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The map label for this gene is thrC [H]

Identifier: 119774044

GI number: 119774044

Start: 1095784

End: 1097070

Strand: Direct

Name: thrC [H]

Synonym: Sama_0907

Alternate gene names: 119774044

Gene position: 1095784-1097070 (Clockwise)

Preceding gene: 119774043

Following gene: 119774045

Centisome position: 25.45

GC content: 54.55

Gene sequence:

>1287_bases
ATGGAATTATACAATCTTAAGCATCCCGATGAGCGGGTAAGCTTTTCTCAGGCGGTAAAGCTGGGACTGGGTAAAGACCG
CGGGCTGTTTTTCCCGACTCATATTCCCAAGCTGGATGATGTTGAAACCCTGCTGACTTTACCGTTTGCGCAGCGCAGTA
AAAAAATACTGGGTGCCTGGCTCGCTGATGAGTTGGGGCAAAATGTGGTGGATGCCCTGGTCGATAAAGCATTTACCTTT
GAGGTGCCGCTGGTCAAGGTAGACGACACGCGTTATTGCCTGGAGCTTTTCCACGGCCCGACTCTGGCATTCAAAGACTT
TGGTGCCCGCTTCATGGCCCAGTGCCTGAACGTGCTTGCCGGTGATGAACGGCTGACCATTCTCACCGCCACCTCAGGTG
ATACTGGGGCTGCTGTGGCCGACGCCTTCTATGGGCTCGATAAGGTGCAGGTCTGCGTGCTTTATCCAAAAGGCAAAATC
AGCCTGCTGCAGGAAAAGATGTTTACTACCCTCGGCAACAACATTCACACGGTGGCGGTTGAATCCGATTTTGACGCCTG
TCAGGCGCTGGTGAAACAGGCCTTTGATGATGCCGACGTCCGTGAAGGACTGCACCTTAATTCGGCTAACTCTATTAATA
TCAGTCGGTTGCTGGCACAGATCTGCTATTACTTCGAGGCCGTGGCTCAGTATCGCAAGAACTTTGTCGATGCACCGGTT
ATTGCCGTGCCCAGCGGCAACTTCGGTAATCTCACCGCTGGTTTCTTTGCCAAGGCCATGGGCCTGCCGGTGAAGCGTTT
TGTGGCCGCCACCAACAGCAACGACACTGTGCCGCGTTATCTCGCCAGCGCAAACTGGCAGGTCAATCCCACAGTGGCCA
CCATGTCCAATGCCATGGATGTGGCAGACCCCAGCAACTGGCCTCGTGTGGAAGCCATCGCCAAGGTCATGGGGTGGTCC
CTTGCTGAGATTGATGGGGTAGCACTGGACGAGCAACAAACCCGTTGTGCTTTGCTGGCATTGCAGGAAGATGGCTACTT
GTCCGAACCCCACGCGGCCATTGCTGCACAAGCGCTTAAGGCCACACTAGGCAAGGACGAGCGGGGTATTTTTCTCGGTA
CGGCTCATCCGGCGAAGTTCAAAGATGTGGTCGACCATGAGCTGTCTCTGGACTTGCCTTTACCCCCAGAGCTTGCGGCG
GTTGCTGACAAGCCGGTTCTGTCGGCCAATCTGGCGCCGGATTTTGCCGCACTCAAGACTCATTTGTTTGAAACCTTGCG
TCATTGA

Upstream 100 bases:

>100_bases
GCTGGAAGCCCATTATCTTACAGAGGGCGGTTTTGCCCACGTGTGCCGCCTGGATATGCAGGGCACCCGAGTCGTAGCGA
GTGAAGGTTAAGGATACGCG

Downstream 100 bases:

>100_bases
GCTGTGTAGCATTCACAAAAGGAGGCCCAGAAGCCTCCTTTTTTATGAAAAAGATCCCGCCAGCCATTTATCTTCAGCAA
TTCGGTAAAGCTTGACTAAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAWLADELGQNVVDALVDKAFTF
EVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLAGDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKI
SLLQEKMFTTLGNNIHTVAVESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMDVADPSNWPRVEAIAKVMGWS
LAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALKATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAA
VADKPVLSANLAPDFAALKTHLFETLRH

Sequences:

>Translated_428_residues
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAWLADELGQNVVDALVDKAFTF
EVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLAGDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKI
SLLQEKMFTTLGNNIHTVAVESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMDVADPSNWPRVEAIAKVMGWS
LAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALKATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAA
VADKPVLSANLAPDFAALKTHLFETLRH
>Mature_428_residues
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAWLADELGQNVVDALVDKAFTF
EVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLAGDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKI
SLLQEKMFTTLGNNIHTVAVESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMDVADPSNWPRVEAIAKVMGWS
LAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALKATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAA
VADKPVLSANLAPDFAALKTHLFETLRH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=440, Percent_Identity=30.4545454545455, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=31.350114416476, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=59.8574821852732, Blast_Score=488, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319901, Length=448, Percent_Identity=33.7053571428571, Blast_Score=203, Evalue=5e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46624; Mature: 46624

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAW
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
LADELGQNVVDALVDKAFTFEVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLA
HHHHHHHHHHHHHHCCCEEEECCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKISLLQEKMFTTLGNNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
ECCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMD
EEECCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHCCCCEECCHHHHHHCCCC
VADPSNWPRVEAIAKVMGWSLAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALK
CCCCCCCHHHHHHHHHHCCCHHHHCCCEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
ATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAAVADKPVLSANLAPDFAALKT
HHHCCCCCCEEEECCCCHHHHHHHCCCCEECCCCCCHHHHHCCCCCEECCCCCHHHHHHH
HLFETLRH
HHHHHHCC
>Mature Secondary Structure
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAW
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
LADELGQNVVDALVDKAFTFEVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLA
HHHHHHHHHHHHHHCCCEEEECCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
GDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKISLLQEKMFTTLGNNIHTVAV
CCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
ECCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMD
EEECCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHCCCCEECCHHHHHHCCCC
VADPSNWPRVEAIAKVMGWSLAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALK
CCCCCCCHHHHHHHHHHCCCHHHHCCCEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHH
ATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAAVADKPVLSANLAPDFAALKT
HHHCCCCCCEEEECCCCHHHHHHHCCCCEECCCCCCHHHHHCCCCCEECCCCCHHHHHHH
HLFETLRH
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]