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The map label for this gene is pdhA [H]

Identifier: 119774845

GI number: 119774845

Start: 2088734

End: 2089912

Strand: Direct

Name: pdhA [H]

Synonym: Sama_1709

Alternate gene names: 119774845

Gene position: 2088734-2089912 (Clockwise)

Preceding gene: 119774844

Following gene: 119774846

Centisome position: 48.51

GC content: 55.89

Gene sequence:

>1179_bases
ATGAGCAACGCATCAACAAACCAAGAGACAGTGCACAAAGTCTCCTTCCTCGACAGGGAGTCGCTGCACATCCCCATTCT
CAAGATCCTTCAGGCAGACGGCACTCCCTACGAGCAAGCCGTTCTGCCTCAAATCGATGAAGCCCTCGCCCAGCGCATCT
ACGACGCCTGCGTGTTTACCCGTGTGCTGGATGAGCGCATGTTGGGCGCACAGCGCCAGGGCCGTATCAGTTTTTACATG
ACCTGTACCGGTGAAGAAGCGGCCATCCTCGGCAGCGTTGCGGCGCTGGATGAGAAAGACGTTATTCTGGCCCAGTACCG
TGAGCACGCCGCGCTGCGTTATCGCGGTTTCACCACCGAGCAGTTTATGAACCAGATGTTCAGTAACGAAAAAGACCTCG
GTAAGGGCCGCCAGATGCCCATTCACTACGGCACCGCAGCGCTGCATTATCAAACCATTTCATCGCCACTGGGTACCCAA
ATCCCACAGGCGACTGGCGTGGGTTACAGCCTGAAGATGAAGGGCGAGCGTAATGTGGCTATTTGCTACTTTGGTGAAGG
CGCCGCATCTGAAGGTGATTTCCACGCCGGCATGAACATGGCTGCTGTGCTCAAGTCTCCGGTAATTTTCTTCTGCCGCA
ACAACGGCTATGCCATTTCCACCCCCACCGAAGAGCAGTTTGCCGGTAACGGCATTGCCAGCCGCGGTGTGGGCTATGGC
ATGCATACTATCCGCGTAGATGGCAACGATATGCTGGCGGTACTCGCCGCTACCCAGCAGGCCCGCGCCTATGCACTGGA
GCATAACGCGCCTGTGCTGATTGAAGCCATGACCTACCGTCTTGGTGCTCACTCAACCTCGGACGATCCTTCCGGCTATC
GCTCCAAGGAAGAAGAGGCCAAGTGGCGCGAGCACGATCCGGTGAAACGCTTCAAGCTGTGGATGATTAATAAAGGTTGG
CTCGCCGAAGCCAACGATGAAGCCCTGTATGAGCGCTACCGGGAAGAAGTCTTGGCCGCTGTGAAAGTGGCTGAGAAGAT
CCCGGCGCCCCGCATCGATGAGATCATTGAGGATGTTTACGATGAGCCAACGCCGCTGCTGAAAAAGCAGCTGGAGTCAC
TGAAGGCTCACGTGAAGAAGTATCCGCAAGCTTATCCAAAAACTGCAGGGAGACTCTAA

Upstream 100 bases:

>100_bases
GTGTAATGATTGTCAGGTAGTTTACGTTAACGTAATGTTCATCCCGCGTTTTACATACAGGTCTGCCGTGGGTGGGCCTC
AATGATAACAAGAGCAGAAT

Downstream 100 bases:

>100_bases
GCCGTGGCTGAAATGAATATGTTGCAAGCCATCAACAGTGCCCTGCGCATTGCGATGGAAAAAGACCCGACCATGTTAGT
GTTCGGGGAAGACGTGGGCC

Product: 3-methyl-2-oxobutanoate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSNASTNQETVHKVSFLDRESLHIPILKILQADGTPYEQAVLPQIDEALAQRIYDACVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAILGSVAALDEKDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGTAALHYQTISSPLGTQ
IPQATGVGYSLKMKGERNVAICYFGEGAASEGDFHAGMNMAAVLKSPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYALEHNAPVLIEAMTYRLGAHSTSDDPSGYRSKEEEAKWREHDPVKRFKLWMINKGW
LAEANDEALYERYREEVLAAVKVAEKIPAPRIDEIIEDVYDEPTPLLKKQLESLKAHVKKYPQAYPKTAGRL

Sequences:

>Translated_392_residues
MSNASTNQETVHKVSFLDRESLHIPILKILQADGTPYEQAVLPQIDEALAQRIYDACVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAILGSVAALDEKDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGTAALHYQTISSPLGTQ
IPQATGVGYSLKMKGERNVAICYFGEGAASEGDFHAGMNMAAVLKSPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYALEHNAPVLIEAMTYRLGAHSTSDDPSGYRSKEEEAKWREHDPVKRFKLWMINKGW
LAEANDEALYERYREEVLAAVKVAEKIPAPRIDEIIEDVYDEPTPLLKKQLESLKAHVKKYPQAYPKTAGRL
>Mature_391_residues
SNASTNQETVHKVSFLDRESLHIPILKILQADGTPYEQAVLPQIDEALAQRIYDACVFTRVLDERMLGAQRQGRISFYMT
CTGEEAAILGSVAALDEKDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGTAALHYQTISSPLGTQI
PQATGVGYSLKMKGERNVAICYFGEGAASEGDFHAGMNMAAVLKSPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYGM
HTIRVDGNDMLAVLAATQQARAYALEHNAPVLIEAMTYRLGAHSTSDDPSGYRSKEEEAKWREHDPVKRFKLWMINKGWL
AEANDEALYERYREEVLAAVKVAEKIPAPRIDEIIEDVYDEPTPLLKKQLESLKAHVKKYPQAYPKTAGRL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=380, Percent_Identity=48.4210526315789, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI258645172, Length=380, Percent_Identity=48.4210526315789, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI4885543, Length=290, Percent_Identity=28.6206896551724, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI291084742, Length=290, Percent_Identity=30, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4505685, Length=290, Percent_Identity=30, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI291084744, Length=283, Percent_Identity=29.6819787985866, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI291084757, Length=290, Percent_Identity=26.551724137931, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=365, Percent_Identity=50.4109589041096, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI86563357, Length=365, Percent_Identity=50.4109589041096, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17536047, Length=342, Percent_Identity=28.6549707602339, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=342, Percent_Identity=28.6549707602339, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=305, Percent_Identity=28.8524590163934, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355903, Length=367, Percent_Identity=46.3215258855586, Blast_Score=347, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24639740, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639746, Length=300, Percent_Identity=30, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639744, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28571106, Length=279, Percent_Identity=31.1827956989247, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639748, Length=279, Percent_Identity=30.4659498207885, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 43749; Mature: 43618

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNASTNQETVHKVSFLDRESLHIPILKILQADGTPYEQAVLPQIDEALAQRIYDACVFT
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAILGSVAALDEKDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGTAALHYQTISSPLGTQIPQATGVGYSLKMKGERNVA
HHHHHHHCCCCCCCCCCCCCEEECCCEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCEE
ICYFGEGAASEGDFHAGMNMAAVLKSPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYALEHNAPVLIEAMTYRLGAHSTSDDPSGYRSKEEEA
EEEEEECCCCEEEEEHHHHHHHHEEECCCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHH
KWREHDPVKRFKLWMINKGWLAEANDEALYERYREEVLAAVKVAEKIPAPRIDEIIEDVY
HHCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DEPTPLLKKQLESLKAHVKKYPQAYPKTAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNASTNQETVHKVSFLDRESLHIPILKILQADGTPYEQAVLPQIDEALAQRIYDACVFT
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAILGSVAALDEKDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGTAALHYQTISSPLGTQIPQATGVGYSLKMKGERNVA
HHHHHHHCCCCCCCCCCCCCEEECCCEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCCEE
ICYFGEGAASEGDFHAGMNMAAVLKSPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYALEHNAPVLIEAMTYRLGAHSTSDDPSGYRSKEEEA
EEEEEECCCCEEEEEHHHHHHHHEEECCCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHH
KWREHDPVKRFKLWMINKGWLAEANDEALYERYREEVLAAVKVAEKIPAPRIDEIIEDVY
HHCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DEPTPLLKKQLESLKAHVKKYPQAYPKTAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA