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The map label for this gene is kdsA

Identifier: 119775693

GI number: 119775693

Start: 3067601

End: 3068449

Strand: Reverse

Name: kdsA

Synonym: Sama_2561

Alternate gene names: 119775693

Gene position: 3068449-3067601 (Counterclockwise)

Preceding gene: 119775694

Following gene: 119775692

Centisome position: 71.26

GC content: 54.3

Gene sequence:

>849_bases
ATGAGTATCAAGACAATCCAACTTGGCGACATCGCCATTGCCAATGACAAGCCCTTTGTACTCTTTGGCGGCATGAACGT
GCTTGAATCGCGGGATCTGGCCATGAGTATTGCCGAGAAATACCTGGAAGTGACCCAAAAGCTTGGGATCCCCTATGTAT
TCAAGGCCTCTTTCGACAAGGCCAACCGCTCGTCTATCAACTCTTACCGTGGTCCCGGGATGGAAGAAGGCCTGAAGATA
TTTCAGGAAATCAAAGACACCTTCAATGTGCCGCTGATCACCGATGTGCACGAGCCTCATCAGTGTGCCCCCGTGGCAGA
AGTGGTCGACATCATTCAGCTGCCAGCCTTTTTGGCACGCCAGACCGATCTGGTGATTGCCATGGCCAGAACCGGCGCCA
TCATCAACGTGAAAAAGCCACAGTTTCTGGCTCCCCACGAGATGCGCCACATAGTGAAGAAATTCAACGAGGCCGGTAAC
GACGAGATTATCCTGTGCGAGCGCGGCAGCTGCTTTGGTTACAACAACCTGGTGGTGGACATGCTGGGCATGGATGAGAT
GAAACAGAGCGGTTATCCGGTAATTTTCGATGCCACCCATGCACTGCAGCGTCCGGGCGGCCGTGAAGATTCTGCCGGTG
GTCGCCGCGCCCAGGCAACTGAGCTTGCCCGCAGTGGTATGGCGCTGGGTCTGGCAGGTCTCTTTATCGAAGCACATCCG
GATCCCGACAATGCCAAGTGCGACGGCCCCTGTGCTCTGCCACTGCATCAGCTGGAAGCTTACCTCAGTCAGATGAAAGC
GGTAGATGACCTGGTGAAATCTTTTCCTGCACTGGATACCAGCAAGTAA

Upstream 100 bases:

>100_bases
TTTGGGCACTTACATGGCGTGGCTCTGTGGCCAGCTCTTGCAGCTGGTGGGCTGATTTTTCCGCCGGCGAGCGCGCCGGT
TTATTCTTTGAGAGGCTTAG

Downstream 100 bases:

>100_bases
ACCACAGCATCAATCGGCTGTGATATGCTCAAACGCCCGGCTTTGCCGGGCGTTTTTTTTGGTCAATAGAGAAAAGGGAG
AGTCTGTATGTGGGTGATGT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSIKTIQLGDIAIANDKPFVLFGGMNVLESRDLAMSIAEKYLEVTQKLGIPYVFKASFDKANRSSINSYRGPGMEEGLKI
FQEIKDTFNVPLITDVHEPHQCAPVAEVVDIIQLPAFLARQTDLVIAMARTGAIINVKKPQFLAPHEMRHIVKKFNEAGN
DEIILCERGSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGREDSAGGRRAQATELARSGMALGLAGLFIEAHP
DPDNAKCDGPCALPLHQLEAYLSQMKAVDDLVKSFPALDTSK

Sequences:

>Translated_282_residues
MSIKTIQLGDIAIANDKPFVLFGGMNVLESRDLAMSIAEKYLEVTQKLGIPYVFKASFDKANRSSINSYRGPGMEEGLKI
FQEIKDTFNVPLITDVHEPHQCAPVAEVVDIIQLPAFLARQTDLVIAMARTGAIINVKKPQFLAPHEMRHIVKKFNEAGN
DEIILCERGSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGREDSAGGRRAQATELARSGMALGLAGLFIEAHP
DPDNAKCDGPCALPLHQLEAYLSQMKAVDDLVKSFPALDTSK
>Mature_281_residues
SIKTIQLGDIAIANDKPFVLFGGMNVLESRDLAMSIAEKYLEVTQKLGIPYVFKASFDKANRSSINSYRGPGMEEGLKIF
QEIKDTFNVPLITDVHEPHQCAPVAEVVDIIQLPAFLARQTDLVIAMARTGAIINVKKPQFLAPHEMRHIVKKFNEAGND
EIILCERGSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGREDSAGGRRAQATELARSGMALGLAGLFIEAHPD
PDNAKCDGPCALPLHQLEAYLSQMKAVDDLVKSFPALDTSK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=284, Percent_Identity=71.4788732394366, Blast_Score=416, Evalue=1e-118,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_SHEAM (A1S8Q7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928433.1
- ProteinModelPortal:   A1S8Q7
- SMR:   A1S8Q7
- STRING:   A1S8Q7
- GeneID:   4604808
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2561
- NMPDR:   fig|326297.7.peg.2401
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   VHEPHQA
- PhylomeDB:   A1S8Q7
- ProtClustDB:   PRK05198
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30890; Mature: 30759

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKTIQLGDIAIANDKPFVLFGGMNVLESRDLAMSIAEKYLEVTQKLGIPYVFKASFDK
CCCEEEEECCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSINSYRGPGMEEGLKIFQEIKDTFNVPLITDVHEPHQCAPVAEVVDIIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHC
QTDLVIAMARTGAIINVKKPQFLAPHEMRHIVKKFNEAGNDEIILCERGSCFGYNNLVVD
CCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEE
MLGMDEMKQSGYPVIFDATHALQRPGGREDSAGGRRAQATELARSGMALGLAGLFIEAHP
CCCHHHHHHCCCCEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHEEEEEEEEECC
DPDNAKCDGPCALPLHQLEAYLSQMKAVDDLVKSFPALDTSK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIKTIQLGDIAIANDKPFVLFGGMNVLESRDLAMSIAEKYLEVTQKLGIPYVFKASFDK
CCEEEEECCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSINSYRGPGMEEGLKIFQEIKDTFNVPLITDVHEPHQCAPVAEVVDIIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHC
QTDLVIAMARTGAIINVKKPQFLAPHEMRHIVKKFNEAGNDEIILCERGSCFGYNNLVVD
CCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEE
MLGMDEMKQSGYPVIFDATHALQRPGGREDSAGGRRAQATELARSGMALGLAGLFIEAHP
CCCHHHHHHCCCCEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHEEEEEEEEECC
DPDNAKCDGPCALPLHQLEAYLSQMKAVDDLVKSFPALDTSK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA