Click here to switch to the map view.

The map label for this gene is cvrA [H]

Identifier: 119773867

GI number: 119773867

Start: 896674

End: 898392

Strand: Direct

Name: cvrA [H]

Synonym: Sama_0729

Alternate gene names: 119773867

Gene position: 896674-898392 (Clockwise)

Preceding gene: 119773863

Following gene: 119773869

Centisome position: 20.82

GC content: 57.71

Gene sequence:

>1719_bases
ATGATTGCAGAAAACATGAATTTGTTGTTTTTGGTCGGCGCCTTGCTGGTGGGACTCAGTGTGGTGTTAAGCCCACTGTC
TTCGCGCTTGGGGGTACCCATATTGCTGGTATTCCTCGGCGTGGGGATCCTCGCCGGAGAGGATGGCCCCGGCGGTATAC
AATTCAACGATTATTCCACGGCCTATCTGGTGAGCAACCTGGCGCTGGCGGTTATCCTGTTGGATGGTGGCCTTCGAACC
AAGATGAGCAGCTTCAGGCTGGCGCTCTGGCCTTCGCTTTCCCTGGCGACACTTGGTGTGGCCATTACCACTGTATTAAC
CGGCTTGCTGGCTGCCTGGCTGTTCGACCTGAATTTGCTTATGGGGCTGCTGATTGGCGCCATTGTTGGCAGTACCGATG
CGGCTGCCGTGTTTTCGCTGCTTAAGGGCAGGGCACTGAACGAGCGCGTGGGTTCGACCCTTGAAATTGAGTCGGGCAGT
AACGACCCCATGGCCGTGTTTCTCACTGTTAGCCTGATTGCCATGATAGCCGCAGGCGGGAACTTTGATGGTCCCGGGCT
GATGCGCGACCTGGCGCTTCAGGCCGGTATGGGGTTGGCCGCGGGTTTTGGTGGTGGGTACCTGATATGGCATCTCGTCA
ATCGCAGCGTGTTGGCAGATGGGCTCTATCCCATTTTGGTGCTGGCGGGCGGCCTGTTGCTGTTTGCCCTGTCCAGTTTG
GCCGGTGGCAGCGGTATCCTGTCTATCTACCTCTATGGTCTGTTTCTTGGTAATCGTGGCATGCGCGGTAAGCACAGTAC
CCTGGCGGTGATGGACGGCCTGACCTGGTTGGCACAGATTGGCATGTTCCTGGTGCTGGGACTACTGCTGACGCCTTCAT
CATTGCTCGAGGTCCTGTTGCCCGGGTTGGTGCTGGCGCTGGGGATGATATTTATTGCCCGGCCACTGGCAGTGTGGATA
AGCCTGGCGCCCTTCAAGCGTTTTGTGGCGCGGGAGCGCTGGTTTATCAGTTGGGTGGGGCTCAGGGGAGCTGTGCCCAT
TATTCTGGCGGTATTCCCCATGATGGCCGGTCTACCCAATGCCGAGCTCTACTTCAACCTGGCCTTTTGTGTGGTGCTGG
TATCTTTACTGCTCCAGGGGTCTACCTTGCCGCTGGCGATGAAGCTCGCCAGGGTAGGGTTGCCGCCCAAGCCAGAGCCC
ATCAGCCGCGCGGGTGTCGACATCTTTCCAGCCAGCGAGTGGGAAATTTTTGTCTATCGCCTCAAACCCAATAAGTGGTG
TGTGGGCGAGCCCTTAAGGCGTTTGTCTATGCCGGAAGGAACCCGCATCGCGGCGCTGTTCAGGGAACATAATTTGCTGC
ACCCCTCGGGCAGTACCGAGCTTGCTGCCGACGATGTGCTGTGCGTGCTGGGCCAGGCCAAAGACTTGCCCGCCCTCAGT
CAGCTCTTCAGTGAGGCGCCGGAAAACCCTGCCATGGCAGGCTTTTTTGGTGACTTTATGTTGGCTACTTCGGTACGTCT
TGCGGATTTGGCGCCGCTTTATGGCTTTGGCCTGCATGAAGACGAAGTGGGGCTGACTCTGGAAGACCTGATGCACCAAA
AGCTGGGTCGCAACCCGGTAGAGGGTGACAGCTTTGAGTGGCAGGGCTGTGATTGGGTGGTGCGTACCATGGAAGGGGAT
TGTCCAACCTGCCTTGGTTTGAAGCTCAAGGCAGGCTGA

Upstream 100 bases:

>100_bases
GGAATTCTATTTTGGGGTTTCGACATTAAATTTGCTTTAAAAAGTCATTATGTCGCACATTGTCTGTATAATTGTCGCGA
TTTATTGATGTGGAGGCGCA

Downstream 100 bases:

>100_bases
GCTGCTGATACCTAACGCGAATTCGAGACGCTGTTACTTGTAGAGCGAAGGCGCATCCTGCTCCGGGCGCGTCTTGAAGC
GGCGATGCAGCCACATGTAT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYSTAYLVSNLALAVILLDGGLRT
KMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLLMGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGS
NDPMAVFLTVSLIAMIAAGGNFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLLPGLVLALGMIFIARPLAVWI
SLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPNAELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEP
ISRAGVDIFPASEWEIFVYRLKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPVEGDSFEWQGCDWVVRTMEGD
CPTCLGLKLKAG

Sequences:

>Translated_572_residues
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYSTAYLVSNLALAVILLDGGLRT
KMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLLMGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGS
NDPMAVFLTVSLIAMIAAGGNFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLLPGLVLALGMIFIARPLAVWI
SLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPNAELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEP
ISRAGVDIFPASEWEIFVYRLKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPVEGDSFEWQGCDWVVRTMEGD
CPTCLGLKLKAG
>Mature_572_residues
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYSTAYLVSNLALAVILLDGGLRT
KMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLLMGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGS
NDPMAVFLTVSLIAMIAAGGNFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLLPGLVLALGMIFIARPLAVWI
SLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPNAELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEP
ISRAGVDIFPASEWEIFVYRLKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPVEGDSFEWQGCDWVVRTMEGD
CPTCLGLKLKAG

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=571, Percent_Identity=57.968476357268, Blast_Score=570, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 60842; Mature: 60842

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCCEEECCCCH
AYLVSNLALAVILLDGGLRTKMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLL
HHHHHHHHHEEEEECCCCHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGSNDPMAVFLTVSLIAMIAAGG
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
NFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
CCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLL
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
PGLVLALGMIFIARPLAVWISLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCC
AELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEPISRAGVDIFPASEWEIFVYR
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEE
LKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
ECCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
EGDSFEWQGCDWVVRTMEGDCPTCLGLKLKAG
CCCCCCCCCCHHHEEECCCCCCCEECCEEECC
>Mature Secondary Structure
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCCEEECCCCH
AYLVSNLALAVILLDGGLRTKMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLL
HHHHHHHHHEEEEECCCCHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGSNDPMAVFLTVSLIAMIAAGG
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
NFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
CCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLL
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
PGLVLALGMIFIARPLAVWISLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCC
AELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEPISRAGVDIFPASEWEIFVYR
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEE
LKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
ECCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
EGDSFEWQGCDWVVRTMEGDCPTCLGLKLKAG
CCCCCCCCCCHHHEEECCCCCCCEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]