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The map label for this gene is serS

Identifier: 119897660

GI number: 119897660

Start: 1490125

End: 1491417

Strand: Direct

Name: serS

Synonym: azo1369

Alternate gene names: 119897660

Gene position: 1490125-1491417 (Clockwise)

Preceding gene: 119897658

Following gene: 119897661

Centisome position: 34.05

GC content: 65.89

Gene sequence:

>1293_bases
ATGCTCGATATCCAACTCCTCCGCGGCCAACTGTCCCAGGTGGCCGAGCGCCTGGCGCTGCGCGGCGTCACGCTCGACAG
CGGGGCCTTCACCGCGCTCGAAGACGAACGCAAGCAGTTGCAGACCCGCACGCAGGAGCTTCAGGCCAAGCGCAATGCGC
TGTCCAAGCAGATCGGCATCCTCAAGGGAAAGGGTGAGGATGCCTCCGCGGTGATGGCTGAAGTCGGCCAGCTCGGCGAC
GAACTGAAGGCCTGCGAGCAGGCCTTGCCGGTGGTGCTGGAAAAGCTCAACGCCTTCCTGGCCGGCCTGCCCAACCTGCC
GCAGGAAGGCGTGCCGGTGGGTGAGGACGAAACCGGCAATGTCGAGGTGCGGCGCTGGGGCACGCCGCGCAGCTTCGACT
TCGAGGTGAAGGATCACGTCGATCTCGGCGCCGCGCTCGGGCTCGATTTCGATACCGGAGCCAAGCTGTCCGGCTCGCGC
TTCACCTTCATGCGCGGCCAGATCGCCCGCCTGCACCGCGCGCTCGCGCAGTTCATGCTCGACACCCAGACATTGGAGCA
TGGCTACACCGAGTGCTACGCGCCCTACATCGTCAACCGCGAGGTGCTGGTCGGCACCGGCCAGCTGCCCAAGTTCAAGG
AAGACATGTTCTGGGTGCTGCGCGGCGGCGACGAGGAGGGCGGTGAGCAGTACCTGATCTCGACCTCCGAGATCCCGCTG
ACCAACACCGTGCGCGAGCAAATCCTCGCGGCCGATGCGCTGCCGATCAAGCTCACCGCGCACAGCCCCTGCTTCCGTTC
CGAGGCGGGCAGCGCCGGGCGCGACACGCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTGGAGATGGTGCAGATCG
TCCATCCGGACGCCAGCAATGCGGCGCTGGAAGAGATGGTCGGCCATGCCGAGGCGATCCTGCAGAAGCTTGAACTGCCG
TATCGGGTCATCACGCTGTGCACTGGCGACATGGGCTTCTCCGCGGCCAAGACCTATGACCTCGAAGTCTGGCTGCCGGC
GCAGAACACCTATCGGGAAATCTCCAGCTGCTCCAACTGCGAAGCCTTCCAGGCGCGCCGGATGCAGGCCCGCTTCAAGA
CCGCGCAGGGCAAGAACGAACTGGTGCATACGCTCAACGGCTCCGGCCTCGCGGTCGGCCGTACGCTGGTCGCGGTGCTG
GAAAACTACCAGCAGGCGGACGGCTCCATCGTCGTACCCAAGGCGTTGGTGCCGTACATGGGCGGCCTCGAGGTGCTGCG
GCCGGCAAGCTGA

Upstream 100 bases:

>100_bases
CGTTTGGACTGTCAAACCAGTGACCTGGACGTTCTAGCTAGAATTCGTCGTCACTTCTGCGCCTAACGCACTGATCGCAA
AACCTTTCAGGAAAACAAGC

Downstream 100 bases:

>100_bases
CGCCTCCCCGGCCCTCATTCGCAGACAAGCCCCGTACCGCGCAGCGGTGCGGGGCTTCTTTTTTGCCCTTGACGCTTCAT
GTCAAAGTGTTTGACACGTA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDIQLLRGQLSQVAERLALRGVTLDSGAFTALEDERKQLQTRTQELQAKRNALSKQIGILKGKGEDASAVMAEVGQLGD
ELKACEQALPVVLEKLNAFLAGLPNLPQEGVPVGEDETGNVEVRRWGTPRSFDFEVKDHVDLGAALGLDFDTGAKLSGSR
FTFMRGQIARLHRALAQFMLDTQTLEHGYTECYAPYIVNREVLVGTGQLPKFKEDMFWVLRGGDEEGGEQYLISTSEIPL
TNTVREQILAADALPIKLTAHSPCFRSEAGSAGRDTRGMIRQHQFDKVEMVQIVHPDASNAALEEMVGHAEAILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMQARFKTAQGKNELVHTLNGSGLAVGRTLVAVL
ENYQQADGSIVVPKALVPYMGGLEVLRPAS

Sequences:

>Translated_430_residues
MLDIQLLRGQLSQVAERLALRGVTLDSGAFTALEDERKQLQTRTQELQAKRNALSKQIGILKGKGEDASAVMAEVGQLGD
ELKACEQALPVVLEKLNAFLAGLPNLPQEGVPVGEDETGNVEVRRWGTPRSFDFEVKDHVDLGAALGLDFDTGAKLSGSR
FTFMRGQIARLHRALAQFMLDTQTLEHGYTECYAPYIVNREVLVGTGQLPKFKEDMFWVLRGGDEEGGEQYLISTSEIPL
TNTVREQILAADALPIKLTAHSPCFRSEAGSAGRDTRGMIRQHQFDKVEMVQIVHPDASNAALEEMVGHAEAILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMQARFKTAQGKNELVHTLNGSGLAVGRTLVAVL
ENYQQADGSIVVPKALVPYMGGLEVLRPAS
>Mature_430_residues
MLDIQLLRGQLSQVAERLALRGVTLDSGAFTALEDERKQLQTRTQELQAKRNALSKQIGILKGKGEDASAVMAEVGQLGD
ELKACEQALPVVLEKLNAFLAGLPNLPQEGVPVGEDETGNVEVRRWGTPRSFDFEVKDHVDLGAALGLDFDTGAKLSGSR
FTFMRGQIARLHRALAQFMLDTQTLEHGYTECYAPYIVNREVLVGTGQLPKFKEDMFWVLRGGDEEGGEQYLISTSEIPL
TNTVREQILAADALPIKLTAHSPCFRSEAGSAGRDTRGMIRQHQFDKVEMVQIVHPDASNAALEEMVGHAEAILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMQARFKTAQGKNELVHTLNGSGLAVGRTLVAVL
ENYQQADGSIVVPKALVPYMGGLEVLRPAS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=340, Percent_Identity=39.1176470588235, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI8923421, Length=442, Percent_Identity=28.7330316742081, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=31.6109422492401, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=62.4708624708625, Blast_Score=533, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539260, Length=417, Percent_Identity=35.0119904076739, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=302, Percent_Identity=31.7880794701987, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=415, Percent_Identity=35.421686746988, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321799, Length=393, Percent_Identity=30.5343511450382, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24581334, Length=431, Percent_Identity=34.1067285382831, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17737985, Length=338, Percent_Identity=34.3195266272189, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_AZOSB (A1K581)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932873.1
- ProteinModelPortal:   A1K581
- SMR:   A1K581
- STRING:   A1K581
- GeneID:   4606835
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1369
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1K581
- ProtClustDB:   PRK05431
- BioCyc:   ASP62928:AZO1369-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47189; Mature: 47189

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRGQLSQVAERLALRGVTLDSGAFTALEDERKQLQTRTQELQAKRNALSKQIGI
CCCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKGKGEDASAVMAEVGQLGDELKACEQALPVVLEKLNAFLAGLPNLPQEGVPVGEDETGN
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRSFDFEVKDHVDLGAALGLDFDTGAKLSGSRFTFMRGQIARLHRALAQFML
EEEEECCCCCCCCEEECCCCCCCHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
DTQTLEHGYTECYAPYIVNREVLVGTGQLPKFKEDMFWVLRGGDEEGGEQYLISTSEIPL
HHHHHHCCCHHHCCCEEECCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
TNTVREQILAADALPIKLTAHSPCFRSEAGSAGRDTRGMIRQHQFDKVEMVQIVHPDASN
HHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
AALEEMVGHAEAILQKLELPYRVITLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNC
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCC
EAFQARRMQARFKTAQGKNELVHTLNGSGLAVGRTLVAVLENYQQADGSIVVPKALVPYM
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH
GGLEVLRPAS
CCHHHCCCCC
>Mature Secondary Structure
MLDIQLLRGQLSQVAERLALRGVTLDSGAFTALEDERKQLQTRTQELQAKRNALSKQIGI
CCCHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKGKGEDASAVMAEVGQLGDELKACEQALPVVLEKLNAFLAGLPNLPQEGVPVGEDETGN
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRSFDFEVKDHVDLGAALGLDFDTGAKLSGSRFTFMRGQIARLHRALAQFML
EEEEECCCCCCCCEEECCCCCCCHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
DTQTLEHGYTECYAPYIVNREVLVGTGQLPKFKEDMFWVLRGGDEEGGEQYLISTSEIPL
HHHHHHCCCHHHCCCEEECCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
TNTVREQILAADALPIKLTAHSPCFRSEAGSAGRDTRGMIRQHQFDKVEMVQIVHPDASN
HHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
AALEEMVGHAEAILQKLELPYRVITLCTGDMGFSAAKTYDLEVWLPAQNTYREISSCSNC
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCC
EAFQARRMQARFKTAQGKNELVHTLNGSGLAVGRTLVAVLENYQQADGSIVVPKALVPYM
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH
GGLEVLRPAS
CCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA