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The map label for this gene is fumC1 [H]

Identifier: 119773959

GI number: 119773959

Start: 1005145

End: 1006518

Strand: Direct

Name: fumC1 [H]

Synonym: Sama_0822

Alternate gene names: 119773959

Gene position: 1005145-1006518 (Clockwise)

Preceding gene: 119773958

Following gene: 119773964

Centisome position: 23.34

GC content: 55.17

Gene sequence:

>1374_bases
ATGGATAGCCGGATTGAAACAGACAGCATGGGTGAGGTATTGGTGCCCGCCGAGGCACTCTATGGCGCGCAAACTCAGCG
GGCGCTGAACAACTTTGCCATTGGCGGCCAGCCGATGCCAAGGGCATTTATTGAGACGCTGTTGCTGATAAAGGCCGCAG
CAGCCCGTGCCAACAGCCAACTGGGCGTGCTGGCAAGTGATTGCGGCCAGGCTATCACCGAGGCGGCTTTATCCTTACGC
CAGGATAAGGCACTGATGCAACACTTCCCCGTGGATGTGTTTCAAACCGGCTCTGGCACCAGCAGCAACATGAATGCCAA
TGAAGTCTTGGCTCGGCTCACCTCAGAGAGTCTTGGTCGGGCTGTCAGTGCCAATGATGAGGTGAATCTTGGACAAAGCA
GCAACGATGTTATTCCAAGTTGTATTCAAATAGCTTCGGCAGGCGTGTTGACCAAGACCCTGCTGCCAGCCCTTACGCAT
CTTAAGTCCTGCATCAGAACCAAGGCGGCGAGCGTGAAGGGAGTCGTAAAAACCGGTCGAACCCATTTGATGGATGCCAT
GCCGGTGCGCTTGAGTCAGAGTTTGGAAACCTGGGCCAGCCAGTTGGATGCCAGAGAGCTGCAATTACAGTCGCAGCTCA
TATCCCTGTGGCAGTTACCCCAGGGAGGCACTGCTGTGGGAACCGGCGTTAATGCTGCGCCGGGATTCCCACAGGCGTTT
TGCCATGAGCTGAATTTGCTTACGGGCCTCGCATTTCAGCCCGCCCCACATCTGTTTACCGGCATTGCCAGCCAGGATAC
CGCAGTGGCTTTGTCCGGTGAACTCAAGGCACTGGCCGTTACCTTAATGAAAATTGCCAACGATTTGCGCTGGATGAACT
CGGGGCCACTGGCAGGTTTGGGGGAAATCCGCTTGCCTGCGCTGCAGCCTGGTTCCTCGATTATGCCCGGTAAGGTCAAT
CCGGTAATCCCTGAAGCGGTTGCCATGGCCTGCGCCCAGGTGATAGGCAATGATGCCTGCATCACTGTGGCTGGACAGTC
GGGTAATTTTGAGCTGAATGTGATGCTGCCAGTGATAGCAGATAACTTACTCTCATCACTCAGGCTTTTGACCAATGCCA
TGATGGCGTTGGCTGATAAGGCCATAGACGGGTTTGAGGTATGTGAAGGACGTATGGCCAAAGAGCTTAGCCGCAATCCG
ATTTTAGTGACAGCACTGAATCCGATTGTGGGTTACGCGAAAGCTGCCGACATTGCCAAGAGAGCGTACGCTGAAGGGCG
GCCAGTATTGGAGGTGGCGCTGGAGATGACCGACATAGACGCCGAAGAGTTGGCGAGGCTGCTTGACCCGGTTCGTTTGA
CGGGGCAGACATAA

Upstream 100 bases:

>100_bases
GCCGTGATTTGTTATCAGCTTGGCAACACAGTTCGCTGGCCATGTCTGGAGCCTGCCCGCCAGGCAACAGGCACAAACCA
TACGCAAACAGGACGTTATT

Downstream 100 bases:

>100_bases
CGTGATGCGCTGAAAACAAAAACGCCTGCAACAGCAGGCGTTTTTGTTTGAATTTGGTGGCCCCTCACGGACTTGAACCG
TGGACCTAACGATTATGAGT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MDSRIETDSMGEVLVPAEALYGAQTQRALNNFAIGGQPMPRAFIETLLLIKAAAARANSQLGVLASDCGQAITEAALSLR
QDKALMQHFPVDVFQTGSGTSSNMNANEVLARLTSESLGRAVSANDEVNLGQSSNDVIPSCIQIASAGVLTKTLLPALTH
LKSCIRTKAASVKGVVKTGRTHLMDAMPVRLSQSLETWASQLDARELQLQSQLISLWQLPQGGTAVGTGVNAAPGFPQAF
CHELNLLTGLAFQPAPHLFTGIASQDTAVALSGELKALAVTLMKIANDLRWMNSGPLAGLGEIRLPALQPGSSIMPGKVN
PVIPEAVAMACAQVIGNDACITVAGQSGNFELNVMLPVIADNLLSSLRLLTNAMMALADKAIDGFEVCEGRMAKELSRNP
ILVTALNPIVGYAKAADIAKRAYAEGRPVLEVALEMTDIDAEELARLLDPVRLTGQT

Sequences:

