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The map label for this gene is tyrR [H]

Identifier: 119775355

GI number: 119775355

Start: 2683698

End: 2685236

Strand: Reverse

Name: tyrR [H]

Synonym: Sama_2220

Alternate gene names: 119775355

Gene position: 2685236-2683698 (Counterclockwise)

Preceding gene: 119775356

Following gene: 119775354

Centisome position: 62.36

GC content: 53.61

Gene sequence:

>1539_bases
ATGCGTTTGGAAGTGAGTTGTCAGGACAGGGTTGGGCTCGCCAAGGATATTCTTATCGTACTGGAAAAGTACGGTATCAA
TTTGCTTGCCATCGATGCCAGTAACCGGGGGTTCCTGTATTTCCAGTTTGCCGAAGTCAGCTTCGATACCTTGAGTGCCC
TGATGCCGCAGATTAGAAAGGTCGAGAGTGTGCACGACGTGCGTACCGTGGCCTTTATGCCGTCAGAGCAGGAACACTAT
GCGCTGAAAACCCTGCTAAGAACCCTGCCAGACTCGGTATTTTCCATCGATGTGAAGGGCCGGGTGCGCATCGTCAACGA
ATCGGCCTTGATGACCCTTGGTATGAAAGAGCACGAGGTGGTGGAAGAATCTTTGAACCACTGGGTCCAGGGTTTCAGCT
TTGGGCGCTGGCTCAGTGAAAGCCAGGTACTTGCCCAGGCAACCCGTGTCCACATAGGTCAGAACGAATATCTGGCGGAG
ATGCTGCCCATTTACCTGCCCGATGAAAATGACAAGAGCATTCTCGCCGGTGCCGTGGTGTCGCTTAAATCCCCCGCCCG
GGTTGGCAAGCAGTTCAATGCCCTGCAAAACCAAACCACAGGCTTTGAAAATGTACTGGCCGTAAGCGATAAGATGAAAG
AAGTGCTCAAACAGGCCAAACGCATGGCACAACTGGACGCGCCCTTACTCATCACAGGTGAAACCGGCACCGGCAAAGAA
TTGATGGCCAGAGCCTGCCATGATGCCAGTATGCGCCGTGAGCGCCCCTTTATTGCCATCAACTGTGCCGCCTTGCCCGA
CAGTGCGGCAGAGGAAGAACTGTTTGGTTTTGTGCGTGATGGTCACATCGTCAAGCGCGGTCTGTTCGAAGAGGCCAAGG
GGGGCAGCGTATTCCTCGACGAAATCGCCGAAATGTCCAAAGCGGCTCAGGTGAAACTGCTGCGACTGCTGACGGAAGGT
TCTTTCAGGCGCATTGGTGGGGATGAAGAGGTGAGGGCCGATGTGCGCATCATCTGCTCCAGCCAGAAAAATCTTGCTGA
ACTGTGCCAGATGGGTGAGTTTCGCGAAGACCTTTACTATCGTATCCACGTACTTTCCTTCCACATGCCTTCCCTACGGG
AGCGTAAGGTGGACATTATTCCGCTTACCGAAATGTTCCTTGAGCATTACAGTCAGCAACTCTCCAGCCCCATGCGGCGG
ATTTCCCCCAATTGTCGTGATCATTTGCTTACCTACGCCTGGCCGGGCAATGTGCGTCAGTTGAAAAACGCGGTGTTCCG
CGCCGTGTCTATGTGGGATGGTTCGGCAGAGCTCACGGTTGAGCAGCTTAAATTGCCGTCTTACGCTGAAGGCTTTGGCT
ACTTTGATAACCAGTTCGAAGGCACTCTGGACGAAGCCATGCGTCAGTTTGAGTCCAGCTTGCTGCGACGCCTTTATCCA
GCTTACCCCAGCACCCGCCAGCTGGCGAAGAAGTTAGGTGTAAGCCACACGGCCATCGCCAACAAGTTGCGGGAATATAA
GATAAGTAAGAAGCGCTGA

Upstream 100 bases:

>100_bases
TCTACCGTATAGCGCCAGGTACTCCAGCGGGATCCCGGCCAATCGCGGACACGAGGTCCCCATTCCCAAGAACAAGATTA
CAAAAGGGATACATTCACAT

Downstream 100 bases:

>100_bases
TACGGTGTAAAAAGAATTTGCCAGCCAGCCGGGCAATTTATCACCAGTGTTGAGTGGAGAGGGGCATGCCATCAGGGGGC
ACTTCTCGCTGTATTTAAAA

Product: transcriptional regulatory protein TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MRLEVSCQDRVGLAKDILIVLEKYGINLLAIDASNRGFLYFQFAEVSFDTLSALMPQIRKVESVHDVRTVAFMPSEQEHY
ALKTLLRTLPDSVFSIDVKGRVRIVNESALMTLGMKEHEVVEESLNHWVQGFSFGRWLSESQVLAQATRVHIGQNEYLAE
MLPIYLPDENDKSILAGAVVSLKSPARVGKQFNALQNQTTGFENVLAVSDKMKEVLKQAKRMAQLDAPLLITGETGTGKE
LMARACHDASMRRERPFIAINCAALPDSAAEEELFGFVRDGHIVKRGLFEEAKGGSVFLDEIAEMSKAAQVKLLRLLTEG
SFRRIGGDEEVRADVRIICSSQKNLAELCQMGEFREDLYYRIHVLSFHMPSLRERKVDIIPLTEMFLEHYSQQLSSPMRR
ISPNCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNQFEGTLDEAMRQFESSLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKISKKR

Sequences:

>Translated_512_residues
MRLEVSCQDRVGLAKDILIVLEKYGINLLAIDASNRGFLYFQFAEVSFDTLSALMPQIRKVESVHDVRTVAFMPSEQEHY
ALKTLLRTLPDSVFSIDVKGRVRIVNESALMTLGMKEHEVVEESLNHWVQGFSFGRWLSESQVLAQATRVHIGQNEYLAE
MLPIYLPDENDKSILAGAVVSLKSPARVGKQFNALQNQTTGFENVLAVSDKMKEVLKQAKRMAQLDAPLLITGETGTGKE
LMARACHDASMRRERPFIAINCAALPDSAAEEELFGFVRDGHIVKRGLFEEAKGGSVFLDEIAEMSKAAQVKLLRLLTEG
SFRRIGGDEEVRADVRIICSSQKNLAELCQMGEFREDLYYRIHVLSFHMPSLRERKVDIIPLTEMFLEHYSQQLSSPMRR
ISPNCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNQFEGTLDEAMRQFESSLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKISKKR
>Mature_512_residues
MRLEVSCQDRVGLAKDILIVLEKYGINLLAIDASNRGFLYFQFAEVSFDTLSALMPQIRKVESVHDVRTVAFMPSEQEHY
ALKTLLRTLPDSVFSIDVKGRVRIVNESALMTLGMKEHEVVEESLNHWVQGFSFGRWLSESQVLAQATRVHIGQNEYLAE
MLPIYLPDENDKSILAGAVVSLKSPARVGKQFNALQNQTTGFENVLAVSDKMKEVLKQAKRMAQLDAPLLITGETGTGKE
LMARACHDASMRRERPFIAINCAALPDSAAEEELFGFVRDGHIVKRGLFEEAKGGSVFLDEIAEMSKAAQVKLLRLLTEG
SFRRIGGDEEVRADVRIICSSQKNLAELCQMGEFREDLYYRIHVLSFHMPSLRERKVDIIPLTEMFLEHYSQQLSSPMRR
ISPNCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNQFEGTLDEAMRQFESSLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKISKKR

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=514, Percent_Identity=48.6381322957198, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1788550, Length=313, Percent_Identity=38.0191693290735, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1788905, Length=282, Percent_Identity=41.4893617021277, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1789233, Length=467, Percent_Identity=29.3361884368308, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1790437, Length=259, Percent_Identity=38.2239382239382, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1790299, Length=327, Percent_Identity=35.1681957186544, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI87082117, Length=330, Percent_Identity=34.5454545454545, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=35.8255451713396, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082152, Length=248, Percent_Identity=42.741935483871, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI1786524, Length=281, Percent_Identity=40.5693950177936, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=39.2241379310345, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789828, Length=260, Percent_Identity=31.1538461538462, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081858, Length=357, Percent_Identity=25.2100840336134, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 58023; Mature: 58023

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVSCQDRVGLAKDILIVLEKYGINLLAIDASNRGFLYFQFAEVSFDTLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VESVHDVRTVAFMPSEQEHYALKTLLRTLPDSVFSIDVKGRVRIVNESALMTLGMKEHEV
HHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCHHEEECCHHHHH
VEESLNHWVQGFSFGRWLSESQVLAQATRVHIGQNEYLAEMLPIYLPDENDKSILAGAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCCCCCCHHHHHHHH
SLKSPARVGKQFNALQNQTTGFENVLAVSDKMKEVLKQAKRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARACHDASMRRERPFIAINCAALPDSAAEEELFGFVRDGHIVKRGLFEEAKGGSVFLD
HHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHH
EIAEMSKAAQVKLLRLLTEGSFRRIGGDEEVRADVRIICSSQKNLAELCQMGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHCCHHEEECCCCCHHHHHHHCHHHHHHHH
RIHVLSFHMPSLRERKVDIIPLTEMFLEHYSQQLSSPMRRISPNCRDHLLTYAWPGNVRQ
EEEEEEECCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNQFEGTLDEAMRQFESSLLRRLYP
HHHHHHHHHHHCCCCCCEEHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKISKKR
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLEVSCQDRVGLAKDILIVLEKYGINLLAIDASNRGFLYFQFAEVSFDTLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VESVHDVRTVAFMPSEQEHYALKTLLRTLPDSVFSIDVKGRVRIVNESALMTLGMKEHEV
HHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCHHEEECCHHHHH
VEESLNHWVQGFSFGRWLSESQVLAQATRVHIGQNEYLAEMLPIYLPDENDKSILAGAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCCCCCCHHHHHHHH
SLKSPARVGKQFNALQNQTTGFENVLAVSDKMKEVLKQAKRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARACHDASMRRERPFIAINCAALPDSAAEEELFGFVRDGHIVKRGLFEEAKGGSVFLD
HHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHH
EIAEMSKAAQVKLLRLLTEGSFRRIGGDEEVRADVRIICSSQKNLAELCQMGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHCCHHEEECCCCCHHHHHHHCHHHHHHHH
RIHVLSFHMPSLRERKVDIIPLTEMFLEHYSQQLSSPMRRISPNCRDHLLTYAWPGNVRQ
EEEEEEECCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNQFEGTLDEAMRQFESSLLRRLYP
HHHHHHHHHHHCCCCCCEEHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKISKKR
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]