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The map label for this gene is aroE

Identifier: 119896998

GI number: 119896998

Start: 754859

End: 755704

Strand: Reverse

Name: aroE

Synonym: azo0707

Alternate gene names: 119896998

Gene position: 755704-754859 (Counterclockwise)

Preceding gene: 119896999

Following gene: 119896997

Centisome position: 17.27

GC content: 74.7

Gene sequence:

>846_bases
ATGGACCGCTACGCCGTCGTCGGCAACCCGATCGCCCACAGCAAGTCGCCGCAGATCCACGCCGCCTTCGCGCACCAGAC
CGGCGAGGCACTGGGCTACGAAGCCATCCTCGCGCCGCTCGACGGCTTCGTGGACACCGTGCTCGCGTTCCGCGCGGTGG
GCGGGCGCGGCATGAACGTGACCGTGCCGTTCAAGCTCGAAGCCCACGCGCTTGCCACGCGCCTCACGCCGCGCGCGGCG
GCCGCGGGCGCCGTCAATACGCTCGCCTTCGGCGGGCCGGAAACCCCGGACGACATCCTCGGCGACAACACCGACGGCGC
CGGCCTGGTGCGCGACCTCACCGTCAATCTCGGCTGTCCCTTGCACGGCCGCCGCGTGCTGCTGCTCGGCGCCGGTGGCG
CGGCGCGCGGCGCGCTGCTGCCGCTGCTGGAGCAGGCGCCGGCCGCGCTGACGATCGCCAACCGCACCGCGGCGAAGGCG
GTGGAACTGGCCGCCGGCTTTGCCGCCGGCCACCCCGGCGTGGCGATTGACGGCGGCGGCTTCGATGCGCTCGCCGGCCG
CCGCTTCGACGTGGTCATCAATGCCACCGCCGCCAGCCTTGCCGACCAGGCGCCGCCGCTGCCGGCTGGCATCTACGCCG
AAGGCGCGCTGGCCTACGACATGATGTACGGCCGCGGCGACACCCCCTTTCTTGCAGCCGCCCGGGCCGACGGTGCCGGG
CGGCTGGCCGACGGGCTGGGCATGCTGGTCGAGCAGGCCGCCGAGAGCTTCCTGCTGTGGCGCGGCGTGCGCCCCGACAC
CGCCCCGGTGCTGGCCGATCTGCGCGCCCGTCTCGCCGCCGCATGA

Upstream 100 bases:

>100_bases
CCGCCGGACATCAGCCGCGACACCGATATCATCGAGATCGTGCGGACCTGGACCTTCACCAATACCGACCAGGTGCGCGC
CAACTAGGAGCCCGCAGCGC

Downstream 100 bases:

>100_bases
AGACGCTGTGGCGCTGGCTCGGCCGCGCCCTGCTCGCCGCCTTCGCGCTGTTGCTGCTCTGGCAGGTCTGGCTGTTCGCG
CAGGTGGCGTGGTGGCGCAC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNVTVPFKLEAHALATRLTPRAA
AAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCPLHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKA
VELAAGFAAGHPGVAIDGGGFDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAG
RLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA

Sequences:

>Translated_281_residues
MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNVTVPFKLEAHALATRLTPRAA
AAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCPLHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKA
VELAAGFAAGHPGVAIDGGGFDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAG
RLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA
>Mature_281_residues
MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNVTVPFKLEAHALATRLTPRAA
AAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCPLHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKA
VELAAGFAAGHPGVAIDGGGFDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAG
RLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=281, Percent_Identity=51.6014234875445, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=30.1418439716312, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=274, Percent_Identity=27.3722627737226, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_AZOSB (A1K3B9)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932211.1
- ProteinModelPortal:   A1K3B9
- SMR:   A1K3B9
- STRING:   A1K3B9
- GeneID:   4609282
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0707
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- PhylomeDB:   A1K3B9
- ProtClustDB:   PRK00258
- BioCyc:   ASP62928:AZO0707-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28497; Mature: 28497

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNV
CCCEEEECCCCCCCCCCCEEEEEHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKLEAHALATRLTPRAAAAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCP
EEEEEECHHHHHHHCCCHHHHCCCHHHEECCCCCCCHHHCCCCCCCCCEEEEEEEECCCC
LHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKAVELAAGFAAGHPGVAIDGGG
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
FDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAG
CHHHCCCEEEEEEECHHHHHHHCCCCCCCCCEECCCEEEEEEECCCCCCEEEEECCCCCC
RLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRYAVVGNPIAHSKSPQIHAAFAHQTGEALGYEAILAPLDGFVDTVLAFRAVGGRGMNV
CCCEEEECCCCCCCCCCCEEEEEHHHCCCHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TVPFKLEAHALATRLTPRAAAAGAVNTLAFGGPETPDDILGDNTDGAGLVRDLTVNLGCP
EEEEEECHHHHHHHCCCHHHHCCCHHHEECCCCCCCHHHCCCCCCCCCEEEEEEEECCCC
LHGRRVLLLGAGGAARGALLPLLEQAPAALTIANRTAAKAVELAAGFAAGHPGVAIDGGG
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCC
FDALAGRRFDVVINATAASLADQAPPLPAGIYAEGALAYDMMYGRGDTPFLAAARADGAG
CHHHCCCEEEEEEECHHHHHHHCCCCCCCCCEECCCEEEEEEECCCCCCEEEEECCCCCC
RLADGLGMLVEQAAESFLLWRGVRPDTAPVLADLRARLAAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA