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The map label for this gene is mutY [H]

Identifier: 119775623

GI number: 119775623

Start: 2992315

End: 2993421

Strand: Direct

Name: mutY [H]

Synonym: Sama_2490

Alternate gene names: 119775623

Gene position: 2992315-2993421 (Clockwise)

Preceding gene: 119775617

Following gene: 119775624

Centisome position: 69.49

GC content: 57.0

Gene sequence:

>1107_bases
ATGTCCGAGCAAACAGCCCGCATTCCTTTTGGAAAGCGTATCGTCCTGTGGTACGACAAACACGGCCGCAAGAGCCTGCC
ATGGCAGCAAAACAAGACGCCTTATAAGGTATGGGTGTCGGAAATCATGCTGCAGCAAACCCAGGTGGCTACCGTTATCC
CCTACTTCGAGCGCTTTATGGCAAGCTTCCCCACGGTGAACGACCTTGCCAACGCCCATGAAGATGAAGTGCTGCACCAC
TGGACCGGCCTTGGCTACTATGCCCGTGCCCGCAACCTGCACAAGGCCGCACAGCTCATCCGCGACGAGCACGGCGGCGA
GTTCCCAACCGAGTTCGATGCCGTGCTGGCACTGCCCGGCATTGGCCGCTCCACGGCAGGTGCCGTGTTGTCATTATCTT
TAGGGCAGCATCATCCTATTCTCGATGGCAATGTAAAAAGAGTGCTGGCGCGACACGGCGCCATCGAAGGCTGGCCCGGC
GAGAAACGGGTCGATACCGCCCTGTGGCAACTCACCGAAGCGCTAACCCCCAAAGAAGACATACAAAAGTACAATCAGGC
CATGATGGATATGGGTGCCAATATCTGCACCCGCAGCCGCCCCAAGTGTGGTGAGTGCCCCGTTGCCATCGACTGCAAGG
CGCAGCTTGCCGGCCGTCAGGGTGAGTTCCCCGGTAAAAAGCCCAAAAAGACCATTCCCGCCCGGGAAGGCTGGATGCTG
ATTCTGCAGCAAGCAAACACCGTCAAGCTTATCAAGCGGCCACCCAGTGGCATCTGGGGCGGCCTCTGGTGCTTCCCCCA
ATTTGATAGCAAGCAAGCGCTCCATGCCTTTGTCGAAGCCAATGGCTTAGATGCAGAAAATCTCACCCTGCTGGATGGCT
TTCGTCACACATTCAGCCACTTCCATCTGGATATTCAGCCGGTCAAACTGCGCCTTGGCAGCACACAGACAGAGGCGCTT
ATCATGGAAGATAACCTGAGTCTCTGGTATAACCTCCTCCAAGGCGAAAATCTTGGGCTTGCCGCCGCCACCGAGCGAAT
TCTGGCAAGCCTTGTAAGCGAACTTAAGCAAGAATCCGGCGGCAGCGCTGCCGCCCACAAGGAGTAA

Upstream 100 bases:

>100_bases
GCTGCCAGCGTCATGGCGCAACTTGGCACCAACCCTTGTGACCGCCATCACTCACGGCTACACTGCCGAGCCATCAGTGT
CAGATTGGTTCACTCTCTCA

Downstream 100 bases:

>100_bases
AACATGGCCCGTACCGTTCAGTGTGTGTATTTGGGTAAAGAAGCCGAAGGTCTGGATTTCCAGCTCTATCCCGGCGAGCT
CGGCAAGCGCATTTTCGACA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSEQTARIPFGKRIVLWYDKHGRKSLPWQQNKTPYKVWVSEIMLQQTQVATVIPYFERFMASFPTVNDLANAHEDEVLHH
WTGLGYYARARNLHKAAQLIRDEHGGEFPTEFDAVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIEGWPG
EKRVDTALWQLTEALTPKEDIQKYNQAMMDMGANICTRSRPKCGECPVAIDCKAQLAGRQGEFPGKKPKKTIPAREGWML
ILQQANTVKLIKRPPSGIWGGLWCFPQFDSKQALHAFVEANGLDAENLTLLDGFRHTFSHFHLDIQPVKLRLGSTQTEAL
IMEDNLSLWYNLLQGENLGLAAATERILASLVSELKQESGGSAAAHKE

Sequences:

>Translated_368_residues
MSEQTARIPFGKRIVLWYDKHGRKSLPWQQNKTPYKVWVSEIMLQQTQVATVIPYFERFMASFPTVNDLANAHEDEVLHH
WTGLGYYARARNLHKAAQLIRDEHGGEFPTEFDAVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIEGWPG
EKRVDTALWQLTEALTPKEDIQKYNQAMMDMGANICTRSRPKCGECPVAIDCKAQLAGRQGEFPGKKPKKTIPAREGWML
ILQQANTVKLIKRPPSGIWGGLWCFPQFDSKQALHAFVEANGLDAENLTLLDGFRHTFSHFHLDIQPVKLRLGSTQTEAL
IMEDNLSLWYNLLQGENLGLAAATERILASLVSELKQESGGSAAAHKE
>Mature_367_residues
SEQTARIPFGKRIVLWYDKHGRKSLPWQQNKTPYKVWVSEIMLQQTQVATVIPYFERFMASFPTVNDLANAHEDEVLHHW
TGLGYYARARNLHKAAQLIRDEHGGEFPTEFDAVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIEGWPGE
KRVDTALWQLTEALTPKEDIQKYNQAMMDMGANICTRSRPKCGECPVAIDCKAQLAGRQGEFPGKKPKKTIPAREGWMLI
LQQANTVKLIKRPPSGIWGGLWCFPQFDSKQALHAFVEANGLDAENLTLLDGFRHTFSHFHLDIQPVKLRLGSTQTEALI
MEDNLSLWYNLLQGENLGLAAATERILASLVSELKQESGGSAAAHKE

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=366, Percent_Identity=34.6994535519126, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI115298648, Length=366, Percent_Identity=34.4262295081967, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI115298654, Length=366, Percent_Identity=34.4262295081967, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI115298652, Length=366, Percent_Identity=34.4262295081967, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI115298650, Length=366, Percent_Identity=34.4262295081967, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI6912520, Length=366, Percent_Identity=34.4262295081967, Blast_Score=191, Evalue=7e-49,
Organism=Escherichia coli, GI1789331, Length=342, Percent_Identity=60.8187134502924, Blast_Score=440, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17554540, Length=136, Percent_Identity=32.3529411764706, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41087; Mature: 40955

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00024 HEMOPEXIN ; PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTARIPFGKRIVLWYDKHGRKSLPWQQNKTPYKVWVSEIMLQQTQVATVIPYFERFM
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFPTVNDLANAHEDEVLHHWTGLGYYARARNLHKAAQLIRDEHGGEFPTEFDAVLALPG
HHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCC
IGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIEGWPGEKRVDTALWQLTEALTPKED
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHH
IQKYNQAMMDMGANICTRSRPKCGECPVAIDCKAQLAGRQGEFPGKKPKKTIPAREGWML
HHHHHHHHHHCCCHHHCCCCCCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCCCCCCEEE
ILQQANTVKLIKRPPSGIWGGLWCFPQFDSKQALHAFVEANGLDAENLTLLDGFRHTFSH
EEECCCEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FHLDIQPVKLRLGSTQTEALIMEDNLSLWYNLLQGENLGLAAATERILASLVSELKQESG
HEEEEEEEEEEECCCCCCEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GSAAAHKE
CCCCCCCC
>Mature Secondary Structure 
SEQTARIPFGKRIVLWYDKHGRKSLPWQQNKTPYKVWVSEIMLQQTQVATVIPYFERFM
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFPTVNDLANAHEDEVLHHWTGLGYYARARNLHKAAQLIRDEHGGEFPTEFDAVLALPG
HHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCC
IGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIEGWPGEKRVDTALWQLTEALTPKED
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHH
IQKYNQAMMDMGANICTRSRPKCGECPVAIDCKAQLAGRQGEFPGKKPKKTIPAREGWML
HHHHHHHHHHCCCHHHCCCCCCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCCCCCCEEE
ILQQANTVKLIKRPPSGIWGGLWCFPQFDSKQALHAFVEANGLDAENLTLLDGFRHTFSH
EEECCCEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FHLDIQPVKLRLGSTQTEALIMEDNLSLWYNLLQGENLGLAAATERILASLVSELKQESG
HEEEEEEEEEEECCCCCCEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GSAAAHKE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]