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The map label for this gene is hemC [H]

Identifier: 119897284

GI number: 119897284

Start: 1067713

End: 1068663

Strand: Direct

Name: hemC [H]

Synonym: azo0993

Alternate gene names: 119897284

Gene position: 1067713-1068663 (Clockwise)

Preceding gene: 119897282

Following gene: 119897285

Centisome position: 24.4

GC content: 72.45

Gene sequence:

>951_bases
GTGACCTCCACCACCTCGTCCTCGCCCGCCGCGCCCGAGCGCATCGTGATCGCAACCCGCGAAAGCCGCCTCGCGCTGTG
GCAGGCCGAGCACGTCAAGGCCCGGCTGGAGGCGCTCTATCCCGCCTGCACGGTCGAGCTGCTCGGCATGACCACGCGCG
GCGACCAGATCCTCGACCGCCCGCTGGCCAAGGTCGGCGGCAAGGGGCTGTTCGTCAAGGAACTCGAAACCGCGCTGCTG
GACGGCCGCGCGGACATCGCCGTGCATTCGATGAAGGACGTGCCGATGGAGATGGGCAAGGCGTTCGCGCTGCCCTGCAT
TTCGGCGCGTGAGGTTCCGCTCGACGCCTTCGTCTCCAACCGCTACGCCAGTCTGGCCGACATGCCGCCGGGCACCGTGG
TCGGCACCTCCTCGCTGCGGCGCGAATCGCAGCTGCATGCGCAGTATCCGTTCCTGGCCGTCACCAGCCTGCGCGGCAAC
CTCGACACCCGCCTGCGCAAGCTCGACGAAGGGCAGTACGACGCGATCATCCTCGCGGCCGCCGGCCTGACGCGTCTTGG
GCTGGCCGACCGCATCCGTGCGACGCTGCCGGCCGAGGTGTCGCTGCCCGCGGCGGGGCAGGGGGCGCTCGGTATCGAAT
GCCTCTCCAGCCGGCCGGAGGTGGCCGCCTGGCTTGCGCCGCTGAACGATCCCGCCACCTCGGCGTGCGTGCGCGCCGAG
CGCGCCGTGGCGCGTGCGCTTGCGGGCAGTTGCGAGGTGCCGCTCGGCGCTTATGCGGAGCTGCGCGGCGCCCGCCTGTG
GTTGCGCGGCTTCGTGGCCCGCCCCGACGGCAGCGAGATCGTGCGTGCGGAGCGCGAGGGCGATCCCGCCGCGGCGGAAG
CGCTGGGTGGCGCGCTGGCCGACGATCTTCGCGCCCAAGGCGCGGAGCGCATCCTCGCCGAACTCGGCTGA

Upstream 100 bases:

>100_bases
GCAGTGCGAAATCCGCGCTGGCCGCGTCGGCTTCCCGGCCACGGCTCGCACGGTCTGTCTGCCGCCTTCCTCTGCTAGCC
CATTCTCCGAGTCTGTTACC

Downstream 100 bases:

>100_bases
GCGGCCGCGTCCGCCATGACGCGGCCCCACGGGCAGACGGACCCGAAACTGCCGCTGGCGGGTCGCCTGGTTGCGGTGAC
GCGGCCGGAAGCCCAGGCGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTSTTSSSPAAPERIVIATRESRLALWQAEHVKARLEALYPACTVELLGMTTRGDQILDRPLAKVGGKGLFVKELETALL
DGRADIAVHSMKDVPMEMGKAFALPCISAREVPLDAFVSNRYASLADMPPGTVVGTSSLRRESQLHAQYPFLAVTSLRGN
LDTRLRKLDEGQYDAIILAAAGLTRLGLADRIRATLPAEVSLPAAGQGALGIECLSSRPEVAAWLAPLNDPATSACVRAE
RAVARALAGSCEVPLGAYAELRGARLWLRGFVARPDGSEIVRAEREGDPAAAEALGGALADDLRAQGAERILAELG

Sequences:

>Translated_316_residues
MTSTTSSSPAAPERIVIATRESRLALWQAEHVKARLEALYPACTVELLGMTTRGDQILDRPLAKVGGKGLFVKELETALL
DGRADIAVHSMKDVPMEMGKAFALPCISAREVPLDAFVSNRYASLADMPPGTVVGTSSLRRESQLHAQYPFLAVTSLRGN
LDTRLRKLDEGQYDAIILAAAGLTRLGLADRIRATLPAEVSLPAAGQGALGIECLSSRPEVAAWLAPLNDPATSACVRAE
RAVARALAGSCEVPLGAYAELRGARLWLRGFVARPDGSEIVRAEREGDPAAAEALGGALADDLRAQGAERILAELG
>Mature_315_residues
TSTTSSSPAAPERIVIATRESRLALWQAEHVKARLEALYPACTVELLGMTTRGDQILDRPLAKVGGKGLFVKELETALLD
GRADIAVHSMKDVPMEMGKAFALPCISAREVPLDAFVSNRYASLADMPPGTVVGTSSLRRESQLHAQYPFLAVTSLRGNL
DTRLRKLDEGQYDAIILAAAGLTRLGLADRIRATLPAEVSLPAAGQGALGIECLSSRPEVAAWLAPLNDPATSACVRAER
AVARALAGSCEVPLGAYAELRGARLWLRGFVARPDGSEIVRAEREGDPAAAEALGGALADDLRAQGAERILAELG

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=40.1812688821752, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=40.1812688821752, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI48994974, Length=299, Percent_Identity=59.866220735786, Blast_Score=336, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.6292834890966, Blast_Score=205, Evalue=7e-54,
Organism=Drosophila melanogaster, GI20130425, Length=263, Percent_Identity=40.6844106463878, Blast_Score=190, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33442; Mature: 33311

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTTSSSPAAPERIVIATRESRLALWQAEHVKARLEALYPACTVELLGMTTRGDQILDR
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLAKVGGKGLFVKELETALLDGRADIAVHSMKDVPMEMGKAFALPCISAREVPLDAFVSN
HHHHHCCCCEEHHHHHHHHHCCCCCEEEEHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHH
RYASLADMPPGTVVGTSSLRRESQLHAQYPFLAVTSLRGNLDTRLRKLDEGQYDAIILAA
HHHHHCCCCCCCEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEE
AGLTRLGLADRIRATLPAEVSLPAAGQGALGIECLSSRPEVAAWLAPLNDPATSACVRAE
CCHHHHCHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCHHHHHHHHH
RAVARALAGSCEVPLGAYAELRGARLWLRGFVARPDGSEIVRAEREGDPAAAEALGGALA
HHHHHHHHCCCCCCCCHHHHHHHHHEEEHHEECCCCCHHHHHHHCCCCHHHHHHHHHHHH
DDLRAQGAERILAELG
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSTTSSSPAAPERIVIATRESRLALWQAEHVKARLEALYPACTVELLGMTTRGDQILDR
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLAKVGGKGLFVKELETALLDGRADIAVHSMKDVPMEMGKAFALPCISAREVPLDAFVSN
HHHHHCCCCEEHHHHHHHHHCCCCCEEEEHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHH
RYASLADMPPGTVVGTSSLRRESQLHAQYPFLAVTSLRGNLDTRLRKLDEGQYDAIILAA
HHHHHCCCCCCCEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEE
AGLTRLGLADRIRATLPAEVSLPAAGQGALGIECLSSRPEVAAWLAPLNDPATSACVRAE
CCHHHHCHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCHHHHHHHHH
RAVARALAGSCEVPLGAYAELRGARLWLRGFVARPDGSEIVRAEREGDPAAAEALGGALA
HHHHHHHHCCCCCCCCHHHHHHHHHEEEHHEECCCCCHHHHHHHCCCCHHHHHHHHHHHH
DDLRAQGAERILAELG
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA