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The map label for this gene is degS [H]

Identifier: 119776206

GI number: 119776206

Start: 3652836

End: 3653906

Strand: Direct

Name: degS [H]

Synonym: Sama_3074

Alternate gene names: 119776206

Gene position: 3652836-3653906 (Clockwise)

Preceding gene: 119776205

Following gene: 119776214

Centisome position: 84.83

GC content: 55.56

Gene sequence:

>1071_bases
ATGAAAAGCGCTTTACTCTATTTAGGCAAAGCCGTGCTCTTTGGCTTAGTGATGGCCGCCGTGTTTCTTCTCGCGCAAAA
CTACCTGGGTAACGACCATGGCAACCTGTTCCGGGATCGTGGCAATGGTGGCAGCGAACTTTCTTTTGCCAAGGCGGTCA
GACGTGCCGCACCCGCGGTCGCCAACATATACAACATCAGCATAGATCAGCGCCAACCGCTCAACAGTGGCGCACTCCAG
GGGCTTGGCTCGGGGGTGATCATCAGCAAGGAAGGCTACATACTCACCAACTACCACGTTATCAAGAAGGCAGATGAAAT
TGTCATCGCCCTGCAGGATGGCCGGCGTTTCAGCGCCGAAGTGGTTGGCTCGGATCCGGAAACAGACCTGAGCGTACTCA
AAATTGAAGGGGATAAGCTGCCTGTGGTGCCACTTAACCTCACCACCCCGCCCCAGGTAGGTGACGTGGTGCTGGCCATC
GGCAATCCCTATAACCTGGGTCAAACCATTACCCAGGGCATTATCAGTGCCACAGGTCGTAACGGTTTGAGCTCCGGTTA
TCAGGACTTCCTGCAGACCGATGCGGCCATTAACGCGGGCAACTCGGGTGGTGCCCTGATAGATACCAATGGCGATGTGA
TAGGCATCAACACCGCCGCCTACCAGATAGGTGATGAAGGCGGTGGACACGGCATCAGCTTTGCGATTCCCATCCGCCTC
GCCTACTCCATCATGGGTAAACTCATCGAACACGGCCGGGTGATCCGCGGTGCCCTTGGGATTTCCGGCGAGGCGCTGAC
ACCCTTTATGGCGCAGGTGCTAAAAATGCAGGAAGTTCGCGGCGTACTGGTGACAGGCGTGGATCGCAACGGACCGGCAG
CCGATGCCCAGATGCAACCCAGGGATGTGATTATTGAATATGGCGGTGAAAGTGTGGTCAGTGCTGAAATGCTGATGGAC
CGCATTGCAGAAACCAAACCCGGTACCGAAGTGCAGATGACCATCATTCGCCAGGGCAAGGCTTACACCTTACCCGTGAT
TATCGGCGAGAAGGCAACCGAGTATAACTAA

Upstream 100 bases:

>100_bases
GATAAGCTGCTACCCCGGTCATAAGCCCAGCCTCCCGCTGGGCTTATTGTTTTGAAACGTGATAATCTAGTTCAACTTTT
TTACAATTCGAATCACCCCA

Downstream 100 bases:

>100_bases
CCGCAGAATACTTGACCTCAGGCAAAAATCCCGGCCACTGGCCGGGATTTTTATTTAATCAATACATGGACATTCACACT
CAGACTTGGAGGCATTGCCT

Product: protease DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKSALLYLGKAVLFGLVMAAVFLLAQNYLGNDHGNLFRDRGNGGSELSFAKAVRRAAPAVANIYNISIDQRQPLNSGALQ
GLGSGVIISKEGYILTNYHVIKKADEIVIALQDGRRFSAEVVGSDPETDLSVLKIEGDKLPVVPLNLTTPPQVGDVVLAI
GNPYNLGQTITQGIISATGRNGLSSGYQDFLQTDAAINAGNSGGALIDTNGDVIGINTAAYQIGDEGGGHGISFAIPIRL
AYSIMGKLIEHGRVIRGALGISGEALTPFMAQVLKMQEVRGVLVTGVDRNGPAADAQMQPRDVIIEYGGESVVSAEMLMD
RIAETKPGTEVQMTIIRQGKAYTLPVIIGEKATEYN

Sequences:

>Translated_356_residues
MKSALLYLGKAVLFGLVMAAVFLLAQNYLGNDHGNLFRDRGNGGSELSFAKAVRRAAPAVANIYNISIDQRQPLNSGALQ
GLGSGVIISKEGYILTNYHVIKKADEIVIALQDGRRFSAEVVGSDPETDLSVLKIEGDKLPVVPLNLTTPPQVGDVVLAI
GNPYNLGQTITQGIISATGRNGLSSGYQDFLQTDAAINAGNSGGALIDTNGDVIGINTAAYQIGDEGGGHGISFAIPIRL
AYSIMGKLIEHGRVIRGALGISGEALTPFMAQVLKMQEVRGVLVTGVDRNGPAADAQMQPRDVIIEYGGESVVSAEMLMD
RIAETKPGTEVQMTIIRQGKAYTLPVIIGEKATEYN
>Mature_356_residues
MKSALLYLGKAVLFGLVMAAVFLLAQNYLGNDHGNLFRDRGNGGSELSFAKAVRRAAPAVANIYNISIDQRQPLNSGALQ
GLGSGVIISKEGYILTNYHVIKKADEIVIALQDGRRFSAEVVGSDPETDLSVLKIEGDKLPVVPLNLTTPPQVGDVVLAI
GNPYNLGQTITQGIISATGRNGLSSGYQDFLQTDAAINAGNSGGALIDTNGDVIGINTAAYQIGDEGGGHGISFAIPIRL
AYSIMGKLIEHGRVIRGALGISGEALTPFMAQVLKMQEVRGVLVTGVDRNGPAADAQMQPRDVIIEYGGESVVSAEMLMD
RIAETKPGTEVQMTIIRQGKAYTLPVIIGEKATEYN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=345, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=35.4838709677419, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI22129776, Length=300, Percent_Identity=33, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI7019477, Length=329, Percent_Identity=32.5227963525836, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1789630, Length=351, Percent_Identity=48.1481481481481, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1789629, Length=273, Percent_Identity=43.5897435897436, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786356, Length=262, Percent_Identity=42.3664122137405, Blast_Score=201, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 37580; Mature: 37580

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSALLYLGKAVLFGLVMAAVFLLAQNYLGNDHGNLFRDRGNGGSELSFAKAVRRAAPAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCH
ANIYNISIDQRQPLNSGALQGLGSGVIISKEGYILTNYHVIKKADEIVIALQDGRRFSAE
HEEEEEECCCCCCCCCHHHHCCCCCEEEECCCEEEEEEEEEECCCEEEEEEECCCEEEEE
VVGSDPETDLSVLKIEGDKLPVVPLNLTTPPQVGDVVLAIGNPYNLGQTITQGIISATGR
EECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NGLSSGYQDFLQTDAAINAGNSGGALIDTNGDVIGINTAAYQIGDEGGGHGISFAIPIRL
CCCHHHHHHHHHCCHHEECCCCCCEEEECCCCEEEEEHEEEEECCCCCCCCEEEEEHHHH
AYSIMGKLIEHGRVIRGALGISGEALTPFMAQVLKMQEVRGVLVTGVDRNGPAADAQMQP
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
RDVIIEYGGESVVSAEMLMDRIAETKPGTEVQMTIIRQGKAYTLPVIIGEKATEYN
CEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MKSALLYLGKAVLFGLVMAAVFLLAQNYLGNDHGNLFRDRGNGGSELSFAKAVRRAAPAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCH
ANIYNISIDQRQPLNSGALQGLGSGVIISKEGYILTNYHVIKKADEIVIALQDGRRFSAE
HEEEEEECCCCCCCCCHHHHCCCCCEEEECCCEEEEEEEEEECCCEEEEEEECCCEEEEE
VVGSDPETDLSVLKIEGDKLPVVPLNLTTPPQVGDVVLAIGNPYNLGQTITQGIISATGR
EECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NGLSSGYQDFLQTDAAINAGNSGGALIDTNGDVIGINTAAYQIGDEGGGHGISFAIPIRL
CCCHHHHHHHHHCCHHEECCCCCCEEEECCCCEEEEEHEEEEECCCCCCCCEEEEEHHHH
AYSIMGKLIEHGRVIRGALGISGEALTPFMAQVLKMQEVRGVLVTGVDRNGPAADAQMQP
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCC
RDVIIEYGGESVVSAEMLMDRIAETKPGTEVQMTIIRQGKAYTLPVIIGEKATEYN
CEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]