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The map label for this gene is tpx [H]

Identifier: 119775598

GI number: 119775598

Start: 2971103

End: 2971678

Strand: Reverse

Name: tpx [H]

Synonym: Sama_2464

Alternate gene names: 119775598

Gene position: 2971678-2971103 (Counterclockwise)

Preceding gene: 119775599

Following gene: 119775596

Centisome position: 69.01

GC content: 51.04

Gene sequence:

>576_bases
ATGTTCAAAAAGGCGTTATGCATCGGCTTGGCCCTGGTTGCTGCCCAGGGTATGGCACAGGACAGAGACAGTGTCACTAT
GGGGGGCAAGCAGGTGATGTTGTCGGGAACCCTGCCACAGGTGGGTGAAACCGCACCTGGGTTTCGTGTCGTTGATGCTT
CTTTCAAACCCGTGGCATTAAGTGATTTTAAGGGCAAAACGGTTCTTATCAGCGCTGTTCCAAGCCTGGATACCGGTGTG
TGTGCATTGCAAACCAAGCGCTTCAATGACGAAGTGGGCAAGTTTGATGGCAAGTCCGTGGTGATGCTGACCCTGAGCAC
CGACCTGCCATTCGCGCAAAAGCGTTTTTGCAAGACTGAAGGTGTTGAGAATATTCAGGTTCTGTCAGATTCAGTTTGGC
GTAACTTTGCCGAAGAGTACGGGCTCTTGATAGAAGACAGAGGTCTGCTTGCCCGTAGTATCTTTATCGTGGATGCCGAG
GGCACCCTAAGATACAAAGAATTGGTTGGTGAAGTCAGTCATCATCCGGACTATGATGCGGCCCTGGCGGCCTTGAAAGA
CATCAGTCAGCAATAA

Upstream 100 bases:

>100_bases
GTAAAAAGCCGGCAATCGCCGGCTTTTTTTATTCGAGGGCTGGCGGTATTGGCCACACTTTGCAACACTCTGCTATCGGT
TAATGACAGGGAGAAAAACA

Downstream 100 bases:

>100_bases
CGAAAACGCCGGCAAAGCCGGCGTTTTTTATGTTGGACTCAGTGGTGAGCATCACTCTGATAGTTAAAGGTTGGCATCGA
CCAGTGGTAACGGATGGCAC

Product: anti-oxidant AhpCTSA family protein

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MFKKALCIGLALVAAQGMAQDRDSVTMGGKQVMLSGTLPQVGETAPGFRVVDASFKPVALSDFKGKTVLISAVPSLDTGV
CALQTKRFNDEVGKFDGKSVVMLTLSTDLPFAQKRFCKTEGVENIQVLSDSVWRNFAEEYGLLIEDRGLLARSIFIVDAE
GTLRYKELVGEVSHHPDYDAALAALKDISQQ

Sequences:

>Translated_191_residues
MFKKALCIGLALVAAQGMAQDRDSVTMGGKQVMLSGTLPQVGETAPGFRVVDASFKPVALSDFKGKTVLISAVPSLDTGV
CALQTKRFNDEVGKFDGKSVVMLTLSTDLPFAQKRFCKTEGVENIQVLSDSVWRNFAEEYGLLIEDRGLLARSIFIVDAE
GTLRYKELVGEVSHHPDYDAALAALKDISQQ
>Mature_191_residues
MFKKALCIGLALVAAQGMAQDRDSVTMGGKQVMLSGTLPQVGETAPGFRVVDASFKPVALSDFKGKTVLISAVPSLDTGV
CALQTKRFNDEVGKFDGKSVVMLTLSTDLPFAQKRFCKTEGVENIQVLSDSVWRNFAEEYGLLIEDRGLLARSIFIVDAE
GTLRYKELVGEVSHHPDYDAALAALKDISQQ

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=141, Percent_Identity=36.1702127659575, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5802974, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505591, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI32455266, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI32455264, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI32483377, Length=130, Percent_Identity=31.5384615384615, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787584, Length=168, Percent_Identity=39.2857142857143, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193204376, Length=133, Percent_Identity=36.8421052631579, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565831, Length=133, Percent_Identity=36.8421052631579, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=135, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320661, Length=135, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357347, Length=134, Percent_Identity=31.3432835820896, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 20689; Mature: 20689

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKALCIGLALVAAQGMAQDRDSVTMGGKQVMLSGTLPQVGETAPGFRVVDASFKPVAL
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCEEE
SDFKGKTVLISAVPSLDTGVCALQTKRFNDEVGKFDGKSVVMLTLSTDLPFAQKRFCKTE
CCCCCCEEEEEECCCCCCCEEEEECCCCCCHHCCCCCCEEEEEEEECCCCHHHHHHHHHC
GVENIQVLSDSVWRNFAEEYGLLIEDRGLLARSIFIVDAEGTLRYKELVGEVSHHPDYDA
CCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHHH
ALAALKDISQQ
HHHHHHHHCCC
>Mature Secondary Structure
MFKKALCIGLALVAAQGMAQDRDSVTMGGKQVMLSGTLPQVGETAPGFRVVDASFKPVAL
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCEEE
SDFKGKTVLISAVPSLDTGVCALQTKRFNDEVGKFDGKSVVMLTLSTDLPFAQKRFCKTE
CCCCCCEEEEEECCCCCCCEEEEECCCCCCHHCCCCCCEEEEEEEECCCCHHHHHHHHHC
GVENIQVLSDSVWRNFAEEYGLLIEDRGLLARSIFIVDAEGTLRYKELVGEVSHHPDYDA
CCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHHH
ALAALKDISQQ
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA