| Definition | Shewanella amazonensis SB2B chromosome, complete genome. |
|---|---|
| Accession | NC_008700 |
| Length | 4,306,142 |
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The map label for this gene is thrA [H]
Identifier: 119774042
GI number: 119774042
Start: 1092368
End: 1094833
Strand: Direct
Name: thrA [H]
Synonym: Sama_0905
Alternate gene names: 119774042
Gene position: 1092368-1094833 (Clockwise)
Preceding gene: 119774039
Following gene: 119774043
Centisome position: 25.37
GC content: 56.29
Gene sequence:
>2466_bases ATGAAAGTCATGAAGTTTGGGGGAACCTCGCTGGCGAACTGGCAGCGATTTGATATGGCGGCCGCTATCGTGGCCGAAGC GGCAAAAGCATCGCAAGTTGCAGCCGTGCTGTCGGCGCCAGCCACAGTGACCAACGGACTGTTGGACATGGTGGATGTTG CCGTCACTGGCGGCGACTATCAGGCAGTGCTTGGGCGGGTTGTCGGTGTGTTTGAGGCGTTGTTTGATGATGCGTGTCAA CATCAGGTACCCCAATGCCGTGAACACCTGTTTGCTGCTCTTTCGGCTCAGAAGCACGCATGGCAAACGCGTCTTGAAGG TGTGGCCTTGCTGGGAGAATGCCCCGATGGCGTACGTGCTGAAATTGTGGTGGCGGGCGAGCGTCTGTCCACCGAGCTGA TGGTGGCCTTGATGAACGCCCACTGGTTAAGCGCCGATAAACTCGATCCCCGGGCGCTGTTTTTAGCCCACGGCACGCCA CTGGAGTCGGTGGTGGACATAGGTGTCAGCAAACCCAGATTCAAACAATTACCGCTGGACAGCAAACGGGTTTGGGTGAT GCCGGGCTTCACCGCCGCCGATGACAAGGGGCGTACAGTTACGCTTGGGCGCAACGGTTCTGACTACTCGGCAGCTGTGC TTGCCGCTTGCCTCGATGCAAGCAGCTGTGAAATCTGGACTGATGTGGATGGGGTATATAACACCGATCCTCGGGTTGTA GCGGACGCCAAGTTACTGTCGCAATTGTCTTATCAGGAGGCCATGGAGCTGTCCTACTTCGGTGCCAAGGTGTTGCACCC CAAGACAATAGCGCCCATCGCCCAGTTTCACATTCCCTGCTACATCAAAAACAGCTTTAATCCCGAGGCCCCGGGTACCC TGGTGTCCAATGCGGTCGATGAAACAGGCCTGCAGGTAAAAGCAATTTCCAGCCTCGACAATCAAACTATGTTTGATGTG TCCGGTCCGGGCATGAAAGGCATGGTAGGTATGGCAAGCCGCACCCTGGGTGCCATTGCCCGCGCCGGTGTCTCTGTATC CCTTATCACCCAAAGTTCTTGCGAATACTCAATCAGCTTTTGTGTTGCAGGAAAAGATGCTGCCAAGGTGCAATCGGCGC TGGAGCAAGAGTTTGAGCTGGAGCTCAAAAGTGAGCTGCTGGAACCGCTGGAAATGCAATCCGGGCTGGCGATAGTGTCG CTTATCGGCGATGGCATGCGCACCCATAAGGGCGTAGCGGCCAAGTTTTTCTCTGCACTGGCACAGGCCAGTGTGAATAT CCGGGCCATAGCTCAGGGGTCTTCCGAGCGTTCTATCTCCGCCGTGGTGGAGCAGCGCAAGGTACAAAATGCCATCGGCG CCTGTCATCAGCGCTTCTTCGATGTACAGCAGTATTTGGACGTGTTCCTGGTTGGCGCGGGTAATGTGGGGGCAGGGCTC CTTGCACAGGTGAAAAATCAGGCAGAAGCGCTCAAAGAGCAGCACATCAGCATCCGCGTCTGTGGTATCGCCAACTCCCG CAAGATGCTGCTGGATGAACGTGGTATTGACCTGGCTAACTGGCAGGGGCTGCTTAACGACAGTGAAACGGGCTGCGACC TTGGCGCCATGCTTGCCTGGGCGAAAGAAAAGCAGCTGCTCAATCCGGTGCTGGTGGACTGCACCTCGTCGGCAGCCGTG GCCGACCGCTATCTTGAGGTCATGGAAGCGGGGATGCACGTTGTGACCCCCAATAAGAAAGCCAATACCCGCGATCTGGG ATACTACCGTGCTCTGCGTGAGGCTGCGCTCAGACACAGACGTCAGTTCCTGTACGAGACCAATGTCGGCGCGGGGCTGC CGGTTATCGATAACCTGAAAAAACTGCTGTGTGCCGGCGATAAACTCCATAAGTTCAATGGCATACTCTCAGGTTCTCTC TCATTTATCTTCGGTAAGCTGGAAGAGGGCATGAGTCTGTCCGAGGCAACCTCCATCGCCCGTGACAAGTGTTTTACCGA