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The map label for this gene is bkdA2 [H]

Identifier: 119774846

GI number: 119774846

Start: 2089916

End: 2090893

Strand: Direct

Name: bkdA2 [H]

Synonym: Sama_1710

Alternate gene names: 119774846

Gene position: 2089916-2090893 (Clockwise)

Preceding gene: 119774845

Following gene: 119774847

Centisome position: 48.53

GC content: 56.03

Gene sequence:

>978_bases
GTGGCTGAAATGAATATGTTGCAAGCCATCAACAGTGCCCTGCGCATTGCGATGGAAAAAGACCCGACCATGTTAGTGTT
CGGGGAAGACGTGGGCCATTTTGGTGGCGTGTTTCGCGCGACCTCCGGCCTGCAGGATACCTTTGGCAGGGGCCGCTGCT
TTAACACCCCGCTGACAGAGCAGGGCATTGCCGGTTTTGCCAATGGTCTGGCCTCTAACGGCACCACTGCTGTGGCCGAA
ATTCAGTTCGCCGACTACATCTTCCCGGCATTCGACCAGATTGTAAACGAGAGTGCCAAGTTCCGTTATCGCTCAGGTAA
CGAGTTCAATGTGGGCGGCCTGGTGTATCGCACCCCTTATGGGGGCGGTATCGCCGGTGGTCACTATCACTCTCAGTCGC
CTGAAGCGTATTTCACCCAGACCCCGGGGCTCAAGGTGGTTGTACCCCGTAACGCACATCAGGCCAAGGGCCTGCTGCTG
GCATCGATTCGCGACAAAAATCCTGTGGTGTTCTTCGAGCCCAAGCGTCTGTACCGTGCCAGTGTTGGCGAAGTGCCTGA
AGGTGATTACGAGCTGCCACTGGGTAAGGCCGAAGTGGTGAAAGAGGGCAAAGACATCACACTGCTCGCTTGGGGCGCGC
AGATGGAAATCGTCGAAAAAGCTGCCGAAATGGCCGAAAAAGAAGGCATTTCCTGTGAAATCATCGACCTTCGCACCCTG
TCACCCTGGGATGTGGACACAGTGGCCGAGTCGGTGAAAAAGACCGGCCGTTTGCTCATTAACCACGAAGCGCCGCTCAC
CGGTGGCTTTGCCGGCGAAATCGCGGCGACCATTCAGGAAGAGTGCTTCCTGTATCTGGAGTCGCCCATCGCCCGGGTTT
GTGGTTTGGATACCCCGTATCCGCTTATCCACGAAAAAGAATACATGCCGGATGCGCTCAAGACATTTGAAGCCATCAAG
GCCAGCGTCAACTTCTAG

Upstream 100 bases:

>100_bases
TGAGCCAACGCCGCTGCTGAAAAAGCAGCTGGAGTCACTGAAGGCTCACGTGAAGAAGTATCCGCAAGCTTATCCAAAAA
CTGCAGGGAGACTCTAAGCC

Downstream 100 bases:

>100_bases
GAGTCCGGTATGATTAAAGATTTTATTTTGCCGGACATCGGTGAAGGTGTGGTCGAGTGCGAATTGGTCGAATGGCTGGT
GAAAGAAGGCGACCATATTG

Product: alpha keto acid dehydrogenase complex, E1 component subunit beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAEMNMLQAINSALRIAMEKDPTMLVFGEDVGHFGGVFRATSGLQDTFGRGRCFNTPLTEQGIAGFANGLASNGTTAVAE
IQFADYIFPAFDQIVNESAKFRYRSGNEFNVGGLVYRTPYGGGIAGGHYHSQSPEAYFTQTPGLKVVVPRNAHQAKGLLL
ASIRDKNPVVFFEPKRLYRASVGEVPEGDYELPLGKAEVVKEGKDITLLAWGAQMEIVEKAAEMAEKEGISCEIIDLRTL
SPWDVDTVAESVKKTGRLLINHEAPLTGGFAGEIAATIQEECFLYLESPIARVCGLDTPYPLIHEKEYMPDALKTFEAIK
ASVNF

Sequences:

>Translated_325_residues
MAEMNMLQAINSALRIAMEKDPTMLVFGEDVGHFGGVFRATSGLQDTFGRGRCFNTPLTEQGIAGFANGLASNGTTAVAE
IQFADYIFPAFDQIVNESAKFRYRSGNEFNVGGLVYRTPYGGGIAGGHYHSQSPEAYFTQTPGLKVVVPRNAHQAKGLLL
ASIRDKNPVVFFEPKRLYRASVGEVPEGDYELPLGKAEVVKEGKDITLLAWGAQMEIVEKAAEMAEKEGISCEIIDLRTL
SPWDVDTVAESVKKTGRLLINHEAPLTGGFAGEIAATIQEECFLYLESPIARVCGLDTPYPLIHEKEYMPDALKTFEAIK
ASVNF
>Mature_324_residues
AEMNMLQAINSALRIAMEKDPTMLVFGEDVGHFGGVFRATSGLQDTFGRGRCFNTPLTEQGIAGFANGLASNGTTAVAEI
QFADYIFPAFDQIVNESAKFRYRSGNEFNVGGLVYRTPYGGGIAGGHYHSQSPEAYFTQTPGLKVVVPRNAHQAKGLLLA
SIRDKNPVVFFEPKRLYRASVGEVPEGDYELPLGKAEVVKEGKDITLLAWGAQMEIVEKAAEMAEKEGISCEIIDLRTLS
PWDVDTVAESVKKTGRLLINHEAPLTGGFAGEIAATIQEECFLYLESPIARVCGLDTPYPLIHEKEYMPDALKTFEAIKA
SVNF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=61.7283950617284, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=61.7283950617284, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI156564403, Length=329, Percent_Identity=34.3465045592705, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI291084858, Length=329, Percent_Identity=32.8267477203647, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17506935, Length=324, Percent_Identity=60.1851851851852, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=36.5853658536585, Blast_Score=204, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6319698, Length=324, Percent_Identity=36.4197530864198, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=57.4074074074074, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=57.4074074074074, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI21358145, Length=303, Percent_Identity=36.963696369637, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24650940, Length=303, Percent_Identity=36.963696369637, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI160714826, Length=65, Percent_Identity=55.3846153846154, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35454; Mature: 35323

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMNMLQAINSALRIAMEKDPTMLVFGEDVGHFGGVFRATSGLQDTFGRGRCFNTPLTE
CCHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHCCHHHHCCCCHHHCCCCEEECCCCCH
QGIAGFANGLASNGTTAVAEIQFADYIFPAFDQIVNESAKFRYRSGNEFNVGGLVYRTPY
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEECCC
GGGIAGGHYHSQSPEAYFTQTPGLKVVVPRNAHQAKGLLLASIRDKNPVVFFEPKRLYRA
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHCCEEEEEECCCCCEEEECCHHHHHH
SVGEVPEGDYELPLGKAEVVKEGKDITLLAWGAQMEIVEKAAEMAEKEGISCEIIDLRTL
HCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECC
SPWDVDTVAESVKKTGRLLINHEAPLTGGFAGEIAATIQEECFLYLESPIARVCGLDTPY
CCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLIHEKEYMPDALKTFEAIKASVNF
CCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEMNMLQAINSALRIAMEKDPTMLVFGEDVGHFGGVFRATSGLQDTFGRGRCFNTPLTE
CHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHCCHHHHCCCCHHHCCCCEEECCCCCH
QGIAGFANGLASNGTTAVAEIQFADYIFPAFDQIVNESAKFRYRSGNEFNVGGLVYRTPY
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEECCC
GGGIAGGHYHSQSPEAYFTQTPGLKVVVPRNAHQAKGLLLASIRDKNPVVFFEPKRLYRA
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHCCEEEEEECCCCCEEEECCHHHHHH
SVGEVPEGDYELPLGKAEVVKEGKDITLLAWGAQMEIVEKAAEMAEKEGISCEIIDLRTL
HCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEECC
SPWDVDTVAESVKKTGRLLINHEAPLTGGFAGEIAATIQEECFLYLESPIARVCGLDTPY
CCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLIHEKEYMPDALKTFEAIKASVNF
CCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3416875; 10426958 [H]