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The map label for this gene is lpxH

Identifier: 119774356

GI number: 119774356

Start: 1500472

End: 1501188

Strand: Reverse

Name: lpxH

Synonym: Sama_1219

Alternate gene names: 119774356

Gene position: 1501188-1500472 (Counterclockwise)

Preceding gene: 119774357

Following gene: 119774354

Centisome position: 34.86

GC content: 52.3

Gene sequence:

>717_bases
ATGCGCACCCTCTTTATCGGCGATCTGCATTTGAGTGCAGATCGCCCCGATATTACCTCGGCCTTTCGTCGCTTTCTCTC
ACAGTCCTTCGATGATGTGGATGCCCTGTATATTCTGGGTGATCTGTTTGAAGTGTGGGTGGGTGATGATATTGCGGAGC
CCTTCGCACTGGATATCGCGGCCGATATTGCTGCGCTCAGCCACAAGCTGCCAATTTATTTCATTCACGGAAACCGTGAT
TTCTTAATTGGGAAGCAGTTTGCAGCTATCAGTAAGATGCAGCTACTTGATGAAGTGCATCAAATCAACCTCTACGGCAT
TCCCACGCTGCTGCTTCACGGCGACAGCCTCTGCACCCTCGACAAGGGTTACCAGCGCTTTCGCTGGTTCAGAAACCAGC
CCTGGGTGAAGTGGATTTACAGCAAGTTATCCCAAAGTAAGCGATTGAGCATCGCCGCTAATCTCAGGGCCAAAAGCAAG
GCTGGCAATCAGCTGAAGAGTCAGTACATCATGGATGCCGAACCCCATGCGGTTGCAGACCTGTTGCAAAAGCACAGCTG
CAGGCAAATGATCCACGGCCATACTCACAGACCGGCCATACACCATGAAAGTGCCGGTACCCGTATTGTCGTGGGAGACT
GGTACAGCCAAAGCAGCGTATTGGAAATGACTGCCGAAGGACCCAACCTTCAGGCTAAGCCCCTTGGCGGCAGCTGA

Upstream 100 bases:

>100_bases
ATCAAGGGCGTAAACACCGGCAACCGCGGCATGCATCAGGACGTTCCGCTGGAAGCCGTTGTTATTCAAAAGGTCAGCAT
CGAAGGCTAATTCAGGTCAG

Downstream 100 bases:

>100_bases
AACCTGGTGCCAACTAAAAGCGCTCAGGTATTCGGCACCCCGCTGTGAAAGCGAAACTCGTCATCTGCACCTTGAATCAA
CGCCGCTTCCACCCCGGCGA

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRTLFIGDLHLSADRPDITSAFRRFLSQSFDDVDALYILGDLFEVWVGDDIAEPFALDIAADIAALSHKLPIYFIHGNRD
FLIGKQFAAISKMQLLDEVHQINLYGIPTLLLHGDSLCTLDKGYQRFRWFRNQPWVKWIYSKLSQSKRLSIAANLRAKSK
AGNQLKSQYIMDAEPHAVADLLQKHSCRQMIHGHTHRPAIHHESAGTRIVVGDWYSQSSVLEMTAEGPNLQAKPLGGS

Sequences:

>Translated_238_residues
MRTLFIGDLHLSADRPDITSAFRRFLSQSFDDVDALYILGDLFEVWVGDDIAEPFALDIAADIAALSHKLPIYFIHGNRD
FLIGKQFAAISKMQLLDEVHQINLYGIPTLLLHGDSLCTLDKGYQRFRWFRNQPWVKWIYSKLSQSKRLSIAANLRAKSK
AGNQLKSQYIMDAEPHAVADLLQKHSCRQMIHGHTHRPAIHHESAGTRIVVGDWYSQSSVLEMTAEGPNLQAKPLGGS
>Mature_238_residues
MRTLFIGDLHLSADRPDITSAFRRFLSQSFDDVDALYILGDLFEVWVGDDIAEPFALDIAADIAALSHKLPIYFIHGNRD
FLIGKQFAAISKMQLLDEVHQINLYGIPTLLLHGDSLCTLDKGYQRFRWFRNQPWVKWIYSKLSQSKRLSIAANLRAKSK
AGNQLKSQYIMDAEPHAVADLLQKHSCRQMIHGHTHRPAIHHESAGTRIVVGDWYSQSSVLEMTAEGPNLQAKPLGGS

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=235, Percent_Identity=47.6595744680851, Blast_Score=218, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_SHEAM (A1S4X0)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927096.1
- ProteinModelPortal:   A1S4X0
- STRING:   A1S4X0
- GeneID:   4603471
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1219
- NMPDR:   fig|326297.7.peg.1150
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- PhylomeDB:   A1S4X0
- ProtClustDB:   PRK05340
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 26866; Mature: 26866

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLFIGDLHLSADRPDITSAFRRFLSQSFDDVDALYILGDLFEVWVGDDIAEPFALDIA
CCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADIAALSHKLPIYFIHGNRDFLIGKQFAAISKMQLLDEVHQINLYGIPTLLLHGDSLCTL
HHHHHHHCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCEEEH
DKGYQRFRWFRNQPWVKWIYSKLSQSKRLSIAANLRAKSKAGNQLKSQYIMDAEPHAVAD
HHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHH
LLQKHSCRQMIHGHTHRPAIHHESAGTRIVVGDWYSQSSVLEMTAEGPNLQAKPLGGS
HHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MRTLFIGDLHLSADRPDITSAFRRFLSQSFDDVDALYILGDLFEVWVGDDIAEPFALDIA
CCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADIAALSHKLPIYFIHGNRDFLIGKQFAAISKMQLLDEVHQINLYGIPTLLLHGDSLCTL
HHHHHHHCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCEEEH
DKGYQRFRWFRNQPWVKWIYSKLSQSKRLSIAANLRAKSKAGNQLKSQYIMDAEPHAVAD
HHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHH
LLQKHSCRQMIHGHTHRPAIHHESAGTRIVVGDWYSQSSVLEMTAEGPNLQAKPLGGS
HHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA