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The map label for this gene is hldE

Identifier: 119773869

GI number: 119773869

Start: 899468

End: 900898

Strand: Direct

Name: hldE

Synonym: Sama_0731

Alternate gene names: 119773869

Gene position: 899468-900898 (Clockwise)

Preceding gene: 119773867

Following gene: 119773870

Centisome position: 20.89

GC content: 59.19

Gene sequence:

>1431_bases
ATGAAGGTTACGCTGCCAGCTTTTGAGAAGGCCCGGGTTTTGGTTGTTGGGGATGTGATGTTGGACCGCTACTGGGTGGG
ACCGACCGGACGTATCTCCCCCGAAGCCCCTGTGCCCGTGGTGCGCATCAATCAGATTGAAGACAGGCCAGGCGGCGCTG
CCAACGTGGCGCTGAACATCGCGGCCCTGGGTGGCAAGGTACAGCTCTCAGGCCTTGTGGGACAGGATGATACCGCAGAT
GCGTTGACCCGCGGGGTGCAGGCACTTGGCGTAGAACCCCATTGGTTGGTGGTGGAAGATAAGCCGACCATCACCAAGCT
CAGGGTGTTGTCCCGCAACCAGCAGCTTATCCGACTCGACTTTGAAGAAGCCTTCGACAAACACAGCAGTGACGCGCTGC
TGAATCAAGCGCAAGCCCGGCTCGATGACGTGGACGTGGTTATCCTGTCGGACTATGCCAAGGGCGCCGTGGGTGAGCCC
GCCGACTTTATTGCCAGCGCCCGCGCCAAAGGGGTGAAGGTACTGGTGGACCCGAAGGGCAGTGACTTTGCCCGCTACCG
TGGCGCAACCCTGCTGACTCCGAACATGAGCGAATTTGAAGCCGTGGTAGGGACTGTCACCAGTGAAGCGGATCTGGTTG
ATAAGGCCCAAAAGCTGCTTCAGGATCTGGCCTTGGATGCGCTGCTGGTGACCCGCTCCGAAAAGGGTATGACCCTGATT
ACCCCCAATGCGCCCGAGCTGCATATTCCCACCGTTGCCCGTGAGGTGTACGACGTCACTGGTGCCGGTGATACCGTGAT
TTCGGCGCTGGCGACGGCTCTCGGCGCTGGCGCTGAGCTGCCGCAGGCCTGTGCCATCGCCAATACCGCTGCCGGTGTGG
TGGTGGGCAAGCTGGGTACCTCAACAGTAAGCCGTATTGAACTGATTGAAGCCCTGAAATCCCATCAGGGTGAGTCTGGC
ATTGGCGTGGTCAGTGAAGATCAACTGGTGTATGCCCTGGAGCAGGCCAAACTTCGTGGTGAGCGGGTGGTCATGACCAA
CGGCTGTTTTGACATTCTCCACGCAGGCCATGTGAGTTATCTGGCTCAAGCCAAGGCGCTCGGCGATCGCCTGATAGTGG
CCGTGAATGACGATGACTCTGTGCGCCGTTTGAAAGGGGATGGCCGTCCTGTGAACTCAGTCGATCGTCGTATGGCGGTG
CTGGCCGGGCTTGCCTCGGTGGACTGGGTGGTGCCCTTCAGTGAAGACACGCCCCAGCGGGTTATTGCCAGACTCTTGCC
AGACCTCCTGGTAAAGGGTGGCGACTATAAGGTGGAAGACATTGCCGGTGGCGCCGAAGTGATTGCCAATGGTGGCCAGG
TGAAGGTGCTTGGTTTTGAAGATGGGGTGTCGACCACAGCCATCATTCAGAACATCATGAGCCGCCACTGA

Upstream 100 bases:

>100_bases
TTGCAAAAATTCGTGCTTATTCTAACGCAAAACATGCGCAACAGCGGGAGAAAATTGGGTACAATCCGCTTTTAGTTTCG
GCAAATTCAATGTGAGTACT

Downstream 100 bases:

>100_bases
TGCCGTGGCGACTGACACTGAATCTGCTGCTGTTGATGGCCTGTTGTGGCCTTAATGCGGCGCAGTTCAGTGGCAGTCTA
CAGGGCCATAAACAGCTGAC

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNIAALGGKVQLSGLVGQDDTAD
ALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLDFEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEP
ADFIASARAKGVKVLVDPKGSDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLI
TPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGTSTVSRIELIEALKSHQGESG
IGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSYLAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAV
LAGLASVDWVVPFSEDTPQRVIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH

Sequences:

>Translated_476_residues
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNIAALGGKVQLSGLVGQDDTAD
ALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLDFEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEP
ADFIASARAKGVKVLVDPKGSDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLI
TPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGTSTVSRIELIEALKSHQGESG
IGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSYLAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAV
LAGLASVDWVVPFSEDTPQRVIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH
>Mature_476_residues
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNIAALGGKVQLSGLVGQDDTAD
ALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLDFEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEP
ADFIASARAKGVKVLVDPKGSDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLI
TPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGTSTVSRIELIEALKSHQGESG
IGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSYLAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAV
LAGLASVDWVVPFSEDTPQRVIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=472, Percent_Identity=63.135593220339, Blast_Score=587, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_SHEAM (A1S3I3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926609.1
- ProteinModelPortal:   A1S3I3
- SMR:   A1S3I3
- STRING:   A1S3I3
- GeneID:   4602984
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0731
- NMPDR:   fig|326297.7.peg.685
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- PhylomeDB:   A1S3I3
- ProtClustDB:   PRK11316
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 50402; Mature: 50402

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNI
CEEECCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEE
AALGGKVQLSGLVGQDDTADALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLD
EEECCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCEEEEEE
FEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEPADFIASARAKGVKVLVDPKG
HHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEEEEECCCC
SDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLI
CCHHHHCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
TPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGT
CCCCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEECCCC
STVSRIELIEALKSHQGESGIGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSY
HHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
LAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAVLAGLASVDWVVPFSEDTPQR
HHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHH
VIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH
HHHHHHHHHHHCCCCEEEHHHCCCHHHEECCCEEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNI
CEEECCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEE
AALGGKVQLSGLVGQDDTADALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLD
EEECCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCEEEEEE
FEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEPADFIASARAKGVKVLVDPKG
HHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCEEEEECCCC
SDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLI
CCHHHHCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
TPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGT
CCCCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEECCCC
STVSRIELIEALKSHQGESGIGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSY
HHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
LAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAVLAGLASVDWVVPFSEDTPQR
HHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHH
VIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH
HHHHHHHHHHHCCCCEEEHHHCCCHHHEECCCEEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA