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The map label for this gene is phoQ [H]

Identifier: 119776139

GI number: 119776139

Start: 3578939

End: 3580276

Strand: Direct

Name: phoQ [H]

Synonym: Sama_3007

Alternate gene names: 119776139

Gene position: 3578939-3580276 (Clockwise)

Preceding gene: 119776138

Following gene: 119776148

Centisome position: 83.11

GC content: 55.9

Gene sequence:

>1338_bases
ATGATCTCCATTCGGGCCAAGCTGAGCCTGTGGTTAACCGGCCTGGTGATAGTCAGCACTATCATCGGGCTGTTTTTGTT
TGAGTCCATGCTCAGACAAGCCTTTCACGACTCCATCATTAATCGTCTCGAAGAAGATCTGGAACACGTGATCCTTGCCA
CCCACATGCAGGATGGCGACATCGGCATAGACTCCTCCATGCTGTCCGGCTTCTATCGCCCCGCTTACTCAGGCCGTTAC
TACCAGCTGAACCTGCCCGATGAGGTCATCCGCTCACGCTCCCTGTGGGACCAGCAACTGGCCATTACGCCACTGGCACC
GAGTGAAACCCGGGTCTGGCAAGCCCGCGGCCCCAAAAACCACGACATGCAGCTGCTCAGTGTGGGGCTAAAGTCCCAGA
ATGGCAAGATTCAGGCCACCCTTACCGTGGCCCAAGACTTGAGTATTGGCCGTAGGGTATTCAGCGAGATTTATGGCACC
AAGCTGATGGTCAATCTCGGCATGCTGCTTGCCATGATAACGGGTATCTTTCTGGTATTGCGCCAGTCCTTCAAGCCGCT
GCGTAAGATTAAAGAAGCCCTGTCACGCTTAAGAGATGGCGACATCGATCGGCTGGCACTGGATAGCATTCCGGCCGAGC
TGCATCCCCTCGCAGCCACCTACAACGAGCTATTGGAATACACAGGCAAACAGATTGCCCGTAGCCGCAACAACCTGGGT
AACTTAAGCCATGGTCTGAAAACGCCATTGGCGGTGATGCAACAACAAGTGGAAGCCCTGGGGCTCAGCGACCCTGAAAT
GGCAGACGCCATGCAGCAACAGCTGGATCTCATCCGCAAGATGATCGAGCGCAAGCTCGCGGCGGCCCGGGTCACCGGTG
ATATGCTGCCTGCGGCGCAAATGCAGATCCCAAGGGATCTGGATAGCCTGACCAACACCCTGAACAAGGTGCATCGCCAC
AAAGATATCCACTTCAGTATCGACATCGCCCGCGGCCTGCATCGACTGCCCATTCACCGGGAAGACGGCATGGAACTGAT
TGGCAACCTGCTGGATAACGCCTGTAAGTGGGCAAAAGGGGAAGTCTCCCTGCGCCTCTACCCGCTGGATAATCGCCTAT
GGCTGGATATTGAGGACGATGGTCCCGGCGTTGCCGACGATGCACTGTCGCAGCTTACAGAGCGTGGCAAACGCCTCGAT
GAGGCCGTGATGGGCCATGGCATTGGCCTGTCCATCGTGAAAGAAATCTGCGAGCAATATGAGCTGAAATTGGATTTCAG
CCGTGGTGTGCGCCTTGGTGGCCTCAAGGTCAGTATAGGATTTGCGCTGACGTCCTGA

Upstream 100 bases:

>100_bases
ATGTGGTGGAGGTTTACGTGACCCACCTGCGTAAAAAACTGGGCAAGACCGCCATCGAAACCCGCCGCGGTCAGGGATAT
ATCTTCCACGGCCTGGACGC

Downstream 100 bases:

>100_bases
TGGTTCGACTGAGCTCACAACAAAAATCCCGGCCAGGCCGGGATTTTTTATGGCTGACATAGGCCGCAGAAGCCGGTCAG
TTTACGTTGGTACTCTCGAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MISIRAKLSLWLTGLVIVSTIIGLFLFESMLRQAFHDSIINRLEEDLEHVILATHMQDGDIGIDSSMLSGFYRPAYSGRY
YQLNLPDEVIRSRSLWDQQLAITPLAPSETRVWQARGPKNHDMQLLSVGLKSQNGKIQATLTVAQDLSIGRRVFSEIYGT
KLMVNLGMLLAMITGIFLVLRQSFKPLRKIKEALSRLRDGDIDRLALDSIPAELHPLAATYNELLEYTGKQIARSRNNLG
NLSHGLKTPLAVMQQQVEALGLSDPEMADAMQQQLDLIRKMIERKLAAARVTGDMLPAAQMQIPRDLDSLTNTLNKVHRH
KDIHFSIDIARGLHRLPIHREDGMELIGNLLDNACKWAKGEVSLRLYPLDNRLWLDIEDDGPGVADDALSQLTERGKRLD
EAVMGHGIGLSIVKEICEQYELKLDFSRGVRLGGLKVSIGFALTS

Sequences:

>Translated_445_residues
MISIRAKLSLWLTGLVIVSTIIGLFLFESMLRQAFHDSIINRLEEDLEHVILATHMQDGDIGIDSSMLSGFYRPAYSGRY
YQLNLPDEVIRSRSLWDQQLAITPLAPSETRVWQARGPKNHDMQLLSVGLKSQNGKIQATLTVAQDLSIGRRVFSEIYGT
KLMVNLGMLLAMITGIFLVLRQSFKPLRKIKEALSRLRDGDIDRLALDSIPAELHPLAATYNELLEYTGKQIARSRNNLG
NLSHGLKTPLAVMQQQVEALGLSDPEMADAMQQQLDLIRKMIERKLAAARVTGDMLPAAQMQIPRDLDSLTNTLNKVHRH
KDIHFSIDIARGLHRLPIHREDGMELIGNLLDNACKWAKGEVSLRLYPLDNRLWLDIEDDGPGVADDALSQLTERGKRLD
EAVMGHGIGLSIVKEICEQYELKLDFSRGVRLGGLKVSIGFALTS
>Mature_445_residues
MISIRAKLSLWLTGLVIVSTIIGLFLFESMLRQAFHDSIINRLEEDLEHVILATHMQDGDIGIDSSMLSGFYRPAYSGRY
YQLNLPDEVIRSRSLWDQQLAITPLAPSETRVWQARGPKNHDMQLLSVGLKSQNGKIQATLTVAQDLSIGRRVFSEIYGT
KLMVNLGMLLAMITGIFLVLRQSFKPLRKIKEALSRLRDGDIDRLALDSIPAELHPLAATYNELLEYTGKQIARSRNNLG
NLSHGLKTPLAVMQQQVEALGLSDPEMADAMQQQLDLIRKMIERKLAAARVTGDMLPAAQMQIPRDLDSLTNTLNKVHRH
KDIHFSIDIARGLHRLPIHREDGMELIGNLLDNACKWAKGEVSLRLYPLDNRLWLDIEDDGPGVADDALSQLTERGKRLD
EAVMGHGIGLSIVKEICEQYELKLDFSRGVRLGGLKVSIGFALTS

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=306, Percent_Identity=29.0849673202614, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789808, Length=277, Percent_Identity=25.2707581227437, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789403, Length=329, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=26.5232974910394, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=23.202614379085, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=283, Percent_Identity=23.6749116607774, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49827; Mature: 49827

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIRAKLSLWLTGLVIVSTIIGLFLFESMLRQAFHDSIINRLEEDLEHVILATHMQDGD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IGIDSSMLSGFYRPAYSGRYYQLNLPDEVIRSRSLWDQQLAITPLAPSETRVWQARGPKN
CCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCCC
HDMQLLSVGLKSQNGKIQATLTVAQDLSIGRRVFSEIYGTKLMVNLGMLLAMITGIFLVL
CCHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQSFKPLRKIKEALSRLRDGDIDRLALDSIPAELHPLAATYNELLEYTGKQIARSRNNLG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLSHGLKTPLAVMQQQVEALGLSDPEMADAMQQQLDLIRKMIERKLAAARVTGDMLPAAQ
CHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MQIPRDLDSLTNTLNKVHRHKDIHFSIDIARGLHRLPIHREDGMELIGNLLDNACKWAKG
HCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
EVSLRLYPLDNRLWLDIEDDGPGVADDALSQLTERGKRLDEAVMGHGIGLSIVKEICEQY
CEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ELKLDFSRGVRLGGLKVSIGFALTS
HEEEEHHCCEEECCEEEEEEEEECC
>Mature Secondary Structure
MISIRAKLSLWLTGLVIVSTIIGLFLFESMLRQAFHDSIINRLEEDLEHVILATHMQDGD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IGIDSSMLSGFYRPAYSGRYYQLNLPDEVIRSRSLWDQQLAITPLAPSETRVWQARGPKN
CCCCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCCC
HDMQLLSVGLKSQNGKIQATLTVAQDLSIGRRVFSEIYGTKLMVNLGMLLAMITGIFLVL
CCHHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQSFKPLRKIKEALSRLRDGDIDRLALDSIPAELHPLAATYNELLEYTGKQIARSRNNLG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLSHGLKTPLAVMQQQVEALGLSDPEMADAMQQQLDLIRKMIERKLAAARVTGDMLPAAQ
CHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
MQIPRDLDSLTNTLNKVHRHKDIHFSIDIARGLHRLPIHREDGMELIGNLLDNACKWAKG
HCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
EVSLRLYPLDNRLWLDIEDDGPGVADDALSQLTERGKRLDEAVMGHGIGLSIVKEICEQY
CEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ELKLDFSRGVRLGGLKVSIGFALTS
HEEEEHHCCEEECCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]