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The map label for this gene is nuoE [H]

Identifier: 119897691

GI number: 119897691

Start: 1527783

End: 1528262

Strand: Direct

Name: nuoE [H]

Synonym: azo1400

Alternate gene names: 119897691

Gene position: 1527783-1528262 (Clockwise)

Preceding gene: 119897690

Following gene: 119897692

Centisome position: 34.91

GC content: 58.54

Gene sequence:

>480_bases
ATGCTGAGCCAGGAATCGCTGCAACAGATCGATCGCGAGATCGCGAAATATCCTCCCGACCAGAAGCAGTCGGCGGCCAT
GTCCGCGCTGCGTATCGCTCAAGTCGAGAAAGGCTGGCTTTCGAAGGAAACGATCGCCTTCGTCGCGGACTACCTCCAGA
TGCCGGCGATCGCCGTCTATGAGGTAGCGAGCTTCTACAACATGTACGACCTGCAGCCGGTGGGGCGCCACAAGATTACC
GTGTGCACCAACCTCCCTTGTGCGCTGTCGGGCGGCGTTCATGCGGCCGAATACATCAAGCAGAAGCTCGGTATCGATTT
CAACGAGACCACGCCCGATGGCAAGTTCACGCTGAAGGAAGGCGAGTGCATGGGCGCCTGTGGTGACGCCCCGGTTCTGC
TGCACAACAACCACACGATGTGCAGCTGGATGACGACTGAGAAAATCGACCAACTCCTGGCCGACCTGGGAAGCAAATGA

Upstream 100 bases:

>100_bases
TCGGAGAGATCGACCGCTAGGGCGACGACCCGCACCAACATACGGGCATGGCCCGACCCAGGACGAACAGACGGCAGGCT
ATCCGGAAGACGAGCACGAC

Downstream 100 bases:

>100_bases
GCGCGCACGGACTGATCCTCGCCGGGCTGGACGGCGACCGCACCTGGCGGCTCCAGGACTACATCGGCCGTGGCGGCTAT
TCGGCGCTGAAGAAGATCAT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MLSQESLQQIDREIAKYPPDQKQSAAMSALRIAQVEKGWLSKETIAFVADYLQMPAIAVYEVASFYNMYDLQPVGRHKIT
VCTNLPCALSGGVHAAEYIKQKLGIDFNETTPDGKFTLKEGECMGACGDAPVLLHNNHTMCSWMTTEKIDQLLADLGSK

Sequences:

>Translated_159_residues
MLSQESLQQIDREIAKYPPDQKQSAAMSALRIAQVEKGWLSKETIAFVADYLQMPAIAVYEVASFYNMYDLQPVGRHKIT
VCTNLPCALSGGVHAAEYIKQKLGIDFNETTPDGKFTLKEGECMGACGDAPVLLHNNHTMCSWMTTEKIDQLLADLGSK
>Mature_159_residues
MLSQESLQQIDREIAKYPPDQKQSAAMSALRIAQVEKGWLSKETIAFVADYLQMPAIAVYEVASFYNMYDLQPVGRHKIT
VCTNLPCALSGGVHAAEYIKQKLGIDFNETTPDGKFTLKEGECMGACGDAPVLLHNNHTMCSWMTTEKIDQLLADLGSK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=155, Percent_Identity=40, Blast_Score=124, Evalue=4e-29,
Organism=Escherichia coli, GI1788621, Length=154, Percent_Identity=36.3636363636364, Blast_Score=92, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561328, Length=155, Percent_Identity=38.7096774193548, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859877, Length=155, Percent_Identity=37.4193548387097, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21355353, Length=155, Percent_Identity=36.7741935483871, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 17588; Mature: 17588

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSQESLQQIDREIAKYPPDQKQSAAMSALRIAQVEKGWLSKETIAFVADYLQMPAIAVY
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
EVASFYNMYDLQPVGRHKITVCTNLPCALSGGVHAAEYIKQKLGIDFNETTPDGKFTLKE
HHHHHHHHHCCCCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEC
GECMGACGDAPVLLHNNHTMCSWMTTEKIDQLLADLGSK
CCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSQESLQQIDREIAKYPPDQKQSAAMSALRIAQVEKGWLSKETIAFVADYLQMPAIAVY
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
EVASFYNMYDLQPVGRHKITVCTNLPCALSGGVHAAEYIKQKLGIDFNETTPDGKFTLKE
HHHHHHHHHCCCCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEC
GECMGACGDAPVLLHNNHTMCSWMTTEKIDQLLADLGSK
CCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]