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The map label for this gene is cusS [H]

Identifier: 119776667

GI number: 119776667

Start: 4166398

End: 4167657

Strand: Direct

Name: cusS [H]

Synonym: Sama_3535

Alternate gene names: 119776667

Gene position: 4166398-4167657 (Clockwise)

Preceding gene: 119776666

Following gene: 119776668

Centisome position: 96.75

GC content: 57.06

Gene sequence:

>1260_bases
GTGACCCTGATCACCGGCGCTTTGCTGTTCACCCTGTACCGTCAGTTGGTCACAGAGCAGCAGTATCAGATAGAACAGCA
TCTGGAAACTGAAAAGCAGCGCTATATTCAACTGGCCCAAACCGTTGACCGGCGAAGCTTTGCCGCCCAAATACGGGCAG
CCGATCCCAAATCCGTATTGGTGGCCTGGCGCAACAGCTTCGACATAGTCGGTTCCCTGAGTCTGATGCCGGAAGATATT
CCCCTGCTGCCGGAAACGGTGGAGTTTCCCATTCTGACCGGCGGCCCGGACAAGCTGCACATACTCACAGGTGGCCTCGT
TATCACCCGCTACGGGCCTGTGCTTATCGCCACCCGTACCGACCAACTGGCGACCCTGATTAAGAAATTTCTGCGGGCTG
CCGTGACCACCATGACCCTGACCATAGTGCTGACCATGGCCCTGGGATATCTGTTTTCCAAAGCCATTCTGCGCCGCTTG
GTGCAATACAACCGGCTGGCACAGCGCATCGAGCGCGGCCACTACGATACCCGACTGCCGGTGAGTTGGCGTCAGGATGA
ATTCGATATGCTGGCGCGCCAGTTTAACCGGGTACTGGACACCCTCGAAGCCAACCTCCAGGCAGTGCGCGGGGTAACCG
ACAATATCGCCCACGACCTGCGCACCCCGCTGTCTCACCTTCGCATCGGGCTGGAACAACTGAGAGATAAGCCCCAGGAA
GAACGCGCAGATAAAGCCGAGCAGTTGATCGAAGAGCTGGACTTTTGTCTCGCCACCTTCGATGCCATGTTGTCTTTGAC
CCGTATCGAAGAAGGGCAGCAACAGCTGGATTTGCAACAGTTAAGTCTGTCGCAGTTGTGTGCCGATTTGGTGGAAATGG
CCGAATTGCTGGCCGAAGAGCGCGGTCAAACCCTCAGTCTGGAACTCGGCCGTGAATGCACGCTGCAGGGCGATAAGCAT
TTGTTGTTTCAAGCGCTGTTTAATCTGGTGGACAACGCCATCAAGTACGCAGGTGACGGCGCGGCAATCAGCATCAGCCA
GAATGGCCGAGAAGTGGTGATTGCCGACAATGGTCCCGGGATCCCGCCGGAAAGCCGTGAGCGGGTGTTCGAGCGCCTGG
TGCGACTCGACCCCAGCCGTCATCATCAGGGCACGGGGCTTGGCCTGTCTATGGTGAAGGCGATATTATCGCGCCATCAG
GCCCATATACGCCTCGAAGACAACCAACCGGGTCTGAGAGCCGTCATCGAGTTTCAATAA

Upstream 100 bases:

>100_bases
CTGATAGAAACAGTCCGGGGAGCGGGTTATCGTCTTCGCCAAAGGCATTAAGCCTCACCAAAGCTCCATTTGGGGCATCA
CCCTGATATTTACCGCGCTG

Downstream 100 bases:

>100_bases
GTTATGTATCGCATCATCGCCGACGAGACGGACTTTCTCGTTATCGACAAGGCACCGGGCGTGCACTTTCACAGCCAGGA
TGGCAGCGCCGGTGTAGTGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTLITGALLFTLYRQLVTEQQYQIEQHLETEKQRYIQLAQTVDRRSFAAQIRAADPKSVLVAWRNSFDIVGSLSLMPEDI
PLLPETVEFPILTGGPDKLHILTGGLVITRYGPVLIATRTDQLATLIKKFLRAAVTTMTLTIVLTMALGYLFSKAILRRL
VQYNRLAQRIERGHYDTRLPVSWRQDEFDMLARQFNRVLDTLEANLQAVRGVTDNIAHDLRTPLSHLRIGLEQLRDKPQE
ERADKAEQLIEELDFCLATFDAMLSLTRIEEGQQQLDLQQLSLSQLCADLVEMAELLAEERGQTLSLELGRECTLQGDKH
LLFQALFNLVDNAIKYAGDGAAISISQNGREVVIADNGPGIPPESRERVFERLVRLDPSRHHQGTGLGLSMVKAILSRHQ
AHIRLEDNQPGLRAVIEFQ

Sequences:

>Translated_419_residues
MTLITGALLFTLYRQLVTEQQYQIEQHLETEKQRYIQLAQTVDRRSFAAQIRAADPKSVLVAWRNSFDIVGSLSLMPEDI
PLLPETVEFPILTGGPDKLHILTGGLVITRYGPVLIATRTDQLATLIKKFLRAAVTTMTLTIVLTMALGYLFSKAILRRL
VQYNRLAQRIERGHYDTRLPVSWRQDEFDMLARQFNRVLDTLEANLQAVRGVTDNIAHDLRTPLSHLRIGLEQLRDKPQE
ERADKAEQLIEELDFCLATFDAMLSLTRIEEGQQQLDLQQLSLSQLCADLVEMAELLAEERGQTLSLELGRECTLQGDKH
LLFQALFNLVDNAIKYAGDGAAISISQNGREVVIADNGPGIPPESRERVFERLVRLDPSRHHQGTGLGLSMVKAILSRHQ
AHIRLEDNQPGLRAVIEFQ
>Mature_418_residues
TLITGALLFTLYRQLVTEQQYQIEQHLETEKQRYIQLAQTVDRRSFAAQIRAADPKSVLVAWRNSFDIVGSLSLMPEDIP
LLPETVEFPILTGGPDKLHILTGGLVITRYGPVLIATRTDQLATLIKKFLRAAVTTMTLTIVLTMALGYLFSKAILRRLV
QYNRLAQRIERGHYDTRLPVSWRQDEFDMLARQFNRVLDTLEANLQAVRGVTDNIAHDLRTPLSHLRIGLEQLRDKPQEE
RADKAEQLIEELDFCLATFDAMLSLTRIEEGQQQLDLQQLSLSQLCADLVEMAELLAEERGQTLSLELGRECTLQGDKHL
LFQALFNLVDNAIKYAGDGAAISISQNGREVVIADNGPGIPPESRERVFERLVRLDPSRHHQGTGLGLSMVKAILSRHQA
HIRLEDNQPGLRAVIEFQ

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=326, Percent_Identity=28.2208588957055, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787894, Length=260, Percent_Identity=30, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=29.1139240506329, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=359, Percent_Identity=27.5766016713092, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=208, Percent_Identity=29.8076923076923, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788279, Length=295, Percent_Identity=27.1186440677966, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=28.2894736842105, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1789403, Length=296, Percent_Identity=27.027027027027, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=26.4285714285714, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=196, Percent_Identity=31.1224489795918, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787374, Length=271, Percent_Identity=23.6162361623616, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=201, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=214, Percent_Identity=25.7009345794392, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=27.8538812785388, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=207, Percent_Identity=25.1207729468599, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=206, Percent_Identity=26.2135922330097, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47358; Mature: 47227

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLITGALLFTLYRQLVTEQQYQIEQHLETEKQRYIQLAQTVDRRSFAAQIRAADPKSVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VAWRNSFDIVGSLSLMPEDIPLLPETVEFPILTGGPDKLHILTGGLVITRYGPVLIATRT
HHCCCCCCHHEECCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEEECCCEEEEECC
DQLATLIKKFLRAAVTTMTLTIVLTMALGYLFSKAILRRLVQYNRLAQRIERGHYDTRLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VSWRQDEFDMLARQFNRVLDTLEANLQAVRGVTDNIAHDLRTPLSHLRIGLEQLRDKPQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHCCCHH
ERADKAEQLIEELDFCLATFDAMLSLTRIEEGQQQLDLQQLSLSQLCADLVEMAELLAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGQTLSLELGRECTLQGDKHLLFQALFNLVDNAIKYAGDGAAISISQNGREVVIADNGPG
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCC
IPPESRERVFERLVRLDPSRHHQGTGLGLSMVKAILSRHQAHIRLEDNQPGLRAVIEFQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECC
>Mature Secondary Structure 
TLITGALLFTLYRQLVTEQQYQIEQHLETEKQRYIQLAQTVDRRSFAAQIRAADPKSVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VAWRNSFDIVGSLSLMPEDIPLLPETVEFPILTGGPDKLHILTGGLVITRYGPVLIATRT
HHCCCCCCHHEECCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCEEEEECCCEEEEECC
DQLATLIKKFLRAAVTTMTLTIVLTMALGYLFSKAILRRLVQYNRLAQRIERGHYDTRLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VSWRQDEFDMLARQFNRVLDTLEANLQAVRGVTDNIAHDLRTPLSHLRIGLEQLRDKPQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHCCCHH
ERADKAEQLIEELDFCLATFDAMLSLTRIEEGQQQLDLQQLSLSQLCADLVEMAELLAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGQTLSLELGRECTLQGDKHLLFQALFNLVDNAIKYAGDGAAISISQNGREVVIADNGPG
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCC
IPPESRERVFERLVRLDPSRHHQGTGLGLSMVKAILSRHQAHIRLEDNQPGLRAVIEFQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]