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The map label for this gene is yciK [H]

Identifier: 119775256

GI number: 119775256

Start: 2566971

End: 2567708

Strand: Direct

Name: yciK [H]

Synonym: Sama_2121

Alternate gene names: 119775256

Gene position: 2566971-2567708 (Clockwise)

Preceding gene: 119775252

Following gene: 119775257

Centisome position: 59.61

GC content: 55.69

Gene sequence:

>738_bases
ATGTTGGAATATAAAGTTGCCCCCGATGCTCTGAAAGGCAAAACGATTCTGGTTACCGGTGCCGGTGACGGTATCGGCCG
CGCTGCGGCACTGGCTTACGCCGCCCACGGCGCCACTGTGATCCTGCTGGGCCGCACTGTGAAGAAACTCGAAGCCGTTT
ACGATGAAATTGAAGCGGCAGGCCAGCCTACTCCGGCCATTGTGCCTTTGGATATGAAAGGCGCTACAGAGCAAAACTAC
CGCGACATGGCAGATACCATCGAAGAGCAATTTGGCCATCTCGACGGCGTGCTGCACAATGCCAGTGTACTGGGCGTGCT
GGGTCCGTTTGAACACATAGATTTGGCTTCACTCGAAGAAGTCATGAAGGTCAACGTTACCGCTCAGGCGATCATGACCA
AAAGCCTGCTCAAGGTGCTGCGCAAGGCGCCTGCCGCCTCGGTTATTTTTACCTCCAGCGGTGTTGGCCGTACTGGCCGG
GCCTACTGGGGCCCTTATGCCTTTTCCAAATTTGCCACCGAAGGCATGATGCAGGTGCTCGCCCACGAATGTGATGGCAC
CAATGTGCGGGCCAATTCAATTAACCCCGGTGCTACCCGTACCAAGATGCGCGCCAACGCTTATCCGGGTGAAGATCCGC
AAACCCTGAAAACGGCCGAAGAGCTGATGCCGCTGTATGTCTATCTGATGGCAGACGACAGCAAAGACCAGAATGGTCAG
GCCTTCAGCGCACAATAA

Upstream 100 bases:

>100_bases
AGTGAACGCCCAATAAACAGTCAATTGTTTTAAACAGCTGTATGACTCATAAAATCCCTCAGTAAAGACGGGAAGTTGCG
CCAAGAGGAAGTTTAAATCC

Downstream 100 bases:

>100_bases
GCTCTATTCACAAGGCCCGCTGCAGCGGGCTTTTTTATATTTACTCTCAGCCAAATACAATAAAGAGCAAAGACTATGAC
AGCTCCCTACCCTATTGGCA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLEYKVAPDALKGKTILVTGAGDGIGRAAALAYAAHGATVILLGRTVKKLEAVYDEIEAAGQPTPAIVPLDMKGATEQNY
RDMADTIEEQFGHLDGVLHNASVLGVLGPFEHIDLASLEEVMKVNVTAQAIMTKSLLKVLRKAPAASVIFTSSGVGRTGR
AYWGPYAFSKFATEGMMQVLAHECDGTNVRANSINPGATRTKMRANAYPGEDPQTLKTAEELMPLYVYLMADDSKDQNGQ
AFSAQ

Sequences:

>Translated_245_residues
MLEYKVAPDALKGKTILVTGAGDGIGRAAALAYAAHGATVILLGRTVKKLEAVYDEIEAAGQPTPAIVPLDMKGATEQNY
RDMADTIEEQFGHLDGVLHNASVLGVLGPFEHIDLASLEEVMKVNVTAQAIMTKSLLKVLRKAPAASVIFTSSGVGRTGR
AYWGPYAFSKFATEGMMQVLAHECDGTNVRANSINPGATRTKMRANAYPGEDPQTLKTAEELMPLYVYLMADDSKDQNGQ
AFSAQ
>Mature_245_residues
MLEYKVAPDALKGKTILVTGAGDGIGRAAALAYAAHGATVILLGRTVKKLEAVYDEIEAAGQPTPAIVPLDMKGATEQNY
RDMADTIEEQFGHLDGVLHNASVLGVLGPFEHIDLASLEEVMKVNVTAQAIMTKSLLKVLRKAPAASVIFTSSGVGRTGR
AYWGPYAFSKFATEGMMQVLAHECDGTNVRANSINPGATRTKMRANAYPGEDPQTLKTAEELMPLYVYLMADDSKDQNGQ
AFSAQ

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=197, Percent_Identity=27.9187817258883, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI157739938, Length=204, Percent_Identity=26.9607843137255, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4504505, Length=245, Percent_Identity=28.1632653061224, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4557649, Length=226, Percent_Identity=27.8761061946903, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=29.0155440414508, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7657478, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=26, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI19923817, Length=212, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20149619, Length=214, Percent_Identity=26.1682242990654, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787526, Length=244, Percent_Identity=50.8196721311475, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87082100, Length=223, Percent_Identity=30.0448430493274, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790717, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789378, Length=236, Percent_Identity=29.2372881355932, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=30.6122448979592, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=196, Percent_Identity=27.5510204081633, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=196, Percent_Identity=29.5918367346939, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=196, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=207, Percent_Identity=29.951690821256, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=223, Percent_Identity=31.390134529148, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=209, Percent_Identity=29.1866028708134, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=196, Percent_Identity=30.1020408163265, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=196, Percent_Identity=26.530612244898, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193210355, Length=235, Percent_Identity=26.3829787234043, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=253, Percent_Identity=28.0632411067194, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=199, Percent_Identity=26.1306532663317, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=240, Percent_Identity=29.5833333333333, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=207, Percent_Identity=31.8840579710145, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=30.9623430962343, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=25.4098360655738, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=208, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=29.2929292929293, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553409, Length=201, Percent_Identity=28.8557213930348, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24647948, Length=201, Percent_Identity=28.8557213930348, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24647946, Length=218, Percent_Identity=27.9816513761468, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26162; Mature: 26162

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEYKVAPDALKGKTILVTGAGDGIGRAAALAYAAHGATVILLGRTVKKLEAVYDEIEAA
CCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHC
GQPTPAIVPLDMKGATEQNYRDMADTIEEQFGHLDGVLHNASVLGVLGPFEHIDLASLEE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHCCHHHHHH
VMKVNVTAQAIMTKSLLKVLRKAPAASVIFTSSGVGRTGRAYWGPYAFSKFATEGMMQVL
HHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AHECDGTNVRANSINPGATRTKMRANAYPGEDPQTLKTAEELMPLYVYLMADDSKDQNGQ
HHHCCCCCEEECCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCC
AFSAQ
EECCC
>Mature Secondary Structure
MLEYKVAPDALKGKTILVTGAGDGIGRAAALAYAAHGATVILLGRTVKKLEAVYDEIEAA
CCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHC
GQPTPAIVPLDMKGATEQNYRDMADTIEEQFGHLDGVLHNASVLGVLGPFEHIDLASLEE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHCCHHHHHH
VMKVNVTAQAIMTKSLLKVLRKAPAASVIFTSSGVGRTGRAYWGPYAFSKFATEGMMQVL
HHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AHECDGTNVRANSINPGATRTKMRANAYPGEDPQTLKTAEELMPLYVYLMADDSKDQNGQ
HHHCCCCCEEECCCCCCCCHHEEECCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCC
AFSAQ
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]