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The map label for this gene is ppiB [H]

Identifier: 119774357

GI number: 119774357

Start: 1501199

End: 1501708

Strand: Reverse

Name: ppiB [H]

Synonym: Sama_1220

Alternate gene names: 119774357

Gene position: 1501708-1501199 (Counterclockwise)

Preceding gene: 119774359

Following gene: 119774356

Centisome position: 34.87

GC content: 50.98

Gene sequence:

>510_bases
ATGAGTACCGCAACGATGATCACATTGCACACCAACTTTGGCGATATCAAAATCGCCCTGAACCACGAAAAAGCACCGGT
CACTGCCGAAAACTTCCAACGCTATGCCAGCGAAGGATTCTTCGATGGCACTATTTTCCACCGTGTTATCGATGGCTTTA
TGATCCAGGGCGGCGGTTTTACCGAAGATATGGTGCAAAAGCGCACCCATGAGCCAGTGAAAAATGAAGCCAACAACGGT
CTGTCCAACAAGGTTGGCACTATCGCCATGGCCCGTACTTCCGATCCGCATTCGGCGACGGCCCAGTTCTTCATCAACGT
AAATGACAACACCTTCCTGGACTTCAAATCGGAATCCATGCAGGGCTGGGGTTACTGCGTGTTCGGTGAAGTAGTTGAAG
GTATGGACGTAGTAAACGCCATCAAGGGCGTAAACACCGGCAACCGCGGCATGCATCAGGACGTTCCGCTGGAAGCCGTT
GTTATTCAAAAGGTCAGCATCGAAGGCTAA

Upstream 100 bases:

>100_bases
GGTGTAAAATCAGGCCTGTGAGTCTATCATGCTCCAAAGCCCTTGAATACTGCACTTTCAGGGCCGTTCCAGATAAGTTA
GAATCCGCCGACACTTTCAA

Downstream 100 bases:

>100_bases
TTCAGGTCAGATGCGCACCCTCTTTATCGGCGATCTGCATTTGAGTGCAGATCGCCCCGATATTACCTCGGCCTTTCGTC
GCTTTCTCTCACAGTCCTTC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSTATMITLHTNFGDIKIALNHEKAPVTAENFQRYASEGFFDGTIFHRVIDGFMIQGGGFTEDMVQKRTHEPVKNEANNG
LSNKVGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDVVNAIKGVNTGNRGMHQDVPLEAV
VIQKVSIEG

Sequences:

>Translated_169_residues
MSTATMITLHTNFGDIKIALNHEKAPVTAENFQRYASEGFFDGTIFHRVIDGFMIQGGGFTEDMVQKRTHEPVKNEANNG
LSNKVGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDVVNAIKGVNTGNRGMHQDVPLEAV
VIQKVSIEG
>Mature_168_residues
STATMITLHTNFGDIKIALNHEKAPVTAENFQRYASEGFFDGTIFHRVIDGFMIQGGGFTEDMVQKRTHEPVKNEANNGL
SNKVGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESMQGWGYCVFGEVVEGMDVVNAIKGVNTGNRGMHQDVPLEAVV
IQKVSIEG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=35.3658536585366, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=35.3658536585366, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=35.3658536585366, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=31.7365269461078, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI7706339, Length=169, Percent_Identity=31.9526627218935, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI24308049, Length=175, Percent_Identity=29.7142857142857, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI310110104, Length=135, Percent_Identity=34.0740740740741, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI310129267, Length=135, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI310120620, Length=135, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=67.2839506172839, Blast_Score=227, Evalue=3e-61,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=54.0372670807453, Blast_Score=176, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=176, Percent_Identity=31.25, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=33.5616438356164, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=167, Percent_Identity=34.7305389221557, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=167, Percent_Identity=33.5329341317365, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=167, Percent_Identity=33.5329341317365, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=175, Percent_Identity=29.7142857142857, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=37.1794871794872, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321848, Length=161, Percent_Identity=37.2670807453416, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=157, Percent_Identity=35.031847133758, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=154, Percent_Identity=32.4675324675325, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922912, Length=147, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24652460, Length=165, Percent_Identity=28.4848484848485, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18534; Mature: 18403

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTATMITLHTNFGDIKIALNHEKAPVTAENFQRYASEGFFDGTIFHRVIDGFMIQGGGF
CCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCC
TEDMVQKRTHEPVKNEANNGLSNKVGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESM
CHHHHHHHCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCC
QGWGYCVFGEVVEGMDVVNAIKGVNTGNRGMHQDVPLEAVVIQKVSIEG
CCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure 
STATMITLHTNFGDIKIALNHEKAPVTAENFQRYASEGFFDGTIFHRVIDGFMIQGGGF
CCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCC
TEDMVQKRTHEPVKNEANNGLSNKVGTIAMARTSDPHSATAQFFINVNDNTFLDFKSESM
CHHHHHHHCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCC
QGWGYCVFGEVVEGMDVVNAIKGVNTGNRGMHQDVPLEAVVIQKVSIEG
CCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]