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The map label for this gene is nuoD [H]

Identifier: 119897690

GI number: 119897690

Start: 1526449

End: 1527702

Strand: Direct

Name: nuoD [H]

Synonym: azo1399

Alternate gene names: 119897690

Gene position: 1526449-1527702 (Clockwise)

Preceding gene: 119897689

Following gene: 119897691

Centisome position: 34.88

GC content: 60.45

Gene sequence:

>1254_bases
ATGGCTGAAATTCGCAACTACACGATCAACTTCGGTCCGCAGCATCCGTCGGCGCACGGTGTGCTGCGCCTGGTTCTGGA
ACTGGATGGCGAAGTCGTCGAGCGCGCCGATCCGCATATCGGCCTGTTGCATCGCGGTACCGAGAAGCTTGCCGAGACGC
GAACCTGGGTTCAGTCGGTGCCTTACATGGACCGTCTCGACTACGTCTCGATGATGTGCAACGAGCACGCCTACTGCATG
GCCATCGAGCGCCTGCTTGGCGTCGAGGTGCCGTTGCGCGCCCAGTACATCCGGGTGATGTTCGATGAAATCACCCGCAT
TTTGAATCATCTGCTGAACATCGGCACCCACGCGCTGGATATCGGTGCGATGACGATGGTGTTGTACACGTTCCGTGAGC
GGGAAGATCTCATGGATGCGTACGAGGCGGTGTCGGGTGCGCGCATGCACGCGGCCTATTACCGTCCGGGCGGGGTGTAT
CGCGACCTTCCGGACCGGATGCCGCAGTACCAGCCCAACAAGTTCAAGAACGCCAATGTCGTCAAGGATCTGAATGCGGC
GCGGCAAGGTTCGCTGCTGGACTTCCTCGACGACTTCACGCAGCGCTTTCCCAGGTATTGCGACGAATACGAAACCCTGC
TGACCGACAACCGTATCTGGAAGCAGCGCACGGTCGGTATCGGCGTTGTCACGCCGGAGCAGGCGCTCGCGTGGGGCTTT
TCCGGTCCGATGATCCGCGGTTCCGGTATTGCCTGGGATCTGCGCAAGAAGCAGCCGTACGAAGTCTACGACAAGGTCGA
CTTCGACATTCCGGTGGGCAAGAACGGTGACTGTTATGACCGTTACCTCTGCCGGATGGAGGAAATGCGTCAGTCCAACC
GCATCATCCGCCAGTGCATTGACTGGCTGCGCAAGAACCCGGGGCCGGTCATCACCGACAACCACAAGGTTGCGCCGCCG
TCGCGCGAGCAGATGAAGTCCAACATGGAAGAGCTGATCCACCACTTCAAGCTCTTCACCGAAGGCATGCACGTACCCAA
GGGCGAAGCCTATGCCGCCGTGGAGCACCCGAAGGGCGAGTTCGGCGTGTATGCGGTGTCCGATGGTGCGAACAAGCCTT
ATCGCCTCAAGCTGCGGGCGCCGGGCTTCGCCCACCTCGCCGCCATGGATGAGATTTCCCGTGGCCACATGATTGCCGAC
GTGGTGGCGATCATCGGGACCATGGACGTGGTGTTCGGAGAGATCGACCGCTAG

Upstream 100 bases:

>100_bases
GACCCGGAGCAGGGGCGCGTGGTGTATCAGCCGGTAACGATCGAGCCTCGCGAGAATACCCCGCGCATCGTGCGTGAAGA
GAATTACGGGGATGTCGGTC

Downstream 100 bases:

>100_bases
GGCGACGACCCGCACCAACATACGGGCATGGCCCGACCCAGGACGAACAGACGGCAGGCTATCCGGAAGACGAGCACGAC
ATGCTGAGCCAGGAATCGCT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIRNYTINFGPQHPSAHGVLRLVLELDGEVVERADPHIGLLHRGTEKLAETRTWVQSVPYMDRLDYVSMMCNEHAYCM
AIERLLGVEVPLRAQYIRVMFDEITRILNHLLNIGTHALDIGAMTMVLYTFREREDLMDAYEAVSGARMHAAYYRPGGVY
RDLPDRMPQYQPNKFKNANVVKDLNAARQGSLLDFLDDFTQRFPRYCDEYETLLTDNRIWKQRTVGIGVVTPEQALAWGF
SGPMIRGSGIAWDLRKKQPYEVYDKVDFDIPVGKNGDCYDRYLCRMEEMRQSNRIIRQCIDWLRKNPGPVITDNHKVAPP
SREQMKSNMEELIHHFKLFTEGMHVPKGEAYAAVEHPKGEFGVYAVSDGANKPYRLKLRAPGFAHLAAMDEISRGHMIAD
VVAIIGTMDVVFGEIDR

Sequences:

>Translated_417_residues
MAEIRNYTINFGPQHPSAHGVLRLVLELDGEVVERADPHIGLLHRGTEKLAETRTWVQSVPYMDRLDYVSMMCNEHAYCM
AIERLLGVEVPLRAQYIRVMFDEITRILNHLLNIGTHALDIGAMTMVLYTFREREDLMDAYEAVSGARMHAAYYRPGGVY
RDLPDRMPQYQPNKFKNANVVKDLNAARQGSLLDFLDDFTQRFPRYCDEYETLLTDNRIWKQRTVGIGVVTPEQALAWGF
SGPMIRGSGIAWDLRKKQPYEVYDKVDFDIPVGKNGDCYDRYLCRMEEMRQSNRIIRQCIDWLRKNPGPVITDNHKVAPP
SREQMKSNMEELIHHFKLFTEGMHVPKGEAYAAVEHPKGEFGVYAVSDGANKPYRLKLRAPGFAHLAAMDEISRGHMIAD
VVAIIGTMDVVFGEIDR
>Mature_416_residues
AEIRNYTINFGPQHPSAHGVLRLVLELDGEVVERADPHIGLLHRGTEKLAETRTWVQSVPYMDRLDYVSMMCNEHAYCMA
IERLLGVEVPLRAQYIRVMFDEITRILNHLLNIGTHALDIGAMTMVLYTFREREDLMDAYEAVSGARMHAAYYRPGGVYR
DLPDRMPQYQPNKFKNANVVKDLNAARQGSLLDFLDDFTQRFPRYCDEYETLLTDNRIWKQRTVGIGVVTPEQALAWGFS
GPMIRGSGIAWDLRKKQPYEVYDKVDFDIPVGKNGDCYDRYLCRMEEMRQSNRIIRQCIDWLRKNPGPVITDNHKVAPPS
REQMKSNMEELIHHFKLFTEGMHVPKGEAYAAVEHPKGEFGVYAVSDGANKPYRLKLRAPGFAHLAAMDEISRGHMIADV
VAIIGTMDVVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.8695652173913, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.2941176470588, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=413, Percent_Identity=38.2566585956416, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1789076, Length=419, Percent_Identity=27.4463007159904, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788832, Length=411, Percent_Identity=27.007299270073, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17555284, Length=414, Percent_Identity=57.2463768115942, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568379, Length=414, Percent_Identity=56.280193236715, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=61.6867469879518, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221459469, Length=417, Percent_Identity=54.1966426858513, Blast_Score=472, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47816; Mature: 47684

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIRNYTINFGPQHPSAHGVLRLVLELDGEVVERADPHIGLLHRGTEKLAETRTWVQSV
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEHAYCMAIERLLGVEVPLRAQYIRVMFDEITRILNHLLNIGTHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IGAMTMVLYTFREREDLMDAYEAVSGARMHAAYYRPGGVYRDLPDRMPQYQPNKFKNANV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHCCCCCCCCCCCCCH
VKDLNAARQGSLLDFLDDFTQRFPRYCDEYETLLTDNRIWKQRTVGIGVVTPEQALAWGF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCHHHHHCCC
SGPMIRGSGIAWDLRKKQPYEVYDKVDFDIPVGKNGDCYDRYLCRMEEMRQSNRIIRQCI
CCCEEECCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPVITDNHKVAPPSREQMKSNMEELIHHFKLFTEGMHVPKGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
FGVYAVSDGANKPYRLKLRAPGFAHLAAMDEISRGHMIADVVAIIGTMDVVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEIRNYTINFGPQHPSAHGVLRLVLELDGEVVERADPHIGLLHRGTEKLAETRTWVQSV
CCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCEEHHHCCHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEHAYCMAIERLLGVEVPLRAQYIRVMFDEITRILNHLLNIGTHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IGAMTMVLYTFREREDLMDAYEAVSGARMHAAYYRPGGVYRDLPDRMPQYQPNKFKNANV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHCCCCCCCCCCCCCH
VKDLNAARQGSLLDFLDDFTQRFPRYCDEYETLLTDNRIWKQRTVGIGVVTPEQALAWGF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCHHHHHCCC
SGPMIRGSGIAWDLRKKQPYEVYDKVDFDIPVGKNGDCYDRYLCRMEEMRQSNRIIRQCI
CCCEEECCCCEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLRKNPGPVITDNHKVAPPSREQMKSNMEELIHHFKLFTEGMHVPKGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
FGVYAVSDGANKPYRLKLRAPGFAHLAAMDEISRGHMIADVVAIIGTMDVVFGEIDR
EEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA