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The map label for this gene is hemD [H]

Identifier: 119897285

GI number: 119897285

Start: 1068679

End: 1069476

Strand: Direct

Name: hemD [H]

Synonym: azo0994

Alternate gene names: 119897285

Gene position: 1068679-1069476 (Clockwise)

Preceding gene: 119897284

Following gene: 119897286

Centisome position: 24.42

GC content: 72.06

Gene sequence:

>798_bases
ATGACGCGGCCCCACGGGCAGACGGACCCGAAACTGCCGCTGGCGGGTCGCCTGGTTGCGGTGACGCGGCCGGAAGCCCA
GGCGCTGTCGCTGTGCGAGGCCATCCGGCGCGCGGGCGGCCAGGTGCTGCTGTTTCCGGTGCTCGCGATCGGCGCGGTTG
AAGATCCCGCCGCACTCGACGAGGCCATCGCCCGGCTCGACCATTTCGACCTCGCTTTCTTCGTCAGTCCCAACGCGGTG
GAGCATGCGCTGGCCGCGGTGAAGGCGCGCCGCCACTGGCCCGAGCGGCTTGAGGTGTCCACCGTGGGCAAGGGCAGCGA
ACGTGCGCTGCGCGAAGCCGGGTTCAGCGCGGTTATCGCCCCTTCCGAAGGCTTCGACTCGGAAGCCGTGCTCGCGCTGC
CCGCGTTTTCGGCGACGGCGATCAACGGCCGCCGCGTCGTCATCTTCCGCGGCGACGGCGGCCGGGAACTCCTCGCCGAT
GCGCTGCGCGCGCGCGGAGCCGTGGTCGAGCAGGTGTCCTGCTACCGGCGCTATCGCCCGGCGGCGGACGCCGCGCCGCT
GATCCAGGCTGCCGGCACGGGGCGGCTGGACGCGCTCGTGCTGACCAGTAGCGAAGGGGTGCGCAACCTGGTGGAGATGG
TGGGCGAGAAGGGCTTCGGCGTGCTGCGGCGCGTCACCGTGTTCGCGCCCCATCCGCGCATCGTGGCGCACGCCCGCGCC
GCCGGCTTCGATCGCGTCGAGGAAACCCCGCCCGGCGATGACGGCCTGCTGGAGACGCTGGTCCGCCACTTTGGTTAA

Upstream 100 bases:

>100_bases
CGCCGCGGCGGAAGCGCTGGGTGGCGCGCTGGCCGACGATCTTCGCGCCCAAGGCGCGGAGCGCATCCTCGCCGAACTCG
GCTGAGCGGCCGCGTCCGCC

Downstream 100 bases:

>100_bases
ACTCTCGGCATGAACGAAGAAACTCCCGCGCTCACCTCGTCCCCGGCCGCCGCGCAGCCGGCCGCCTCCGTAGAACCTCC
CCCGTCGGACCCGCGTCCGG

Product: HemD protein

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTRPHGQTDPKLPLAGRLVAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPNAV
EHALAAVKARRHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFSATAINGRRVVIFRGDGGRELLAD
ALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLDALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARA
AGFDRVEETPPGDDGLLETLVRHFG

Sequences:

>Translated_265_residues
MTRPHGQTDPKLPLAGRLVAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPNAV
EHALAAVKARRHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFSATAINGRRVVIFRGDGGRELLAD
ALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLDALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARA
AGFDRVEETPPGDDGLLETLVRHFG
>Mature_264_residues
TRPHGQTDPKLPLAGRLVAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPNAVE
HALAAVKARRHWPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFSATAINGRRVVIFRGDGGRELLADA
LRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLDALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARAA
GFDRVEETPPGDDGLLETLVRHFG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=247, Percent_Identity=28.3400809716599, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28243; Mature: 28111

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPHGQTDPKLPLAGRLVAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALD
CCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHH
EAIARLDHFDLAFFVSPNAVEHALAAVKARRHWPERLEVSTVGKGSERALREAGFSAVIA
HHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCEEEECCCCHHHHHHHCCCEEEEC
PSEGFDSEAVLALPAFSATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRP
CCCCCCCCEEEEECCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCC
AADAAPLIQAAGTGRLDALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARA
CCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHEEECCCCHHHHHHHH
AGFDRVEETPPGDDGLLETLVRHFG
CCCCHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TRPHGQTDPKLPLAGRLVAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALD
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHH
EAIARLDHFDLAFFVSPNAVEHALAAVKARRHWPERLEVSTVGKGSERALREAGFSAVIA
HHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCEEEECCCCHHHHHHHCCCEEEEC
PSEGFDSEAVLALPAFSATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRP
CCCCCCCCEEEEECCCCEEEECCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCC
AADAAPLIQAAGTGRLDALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARA
CCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHEEECCCCHHHHHHHH
AGFDRVEETPPGDDGLLETLVRHFG
CCCCHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]