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The map label for this gene is uppS [H]

Identifier: 119774280

GI number: 119774280

Start: 1392485

End: 1393285

Strand: Direct

Name: uppS [H]

Synonym: Sama_1143

Alternate gene names: 119774280

Gene position: 1392485-1393285 (Clockwise)

Preceding gene: 119774279

Following gene: 119774281

Centisome position: 32.34

GC content: 52.56

Gene sequence:

>801_bases
ATGTCTTCCAATAGGGAAATTGCCGCTGATTTGGCGTTGGATGCTCAACTCGGTGATGTCTCAGGGTTGGTCAACCAGTC
TCTGCCCCAGCATGTGGCCATCATTATGGATGGCAATGGCCGTTGGGCACAGGCACAGGGCAAACCCAGAGTAATGGGGC
ACAAGGCGGGTGTTAAGGCCGTGCGCCGGGCTGTGAGCACGGCAAGCCAATTGGGCATCAAGTCGTTAACCCTGTTTGCC
TTTTCCAGTGAAAACTGGCGTCGTCCCGATGCTGAAGTCAGCTTGCTGATGGAACTGTTTTTCACGGTGCTGAAACGGGA
AATCAAGCTGCTCAGCAAAAATGGGGTCAGGTTGAACATTATCGGTGATACCAGCCGTTTTTCGGACAGGCTGCAACAGC
AAATTCGCGACGCCGAAGAAAAAACGGCGGCAAACACAGGCCTTATTCTGAACGTTGCCGCCAATTACGGTGGGCGCTGG
GACATACTCCAGGCAGCACAGCAGCTGGCACAAAAGCTGGCATCTGGTGAAATCGACAGCAGTCAGTTTACCGAAGAGGC
CTTAAGTCAGCATTTATGCATGCAAAGTCAGGGCGAAGTTGATTTAATGATCCGTACTGGTGGCGATTACCGCATCAGCA
ATTTTGTGCTCTGGCAGGCAGCCTACGCTGAGTTGGTGTTTACTGACACCCTGTGGCCGGACTTCGACGAGCAATGTTTC
AAAGAGGCTATCGCTTTATTTGCGAGCCGCCAGCGCCGTTTTGGTTTGACCGGAAGTCAAATCGAAGCCTTGCGTGCTTA
A

Upstream 100 bases:

>100_bases
GAGTTGATGGAGGTCTAACCCTCCGGTCAGCAAGCTAGAGTTAAGACGCCGTGTAGGGGTATACTACACGGCGTTTGTTT
ATTTATAGGGTTGTATATCG

Downstream 100 bases:

>100_bases
GTCATCTTTTACGAGGGACGTTTTTTGCTAAAACAACGAATAATAACAGCAATCTGGCTTATCCCACTGGTATTTGGCGC
TATCTTCTATTTGCCTTCAT

Product: di-trans,poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSSNREIAADLALDAQLGDVSGLVNQSLPQHVAIIMDGNGRWAQAQGKPRVMGHKAGVKAVRRAVSTASQLGIKSLTLFA
FSSENWRRPDAEVSLLMELFFTVLKREIKLLSKNGVRLNIIGDTSRFSDRLQQQIRDAEEKTAANTGLILNVAANYGGRW
DILQAAQQLAQKLASGEIDSSQFTEEALSQHLCMQSQGEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEQCF
KEAIALFASRQRRFGLTGSQIEALRA

Sequences:

>Translated_266_residues
MSSNREIAADLALDAQLGDVSGLVNQSLPQHVAIIMDGNGRWAQAQGKPRVMGHKAGVKAVRRAVSTASQLGIKSLTLFA
FSSENWRRPDAEVSLLMELFFTVLKREIKLLSKNGVRLNIIGDTSRFSDRLQQQIRDAEEKTAANTGLILNVAANYGGRW
DILQAAQQLAQKLASGEIDSSQFTEEALSQHLCMQSQGEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEQCF
KEAIALFASRQRRFGLTGSQIEALRA
>Mature_265_residues
SSNREIAADLALDAQLGDVSGLVNQSLPQHVAIIMDGNGRWAQAQGKPRVMGHKAGVKAVRRAVSTASQLGIKSLTLFAF
SSENWRRPDAEVSLLMELFFTVLKREIKLLSKNGVRLNIIGDTSRFSDRLQQQIRDAEEKTAANTGLILNVAANYGGRWD
ILQAAQQLAQKLASGEIDSSQFTEEALSQHLCMQSQGEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEQCFK
EAIALFASRQRRFGLTGSQIEALRA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=34.9775784753363, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=34.9775784753363, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=62.6050420168067, Blast_Score=310, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=32.8638497652582, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=36.2385321100917, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=33.0143540669856, Blast_Score=124, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29451; Mature: 29320

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNREIAADLALDAQLGDVSGLVNQSLPQHVAIIMDGNGRWAQAQGKPRVMGHKAGVKA
CCCCCCCHHHHEECCCHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHH
VRRAVSTASQLGIKSLTLFAFSSENWRRPDAEVSLLMELFFTVLKREIKLLSKNGVRLNI
HHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IGDTSRFSDRLQQQIRDAEEKTAANTGLILNVAANYGGRWDILQAAQQLAQKLASGEIDS
EECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCH
SQFTEEALSQHLCMQSQGEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEQCF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHEECCCCCCHHHHHH
KEAIALFASRQRRFGLTGSQIEALRA
HHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
SSNREIAADLALDAQLGDVSGLVNQSLPQHVAIIMDGNGRWAQAQGKPRVMGHKAGVKA
CCCCCCHHHHEECCCHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHH
VRRAVSTASQLGIKSLTLFAFSSENWRRPDAEVSLLMELFFTVLKREIKLLSKNGVRLNI
HHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IGDTSRFSDRLQQQIRDAEEKTAANTGLILNVAANYGGRWDILQAAQQLAQKLASGEIDS
EECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCH
SQFTEEALSQHLCMQSQGEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEQCF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHEECCCCCCHHHHHH
KEAIALFASRQRRFGLTGSQIEALRA
HHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]