGACGACGACAAG
GAAGAGACCGTCAAGAAGCGCCTGGACGTCTACCACGCCCAGACCAAGCCGCTGGTCGAGTACTACAGCAGCTGGGCCGC
CTCCGGCGACGCCAAGGCGCCCAAGGTGCGCAAGATCTCCGGCCTCGGTGCCGTGGATGAGATTACCGCCCGCGCCTTCG
ACGCGCTGAAGTAA

Upstream 100 bases:

>100_bases
CGGTTTGACCGTGCCGGTCGAGTCGTTTAAGTTTCGGCCTTTTGGTTCATCTAGTTCATAAAGCAGGCCGGCAGCACAGG
CCAAAATCTCGGGAGGGTGT

Downstream 100 bases:

>100_bases
TCCGGCGCCCGGCGCCGTCATCCGACGCGGTCGGTACCGAACCCGGTGCCGGCCGCGTTTGTCTTTGCAGGTGTGATCCG
GCGCATGCGCGCCGCTGTCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRLILLGPPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDEIIIGLVKDRLQQDDCKAG
YMFDGFPRTIPQADAMKDAGVPIDFVLEIDVPDSEIVERMSGRRAHLASGRTYHVKYNPPKVEGKDDVTGEDLVQRDDDK
EETVKKRLDVYHAQTKPLVEYYSSWAASGDAKAPKVRKISGLGAVDEITARAFDALK

Sequences:

>Translated_217_residues
MRLILLGPPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDEIIIGLVKDRLQQDDCKAG
YMFDGFPRTIPQADAMKDAGVPIDFVLEIDVPDSEIVERMSGRRAHLASGRTYHVKYNPPKVEGKDDVTGEDLVQRDDDK
EETVKKRLDVYHAQTKPLVEYYSSWAASGDAKAPKVRKISGLGAVDEITARAFDALK
>Mature_217_residues
MRLILLGPPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDEIIIGLVKDRLQQDDCKAG
YMFDGFPRTIPQADAMKDAGVPIDFVLEIDVPDSEIVERMSGRRAHLASGRTYHVKYNPPKVEGKDDVTGEDLVQRDDDK
EETVKKRLDVYHAQTKPLVEYYSSWAASGDAKAPKVRKISGLGAVDEITARAFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=218, Percent_Identity=46.3302752293578, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=46.5437788018433, Blast_Score=200, Evalue=6e-52,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=44.5054945054945, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=41.8478260869565, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=41.8478260869565, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=41.8478260869565, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=41.8478260869565, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI22749187, Length=194, Percent_Identity=29.8969072164948, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502011, Length=220, Percent_Identity=29.5454545454545, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI7706497, Length=214, Percent_Identity=29.4392523364486, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI21450759, Length=151, Percent_Identity=25.1655629139073, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI237858799, Length=150, Percent_Identity=25.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786680, Length=196, Percent_Identity=67.8571428571429, Blast_Score=284, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=48.3870967741936, Blast_Score=193, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=35.4838709677419, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=30.952380952381, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=220, Percent_Identity=28.6363636363636, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=28.804347826087, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=50.990099009901, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=42.9347826086957, Blast_Score=148, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=30.1075268817204, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=53.551912568306, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=42.8571428571429, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=42.8571428571429, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=29.5774647887324, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=29.5774647887324, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23600; Mature: 23600

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DEIIIGLVKDRLQQDDCKAGYMFDGFPRTIPQADAMKDAGVPIDFVLEIDVPDSEIVERM
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEEEECCCCHHHHHHH
SGRRAHLASGRTYHVKYNPPKVEGKDDVTGEDLVQRDDDKEETVKKRLDVYHAQTKPLVE
CCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
YYSSWAASGDAKAPKVRKISGLGAVDEITARAFDALK
HHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DEIIIGLVKDRLQQDDCKAGYMFDGFPRTIPQADAMKDAGVPIDFVLEIDVPDSEIVERM
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEEEECCCCHHHHHHH
SGRRAHLASGRTYHVKYNPPKVEGKDDVTGEDLVQRDDDKEETVKKRLDVYHAQTKPLVE
CCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
YYSSWAASGDAKAPKVRKISGLGAVDEITARAFDALK
HHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA