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The map label for this gene is tlpA [H]

Identifier: 119776644

GI number: 119776644

Start: 4147122

End: 4149065

Strand: Direct

Name: tlpA [H]

Synonym: Sama_3512

Alternate gene names: 119776644

Gene position: 4147122-4149065 (Clockwise)

Preceding gene: 119776643

Following gene: 119776647

Centisome position: 96.31

GC content: 56.89

Gene sequence:

>1944_bases
ATGAAAATTTCGACCCTGTCTCTGGGCGCATCTGCCTTGCTGTTGGTACTGGCAAGCCTGATGGCCGCCACCCTGTTGTG
GACCAGCAATCAGCGGCAGCAACTGGAATTCCAAACCAGCGAGCTCAATCGACTGCAGCAACACTTTGTCATTGATGTCA
GGCGTTTACTCGAGTCATACCTCACCAGTGGCGATGCCAGCCGCTTGGAGGACGCACGCAATCAATTAGCCGAAATGAGC
ACATCGCTGGCAGTATTGGAGCCCTCCCAGGCCAGGTTACTGGCAAGCAGGCTCGACATCTTTGGCACCGAACTCGATGG
CAAATACCGCGCAGCCGGCAAGCTGGCCGGTAACCCACGCCAATTGTTATCCCACGCTGAGACTGAGCTGCTCGACTTTA
ACCGCCTGTTGGCCGCCTATGCCCGTGAAGGACTGGAAACCTCGCCCGACAAGGCAAACCAACTTCTTGACCTGACTGCC
GAACTCCCTCCCCTTGTTTACGCCTTGTCCCAGCAAACCCACGGCTATCTTATTGACAAAGATACTCGTCTTAAGGGCAT
TCTGGATTCGAGTCTGGACAGCCTCGAGCAATGGCGCGCTGCGCTCACCAAGGCGCCTTTACTTGGGCTACTGGAAACCC
TGGATGAAGATTCTCTGATGCCCGGCGAAGCCCCCCCACCGGCACAGGACAGGGCCGAAGGCCTGATAGCCGAACTCGAC
AGTCTCAGCGGACGCTATCGCCGTGAAATCGACAATACCCACAAGCTGCTGACCGACAACCAACAAACCCAGGCCGCGCT
GCGCACAGCCATTGCCGATACCGAAAGTCTGCTACTCGCCATGGTTGACGAGCAGGATCAGCGCAGCCAACGCCTCAAGC
AGCAAATGCAGCTTATTCTCTATGCCATGGCAGCTGCACTGGCTATCTATGCCTTCTTCTATCTGGTGATACAGCAAAAA
AGGGTGGTGAAGCCACTCAAACGACTCAATCAGGCGTTTATGCAGCTCACAGAAACCGGGCAGCGGCAGCAATTGGATGT
CCGCAGTCGTTGCGAAACCGGTCAGATAGCCGGCCACTTTAACCGTCTGCTGCACCGCTTTGAAGAAGAAGACGAAGCGC
AGCGGCACAGGATCAGCGGCATTTCAGCCACCCTCGACCAACTCAGACGCCAAATCGCCGACATGGCCAACAGTGCCGAG
GCCACAGGTGAGATTGTCACCCAGGCGCAGGAACGCACCGACGAGTTAAAAATGCTGGCCAGCGAGGTCAGCGACAACTC
CACCCAGGTGGCCAGCGACGCCAACATCACGGTGGAGCGTATGACTCAAAGTCAGGCGGGTGCAGAAGAAATGCTGAGCG
CAATCAAGGAAACCCGCGGTGCCGTTGAAGATTGCAATAGCTCACTGCTGAGCCTGAACGGTTCCGTCAGTAAGGTCGCC
GGCATCATAGACGTGATTGGAAATATCGCCGAACAAACCAACCTGCTGGCCCTCAACGCCGCTATCGAAGCTGCCAGAGC
CGGAGAACAGGGGCGCGGCTTTGCTGTGGTGGCCGATGAGGTACGCAGCCTGTCTCAGCGCACCCAGGTTTCGCTCAAGG
AAATCCAGAATATTCTGGGTGAACTCAAAGGCGCCAGCGATCAATTGGCACTGAGAGTGAATGGCATAGATTCAGCCACG
GGAACACAGCAACAAAAGGCCAGCCAGCTGTGGGAAGCGGCCGAGGCTGTCCGGGAACATGCTGGAGTGATGGCGGGCAC
CGCCGAAGAGGGGCTAAACAATGCCAGAACCCAAATGCTCTGCCTTGAAGCTTTTAACGACGCCATGACCGCCCTGTTGG
CCCAATCAGGTCAGGCAGTCAAGGATAGCCAGGCCATTGCCGCCGAAGTTGCCACCCAGGTTGCCGCCATCGAACACGCC
CTGAGTGGCAAGGTACAGACCTAA

Upstream 100 bases:

>100_bases
TGAAAGCCGAGGTATTTTTACCGCTGGAATAAGTCAGCTTCATAAAATTGTCATCCTATCGTCATAAGCTGATGAAAATC
GGCCTTAAACGTGAATCCGG

Downstream 100 bases:

>100_bases
TCCAGACCCGGCTTACAGAGCGGCCAACACCACTTCGGCTTTGCTGACTTCGAAGGCTTTTGGCGCTTCAACATTCAGTA
AGGTGACCACGCCATTGTCT

Product: putative methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MKISTLSLGASALLLVLASLMAATLLWTSNQRQQLEFQTSELNRLQQHFVIDVRRLLESYLTSGDASRLEDARNQLAEMS
TSLAVLEPSQARLLASRLDIFGTELDGKYRAAGKLAGNPRQLLSHAETELLDFNRLLAAYAREGLETSPDKANQLLDLTA
ELPPLVYALSQQTHGYLIDKDTRLKGILDSSLDSLEQWRAALTKAPLLGLLETLDEDSLMPGEAPPPAQDRAEGLIAELD
SLSGRYRREIDNTHKLLTDNQQTQAALRTAIADTESLLLAMVDEQDQRSQRLKQQMQLILYAMAAALAIYAFFYLVIQQK
RVVKPLKRLNQAFMQLTETGQRQQLDVRSRCETGQIAGHFNRLLHRFEEEDEAQRHRISGISATLDQLRRQIADMANSAE
ATGEIVTQAQERTDELKMLASEVSDNSTQVASDANITVERMTQSQAGAEEMLSAIKETRGAVEDCNSSLLSLNGSVSKVA
GIIDVIGNIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQVSLKEIQNILGELKGASDQLALRVNGIDSAT
GTQQQKASQLWEAAEAVREHAGVMAGTAEEGLNNARTQMLCLEAFNDAMTALLAQSGQAVKDSQAIAAEVATQVAAIEHA
LSGKVQT

Sequences:

>Translated_647_residues
MKISTLSLGASALLLVLASLMAATLLWTSNQRQQLEFQTSELNRLQQHFVIDVRRLLESYLTSGDASRLEDARNQLAEMS
TSLAVLEPSQARLLASRLDIFGTELDGKYRAAGKLAGNPRQLLSHAETELLDFNRLLAAYAREGLETSPDKANQLLDLTA
ELPPLVYALSQQTHGYLIDKDTRLKGILDSSLDSLEQWRAALTKAPLLGLLETLDEDSLMPGEAPPPAQDRAEGLIAELD
SLSGRYRREIDNTHKLLTDNQQTQAALRTAIADTESLLLAMVDEQDQRSQRLKQQMQLILYAMAAALAIYAFFYLVIQQK
RVVKPLKRLNQAFMQLTETGQRQQLDVRSRCETGQIAGHFNRLLHRFEEEDEAQRHRISGISATLDQLRRQIADMANSAE
ATGEIVTQAQERTDELKMLASEVSDNSTQVASDANITVERMTQSQAGAEEMLSAIKETRGAVEDCNSSLLSLNGSVSKVA
GIIDVIGNIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQVSLKEIQNILGELKGASDQLALRVNGIDSAT
GTQQQKASQLWEAAEAVREHAGVMAGTAEEGLNNARTQMLCLEAFNDAMTALLAQSGQAVKDSQAIAAEVATQVAAIEHA
LSGKVQT
>Mature_647_residues
MKISTLSLGASALLLVLASLMAATLLWTSNQRQQLEFQTSELNRLQQHFVIDVRRLLESYLTSGDASRLEDARNQLAEMS
TSLAVLEPSQARLLASRLDIFGTELDGKYRAAGKLAGNPRQLLSHAETELLDFNRLLAAYAREGLETSPDKANQLLDLTA
ELPPLVYALSQQTHGYLIDKDTRLKGILDSSLDSLEQWRAALTKAPLLGLLETLDEDSLMPGEAPPPAQDRAEGLIAELD
SLSGRYRREIDNTHKLLTDNQQTQAALRTAIADTESLLLAMVDEQDQRSQRLKQQMQLILYAMAAALAIYAFFYLVIQQK
RVVKPLKRLNQAFMQLTETGQRQQLDVRSRCETGQIAGHFNRLLHRFEEEDEAQRHRISGISATLDQLRRQIADMANSAE
ATGEIVTQAQERTDELKMLASEVSDNSTQVASDANITVERMTQSQAGAEEMLSAIKETRGAVEDCNSSLLSLNGSVSKVA
GIIDVIGNIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQVSLKEIQNILGELKGASDQLALRVNGIDSAT
GTQQQKASQLWEAAEAVREHAGVMAGTAEEGLNNARTQMLCLEAFNDAMTALLAQSGQAVKDSQAIAAEVATQVAAIEHA
LSGKVQT

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=266, Percent_Identity=31.9548872180451, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787690, Length=255, Percent_Identity=29.0196078431373, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788194, Length=261, Percent_Identity=30.2681992337165, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789453, Length=255, Percent_Identity=25.8823529411765, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788195, Length=78, Percent_Identity=55.1282051282051, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 70595; Mature: 70595

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISTLSLGASALLLVLASLMAATLLWTSNQRQQLEFQTSELNRLQQHFVIDVRRLLESY
CCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTSGDASRLEDARNQLAEMSTSLAVLEPSQARLLASRLDIFGTELDGKYRAAGKLAGNPR
HCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHH
QLLSHAETELLDFNRLLAAYAREGLETSPDKANQLLDLTAELPPLVYALSQQTHGYLIDK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEECC
DTRLKGILDSSLDSLEQWRAALTKAPLLGLLETLDEDSLMPGEAPPPAQDRAEGLIAELD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
SLSGRYRREIDNTHKLLTDNQQTQAALRTAIADTESLLLAMVDEQDQRSQRLKQQMQLIL
HHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YAMAAALAIYAFFYLVIQQKRVVKPLKRLNQAFMQLTETGQRQQLDVRSRCETGQIAGHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCCHHHHHH
NRLLHRFEEEDEAQRHRISGISATLDQLRRQIADMANSAEATGEIVTQAQERTDELKMLA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SEVSDNSTQVASDANITVERMTQSQAGAEEMLSAIKETRGAVEDCNSSLLSLNGSVSKVA
HHHCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCHHHHHCCCCHHHHH
GIIDVIGNIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQVSLKEIQNILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
ELKGASDQLALRVNGIDSATGTQQQKASQLWEAAEAVREHAGVMAGTAEEGLNNARTQML
HHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
CLEAFNDAMTALLAQSGQAVKDSQAIAAEVATQVAAIEHALSGKVQT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKISTLSLGASALLLVLASLMAATLLWTSNQRQQLEFQTSELNRLQQHFVIDVRRLLESY
CCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTSGDASRLEDARNQLAEMSTSLAVLEPSQARLLASRLDIFGTELDGKYRAAGKLAGNPR
HCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHH
QLLSHAETELLDFNRLLAAYAREGLETSPDKANQLLDLTAELPPLVYALSQQTHGYLIDK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEECC
DTRLKGILDSSLDSLEQWRAALTKAPLLGLLETLDEDSLMPGEAPPPAQDRAEGLIAELD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
SLSGRYRREIDNTHKLLTDNQQTQAALRTAIADTESLLLAMVDEQDQRSQRLKQQMQLIL
HHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YAMAAALAIYAFFYLVIQQKRVVKPLKRLNQAFMQLTETGQRQQLDVRSRCETGQIAGHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCCHHHHHH
NRLLHRFEEEDEAQRHRISGISATLDQLRRQIADMANSAEATGEIVTQAQERTDELKMLA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SEVSDNSTQVASDANITVERMTQSQAGAEEMLSAIKETRGAVEDCNSSLLSLNGSVSKVA
HHHCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCHHHHHCCCCHHHHH
GIIDVIGNIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLSQRTQVSLKEIQNILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
ELKGASDQLALRVNGIDSATGTQQQKASQLWEAAEAVREHAGVMAGTAEEGLNNARTQML
HHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
CLEAFNDAMTALLAQSGQAVKDSQAIAAEVATQVAAIEHALSGKVQT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]