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The map label for this gene is cusR [H]

Identifier: 119776666

GI number: 119776666

Start: 4165671

End: 4166348

Strand: Direct

Name: cusR [H]

Synonym: Sama_3534

Alternate gene names: 119776666

Gene position: 4165671-4166348 (Clockwise)

Preceding gene: 119776665

Following gene: 119776667

Centisome position: 96.74

GC content: 55.6

Gene sequence:

>678_bases
GTGAAAATCCTTTTGGTTGAAGACGACAACACCACTTCAGAATACATAGTCAAAGGTTTTTCCGAACAGGGACACAATAT
TGAAGCGGCCGCCGATGGTCACCAGGGCCTGTTGCTGGCCACCAGCAACCAGTATGACCTGATTATTCTCGACCGCATGC
TACCCGGTCTCGATGGGCTGGCACTGCTGGCGGCGCTGCGTGCCAACGCCAATCAAACCCCGGTGCTTATCCTTTCAGCC
TTGTCCAACGTGGACGAGCGGGTAAAGGGCCTGCGCAGCGGCGGCGACGATTATATGACCAAGCCTTTCGCCTTCTCAGA
GCTTCTGGTGCGCGCCGAAATTCTGGTGTCCCGGGGGCAAACCGCGCCGGTGCAGACACACCTGCAAGCGGGCCCACTGG
AAATGGAGCTGCTCACCCGCAACGTGACTCTCGATGGCCACGAGCTGATGCTGCAACCCAAAGAGTTTCAACTGCTCAAG
TACCTGATGGAACACCCTAATCAGGTCATAAGCCGTACCCTGTTGTTCGAGGCTGTGTGGGATTATCACTTCGATCCGCG
CACCAATGTGATCGACGTACATATCGCCAAACTCAGACGCAAGTTTGAAGAGCTGGGCTACGGCGAGCTGATAGAAACAG
TCCGGGGAGCGGGTTATCGTCTTCGCCAAAGGCATTAA

Upstream 100 bases:

>100_bases
GTGGATGAAAACGGCAAGCGCAAACACGCCTTTGACATCCAAAAGCTTAAACCCTTGCCAATGCTGCAATGGGAACGCTG
AGCCACACTAAGGAGCAACA

Downstream 100 bases:

>100_bases
GCCTCACCAAAGCTCCATTTGGGGCATCACCCTGATATTTACCGCGCTGGTGACCCTGATCACCGGCGCTTTGCTGTTCA
CCCTGTACCGTCAGTTGGTC

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILLVEDDNTTSEYIVKGFSEQGHNIEAAADGHQGLLLATSNQYDLIILDRMLPGLDGLALLAALRANANQTPVLILSA
LSNVDERVKGLRSGGDDYMTKPFAFSELLVRAEILVSRGQTAPVQTHLQAGPLEMELLTRNVTLDGHELMLQPKEFQLLK
YLMEHPNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGYGELIETVRGAGYRLRQRH

Sequences:

>Translated_225_residues
MKILLVEDDNTTSEYIVKGFSEQGHNIEAAADGHQGLLLATSNQYDLIILDRMLPGLDGLALLAALRANANQTPVLILSA
LSNVDERVKGLRSGGDDYMTKPFAFSELLVRAEILVSRGQTAPVQTHLQAGPLEMELLTRNVTLDGHELMLQPKEFQLLK
YLMEHPNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGYGELIETVRGAGYRLRQRH
>Mature_225_residues
MKILLVEDDNTTSEYIVKGFSEQGHNIEAAADGHQGLLLATSNQYDLIILDRMLPGLDGLALLAALRANANQTPVLILSA
LSNVDERVKGLRSGGDDYMTKPFAFSELLVRAEILVSRGQTAPVQTHLQAGPLEMELLTRNVTLDGHELMLQPKEFQLLK
YLMEHPNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGYGELIETVRGAGYRLRQRH

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=43.4389140271493, Blast_Score=194, Evalue=3e-51,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=44.2922374429224, Blast_Score=185, Evalue=2e-48,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=38.8392857142857, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.841628959276, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.7777777777778, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=28.310502283105, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=32.1266968325792, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.0043668122271, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=35.8407079646018, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32.8888888888889, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786911, Length=204, Percent_Identity=29.9019607843137, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=31.5555555555556, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.9475982532751, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=38.6138613861386, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=145, Percent_Identity=28.9655172413793, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=28.8135593220339, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25359; Mature: 25359

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVEDDNTTSEYIVKGFSEQGHNIEAAADGHQGLLLATSNQYDLIILDRMLPGLDGL
CEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEHHHHCCCCCHH
ALLAALRANANQTPVLILSALSNVDERVKGLRSGGDDYMTKPFAFSELLVRAEILVSRGQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
TAPVQTHLQAGPLEMELLTRNVTLDGHELMLQPKEFQLLKYLMEHPNQVISRTLLFEAVW
CCCHHHHCCCCCEEEEEEEEECEECCHHEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGYGELIETVRGAGYRLRQRH
HCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MKILLVEDDNTTSEYIVKGFSEQGHNIEAAADGHQGLLLATSNQYDLIILDRMLPGLDGL
CEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEHHHHCCCCCHH
ALLAALRANANQTPVLILSALSNVDERVKGLRSGGDDYMTKPFAFSELLVRAEILVSRGQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
TAPVQTHLQAGPLEMELLTRNVTLDGHELMLQPKEFQLLKYLMEHPNQVISRTLLFEAVW
CCCHHHHCCCCCEEEEEEEEECEECCHHEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGYGELIETVRGAGYRLRQRH
HCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]