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The map label for this gene is ltaE [H]

Identifier: 119775596

GI number: 119775596

Start: 2969212

End: 2970222

Strand: Reverse

Name: ltaE [H]

Synonym: Sama_2462

Alternate gene names: 119775596

Gene position: 2970222-2969212 (Counterclockwise)

Preceding gene: 119775598

Following gene: 119775595

Centisome position: 68.98

GC content: 57.96

Gene sequence:

>1011_bases
ATGAAGGCAGATTTCAGAAGCGATACAGTCACTCAGCCAACCGCAGCGATGCGCCAGGCCATGTCACAGGCCCAGGTGGG
GGACGATGTGTATGGCGACGATCCTACGGTCAATCGTCTCGAAGCCATGGCGGCCGAGATGCTGGGGTTTGACGCCGCAC
TTTTTACCAGTTCGGGTACCCAGGCCAATCTGCTGGCGCTGATGAGCCATTGTGAGCGCGGAGATGAATATATCTGTGGC
CAGGATGCCCACAACTACCGATTTGAGGGGGGCGGCGCCGCAGTGCTTGGCAGCATTCAGCCCCAGCCGCTACTCAATCA
GGCCGATGGCACCATCGCCCTTGGCGACATAGAGGCCGCCATCAAACCCGATGATGTACATTATGCCCGAACCCGCTTGC
TGAGCCTGGAAAACACCATTGGTGGCAAGGTGTTGCCTATGGGGTATCTGGCGAATGCTCAGGCGCTGGCCTTTAACCGT
GGCCTTAAGATCCACCTCGATGGTGCCCGCCTTGCCAACGCAGCGGTGGCGCTGAACAAGCCAATGGCCGAGATTGCCGG
GCACTTTGATTCTGTTTCCCTGTGTCTGTCCAAGGGCCTGTGCGCGCCAGTGGGCTCTTTGCTGCTGGGGGATGACAGAC
TGATTAAAAAGGCGCGTCGCTGGCGCAAAATGCTGGGCGGCGGCATGCGCCAGGCGGGGATTCTGGCTGCTGCGGGCATC
ATTGCGCTGGAGTCTCAGTGGCAAAGGTTGGCCGAAGATCACGACAATGCCGCGCTCCTTGGCCGTGAATTGTCCATGAT
TGATGGTTTTGAGGTCAACACGGCTTCAATCCAGACCAATATGGTGTTTGCCAGGGTTGCCGAGCATATCGACATCAAGC
ATGTTGCTGCCGAGTTGGCGAGCCTGGGCTTTATTATCAGCCCTGCCAAAAATTTGCGTCTGGTCACCCACAATGACATC
AGTCGCGATGCTGTGCTGGCCTTCGTGGCGGCGCTGAAAAGCGCACTCTGA

Upstream 100 bases:

>100_bases
CAGCACGTCTCAGCAGAGGATGGCACAAAGATGCTGGCCTTCAGGTGGTAAGGTCTGGATAATCGGCCAGTCAGTTGTAT
TACTACCCCGGGGGATTAGC

Downstream 100 bases:

>100_bases
TTGCGCTTTTAATGTGCATGACGCGCATTGCTGGTGCAAAAATCAGCGTTTTAGAACAGCCGGTTTTTTTAATTTATTGA
AATATAAGATTTAAAATATT

Product: threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKADFRSDTVTQPTAAMRQAMSQAQVGDDVYGDDPTVNRLEAMAAEMLGFDAALFTSSGTQANLLALMSHCERGDEYICG
QDAHNYRFEGGGAAVLGSIQPQPLLNQADGTIALGDIEAAIKPDDVHYARTRLLSLENTIGGKVLPMGYLANAQALAFNR
GLKIHLDGARLANAAVALNKPMAEIAGHFDSVSLCLSKGLCAPVGSLLLGDDRLIKKARRWRKMLGGGMRQAGILAAAGI
IALESQWQRLAEDHDNAALLGRELSMIDGFEVNTASIQTNMVFARVAEHIDIKHVAAELASLGFIISPAKNLRLVTHNDI
SRDAVLAFVAALKSAL

Sequences:

>Translated_336_residues
MKADFRSDTVTQPTAAMRQAMSQAQVGDDVYGDDPTVNRLEAMAAEMLGFDAALFTSSGTQANLLALMSHCERGDEYICG
QDAHNYRFEGGGAAVLGSIQPQPLLNQADGTIALGDIEAAIKPDDVHYARTRLLSLENTIGGKVLPMGYLANAQALAFNR
GLKIHLDGARLANAAVALNKPMAEIAGHFDSVSLCLSKGLCAPVGSLLLGDDRLIKKARRWRKMLGGGMRQAGILAAAGI
IALESQWQRLAEDHDNAALLGRELSMIDGFEVNTASIQTNMVFARVAEHIDIKHVAAELASLGFIISPAKNLRLVTHNDI
SRDAVLAFVAALKSAL
>Mature_336_residues
MKADFRSDTVTQPTAAMRQAMSQAQVGDDVYGDDPTVNRLEAMAAEMLGFDAALFTSSGTQANLLALMSHCERGDEYICG
QDAHNYRFEGGGAAVLGSIQPQPLLNQADGTIALGDIEAAIKPDDVHYARTRLLSLENTIGGKVLPMGYLANAQALAFNR
GLKIHLDGARLANAAVALNKPMAEIAGHFDSVSLCLSKGLCAPVGSLLLGDDRLIKKARRWRKMLGGGMRQAGILAAAGI
IALESQWQRLAEDHDNAALLGRELSMIDGFEVNTASIQTNMVFARVAEHIDIKHVAAELASLGFIISPAKNLRLVTHNDI
SRDAVLAFVAALKSAL

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=328, Percent_Identity=56.0975609756098, Blast_Score=346, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.6184971098266, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.6184971098266, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.6184971098266, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6320789, Length=284, Percent_Identity=39.7887323943662, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21355439, Length=298, Percent_Identity=44.6308724832215, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 35802; Mature: 35802

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKADFRSDTVTQPTAAMRQAMSQAQVGDDVYGDDPTVNRLEAMAAEMLGFDAALFTSSGT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCC
QANLLALMSHCERGDEYICGQDAHNYRFEGGGAAVLGSIQPQPLLNQADGTIALGDIEAA
HHHHHHHHHHHCCCCCEECCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEECEEEC
IKPDDVHYARTRLLSLENTIGGKVLPMGYLANAQALAFNRGLKIHLDGARLANAAVALNK
CCCCCHHHHHHHHHHHHHCCCCEEEECHHHCCCCEEEECCCCEEEECCHHHHHHHHHHCC
PMAEIAGHFDSVSLCLSKGLCAPVGSLLLGDDRLIKKARRWRKMLGGGMRQAGILAAAGI
CHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IALESQWQRLAEDHDNAALLGRELSMIDGFEVNTASIQTNMVFARVAEHIDIKHVAAELA
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
SLGFIISPAKNLRLVTHNDISRDAVLAFVAALKSAL
HCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKADFRSDTVTQPTAAMRQAMSQAQVGDDVYGDDPTVNRLEAMAAEMLGFDAALFTSSGT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEECCCC
QANLLALMSHCERGDEYICGQDAHNYRFEGGGAAVLGSIQPQPLLNQADGTIALGDIEAA
HHHHHHHHHHHCCCCCEECCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEECEEEC
IKPDDVHYARTRLLSLENTIGGKVLPMGYLANAQALAFNRGLKIHLDGARLANAAVALNK
CCCCCHHHHHHHHHHHHHCCCCEEEECHHHCCCCEEEECCCCEEEECCHHHHHHHHHHCC
PMAEIAGHFDSVSLCLSKGLCAPVGSLLLGDDRLIKKARRWRKMLGGGMRQAGILAAAGI
CHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IALESQWQRLAEDHDNAALLGRELSMIDGFEVNTASIQTNMVFARVAEHIDIKHVAAELA
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
SLGFIISPAKNLRLVTHNDISRDAVLAFVAALKSAL
HCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]