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The map label for this gene is envZ [H]

Identifier: 119776643

GI number: 119776643

Start: 4145737

End: 4147053

Strand: Direct

Name: envZ [H]

Synonym: Sama_3511

Alternate gene names: 119776643

Gene position: 4145737-4147053 (Clockwise)

Preceding gene: 119776642

Following gene: 119776644

Centisome position: 96.27

GC content: 55.28

Gene sequence:

>1317_bases
ATGAAACTTCGCTGGTGGCAGCGCTTGCTGCCCCGCAGCGCCTTCAGTCAAACCGTGATGCTGATAGGCTGTTTGCTGTT
GATTAATCAGCTGTTTTCCTATGTGTCTGTGGCGCTTTACGTCATCAAACCCAGCTATCAGCAAATCAACCAGCTCATTG
CCCGGCAAATCAATTTTTTGTTTACCGAAGAGGCGGTCATTGGCCGCGAATATCTGAGTTTGGTGGATGCCCTCAATGCC
AAGGTCGGCGATGGCAGCATGCACGTTTTCAACCAAAAGCAGGCCAGGGAAGCCGGCATAGACAGCGCCACCTATTACGG
TTTGCTGTCGAATCAGATGTCAGAATACCTCGGCGGCAGCGCCGAAGTACGCATCACCCAGGGCGAAACAGTGCAGATTT
GGATCCGCCCGCCACAGGCGCCCAGTGTTTGGATACGGGTACCTCTGTCGAGTTTCAACGAACTGGAAATGTCGCTGCTG
ACCCTGTATCTGATGGTGATTGGTGCGCTCAGTGTCGCCGGCGGCTGGCTGTTTGCCCGCCGCCAGAGCAAACCCCTTAA
GGCGCTGCAGAAGGCCGCCATCAATGTATCGCGGGGGGAATACCCCGAAGCCATTCCCCCTGCCGGCTCCAGTGAAATAG
TGGAAGTGACCCACGCCTTTAACCAGATGGCCCACAGCATGCGAATGTTGGAACAGGACCGGGCGTTGATGATGGCGGGG
ATCTCCCACGATCTGCGCACACCCCTTACCCGAATTCGTCTGGCCTCTGAAATGATGGTGGATGAGGATGCCTACCTCAG
AGACGGCATCATCGCCGACATCGATGACATGAACGCCATCATCAATCAGTTCATCGCCTACATACGCCAGGATCAGGAAG
CTGTTTGGGAGAAGGCCGACATCAATCAGCTGGTGAGCGAATATGCCCAGGCCGAGTCCAAACGTGATGGGGTAATTGAA
CTGGCACTCGGCCCCTGTATAGGGATCCCGGTGCAGGTTATCGCCATCAAACGGGTGCTGGGTAATCTGGTAGAAAACGC
CTTTCGCTATGGTCGGGGCTGGATACGCATTTCAACCCGGATGGAGAAGTCCTCTTTGGTGCTAACCGTGGAAGATAACG
GCCCCGGCATTCCGGTTGATCAAATCCCCAAACTCTTTCAACCCTTTACCCAGGGCGACATGGCGCGGGGCAGCCTTGGC
TCCGGTCTGGGGCTGGCCATTATCAAGCGCATTGTCGACCGCCATCAGGGCAAGGTGAAACTCAGTAACCGGGTTGAAGG
TGGTCTGAAAGCCGAGGTATTTTTACCGCTGGAATAA

Upstream 100 bases:

>100_bases
AAAAGATCCCGCCAATCCAAGGTATATCCAAACCGTGTGGGGCCTGGGCTATGTGTTTGTACCCGACGGCAGCGCCCGTC
GTTAAGCCCGGAGCAAAATC

Downstream 100 bases:

>100_bases
GTCAGCTTCATAAAATTGTCATCCTATCGTCATAAGCTGATGAAAATCGGCCTTAAACGTGAATCCGGATGAAAATTTCG
ACCCTGTCTCTGGGCGCATC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKLRWWQRLLPRSAFSQTVMLIGCLLLINQLFSYVSVALYVIKPSYQQINQLIARQINFLFTEEAVIGREYLSLVDALNA
KVGDGSMHVFNQKQAREAGIDSATYYGLLSNQMSEYLGGSAEVRITQGETVQIWIRPPQAPSVWIRVPLSSFNELEMSLL
TLYLMVIGALSVAGGWLFARRQSKPLKALQKAAINVSRGEYPEAIPPAGSSEIVEVTHAFNQMAHSMRMLEQDRALMMAG
ISHDLRTPLTRIRLASEMMVDEDAYLRDGIIADIDDMNAIINQFIAYIRQDQEAVWEKADINQLVSEYAQAESKRDGVIE
LALGPCIGIPVQVIAIKRVLGNLVENAFRYGRGWIRISTRMEKSSLVLTVEDNGPGIPVDQIPKLFQPFTQGDMARGSLG
SGLGLAIIKRIVDRHQGKVKLSNRVEGGLKAEVFLPLE

Sequences:

>Translated_438_residues
MKLRWWQRLLPRSAFSQTVMLIGCLLLINQLFSYVSVALYVIKPSYQQINQLIARQINFLFTEEAVIGREYLSLVDALNA
KVGDGSMHVFNQKQAREAGIDSATYYGLLSNQMSEYLGGSAEVRITQGETVQIWIRPPQAPSVWIRVPLSSFNELEMSLL
TLYLMVIGALSVAGGWLFARRQSKPLKALQKAAINVSRGEYPEAIPPAGSSEIVEVTHAFNQMAHSMRMLEQDRALMMAG
ISHDLRTPLTRIRLASEMMVDEDAYLRDGIIADIDDMNAIINQFIAYIRQDQEAVWEKADINQLVSEYAQAESKRDGVIE
LALGPCIGIPVQVIAIKRVLGNLVENAFRYGRGWIRISTRMEKSSLVLTVEDNGPGIPVDQIPKLFQPFTQGDMARGSLG
SGLGLAIIKRIVDRHQGKVKLSNRVEGGLKAEVFLPLE
>Mature_438_residues
MKLRWWQRLLPRSAFSQTVMLIGCLLLINQLFSYVSVALYVIKPSYQQINQLIARQINFLFTEEAVIGREYLSLVDALNA
KVGDGSMHVFNQKQAREAGIDSATYYGLLSNQMSEYLGGSAEVRITQGETVQIWIRPPQAPSVWIRVPLSSFNELEMSLL
TLYLMVIGALSVAGGWLFARRQSKPLKALQKAAINVSRGEYPEAIPPAGSSEIVEVTHAFNQMAHSMRMLEQDRALMMAG
ISHDLRTPLTRIRLASEMMVDEDAYLRDGIIADIDDMNAIINQFIAYIRQDQEAVWEKADINQLVSEYAQAESKRDGVIE
LALGPCIGIPVQVIAIKRVLGNLVENAFRYGRGWIRISTRMEKSSLVLTVEDNGPGIPVDQIPKLFQPFTQGDMARGSLG
SGLGLAIIKRIVDRHQGKVKLSNRVEGGLKAEVFLPLE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=441, Percent_Identity=41.4965986394558, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=31.7343173431734, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=28.6245353159851, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=29.3515358361775, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=30.7339449541284, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=33.1818181818182, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=272, Percent_Identity=30.5147058823529, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=249, Percent_Identity=27.710843373494, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=25.9786476868327, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994928, Length=216, Percent_Identity=27.3148148148148, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=278, Percent_Identity=25.1798561151079, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=24, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=24.7011952191235, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=241, Percent_Identity=26.5560165975104, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=26.1194029850746, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=23.3644859813084, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48862; Mature: 48862

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRWWQRLLPRSAFSQTVMLIGCLLLINQLFSYVSVALYVIKPSYQQINQLIARQINFL
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FTEEAVIGREYLSLVDALNAKVGDGSMHVFNQKQAREAGIDSATYYGLLSNQMSEYLGGS
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
AEVRITQGETVQIWIRPPQAPSVWIRVPLSSFNELEMSLLTLYLMVIGALSVAGGWLFAR
CEEEEECCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHEEC
RQSKPLKALQKAAINVSRGEYPEAIPPAGSSEIVEVTHAFNQMAHSMRMLEQDRALMMAG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISHDLRTPLTRIRLASEMMVDEDAYLRDGIIADIDDMNAIINQFIAYIRQDQEAVWEKAD
CCHHHHHHHHHHHHHHHHHHCCCHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
INQLVSEYAQAESKRDGVIELALGPCIGIPVQVIAIKRVLGNLVENAFRYGRGWIRISTR
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
MEKSSLVLTVEDNGPGIPVDQIPKLFQPFTQGDMARGSLGSGLGLAIIKRIVDRHQGKVK
ECCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
LSNRVEGGLKAEVFLPLE
ECCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKLRWWQRLLPRSAFSQTVMLIGCLLLINQLFSYVSVALYVIKPSYQQINQLIARQINFL
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FTEEAVIGREYLSLVDALNAKVGDGSMHVFNQKQAREAGIDSATYYGLLSNQMSEYLGGS
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
AEVRITQGETVQIWIRPPQAPSVWIRVPLSSFNELEMSLLTLYLMVIGALSVAGGWLFAR
CEEEEECCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHEEC
RQSKPLKALQKAAINVSRGEYPEAIPPAGSSEIVEVTHAFNQMAHSMRMLEQDRALMMAG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ISHDLRTPLTRIRLASEMMVDEDAYLRDGIIADIDDMNAIINQFIAYIRQDQEAVWEKAD
CCHHHHHHHHHHHHHHHHHHCCCHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
INQLVSEYAQAESKRDGVIELALGPCIGIPVQVIAIKRVLGNLVENAFRYGRGWIRISTR
HHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
MEKSSLVLTVEDNGPGIPVDQIPKLFQPFTQGDMARGSLGSGLGLAIIKRIVDRHQGKVK
ECCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
LSNRVEGGLKAEVFLPLE
ECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]