GCCGGATCCGAGGGATGATCTCTCCGGCATGGATGTGGCCCGTAAGGTGCTGATTCTTGCCCGCGAGGTGGGGATGCCAC TTGAGCTTGAGGATGTGGTGGTGGACTCAGTACTGCCTGCATCTTTCGATGCCAATGGCGATGTGAGTACCTTTATGGCC AATCTTCACAAGGCGGATACAGAGATAGCCACCATGGTGGAAAATGCCCGCAGTGAGGGCAAGGTCCTGCGCTACGTGGG CCAGATTGATGAATCTGGCTGTCGGGTGAGTATTCAGGCCGTGGGTCCGGAAGCTCCACTCTTCAGCGTCAAGGGCGGCG AGAATGCGCTCGCTTTCTACAGCCGTTACTATCAACCCATTCCGTTTGTATTGCGGGGATATGGTGCGGGTACCGATGTG ACTGCGGCAGGCGCTTTTGCTGACCTGCTGCGTACCCTGAACTGGACCCGCGAGGTGAGTTTATGA
Upstream 100 bases:
>100_bases GGGCTGATTTTACCCTGAAAAGAATGAACATTAAGGCCCGCTCCCCCAAAAGGAGCGGGTTTTTTGTTTCTGGGGCGAGC GAGGTAAACGGAGTAGCAAG
Downstream 100 bases:
>100_bases GTTTGACCGTGTATGCCCCGGCCTCTATGGGTAATGTGGGTGTAGGATTCGATTTGCTCGGTGCGGCGCTTGCGCCCATC GAGGGCAGTTTACTGGGTGA
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 821; Mature: 821
Protein sequence:
>821_residues MKVMKFGGTSLANWQRFDMAAAIVAEAAKASQVAAVLSAPATVTNGLLDMVDVAVTGGDYQAVLGRVVGVFEALFDDACQ HQVPQCREHLFAALSAQKHAWQTRLEGVALLGECPDGVRAEIVVAGERLSTELMVALMNAHWLSADKLDPRALFLAHGTP LESVVDIGVSKPRFKQLPLDSKRVWVMPGFTAADDKGRTVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVV ADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPEAPGTLVSNAVDETGLQVKAISSLDNQTMFDV SGPGMKGMVGMASRTLGAIARAGVSVSLITQSSCEYSISFCVAGKDAAKVQSALEQEFELELKSELLEPLEMQSGLAIVS LIGDGMRTHKGVAAKFFSALAQASVNIRAIAQGSSERSISAVVEQRKVQNAIGACHQRFFDVQQYLDVFLVGAGNVGAGL LAQVKNQAEALKEQHISIRVCGIANSRKMLLDERGIDLANWQGLLNDSETGCDLGAMLAWAKEKQLLNPVLVDCTSSAAV ADRYLEVMEAGMHVVTPNKKANTRDLGYYRALREAALRHRRQFLYETNVGAGLPVIDNLKKLLCAGDKLHKFNGILSGSL SFIFGKLEEGMSLSEATSIARDKCFTEPDPRDDLSGMDVARKVLILAREVGMPLELEDVVVDSVLPASFDANGDVSTFMA NLHKADTEIATMVENARSEGKVLRYVGQIDESGCRVSIQAVGPEAPLFSVKGGENALAFYSRYYQPIPFVLRGYGAGTDV TAAGAFADLLRTLNWTREVSL
Sequences:
>Translated_821_residues MKVMKFGGTSLANWQRFDMAAAIVAEAAKASQVAAVLSAPATVTNGLLDMVDVAVTGGDYQAVLGRVVGVFEALFDDACQ HQVPQCREHLFAALSAQKHAWQTRLEGVALLGECPDGVRAEIVVAGERLSTELMVALMNAHWLSADKLDPRALFLAHGTP LESVVDIGVSKPRFKQLPLDSKRVWVMPGFTAADDKGRTVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVV ADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPEAPGTLVSNAVDETGLQVKAISSLDNQTMFDV SGPGMKGMVGMASRTLGAIARAGVSVSLITQSSCEYSISFCVAGKDAAKVQSALEQEFELELKSELLEPLEMQSGLAIVS LIGDGMRTHKGVAAKFFSALAQASVNIRAIAQGSSERSISAVVEQRKVQNAIGACHQRFFDVQQYLDVFLVGAGNVGAGL LAQVKNQAEALKEQHISIRVCGIANSRKMLLDERGIDLANWQGLLNDSETGCDLGAMLAWAKEKQLLNPVLVDCTSSAAV ADRYLEVMEAGMHVVTPNKKANTRDLGYYRALREAALRHRRQFLYETNVGAGLPVIDNLKKLLCAGDKLHKFNGILSGSL SFIFGKLEEGMSLSEATSIARDKCFTEPDPRDDLSGMDVARKVLILAREVGMPLELEDVVVDSVLPASFDANGDVSTFMA NLHKADTEIATMVENARSEGKVLRYVGQIDESGCRVSIQAVGPEAPLFSVKGGENALAFYSRYYQPIPFVLRGYGAGTDV TAAGAFADLLRTLNWTREVSL >Mature_821_residues MKVMKFGGTSLANWQRFDMAAAIVAEAAKASQVAAVLSAPATVTNGLLDMVDVAVTGGDYQAVLGRVVGVFEALFDDACQ HQVPQCREHLFAALSAQKHAWQTRLEGVALLGECPDGVRAEIVVAGERLSTELMVALMNAHWLSADKLDPRALFLAHGTP LESVVDIGVSKPRFKQLPLDSKRVWVMPGFTAADDKGRTVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVV ADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPEAPGTLVSNAVDETGLQVKAISSLDNQTMFDV SGPGMKGMVGMASRTLGAIARAGVSVSLITQSSCEYSISFCVAGKDAAKVQSALEQEFELELKSELLEPLEMQSGLAIVS LIGDGMRTHKGVAAKFFSALAQASVNIRAIAQGSSERSISAVVEQRKVQNAIGACHQRFFDVQQYLDVFLVGAGNVGAGL LAQVKNQAEALKEQHISIRVCGIANSRKMLLDERGIDLANWQGLLNDSETGCDLGAMLAWAKEKQLLNPVLVDCTSSAAV ADRYLEVMEAGMHVVTPNKKANTRDLGYYRALREAALRHRRQFLYETNVGAGLPVIDNLKKLLCAGDKLHKFNGILSGSL SFIFGKLEEGMSLSEATSIARDKCFTEPDPRDDLSGMDVARKVLILAREVGMPLELEDVVVDSVLPASFDANGDVSTFMA NLHKADTEIATMVENARSEGKVLRYVGQIDESGCRVSIQAVGPEAPLFSVKGGENALAFYSRYYQPIPFVLRGYGAGTDV TAAGAFADLLRTLNWTREVSL
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=56.8292682926829, Blast_Score=904, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=827, Percent_Identity=32.1644498186215, Blast_Score=359, Evalue=1e-100, Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=31.3978494623656, Blast_Score=185, Evalue=1e-47, Organism=Saccharomyces cerevisiae, GI6322599, Length=338, Percent_Identity=33.4319526627219, Blast_Score=166, Evalue=2e-41, Organism=Saccharomyces cerevisiae, GI6320893, Length=501, Percent_Identity=25.3493013972056, Blast_Score=143, Evalue=1e-34,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88272; Mature: 88272
Theoretical pI: Translated: 5.37; Mature: 5.37
Prosite motif: PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVMKFGGTSLANWQRFDMAAAIVAEAAKASQVAAVLSAPATVTNGLLDMVDVAVTGGDY CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH QAVLGRVVGVFEALFDDACQHQVPQCREHLFAALSAQKHAWQTRLEGVALLGECPDGVRA HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEE EIVVAGERLSTELMVALMNAHWLSADKLDPRALFLAHGTPLESVVDIGVSKPRFKQLPLD EEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCHHCCCCC SKRVWVMPGFTAADDKGRTVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVV CCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEE ADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPEAPGTLVSNAVD HHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHH ETGLQVKAISSLDNQTMFDVSGPGMKGMVGMASRTLGAIARAGVSVSLITQSSCEYSISF HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEE CVAGKDAAKVQSALEQEFELELKSELLEPLEMQSGLAIVSLIGDGMRTHKGVAAKFFSAL EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHHHHH AQASVNIRAIAQGSSERSISAVVEQRKVQNAIGACHQRFFDVQQYLDVFLVGAGNVGAGL HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH LAQVKNQAEALKEQHISIRVCGIANSRKMLLDERGIDLANWQGLLNDSETGCDLGAMLAW HHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHH AKEKQLLNPVLVDCTSSAAVADRYLEVMEAGMHVVTPNKKANTRDLGYYRALREAALRHR HHHHHHCCHHHEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHH RQFLYETNVGAGLPVIDNLKKLLCAGDKLHKFNGILSGSLSFIFGKLEEGMSLSEATSIA HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH RDKCFTEPDPRDDLSGMDVARKVLILAREVGMPLELEDVVVDSVLPASFDANGDVSTFMA HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH NLHKADTEIATMVENARSEGKVLRYVGQIDESGCRVSIQAVGPEAPLFSVKGGENALAFY HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCHHHHH SRYYQPIPFVLRGYGAGTDVTAAGAFADLLRTLNWTREVSL HHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHCCCC >Mature Secondary Structure MKVMKFGGTSLANWQRFDMAAAIVAEAAKASQVAAVLSAPATVTNGLLDMVDVAVTGGDY CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH QAVLGRVVGVFEALFDDACQHQVPQCREHLFAALSAQKHAWQTRLEGVALLGECPDGVRA HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEE EIVVAGERLSTELMVALMNAHWLSADKLDPRALFLAHGTPLESVVDIGVSKPRFKQLPLD EEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCHHCCCCC SKRVWVMPGFTAADDKGRTVTLGRNGSDYSAAVLAACLDASSCEIWTDVDGVYNTDPRVV CCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEE ADAKLLSQLSYQEAMELSYFGAKVLHPKTIAPIAQFHIPCYIKNSFNPEAPGTLVSNAVD HHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHH ETGLQVKAISSLDNQTMFDVSGPGMKGMVGMASRTLGAIARAGVSVSLITQSSCEYSISF HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEE CVAGKDAAKVQSALEQEFELELKSELLEPLEMQSGLAIVSLIGDGMRTHKGVAAKFFSAL EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHHHHH AQASVNIRAIAQGSSERSISAVVEQRKVQNAIGACHQRFFDVQQYLDVFLVGAGNVGAGL HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH LAQVKNQAEALKEQHISIRVCGIANSRKMLLDERGIDLANWQGLLNDSETGCDLGAMLAW HHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHH AKEKQLLNPVLVDCTSSAAVADRYLEVMEAGMHVVTPNKKANTRDLGYYRALREAALRHR HHHHHHCCHHHEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHH RQFLYETNVGAGLPVIDNLKKLLCAGDKLHKFNGILSGSLSFIFGKLEEGMSLSEATSIA HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH RDKCFTEPDPRDDLSGMDVARKVLILAREVGMPLELEDVVVDSVLPASFDANGDVSTFMA HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH NLHKADTEIATMVENARSEGKVLRYVGQIDESGCRVSIQAVGPEAPLFSVKGGENALAFY HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCHHHHH SRYYQPIPFVLRGYGAGTDVTAAGAFADLLRTLNWTREVSL HHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]