>Translated_457_residues
MDSRIETDSMGEVLVPAEALYGAQTQRALNNFAIGGQPMPRAFIETLLLIKAAAARANSQLGVLASDCGQAITEAALSLR
QDKALMQHFPVDVFQTGSGTSSNMNANEVLARLTSESLGRAVSANDEVNLGQSSNDVIPSCIQIASAGVLTKTLLPALTH
LKSCIRTKAASVKGVVKTGRTHLMDAMPVRLSQSLETWASQLDARELQLQSQLISLWQLPQGGTAVGTGVNAAPGFPQAF
CHELNLLTGLAFQPAPHLFTGIASQDTAVALSGELKALAVTLMKIANDLRWMNSGPLAGLGEIRLPALQPGSSIMPGKVN
PVIPEAVAMACAQVIGNDACITVAGQSGNFELNVMLPVIADNLLSSLRLLTNAMMALADKAIDGFEVCEGRMAKELSRNP
ILVTALNPIVGYAKAADIAKRAYAEGRPVLEVALEMTDIDAEELARLLDPVRLTGQT
>Mature_457_residues
MDSRIETDSMGEVLVPAEALYGAQTQRALNNFAIGGQPMPRAFIETLLLIKAAAARANSQLGVLASDCGQAITEAALSLR
QDKALMQHFPVDVFQTGSGTSSNMNANEVLARLTSESLGRAVSANDEVNLGQSSNDVIPSCIQIASAGVLTKTLLPALTH
LKSCIRTKAASVKGVVKTGRTHLMDAMPVRLSQSLETWASQLDARELQLQSQLISLWQLPQGGTAVGTGVNAAPGFPQAF
CHELNLLTGLAFQPAPHLFTGIASQDTAVALSGELKALAVTLMKIANDLRWMNSGPLAGLGEIRLPALQPGSSIMPGKVN
PVIPEAVAMACAQVIGNDACITVAGQSGNFELNVMLPVIADNLLSSLRLLTNAMMALADKAIDGFEVCEGRMAKELSRNP
ILVTALNPIVGYAKAADIAKRAYAEGRPVLEVALEMTDIDAEELARLLDPVRLTGQT

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=41.9565217391304, Blast_Score=345, Evalue=4e-95,
Organism=Escherichia coli, GI1787896, Length=433, Percent_Identity=46.189376443418, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI87082375, Length=444, Percent_Identity=39.4144144144144, Blast_Score=278, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=42.8260869565217, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=42.3312883435583, Blast_Score=275, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=43.1372549019608, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=41.7391304347826, Blast_Score=358, Evalue=6e-99,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=41.7391304347826, Blast_Score=357, Evalue=8e-99,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=41.648590021692, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=42.4568965517241, Blast_Score=351, Evalue=7e-97,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=38.2289416846652, Blast_Score=322, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48107; Mature: 48107

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSRIETDSMGEVLVPAEALYGAQTQRALNNFAIGGQPMPRAFIETLLLIKAAAARANSQ
CCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LGVLASDCGQAITEAALSLRQDKALMQHFPVDVFQTGSGTSSNMNANEVLARLTSESLGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC
AVSANDEVNLGQSSNDVIPSCIQIASAGVLTKTLLPALTHLKSCIRTKAASVKGVVKTGR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
THLMDAMPVRLSQSLETWASQLDARELQLQSQLISLWQLPQGGTAVGTGVNAAPGFPQAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHH
CHELNLLTGLAFQPAPHLFTGIASQDTAVALSGELKALAVTLMKIANDLRWMNSGPLAGL
HHHHHHHHCCCCCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GEIRLPALQPGSSIMPGKVNPVIPEAVAMACAQVIGNDACITVAGQSGNFELNVMLPVIA
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHH
DNLLSSLRLLTNAMMALADKAIDGFEVCEGRMAKELSRNPILVTALNPIVGYAKAADIAK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
RAYAEGRPVLEVALEMTDIDAEELARLLDPVRLTGQT
HHHHCCCCHHHHHHHHHCCCHHHHHHHHCCHHCCCCC
>Mature Secondary Structure
MDSRIETDSMGEVLVPAEALYGAQTQRALNNFAIGGQPMPRAFIETLLLIKAAAARANSQ
CCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LGVLASDCGQAITEAALSLRQDKALMQHFPVDVFQTGSGTSSNMNANEVLARLTSESLGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC
AVSANDEVNLGQSSNDVIPSCIQIASAGVLTKTLLPALTHLKSCIRTKAASVKGVVKTGR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
THLMDAMPVRLSQSLETWASQLDARELQLQSQLISLWQLPQGGTAVGTGVNAAPGFPQAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHH
CHELNLLTGLAFQPAPHLFTGIASQDTAVALSGELKALAVTLMKIANDLRWMNSGPLAGL
HHHHHHHHCCCCCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
GEIRLPALQPGSSIMPGKVNPVIPEAVAMACAQVIGNDACITVAGQSGNFELNVMLPVIA
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHH
DNLLSSLRLLTNAMMALADKAIDGFEVCEGRMAKELSRNPILVTALNPIVGYAKAADIAK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
RAYAEGRPVLEVALEMTDIDAEELARLLDPVRLTGQT
HHHHCCCCHHHHHHHHHCCCHHHHHHHHCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]