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The map label for this gene is thrB [H]

Identifier: 119774043

GI number: 119774043

Start: 1094830

End: 1095774

Strand: Direct

Name: thrB [H]

Synonym: Sama_0906

Alternate gene names: 119774043

Gene position: 1094830-1095774 (Clockwise)

Preceding gene: 119774042

Following gene: 119774044

Centisome position: 25.42

GC content: 57.04

Gene sequence:

>945_bases
ATGAGTTTGACCGTGTATGCCCCGGCCTCTATGGGTAATGTGGGTGTAGGATTCGATTTGCTCGGTGCGGCGCTTGCGCC
CATCGAGGGCAGTTTACTGGGTGACAGAGTGATGATTGCCGAGGCGAATGCGGGCCTGACGCTTAATACCACTGGCGCCT
GGGCCCACAAGCTGCCTGCCAATCCCAGGGAGAACATCGTTTGGCAGTGTGCCGAGTTTTTCTTACAGCGTTTAGGCAAA
GAAGAGCTTGGTATTGCGCTGACCCTTGAGAAGAACCTGCCGGTGGGTAGTGGTTTGGGGTCCAGTGCCAGCTCTGTGGT
GGCGGCGCTCTATGCCTTGAACGAATATTTCGACAAGCCGTTCGATGAGCAGGCGCTGTTGGCGCTGATGGGCGAGTTTG
AAGGCAAAATCAGCGGCTCTGTGCATTACGACAACGTGGCGCCCTGTTACCTCGGTGGTATGCAGCTGATGCTGGATTTG
CCCGGGCGCATCTGCGAGTCCATCCCCAGCTTCGAGCACTGGTATTGGGTGGTGGCGTATCCGGGGATTTCACTGTCAAC
TGCCAAAATGCGGGCGCTGATGCCGGACAGCTATGATAAGTCCGTGGTCATCGATTTTGGTCGTCACCTGTCTGCTTTTG
TGCACGCTTCTTATCGTCAGGATGAAGCCCTGGCGTTGGCGGTGCTTAAGGATGTGCTGGCCGAACCTTATCGCGCACCT
GCTATTCCGGGGTATCTCGAGGCCCGAGATGCGTTGGCTGAGCTTGGTATGCTCACCAGTGGAATTTCCGGTAGCGGCCC
CACGCTCTTTTCAGTTACTTCCTGCCTCGAGACAGCTGAGGCGGCCAAGGCCTGGCTGGAAGCCCATTATCTTACAGAGG
GCGGTTTTGCCCACGTGTGCCGCCTGGATATGCAGGGCACCCGAGTCGTAGCGAGTGAAGGTTAA

Upstream 100 bases:

>100_bases
CGTTTGTATTGCGGGGATATGGTGCGGGTACCGATGTGACTGCGGCAGGCGCTTTTGCTGACCTGCTGCGTACCCTGAAC
TGGACCCGCGAGGTGAGTTT

Downstream 100 bases:

>100_bases
GGATACGCGATGGAATTATACAATCTTAAGCATCCCGATGAGCGGGTAAGCTTTTCTCAGGCGGTAAAGCTGGGACTGGG
TAAAGACCGCGGGCTGTTTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIEGSLLGDRVMIAEANAGLTLNTTGAWAHKLPANPRENIVWQCAEFFLQRLGK
EELGIALTLEKNLPVGSGLGSSASSVVAALYALNEYFDKPFDEQALLALMGEFEGKISGSVHYDNVAPCYLGGMQLMLDL
PGRICESIPSFEHWYWVVAYPGISLSTAKMRALMPDSYDKSVVIDFGRHLSAFVHASYRQDEALALAVLKDVLAEPYRAP
AIPGYLEARDALAELGMLTSGISGSGPTLFSVTSCLETAEAAKAWLEAHYLTEGGFAHVCRLDMQGTRVVASEG

Sequences:

>Translated_314_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIEGSLLGDRVMIAEANAGLTLNTTGAWAHKLPANPRENIVWQCAEFFLQRLGK
EELGIALTLEKNLPVGSGLGSSASSVVAALYALNEYFDKPFDEQALLALMGEFEGKISGSVHYDNVAPCYLGGMQLMLDL
PGRICESIPSFEHWYWVVAYPGISLSTAKMRALMPDSYDKSVVIDFGRHLSAFVHASYRQDEALALAVLKDVLAEPYRAP
AIPGYLEARDALAELGMLTSGISGSGPTLFSVTSCLETAEAAKAWLEAHYLTEGGFAHVCRLDMQGTRVVASEG
>Mature_313_residues
SLTVYAPASMGNVGVGFDLLGAALAPIEGSLLGDRVMIAEANAGLTLNTTGAWAHKLPANPRENIVWQCAEFFLQRLGKE
ELGIALTLEKNLPVGSGLGSSASSVVAALYALNEYFDKPFDEQALLALMGEFEGKISGSVHYDNVAPCYLGGMQLMLDLP
GRICESIPSFEHWYWVVAYPGISLSTAKMRALMPDSYDKSVVIDFGRHLSAFVHASYRQDEALALAVLKDVLAEPYRAPA
IPGYLEARDALAELGMLTSGISGSGPTLFSVTSCLETAEAAKAWLEAHYLTEGGFAHVCRLDMQGTRVVASEG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=309, Percent_Identity=55.663430420712, Blast_Score=356, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33556; Mature: 33425

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTVYAPASMGNVGVGFDLLGAALAPIEGSLLGDRVMIAEANAGLTLNTTGAWAHKLPA
CEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCC
NPRENIVWQCAEFFLQRLGKEELGIALTLEKNLPVGSGLGSSASSVVAALYALNEYFDKP
CCHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
FDEQALLALMGEFEGKISGSVHYDNVAPCYLGGMQLMLDLPGRICESIPSFEHWYWVVAY
CCHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCHHHHHHCCHHHHHHCCCCCCEEEEEEE
PGISLSTAKMRALMPDSYDKSVVIDFGRHLSAFVHASYRQDEALALAVLKDVLAEPYRAP
CCCEECHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
AIPGYLEARDALAELGMLTSGISGSGPTLFSVTSCLETAEAAKAWLEAHYLTEGGFAHVC
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RLDMQGTRVVASEG
EECCCCCEEEECCC
>Mature Secondary Structure 
SLTVYAPASMGNVGVGFDLLGAALAPIEGSLLGDRVMIAEANAGLTLNTTGAWAHKLPA
EEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCC
NPRENIVWQCAEFFLQRLGKEELGIALTLEKNLPVGSGLGSSASSVVAALYALNEYFDKP
CCHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
FDEQALLALMGEFEGKISGSVHYDNVAPCYLGGMQLMLDLPGRICESIPSFEHWYWVVAY
CCHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCHHHHHHCCHHHHHHCCCCCCEEEEEEE
PGISLSTAKMRALMPDSYDKSVVIDFGRHLSAFVHASYRQDEALALAVLKDVLAEPYRAP
CCCEECHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
AIPGYLEARDALAELGMLTSGISGSGPTLFSVTSCLETAEAAKAWLEAHYLTEGGFAHVC
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RLDMQGTRVVASEG
EECCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]